{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:41:00Z","timestamp":1789663260884,"version":"4.0.1"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013794","name":"Department of Education, Shanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["201603D321063"],"award-info":[{"award-number":["201603D321063"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015401","name":"Key Research and Development Projects of Shaanxi Province","doi-asserted-by":"publisher","award":["201903D321123"],"award-info":[{"award-number":["201903D321123"]}],"id":[{"id":"10.13039\/501100015401","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.jgar.2020.11.013","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T12:24:21Z","timestamp":1606134261000},"page":"32-39","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Aspirin and verapamil increase the sensitivity of Candida albicans to caspofungin under planktonic and biofilm conditions"],"prefix":"10.1016","volume":"24","author":[{"given":"Wenli","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqin","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2020.11.013_bib0005","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/21505594.2014.1000752","article-title":"Looking into Candida albicans infection, host response, and antifungal strategies","volume":"6","author":"Wang","year":"2015","journal-title":"Virulence"},{"key":"10.1016\/j.jgar.2020.11.013_bib0010","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2174\/1871526515666150320162036","article-title":"Candidiasis: a fungal infection\u2014current challenges and progress in prevention and treatment","volume":"15","author":"Hani","year":"2015","journal-title":"Infect Disord Drug Targets"},{"key":"10.1016\/j.jgar.2020.11.013_bib0015","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/jac\/dku374","article-title":"In vitro interactions between farnesol and fluconazole, amphotericin B or micafungin against Candida albicans biofilms","volume":"70","author":"Katragkou","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2020.11.013_bib0020","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrmicro.2017.107","article-title":"Development and regulation of single- and multi-species Candida albicans biofilms","volume":"16","author":"Lohse","year":"2018","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jgar.2020.11.013_bib0025","doi-asserted-by":"crossref","first-page":"759","DOI":"10.2174\/1568026618666180528121707","article-title":"Emerging virulence, drug resistance and future anti-fungal drugs for Candida pathogens","volume":"18","author":"Srivastava","year":"2018","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.jgar.2020.11.013_bib0030","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jfda.2016.12.014","article-title":"Evaluation of synergistic anticandidal and apoptotic effects of ferulic acid and caspofungin against Candida albicans","volume":"26","author":"Canturk","year":"2018","journal-title":"J Food Drug Anal"},{"key":"10.1016\/j.jgar.2020.11.013_bib0035","doi-asserted-by":"crossref","first-page":"e01056","DOI":"10.1128\/AAC.01056-17","article-title":"In vitro interactions of echinocandins with triazoles against multidrug-resistant Candida auris","volume":"61","author":"Fakhim","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2020.11.013_bib0040","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1093\/jac\/dkw316","article-title":"In vitro activity of anidulafungin in combination with amphotericin B or voriconazole against biofilms of five Candida species","volume":"71","author":"Valentin","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2020.11.013_bib0045","first-page":"26","article-title":"Indifferent effect of nonsteroidal anti-inflammatory drugs (NSAIDs) combined with fluconazole against multidrug-resistant Candida auris","volume":"5","author":"Ahangarkani","year":"2019","journal-title":"Curr Med Mycol"},{"key":"10.1016\/j.jgar.2020.11.013_bib0050","doi-asserted-by":"crossref","first-page":"e0176755","DOI":"10.1371\/journal.pone.0176755","article-title":"Characterization of a novel antibiofilm effect of nitric oxide-releasing aspirin (NCX-4040) on Candida albicans isolates from denture stomatitis patients","volume":"12","author":"Madariaga-Venegas","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jgar.2020.11.013_bib0055","doi-asserted-by":"crossref","first-page":"4799","DOI":"10.1128\/AAC.02810-15","article-title":"Repurposing of aspirin and ibuprofen as candidate anti-Cryptococcus drugs","volume":"60","author":"Ogundeji","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2020.11.013_bib0060","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1128\/EC.00041-08","article-title":"Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance","volume":"7","author":"Cowen","year":"2008","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.jgar.2020.11.013_bib0065","first-page":"422","article-title":"Calcium homeostasis systems and calcium signaling pathways in Candida albicans\u2014a review [in Chinese]","volume":"52","author":"Yu","year":"2012","journal-title":"Wei Sheng Wu Xue Bao"},{"key":"10.1016\/j.jgar.2020.11.013_bib0070","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijantimicag.2012.10.009","article-title":"In vitro activity of verapamil alone and in combination with fluconazole or tunicamycin against Candida albicans biofilms","volume":"41","author":"Yu","year":"2013","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jgar.2020.11.013_bib0075","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1007\/s42770-020-00354-6","article-title":"Factors influencing susceptibility testing of antifungal drugs: a critical review of document M27-A4 from the Clinical and Laboratory Standards