{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:31:50Z","timestamp":1790087510934,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jgar.2020.03.011","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T11:10:54Z","timestamp":1585739454000},"page":"477-482","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["High prevalence of blaCMY AmpC beta-lactamase in ESBL co-producing Escherichia coli and Klebsiella spp. clinical isolates in the northeast of Iran"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4392-285X","authenticated-orcid":false,"given":"Kobra Salimiyan","family":"Rizi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8408-4664","authenticated-orcid":false,"given":"Arman","family":"Mosavat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Youssefi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid Amel","family":"Jamehdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiarash","family":"Ghazvini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Safdari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Amini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4738-0245","authenticated-orcid":false,"given":"Hadi","family":"Farsiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2020.03.011_bib0005","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.drup.2006.05.005","article-title":"What\u2019s new in antibiotic resistance? Focus on beta-lactamases","volume":"9","author":"Babic","year":"2006","journal-title":"Drug Resist Update"},{"key":"10.1016\/j.jgar.2020.03.011_bib0010","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s15010-019-01291-9","article-title":"AmpC \u03b2-lactamase-producing Enterobacterales: what a clinician should know","volume":"47","author":"Meini","year":"2019","journal-title":"Infection"},{"key":"10.1016\/j.jgar.2020.03.011_bib0015","article-title":"ESBLs: a clear and present danger?","volume":"2012","author":"RH-P","year":"2012","journal-title":"Crit Care Res Pract"},{"key":"10.1016\/j.jgar.2020.03.011_bib0020","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/CMR.00036-08","article-title":"AmpC \u03b2-lactamases","volume":"22","author":"Jacoby","year":"2009","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jgar.2020.03.011_bib0025","first-page":"13","article-title":"AmpC beta-lactamase producing multidrug resistant strains of Klebsiella spp. and Escherichia coli isolated from children under five in Chennai","volume":"117","author":"Subha","year":"2003","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.jgar.2020.03.011_bib0030","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/BF01650718","article-title":"Extended broad spectrum \u03b2-lactamase in Klebsiella pneumoniae including resistance to cephamycins","volume":"17","author":"Bauernfeind","year":"1989","journal-title":"Infection"},{"key":"10.1016\/j.jgar.2020.03.011_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/AAC.46.1.1-11.2002","article-title":"Plasmid-determined AmpC-type beta-lactamases","volume":"46","author":"Philippon","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2020.03.011_bib0040","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1007\/s10096-014-2305-6","article-title":"The MAST(R) D68C test: an interesting tool for detecting extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae","volume":"34","author":"Nourrisson","year":"2015","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jgar.2020.03.011_bib0045","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4103\/0974-777X.68531","article-title":"Extended-spectrum \u03b2-lactamases in Gram negative bacteria","volume":"2","author":"Rawat","year":"2010","journal-title":"J Glob Infect Dis"},{"key":"10.1016\/j.jgar.2020.03.011_bib0050","article-title":"Phenotypic and molecular characterization of plasmid mediated AmpC \u03b2-lactamases among Escherichia coli, Klebsiella spp., and Proteus mirabilis isolated from urinary tract infections in Egyptian hospitals","volume":"2014","author":"Helmy","year":"2014","journal-title":"Bio Med Res Int"},{"key":"10.1016\/j.jgar.2020.03.011_bib0055","series-title":"Antibiotics in laboratory medicine","author":"Lorian","year":"2005"},{"key":"10.1016\/j.jgar.2020.03.011_bib0060","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1128\/JCM.41.2.772-777.2003","article-title":"Occurrence of extended-spectrum and AmpC beta-lactamases in bloodstream isolates of Klebsiella pneumoniae: isolates harbor plasmid-mediated FOX-5 and ACT-1 AmpC beta-lactamases","volume":"41","author":"Coudron","year":"2003","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2020.03.011_bib0065","article-title":"Genotypic