{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:19:43Z","timestamp":1791688783708,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372998"],"award-info":[{"award-number":["81372998"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902066"],"award-info":[{"award-number":["81902066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2017CFB238"],"award-info":[{"award-number":["2017CFB238"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010228","name":"Natural Science Foundation of Shaanxi Provincial Department of Education","doi-asserted-by":"publisher","award":["B2019113"],"award-info":[{"award-number":["B2019113"]}],"id":[{"id":"10.13039\/501100010228","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jgar.2020.06.022","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T02:06:24Z","timestamp":1594173984000},"page":"835-841","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Occurrence of two NDM-1-producing Raoultella ornithinolytica and Enterobacter cloacae in a single patient in China: probable a novel antimicrobial resistance plasmid transfer in vivo by conjugation"],"prefix":"10.1016","volume":"22","author":[{"given":"Chunfang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huailan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiong","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2020.06.022_bib0005","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0140-6736(84)91368-0","article-title":"Klebsiella trevisanii colonisation and septicaemia","volume":"1","author":"Freney","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.jgar.2020.06.022_bib0010","doi-asserted-by":"crossref","first-page":"3462","DOI":"10.1128\/AEM.68.7.3462-3466.2002","article-title":"Klebsiella pneumoniae produces no histamine: raoultella planticola and Raoultella ornithinolytica strains are histamine producers","volume":"68","author":"Kanki","year":"2002","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jgar.2020.06.022_bib0015","doi-asserted-by":"crossref","first-page":"3193","DOI":"10.2169\/internalmedicine.51.8349","article-title":"Raoultella ornithinolytica bacteremia in cancer patients: report of three cases","volume":"51","author":"Hadano","year":"2012","journal-title":"Intern Med"},{"key":"10.1016\/j.jgar.2020.06.022_bib0020","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jiac.2014.05.005","article-title":"Clinical characteristics of Raoultella ornithinolytica bacteremia: a case series and literature review","volume":"20","author":"Haruki","year":"2014","journal-title":"J Infect Chemother"},{"key":"10.1016\/j.jgar.2020.06.022_bib0025","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4103\/0256-4947.75794","article-title":"A rare human infection of Raoultella ornithinolytica in a diabetic foot lesion","volume":"31","author":"Solak","year":"2011","journal-title":"Ann Saudi Med"},{"key":"10.1016\/j.jgar.2020.06.022_bib0030","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s15010-016-0930-y","article-title":"Septic arthritis of the knee due to Raoultella ornithinolytica","volume":"44","author":"Venus","year":"2016","journal-title":"Infection"},{"key":"10.1016\/j.jgar.2020.06.022_bib0035","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ijid.2016.02.014","article-title":"Emerging role of Raoultella ornithinolytica in human infections: a series of cases and review of the literature","volume":"45","author":"Seng","year":"2016","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jgar.2020.06.022_bib0040","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1097\/INF.0b013e31822bf4f6","article-title":"Raoultella infection causing fever of unknown origin","volume":"30","author":"Sener","year":"2011","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jgar.2020.06.022_bib0045","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s15010-014-0696-z","article-title":"Clinical characteristics of Raoultella ornithinolytica bacteremia","volume":"43","author":"Chun","year":"2015","journal-title":"Infection"},{"key":"10.1016\/j.jgar.2020.06.022_bib0050","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1128\/JCM.01709-08","article-title":"Enteric fever-like syndrome caused by Raoultella ornithinolytica (Klebsiella ornithinolytica)","volume":"47","author":"Morais","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2020.06.022_bib0055","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/INF.0b013e3181ce9227","article-title":"Raoultella ornithinolytica bacteremia in an infant with visceral heterotaxy","volume":"29","author":"Mau","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.jgar.2020.06.022_bib0060","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1399-302x.2004.00174.x","article-title":"Alkali-resistant bacteria in root canal systems","volume":"19","author":"Nakajo","year":"2004","journal-title":"Oral Microbiol Immunol"},{"issue":"12","key":"10.1016\/j.jgar.2020.06.022_bib0065","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1128\/AAC.00774-09","article-title":"Characterization of a new metallo-\u03b2-lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India","volume":"53","author":"Yong","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2020.06.022_bib0070","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S1473-3099(10)70143-2","article-title":"Emergence of a new antibiotic resistance