{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:00:38Z","timestamp":1780452038120,"version":"3.54.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T00:00:00Z","timestamp":1658188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Ministerio de Ciencia, Innovaci\u00f3n y Universidades","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.jgar.2022.07.017","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T12:37:01Z","timestamp":1658493421000},"page":"399-402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Community-acquired bacteraemia by Klebsiella pneumoniae producing KPC-3 and resistant to ceftazidime\/avibactam"],"prefix":"10.1016","volume":"30","author":[{"given":"Isabel","family":"Machuca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2199-7949","authenticated-orcid":false,"given":"Julia","family":"Guzm\u00e1n-Puche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6796-1813","authenticated-orcid":false,"given":"E","family":"P\u00e9rez-Nadales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Gracia-Ahufinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0810-6497","authenticated-orcid":false,"given":"A","family":"Mendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JJ","family":"Cast\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1529-6302","authenticated-orcid":false,"given":"J","family":"Torre-Cisneros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6091-4045","authenticated-orcid":false,"given":"L","family":"Mart\u00ednez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2022.07.017_bib0001","article-title":"WHO releases list of 10 threats to global health","year":"2019","journal-title":"NEJM J Watch"},{"key":"10.1016\/j.jgar.2022.07.017_bib0002","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.1128\/AAC.01019-15","article-title":"Carbapenemase-producing Klebsiella pneumoniae, a key pathogen set for global nosocomial dominance","volume":"59","author":"Pitout","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2022.07.017_bib0003","doi-asserted-by":"crossref","first-page":"e02101","DOI":"10.1128\/AAC.02101-17","article-title":"Successive emergence of ceftazidime-avibactam resistance through distinct genomic adaptations in blaKPC-2-harboring klebsiella pneumoniae sequence type 307 isolates","volume":"62","author":"Giddins","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2022.07.017_bib0004","first-page":"e02097","article-title":"Emergence of ceftazidime-avibactam resistance due to plasmid-borne blaKPC-3 mutations during treatment of carbapenem-resistant Klebsiella pneumoniae infections","volume":"61","author":"Shields","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.jgar.2022.07.017_bib0005","doi-asserted-by":"crossref","first-page":"136.e1","DOI":"10.1016\/j.cmi.2021.05.026","article-title":"Emergence of transferable ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae due to a novel CMY AmpC \u03b2-lactamase in China","volume":"28","author":"Xu","year":"2021","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jgar.2022.07.017_bib0006","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/21505594.2016.1255381","article-title":"Screening for carbapenem-resistant Enterobacteriaceae: who, when, and how?","volume":"8","author":"Richter","year":"2017","journal-title":"Virulence"},{"key":"10.1016\/j.jgar.2022.07.017_bib0007","unstructured":"The European Committee on Antimicrobial Susceptibility Testing. EUCAST: Clinical breakpoints and dosing of antibiotics. https:\/\/eucast.org\/clinical_breakpoints\/. Accessed July 5, 2020."},{"key":"10.1016\/j.jgar.2022.07.017_bib0008","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.ijantimicag.2014.08.006","article-title":"Characterisation of the first ongoing outbreak due to KPC-3-producing Klebsiella pneumoniae (ST512) in Spain","volume":"44","author":"L\u00f3pez-Cerero","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jgar.2022.07.017_bib0009","doi-asserted-by":"crossref","first-page":"e00989","DOI":"10.1128\/AAC.00989-17","article-title":"Resistance to ceftazidime-avibactam is due to transposition of kpc in a porin-deficient strain of Klebsiella pneumoniae with increased efflux activity","volume":"61","author":"Nelson","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2022.07.017_bib0010","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jgar.2019.12.009","article-title":"Resistance to ceftazidime\u2013avibactam and underlying mechanisms","volume":"22","author":"Wang","year":"2020","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.jgar.2022.07.017_bib0011","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1093\/jac\/dkx066","article-title":"High ceftazidime hydrolysis activity and porin OmpK35 deficiency contribute to the decreased susceptibility to ceftazidime\/avibactam in KPC-producing Klebsiella pneumoniae","volume":"72","author":"Shen","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2022.07.017_bib0012","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1128\/AAC.00156-11","article-title":"In vitro selection of ramR and soxR mutants overexpressing efflux systems by fluoroquinolones as well as cefoxitin in Klebsiella pneumoniae","volume":"55","author":"Bialek-Davenet","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2022.07.017_bib0013","doi-asserted-by":"crossref","first-page":"e01551","DOI":"10.1128\/AAC.01551-18","article-title":"Meropenem-vaborbactam as salvage therapy for ceftazidime-avibactam-resistant klebsiella pneumoniae bacteremia and abscess in a liver transplant