{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T02:50:02Z","timestamp":1790563802466,"version":"4.1.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016295","name":"Jar\u00f0v\u00edsindastofnun","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016295","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.jgar.2023.04.012","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T02:35:58Z","timestamp":1682390158000},"page":"249-255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Distribution and quantification of antibiotic resistance genes in a large subalpine lake (Lugano Lake) and tributary rivers"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8502-8798","authenticated-orcid":false,"given":"Federica","family":"Mauri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Pianta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2023.04.012_bib0001","first-page":"28564","article-title":"Environmental dissemination of antibiotic resistance genes and correlation to anthropogenic contamination with antibiotics","volume":"5","author":"Berglund","year":"2015","journal-title":"Infect Ecol Epidemiol"},{"key":"10.1016\/j.jgar.2023.04.012_bib0002","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.scitotenv.2018.02.083","article-title":"Antibiotic resistance along an urban river impacted by treated wastewaters","volume":"628\u20139","author":"Proia","year":"2018","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jgar.2023.04.012_bib0003","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00253-008-1829-z","article-title":"Antibiotic resistance genes in water environment","volume":"82","author":"Zhang","year":"2009","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.jgar.2023.04.012_bib0004","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.microc.2017.02.006","article-title":"Ecological effects of antibiotics on natural ecosystems: a review","volume":"136","author":"Grenni","year":"2018","journal-title":"Microchem J"},{"key":"10.1016\/j.jgar.2023.04.012_bib0005","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/etc.5289","article-title":"Antimicrobial resistance in rivers: a review of the genes detected and new challenges","volume":"41","author":"Grenni","year":"2022","journal-title":"Environ Toxicol Chem"},{"key":"10.1016\/j.jgar.2023.04.012_bib0006","doi-asserted-by":"crossref","first-page":"855","DOI":"10.2166\/wh.2020.002","article-title":"Editorial: Antimicrobial resistance in the water environment","volume":"18","author":"Toranzos","year":"2020","journal-title":"J Water Health"},{"key":"10.1016\/j.jgar.2023.04.012_bib0007","first-page":"231","article-title":"Antimicrobial resistance: the role of aquatic environments","volume":"2","author":"Ram\u00edrez-Castillo","year":"2014","journal-title":"Int J Curr Res Acad Rev"},{"key":"10.1016\/j.jgar.2023.04.012_bib0008","unstructured":"ECDC. Antimicrobial consumption in the EU\/EEA (ESAC-Net). 2021."},{"key":"10.1016\/j.jgar.2023.04.012_bib0009","unstructured":"Federal Office of Public Health (FOPH), Federal Food Safety and Veterinary Office (FSVO), Daniela M\u00fcller Brodmann, Division of Communicable Diseases, Dagmar Heim, Veterinary Medicinal Products and One-Health (2020) Swiss Antibiotic \u00ad Resistance Report 2020."},{"key":"10.1016\/j.jgar.2023.04.012_bib0010","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.scitotenv.2019.03.162","article-title":"Antibiotic resistance in drinking water systems: occurrence, removal, and human health risks","volume":"669","author":"Sanganyado","year":"2019","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jgar.2023.04.012_bib0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2013.00130","article-title":"Reclaimed water as a reservoir of antibiotic resistance genes: distribution system and irrigation implications","volume":"4","author":"Fahrenfeld","year":"2013","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgar.2023.04.012_bib0012","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/j.scitotenv.2017.10.180","article-title":"Human exposure assessment to antibiotic-resistant Escherichia coli through drinking water","volume":"616\u20137","author":"O'Flaherty","year":"2018","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jgar.2023.04.012_bib0013","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.scitotenv.2018.09.018","article-title":"The