mechanism in India, Pakistan and the UK: a molecular, biological, and epidemiological study","volume":"10","author":"Kumarasamy","year":"2010","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jgar.2020.06.022_bib0075","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1089\/mdr.2017.0230","article-title":"NDM-1 hazard in the Balkan States. Evidence of the first outbreak of NDM-1-Producing Klebsiella pneumoniae in Bulgaria","volume":"24","author":"Savov","year":"2018","journal-title":"Microb Drug Resist"},{"key":"10.1016\/j.jgar.2020.06.022_bib0080","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1089\/mdr.2014.0171","article-title":"Coproduction of NDM-1 and KPC-2 in Enterobacter hormaechei from Brazil","volume":"21","author":"Pereira","year":"2015","journal-title":"Microb Drug Resist"},{"key":"10.1016\/j.jgar.2020.06.022_bib0085","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1093\/jac\/dkr082","article-title":"Emergence of NDM-1-producing Acinetobacter baumannii in China","volume":"66","author":"Chen","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2020.06.022_bib0090","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.diagmicrobio.2013.01.006","article-title":"Emergence of blaNDM-1 among Klebsiella pneumoniae ST15 and novel ST1031 clinical isolates in China Diagn","volume":"75","author":"Hu","year":"2013","journal-title":"Microbiol Infect Dis"},{"key":"10.1016\/j.jgar.2020.06.022_bib0095","article-title":"Identification and characterization of the first Escherichia coli strain carrying NDM-1 gene in China","volume":"8","author":"Liu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jgar.2020.06.022_bib0100","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/jac\/dks192","article-title":"Epidemiological characteristics and genetic structure of blaNDM-1 in non-baumannii Acinetobacter spp. In China","volume":"67","author":"Fu","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2020.06.022_bib0105","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1089\/mdr.2013.0100","article-title":"An outbreak of a nosocomial NDM-1-producing Klebsiella pneumoniae ST147 at a teaching hospital in mainland China","volume":"20","author":"Wang","year":"2014","journal-title":"Microb Drug Resist"},{"key":"10.1016\/j.jgar.2020.06.022_bib0110","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/1471-2180-13-282","article-title":"First identification of coexistence of blaNDM-1 and blaCMY-42 among Escherichia coli ST167 clinical isolates","volume":"13","author":"Zhang","year":"2013","journal-title":"BMC Microbiol"},{"issue":"11","key":"10.1016\/j.jgar.2020.06.022_bib0115","first-page":"1873","article-title":"Outbreak of NDM-1-producting Klebsiella pnueumoniae ST571 isolates in a neonatal unit, China","volume":"21","author":"Jia","year":"2017","journal-title":"Chin J Lab Diagn"},{"issue":"9","key":"10.1016\/j.jgar.2020.06.022_bib0120","first-page":"818","article-title":"Analysis of the drug resistance of and detection of genes for carbapenem resistance in certain fermenting Enterobacteriaceae","volume":"12","author":"Wang","year":"2017","journal-title":"Journal of Pathogen Biology"},{"key":"10.1016\/j.jgar.2020.06.022_bib0125","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jgar.2019.10.025","article-title":"Genomic characterisation of a Proteus mirabilis clinical isolate from China carrying blaNDM-5 on an IncX3 plasmid","volume":"19","author":"Suna","year":"2019","journal-title":"J Glob Antimicrob Re"},{"key":"10.1016\/j.jgar.2020.06.022_bib0130","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/bioinformatics\/btm009","article-title":"Identifying bacterial genes and endosymbiont DNA with Glimmer","volume":"23","author":"Delcher","year":"2007","journal-title":"Bioinformatics"},{"issue":"6","key":"10.1016\/j.jgar.2020.06.022_bib0135","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1128\/AAC.01539-07","article-title":"Emergence of Serratia marcescens, Klebsiella pneumoniae, and Escherichia coli isolates possessing the plasmid-mediated carbapenem-hydrolyzing betalactamase KPC-2 in intensive care units of a Chinese hospital","volume":"52","author":"Cai","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2020.06.022_bib0140","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1128\/JB.01327-06","article-title":"Novel type IV secretion system involved in propagation of genomic islands","volume":"189","author":"Juhas","year":"2007","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jgar.2020.06.022_bib0145","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1111\/j.1462-5822.2008.01187.x","article-title":"Type IV secretion systems: tools of bacterial horizontal gene transfer and virulence","volume":"10","author":"Juhas","year":"2008","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.jgar.2020.06.022_bib0150","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1093\/nar\/25.24.4876","article-title":"The CLUSTAL_X Windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools","volume":"25","author":"Thompson","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jgar.2020.06.022_bib0155","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: molecular evolutionary genetics analysis (MEGA) software version 