recipient","volume":"63","author":"Athans","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2022.07.017_bib0014","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jgar.2019.11.007","article-title":"Use of carbapenems in the combined treatment of emerging ceftazidime\/avibactam-resistant and carbapenem-susceptible KPC-producing Klebsiella pneumoniae infections: report of a case and review of the literature","volume":"22","author":"Cano","year":"2020","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.jgar.2022.07.017_bib0015","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2020.25.3.2000028","article-title":"Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019","volume":"25","author":"Galani","year":"2020","journal-title":"Eurosurveillance"},{"issue":"10","key":"10.1016\/j.jgar.2022.07.017_bib0016","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.1128\/AAC.01165-15","article-title":"First report of ceftazidime-avibactam resistance in a KPC-3-expressing Klebsiella pneumoniae isolate","volume":"59","author":"Humphries","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"issue":"12","key":"10.1016\/j.jgar.2022.07.017_bib0017","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1093\/cid\/ciw636","article-title":"Clinical Outcomes, Drug Toxicity, and Emergence of Ceftazidime-Avibactam Resistance Among Patients Treated for Carbapenem-Resistant Enterobacteriaceae Infections","volume":"63","author":"Shields","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"3","key":"10.1016\/j.jgar.2022.07.017_bib0018","doi-asserted-by":"crossref","first-page":"e02369-16","DOI":"10.1128\/AAC.02369-16","article-title":"Low Frequency of Ceftazidime-Avibactam Resistance among Enterobacteriaceae Isolates Carrying blaKPC Collected in U.S. Hospitals from 2012 to 2015","volume":"61","author":"Castanheira","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"10.1016\/j.jgar.2022.07.017_bib0019","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ofid\/ofx101","article-title":"Emergence of ceftazidime-avibactam resistance and restoration of carbapenem susceptibility in Klebsiellapneumoniae carbapenemase- producing K pneumoniae: A case report and review of literature","volume":"4","author":"Shields","year":"2017","journal-title":"Open Forum Infect Dis"},{"issue":"10","key":"10.1016\/j.jgar.2022.07.017_bib0020","doi-asserted-by":"crossref","first-page":"6605","DOI":"10.1128\/AAC.01165-15","article-title":"First report of ceftazidime-avibactam resistance in a KPC-3-expressing Klebsiella pneumoniae isolate","volume":"59","author":"Humphries","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"issue":"62","key":"10.1016\/j.jgar.2022.07.017_bib0021","doi-asserted-by":"crossref","first-page":"e02497-17","DOI":"10.1128\/AAC.02497-17","article-title":"Pneumonia and Renal Replacement Therapy Are Risk Factors for Ceftazidime-Avibactam Treatment Failures and Resistance among Patients with Carbapenem-Resistant Enterobacteriaceae Infections","volume":"26","author":"Shields","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"issue":"19","key":"10.1016\/j.jgar.2022.07.017_bib0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2807\/1560-7917.ES.2019.24.19.1900256","article-title":"Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018","volume":"24","author":"R\u00e4is\u00e4nen","year":"2019","journal-title":"Eurosurveillance"},{"issue":"6","key":"10.1016\/j.jgar.2022.07.017_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmi.2019.03.011","article-title":"Genomic characterization of a KPC-23-producing Klebsiella pneumoniae ST258 clinical isolate resistant to ceftazidime-avibactam","volume":"25","author":"Galani","year":"2019","journal-title":"Clin Microbiol Infect"},{"issue":"2","key":"10.1016\/j.jgar.2022.07.017_bib0024","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2020.25.2.1900766","article-title":"Detection in two hospitals of transferable ceftazidime-avibactam resistance in Klebsiella pneumoniae due to a novel VEB \u03b2-lactamase variant with a Lys234Arg substitution, Greece, 2019","volume":"25","author":"Voulgari","year":"2020","journal-title":"Euro Surveill"},{"key":"10.1016\/j.jgar.2022.07.017_bib0025","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.2147\/IDR.S207993","article-title":"Molecular and phenotypical characterization of two cases of antibiotic-driven ceftazidime-avibactam resistance in blaKPC-3-harboring Klebsiella pneumoniae","volume":"12","author":"Venditti","year":"2019","journal-title":"Infect Drug Resist"},{"issue":"5","key":"10.1016\/j.jgar.2022.07.017_bib0026","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.jiac.2021.01.014","article-title":"Ceftazidime-avibactam resistance and restoration of carbapenem susceptibility in KPC-producing Klebsiella pneumoniae infections: A case series","volume":"27","author":"Van Asten","year":"2021","journal-title":"J Infect Chemother"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716522001850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716522001850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:00:50Z","timestamp":1761991250000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716522001850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":26,"alternative-id":["S2213716522001850"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2022.07.017","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Community-acquired bacteraemia by Klebsiella pneumoniae producing KPC-3 and resistant to ceftazidime\/avibactam","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2022.07.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}