and phenotypic detection of AmpC \u03b2-lactamases in Enterobacter spp. isolated from a teaching hospital in Malaysia","volume":"11","author":"Khari","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jgar.2020.03.011_bib0070","series-title":"EUCAST guidelines for detection of resistance mechanisms and specific resistances of clinical and\/or epidemiological importance. Version 1.0 (2013-12-11); 2013","author":"Giske","year":"2017"},{"key":"10.1016\/j.jgar.2020.03.011_bib0075","doi-asserted-by":"crossref","first-page":"139","DOI":"10.4103\/0377-4929.40428","article-title":"Prevalence of extended-spectrum \u03b2-lactamases among Escherichia coli and Klebsiella pneumoniae isolates in a tertiary care hospital","volume":"51","author":"Agrawal","year":"2008","journal-title":"Indian J Pathol Microbiol"},{"key":"10.1016\/j.jgar.2020.03.011_bib0080","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1128\/JCM.40.6.2153-2162.2002","article-title":"Detection of plasmid-mediated AmpC \u03b2-lactamase genes in clinical isolates by using multiplex PCR","volume":"40","author":"P\u00e9rez-P\u00e9rez","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2020.03.011_bib0085","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.idc.2016.02.004","article-title":"Multidrug-resistant bacteria in the community: trends and lessons learned","volume":"30","author":"van Duin","year":"2016","journal-title":"Infect Dis Clin North Am"},{"key":"10.1016\/j.jgar.2020.03.011_bib0090","first-page":"11","article-title":"Prevalence of extended spectrum beta-lactamase, AmpC beta-lactamase and metallo-beta-lactamase enzymes among clinical isolates recovered from patients with urinary tract infections in Benin City","volume":"72","author":"Ibadin","year":"2018","journal-title":"Nigeria. New Zeal J Med Lab Sci"},{"key":"10.1016\/j.jgar.2020.03.011_bib0095","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1590\/S1517-83822010000300009","article-title":"AmpC beta lactamases among Gram negative clinical isolates from a tertiary hospital, South India","volume":"41","author":"Mohamudha","year":"2010","journal-title":"Braz J Microbiol"},{"key":"10.1016\/j.jgar.2020.03.011_bib0100","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jgar.2018.05.016","article-title":"High prevalence of sequence type 131 isolates producing CTX-M-15 among extended-spectrum \u03b2-lactamase-producing Escherichia coli strains in northeast Iran","volume":"15","author":"Moghanni","year":"2018","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.jgar.2020.03.011_bib0105","first-page":"513","article-title":"Carbapenem-sparing options for the treatment of ESBL-and AmpC-producing Enterobacteriaceae in hemodynamically stable patients \u2013 an in vitro study","volume":"4","author":"Amreliwala","year":"2015","journal-title":"Int J Curr Microbiol Appl Sci"},{"key":"10.1016\/j.jgar.2020.03.011_bib0110","doi-asserted-by":"crossref","first-page":"e00079","DOI":"10.1128\/CMR.00079-17","article-title":"Treatment of infections caused by extended-spectrum-beta-lactamase-, AmpC-, and carbapenemase-producing Enterobacteriaceae","volume":"31","author":"Rodr\u00edguez-Ba\u00f1o","year":"2018","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jgar.2020.03.011_bib0115","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1128\/AAC.49.1.358-365.2005","article-title":"Molecular characterization of cefoxitin-resistant Escherichia coli from Canadian hospitals","volume":"49","author":"Mulvey","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2020.03.011_bib0120","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.phrp.2015.02.001","article-title":"High prevalence of AmpC \u03b2-lactamases in clinical isolates of Escherichia coli in Ilam, Iran","volume":"6","author":"Maleki","year":"2015","journal-title":"Osong Public Health Res Perspect"},{"key":"10.1016\/j.jgar.2020.03.011_bib0125","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1099\/jmm.0.029140-0","article-title":"Comparison of methods for AmpC \u03b2-lactamase detection in Enterobacteriaceae","volume":"60","author":"Ingram","year":"2011","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jgar.2020.03.011_bib0130","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4103\/0971-5916.93433","article-title":"Molecular description of plasmid-mediated AmpC \u03b2-lactamases among nosocomial isolates of Escherichia coli and Klebsiella pneumoniae from six different hospitals in India","volume":"135","author":"Mohamudha","year":"2012","journal-title":"Indian