{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T13:56:22Z","timestamp":1784901382704,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016305","name":"First Affiliated Hospital of Zhengzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016305","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.jgar.2021.09.018","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T03:25:29Z","timestamp":1637205929000},"page":"413-419","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Trends in antimicrobial resistance in bloodstream infections at a large tertiary-care hospital in China: a 10-year retrospective study (2010\u20132019)"],"prefix":"10.1016","volume":"29","author":[{"given":"Cailin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogai","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyue","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2021.09.018_bib0001","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/1469-0691.12028","article-title":"The changing epidemiology of bacteraemias in Europe: trends from the European Antimicrobial Resistance Surveillance System","volume":"19","author":"De Kraker","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jgar.2021.09.018_bib0002","doi-asserted-by":"crossref","first-page":"30319","DOI":"10.2807\/1560-7917.ES.2016.21.33.30319","article-title":"TIMBER Study Group. The health and economic burden of bloodstream infections caused by antimicrobial-susceptible and non-susceptible Enterobacteriaceae and Staphylococcus aureus in European hospitals, 2010 and 2011: a multicentre retrospective cohort study","volume":"21","author":"Stewardson","year":"2016","journal-title":"Euro Surveill"},{"key":"10.1016\/j.jgar.2021.09.018_bib0003","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00355-19","article-title":"The microbiology of bloodstream infection: 20-year trends from the SENTRY Antimicrobial Surveillance Program","volume":"63","author":"Diekema","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2021.09.018_bib0004","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/jcpt.12432","article-title":"Correlation between antimicrobial consumption and antimicrobial resistance of Pseudomonas aeruginosa in a hospital setting: a 10-year study","volume":"41","author":"Mladenovic-Antic","year":"2016","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.jgar.2021.09.018_bib0005","series-title":"CLSI supplement M100","article-title":"Performance standards for antimicrobial susceptibility testing","year":"2019"},{"key":"10.1016\/j.jgar.2021.09.018_bib0006","series-title":"Analysis and presentation of cumulative antimicrobial susceptibility test data; approved guideline\u2014fourth edition. CLSI document M39-A4","year":"2014"},{"key":"10.1016\/j.jgar.2021.09.018_bib0007","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1186\/s12889-018-6013-5","article-title":"Antimicrobial resistance of pathogens causing nosocomial bloodstream infection in Hubei Province, China, from 2014 to 2016: a multicenter retrospective study","volume":"18","author":"Tian","year":"2018","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jgar.2021.09.018_bib0008","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2018.23.42.1800047","article-title":"Antimicrobial resistance of major clinical pathogens in South Korea, May 2016 to April 2017: first one-year report from Kor-GLASS","volume":"23","author":"Lee","year":"2018","journal-title":"Euro Surveill"},{"key":"10.1016\/j.jgar.2021.09.018_bib0009","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10096-016-2830-6","article-title":"Swiss Centre for Antibiotic Resistance (ANRESIS). Patterns and trends of pediatric bloodstream infections: a 7-year surveillance study","volume":"36","author":"Buetti","year":"2017","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jgar.2021.09.018_bib0010","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13756-016-0162-z","article-title":"Bacterial etiology of bloodstream infections and antimicrobial resistance in Dhaka, Bangladesh, 2005\u20132014","volume":"6","author":"Ahmed","year":"2017","journal-title":"Antimicrob Resist Infect Control"},{"key":"10.1016\/j.jgar.2021.09.018_bib0011","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/S1473-3099(17)30394-8","article-title":"Trends in antimicrobial resistance in bloodstream infection isolates at a large urban hospital in Malawi (1998\u20132016): a surveillance study","volume":"17","author":"Musicha","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jgar.2021.09.018_bib0012","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s10096-018-3292-9","article-title":"Incidence and antimicrobial resistance trends in bloodstream infections caused by ESKAPE and Escherichia coli at a large teaching hospital in Rome, a 9-year analysis (2007\u20132015)","volume":"37","author":"De Angelis","year":"2018","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jgar.2021.09.018_bib0013","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13756-019-0499-1","article-title":"Shifting trends and age distribution of ESKAPEEc resistance in bloodstream infection, Southwest China, 2012\u20132017","volume":"8","author":"Yang","year":"2019","journal-title":"Antimicrob Resist Infect Control"},{"key":"10.1016\/j.jgar.2021.09.018_bib0014","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jgar.2017.04.013","article-title":"Antimicrobial resistance patterns of Gram-negative bacteria isolated from bloodstream infections in an Iranian referral paediatric hospital: a 5.5-year study","volume":"11","author":"Mahmoudi","year":"2017","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.jgar.2021.09.018_bib0015","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13756-019-0545-z","article-title":"Antimicrobial resistance trends in bloodstream infections at a large teaching hospital in China: a 20-year surveillance study (1998\u20132017)","volume":"8","author":"Tian","year":"2019","journal-title":"Antimicrob Resist Infect Control"},{"issue":"1","key":"10.1016\/j.jgar.2021.09.018_bib0016","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.cmi.2015.09.015","article-title":"National epidemiology of carbapenem-resistant and extensively drug-resistant Gram-negative bacteria isolated from blood samples in China in 2013","volume":"22","author":"Xu","year":"2016","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"10.1016\/j.jgar.2021.09.018_bib0017","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/j.cmi.2016.01.001","article-title":"Resistance trends among clinical isolates in China reported from CHINET surveillance of bacterial resistance, 2005\u20132014","volume":"22","author":"Hu","year":"2016","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jgar.2021.09.018_bib0018","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00845-19","article-title":"Antecedent carbapenem exposure as a risk factor for non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae and carbapenemase-producing Enterobacteriaceae","volume":"63","author":"Marimuthu","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2021.09.018_bib0019","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02040-18","article-title":"Diverse