Institute (CLSI)","volume":"51","author":"de Sousa","year":"2020","journal-title":"Braz J Microbiol"},{"key":"10.1016\/j.jgar.2020.11.013_bib0080","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/lam.13248","article-title":"Mrr2 mutations and upregulation are associated with increased fluconazole resistance in Candida albicans isolates from patients with vulvovaginal candidiasis","volume":"70","author":"Feng","year":"2020","journal-title":"Lett Appl Microbiol"},{"key":"10.1016\/j.jgar.2020.11.013_bib0085","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/13693780500536893","article-title":"In vitro antifungal oral drug and drug-combination activity against onychomycosis causative dermatophytes","volume":"44","author":"Santos","year":"2006","journal-title":"Med Mycol"},{"key":"10.1016\/j.jgar.2020.11.013_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/1348-0421.12109","article-title":"In vitro susceptibility of dermatomycoses agents to six antifungal drugs and evaluation by fractional inhibitory concentration index of combined effects of amorolfine and itraconazole in dermatophytes","volume":"58","author":"Tamura","year":"2014","journal-title":"Microbiol Immunol"},{"key":"10.1016\/j.jgar.2020.11.013_bib0095","doi-asserted-by":"crossref","first-page":"4780746","DOI":"10.1155\/2017\/4780746","article-title":"Antifungal activity of the ethanol extract from Flos Rosae Chinensis with activity against fluconazole-resistant clinical Candida","volume":"2017","author":"Zhang","year":"2017","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jgar.2020.11.013_bib0100","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-micro-091014-104330","article-title":"Candida albicans biofilms and human disease","volume":"69","author":"Nobile","year":"2015","journal-title":"Annu Rev Microbiol"},{"key":"10.1016\/j.jgar.2020.11.013_bib0105","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00284-019-01678-9","article-title":"Synergy over monotherapy","volume":"76","author":"Jezikova","year":"2019","journal-title":"Curr Microbiol"},{"key":"10.1016\/j.jgar.2020.11.013_bib0110","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s00204-016-1916-3","article-title":"New developments and directions in the clinical application of the echinocandins","volume":"91","author":"Chang","year":"2017","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.jgar.2020.11.013_bib0115","doi-asserted-by":"crossref","first-page":"e00710","DOI":"10.1128\/AAC.00710-17","article-title":"Caspofungin-mediated growth inhibition and paradoxical growth in Aspergillus fumigatus involve fungicidal hyphal tip lysis coupled with regenerative intrahyphal growth and dynamic changes in \u03b2-1,3-glucan synthase localization","volume":"61","author":"Moreno-Velasquez","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2020.11.013_bib0120","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1590\/S1517-83822014000400031","article-title":"Treatment with some anti-inflammatory drugs reduces germ tube formation in Candida albicans strains","volume":"45","author":"Rusu","year":"2014","journal-title":"Braz J Microbiol"},{"key":"10.1016\/j.jgar.2020.11.013_bib0125","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1128\/AAC.48.1.41-47.2004","article-title":"Effects of aspirin and other nonsteroidal anti-inflammatory drugs on biofilms and planktonic cells of Candida albicans","volume":"48","author":"Alem","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2020.11.013_bib0130","doi-asserted-by":"crossref","first-page":"e0157047","DOI":"10.1371\/journal.pone.0157047","article-title":"In vitro interactions between non-steroidal anti-inflammatory drugs and antifungal agents against planktonic and biofilm forms of Trichosporon asahii","volume":"11","author":"Yang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.jgar.2020.11.013_bib0135","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1128\/AAC.01397-07","article-title":"Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms","volume":"52","author":"Uppuluri","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2020.11.013_bib0140","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/j.1365-2958.2008.06592.x","article-title":"Calcium homeostasis is required for contact-dependent helical and sinusoidal tip growth in Candida albicans hyphae","volume":"71","author":"Brand","year":"2009","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.jgar.2020.11.013_bib0145","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2165\/00003088-198409010-00002","article-title":"Clinical pharmacokinetics of verapamil","volume":"9","author":"Hamann","year":"1984","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.jgar.2020.11.013_bib0150","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/1567-1364.12150","article-title":"Inhibitory effect of verapamil on Candida albicans hyphal development, adhesion and gastrointestinal colonization","volume":"14","author":"Yu","year":"2014","journal-title":"FEMS Yeast Res"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221371652030299X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221371652030299X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:54:06Z","timestamp":1761990846000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221371652030299X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":30,"alternative-id":["S221371652030299X"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2020.11.013","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aspirin and verapamil increase the sensitivity of Candida albicans to caspofungin under planktonic and biofilm conditions","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2020.11.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}