4.0","volume":"24","author":"Tamura","year":"2007","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.jgar.2020.06.022_bib0160","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1128\/JB.183.4.1495-1498.2001","article-title":"OmpC is the receptor for Gifsy-1 and Gifsy-2 bacteriophages of Salmonella","volume":"183","author":"Ho","year":"2001","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jgar.2020.06.022_bib0165","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1473-3099(11)70059-7","article-title":"Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: an environmental point prevalence study","volume":"11","author":"Walsh","year":"2011","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jgar.2020.06.022_bib0170","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/AAC.05116-11","article-title":"Evolution of IncA\/C blaCMY-2 carrying plasmids by acquisition of the blaNDM-1 carbapenemase gene","volume":"56","author":"Carattoli","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2020.06.022_bib0175","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1099\/jmm.0.057091-0","article-title":"Genetic characteristics of blaNDM-1-positive plasmid in Citrobacter freundii isolate separated from a clinical infectious patient","volume":"62","author":"Du","year":"2013","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.jgar.2020.06.022_bib0180","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1128\/AAC.05620-11","article-title":"Tn125-related acquisition and expression of blaNDM-like genes in Acinetobacter baumannii","volume":"56","author":"Poirel","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2020.06.022_bib0185","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1093\/jac\/dkr256","article-title":"Molecular characterization of blaNDM-1 in an Acinetobacter baumannii strain isolated in Germany in 2007","volume":"66","author":"Pfeifer","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2020.06.022_bib0190","doi-asserted-by":"crossref","first-page":"e89893","DOI":"10.1371\/journal.pone.0089893","article-title":"Sequential isolation in a patient of Raoultella planticola and Escherichia coli bearing a novel ISCR1 element carrying blaNDM-1","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jgar.2020.06.022_bib0195","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijid.2015.02.020","article-title":"NDM-1-producing Enterobacteriaceae in a teaching hospital in Shanghai, China: IncX3-type plasmids may contribute to the dissemination of blaNDM-1","volume":"34","author":"Qu","year":"2015","journal-title":"Int J Infect Dis"},{"key":"10.1016\/j.jgar.2020.06.022_bib0200","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1128\/JCM.00535-17","article-title":"Outbreak of NDM-1-Producing Klebsiella pneumoniae in a dutch hospital, with interspecies transfer of the resistance plasmid and unexpected occurrence in unrelated health care centers","volume":"55","author":"Bosch","year":"2017","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2020.06.022_bib0205","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1093\/jac\/dkw289","article-title":"Use of WGS data for investigation of a long-term NDM-1-producing Citrobacter freundii outbreak and secondary in vivo spread of blaNDM-1 to Escherichia coli, Klebsiella pneumoniae and Klebsiella oxytoca","volume":"71","author":"Hammerum","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2020.06.022_bib0210","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1093\/jac\/dkz542","article-title":"Occurrence of NDM-1-producing Morganella morganii and Proteus mirabilis in a single patient in Portugal: probable in vivo transfer by conjugation","volume":"75","author":"Aires-de-Sousa","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2020.06.022_bib0215","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3201\/eid1402.070350","article-title":"Dissemination of clonally related Escherichia coli strains expressing extended-spectrum beta-lactamase CTX-M-15","volume":"14","author":"Coque","year":"2008","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jgar.2020.06.022_bib0220","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1128\/AAC.49.7.2949-2953.2005","article-title":"Worldwide disseminated armA aminoglycoside resistance methylase gene is borne by composite transposon Tn1548","volume":"49","author":"Galimand","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2020.06.022_bib0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-1097(03)00430-0","article-title":"Factor conjugation is a true type IV secretion system","volume":"224","author":"Lawley","year":"2003","journal-title":"FEMS Microbiol Lett"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716520301673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716520301673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:58:31Z","timestamp":1761991111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716520301673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":45,"alternative-id":["S2213716520301673"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2020.06.022","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Occurrence of two NDM-1-producing Raoultella ornithinolytica and Enterobacter cloacae in a single patient in China: probable a novel antimicrobial resistance plasmid transfer in vivo by conjugation","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2020.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}