vectors and mechanisms spread New Delhi metallo-\u03b2-lactamases among carbapenem-resistant Enterobacteriaceae in the Greater Boston Area","volume":"63","author":"Pecora","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2021.09.018_bib0020","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3389\/fmicb.2018.00571","article-title":"New Delhi metallo-\u03b2-lactamase-producing Enterobacteriaceae in South Korea between 2010 and 2015","volume":"9","author":"Yoon","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgar.2021.09.018_bib0021","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/23744235.2017.1421772","article-title":"Risk factors, outcomes and genotypes of carbapenem-nonsusceptible Klebsiella pneumoniae bloodstream infection: a three-year retrospective study in a large tertiary hospital in Northern China","volume":"50","author":"Zheng","year":"2018","journal-title":"Infect Dis (Lond)"},{"key":"10.1016\/j.jgar.2021.09.018_bib0022","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1017\/S0950268819000256","article-title":"Risk factors and epidemiologic predictors of blood stream infections with New Delhi metallo-\u03b2-lactamase (NDM-1) producing Enterobacteriaceae","volume":"147","author":"Snyder","year":"2019","journal-title":"Epidemiol Infect"},{"key":"10.1016\/j.jgar.2021.09.018_bib0023","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S1473-3099(17)30228-1","article-title":"Effect of appropriate combination therapy on mortality of patients with bloodstream infections due to carbapenemase-producing Enterobacteriaceae (INCREMENT): a retrospective cohort study","volume":"17","author":"Gutierrez-Gutierrez","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jgar.2021.09.018_bib0024","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4103\/0974-777X.68538","article-title":"Multidrug resistant Acinetobacter","volume":"2","author":"Manchanda","year":"2010","journal-title":"J Glob Infect Dis"},{"key":"10.1016\/j.jgar.2021.09.018_bib0025","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.cmi.2020.02.004","article-title":"Using machine learning to optimize antibiotic combinations: dosing strategies for meropenem and polymyxin B against carbapenem-resistant Acinetobacter baumannii","volume":"26","author":"Smith","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jgar.2021.09.018_bib0026","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jmii.2019.03.004","article-title":"Clinical characteristics and outcomes of community and hospital-acquired Acinetobacter baumannii bacteremia","volume":"52","author":"Chusri","year":"2019","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jgar.2021.09.018_bib0027","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ijantimicag.2011.04.022","article-title":"Analysis of resistance, cross-resistance and antimicrobial combinations for Pseudomonas aeruginosa isolates from 1997 to 2009","volume":"38","author":"Master","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jgar.2021.09.018_bib0028","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/jcpt.12432","article-title":"Correlation between antimicrobial consumption and antimicrobial resistance of Pseudomonas aeruginosa in a hospital setting: a 10-year study","volume":"41","author":"Mladenovic-Antic","year":"2016","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.jgar.2021.09.018_bib0029","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1128\/AAC.01278-06","article-title":"Development and persistence of antimicrobial resistance in Pseudomonas aeruginosa: a longitudinal observation in mechanically ventilated patients","volume":"51","author":"Reinhardt","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2021.09.018_bib0030","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1128\/JCM.00967-10","article-title":"Coagulase-negative staphylococcal skin carriage among neonatal intensive care unit personnel: from population to infection","volume":"48","author":"Hira","year":"2010","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2021.09.018_bib0031","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jgar.2018.12.016","article-title":"Bacterial susceptibility in bloodstream infections: results from China Antimicrobial Resistance Surveillance Trial (CARST) program, 2015\u20132016","volume":"17","author":"Zhang","year":"2019","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.jgar.2021.09.018_bib0032","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/1120009X.2018.1516272","article-title":"Distribution of main Gram-positive pathogens causing bloodstream infections in United States and European hospitals during the SENTRY Antimicrobial Surveillance Program (2010\u20132016): concomitant analysis of oritavancin in vitro activity","volume":"30","author":"Mendes","year":"2018","journal-title":"J Chemother"},{"key":"10.1016\/j.jgar.2021.09.018_bib0033","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1001\/jama.2010.1125","article-title":"Decline in invasive MRSA infection: where to go from here?","volume":"304","author":"Perencevich","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.jgar.2021.09.018_bib0034","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.cmi.2015.04.017","article-title":"Worldwide decrease in methicillin-resistant Staphylococcus aureus: do we understand something?","volume":"21","author":"Rolain","year":"2015","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jgar.2021.09.018_bib0035","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0732-8893(98)00149-7","volume":"33","author":"Pfaller","year":"1999","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jgar.2021.09.018_bib0036","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1128\/JCM.00376-11","article-title":"Nosocomial bloodstream infections in Brazilian hospitals: analysis of 2,563 cases from a prospective nationwide surveillance study","volume":"49","author":"Marra","year":"2011","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2021.09.018_bib0037","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1093\/jac\/dkw319","article-title":"Longitudinal (2001\u201314) analysis of enterococci and VRE causing invasive infections in European and US hospitals, including a contemporary (2010\u201313) analysis of oritavancin in vitro potency","volume":"71","author":"Mendes","year":"2016","journal-title":"J Antimicrob Chemother"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716521002411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716521002411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:03:25Z","timestamp":1761991405000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716521002411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":37,"alternative-id":["S2213716521002411"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2021.09.018","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trends in antimicrobial resistance in bloodstream infections at a large tertiary-care hospital in China: a 10-year retrospective study (2010\u20132019)","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2021.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}