J Med Res"},{"issue":"12","key":"10.1016\/j.jgar.2020.03.011_bib0135","doi-asserted-by":"crossref","DOI":"10.5812\/jjm.39121","article-title":"Prevalence of AmpC \u03b2-lactamase in clinical isolates of Escherichia coli, Klebsiella spp., and Proteus mirabilis in a Tertiary Hospital in Tehran, Iran","volume":"9","author":"Saffar","year":"2016","journal-title":"Jundishapur J Microbiol"},{"key":"10.1016\/j.jgar.2020.03.011_bib0140","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/171548","article-title":"Phenotypic and molecular characterization of plasmid mediated AmpC beta-lactamases among Escherichia coli, Klebsiella spp., and Proteus mirabilis isolated from urinary tract infections in Egyptian hospitals","volume":"2014","author":"Helmy","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.jgar.2020.03.011_bib0145","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1007\/s10096-016-2752-3","article-title":"Bloodstream infections caused by Escherichia coli producing AmpC \u03b2-lactamases: epidemiology and clinical features","volume":"35","author":"Pascual","year":"2016","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"10","key":"10.1016\/j.jgar.2020.03.011_bib0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204864","article-title":"Decline in AmpC \u03b2-lactamase-producing Escherichia coli in a Dutch teaching hospital (2013\u20132016)","volume":"13","author":"den Drijver","year":"2018","journal-title":"PLoS ONE"},{"issue":"8","key":"10.1016\/j.jgar.2020.03.011_bib0155","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofz353","article-title":"Molecular epidemiology of ceftriaxone-nonsusceptible Enterobacterales isolates in an academic medical center in the United States","volume":"6","author":"Tamma","year":"2019","journal-title":"Open Forum Infect Dis"},{"issue":"3","key":"10.1016\/j.jgar.2020.03.011_bib0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120688","article-title":"Microbiological screening is necessary to distinguish carriers of plasmid-mediated AmpC beta-lactamase-producing enterobacteriaceae and extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae because of clinical similarity","volume":"10","author":"Conen","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jgar.2020.03.011_bib0165","first-page":"359","article-title":"Phenotypic and molecular characterization of AmpC beta-lactamases among Escherichia coli, Klebsiella spp. and Enterobacter spp. from five Indian Medical Centers","volume":"135","author":"Manoharan","year":"2012","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.jgar.2020.03.011_bib0170","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.diagmicrobio.2007.07.018","article-title":"Prevalence of AmpC and other beta-lactamases in enterobacteria at a large urban university hospital in Brazil","volume":"60","author":"da Silva Dias","year":"2008","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jgar.2020.03.011_bib0175","first-page":"53","article-title":"Detection of plasmid-mediated AmpC beta-lactamase in Escherichia coli and Klebsiella pneumoniae","volume":"31","author":"Yilmaz","year":"2013","journal-title":"Indian J Med"},{"key":"10.1016\/j.jgar.2020.03.011_bib0180","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4103\/1947-2714.103315","article-title":"Bacteriological and resistance profile in isolates from diabetic patients","volume":"4","author":"Rawat","year":"2012","journal-title":"N Am J Med Sci"},{"key":"10.1016\/j.jgar.2020.03.011_bib0185","doi-asserted-by":"crossref","first-page":"e4817","DOI":"10.1371\/journal.pone.0004817","article-title":"Efflux pump, the masked side of beta-lactam resistance in Klebsiella pneumoniae clinical isolates","volume":"4","author":"Pages","year":"2009","journal-title":"PLoS ONE"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716520300758?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716520300758?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:01:31Z","timestamp":1761991291000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716520300758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":37,"alternative-id":["S2213716520300758"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2020.03.011","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High prevalence of blaCMY AmpC beta-lactamase in ESBL co-producing Escherichia coli and Klebsiella spp. clinical isolates in the northeast of Iran","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2020.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}