potential human exposure to antibiotic resistant-Escherichia coli through recreational water","volume":"650","author":"O'Flaherty","year":"2019","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jgar.2023.04.012_bib0014","doi-asserted-by":"crossref","DOI":"10.3390\/w10060805","article-title":"Presence of antibiotic-resistant Escherichia coli in wastewater treatment plant effluents utilized as water reuse for irrigation","author":"Aslan","year":"2018","journal-title":"Water"},{"key":"10.1016\/j.jgar.2023.04.012_bib0015","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.tim.2016.11.014","article-title":"Assessing the risk of antibiotic resistance transmission from the environment to humans: non-direct proportionality between abundance and risk","volume":"25","author":"Manaia","year":"2017","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.jgar.2023.04.012_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117402","article-title":"Distribution of antibiotic resistance genes in the environment","volume":"285","author":"Zhuang","year":"2021","journal-title":"Environ Pollut"},{"key":"10.1016\/j.jgar.2023.04.012_bib0017","unstructured":"Stroud C. Annual Report of One Health Commission, 2021."},{"key":"10.1016\/j.jgar.2023.04.012_bib0018","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.envint.2018.04.041","article-title":"Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistance","volume":"117","author":"Larsson","year":"2018","journal-title":"Environ Int"},{"key":"10.1016\/j.jgar.2023.04.012_bib0019","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1002-0160(18)60062-1","article-title":"Antibiotic resistance genes in the human-impacted environment: a One Health perspective","volume":"29","author":"Tiedje","year":"2019","journal-title":"Pedosphere"},{"key":"10.1016\/j.jgar.2023.04.012_bib0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.05.074","article-title":"A conceptual framework for the environmental surveillance of antibiotics and antibiotic resistance","volume":"130","author":"Huijbers","year":"2019","journal-title":"Environ Int"},{"key":"10.1016\/j.jgar.2023.04.012_bib0021","article-title":"(2021) Ricerche sull'evoluzione del Lago di Lugano. Aspetti limnologici. Programma quinquennale 2019\u20132021","year":"2020","journal-title":"Campagna"},{"key":"10.1016\/j.jgar.2023.04.012_bib0022","article-title":"Ricerche sull'evoluzione del Lago di Lugano. Aspetti limnologici. Programma quinquennale 2016\u20132018","year":"2016","journal-title":"Campagna"},{"key":"10.1016\/j.jgar.2023.04.012_bib0023","article-title":"Ricerche sull'evoluzione del Lago di Lugano. Aspetti limnologici. Programma quinquennale 2016\u20132018","year":"2017","journal-title":"Campagna"},{"key":"10.1016\/j.jgar.2023.04.012_bib0024","article-title":"Ricerche sull'evoluzione del Lago di Lugano. Aspetti limnologici. Programma quinquennale 2016\u20132018","year":"2018","journal-title":"Campagna"},{"key":"10.1016\/j.jgar.2023.04.012_bib0025","article-title":"Ricerche sull'evoluzione del Lago di Lugano. Aspetti limnologici. Programma quinquennale 2016\u20132018","year":"2019","journal-title":"Campagna"},{"key":"10.1016\/j.jgar.2023.04.012_bib0026","first-page":"5","article-title":"Physico-chemical parameter: an indicator of water pollution","volume":"5","author":"Beniwal","year":"2021","journal-title":"J Environ Res"},{"key":"10.1016\/j.jgar.2023.04.012_bib0027","doi-asserted-by":"crossref","first-page":"e62838","DOI":"10.1371\/journal.pone.0062838","article-title":"Aquaculture can promote the presence and spread of antibiotic-resistant Enterococci in marine sediments","volume":"8","author":"Di Cesare","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jgar.2023.04.012_bib0028","doi-asserted-by":"crossref","unstructured":"Taylor P, Hornung RW, Reed LD, Hornung RW, Reed LD. Nondetectable values estimation of average concentration in the presence of nondetectable values. 1990;46\u201351.","DOI":"10.1080\/1047322X.1990.10389587"},{"key":"10.1016\/j.jgar.2023.04.012_bib0029","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/enfo.2001.0061","article-title":"Detecting trends using Spearman's rank correlation coefficient","volume":"2","author":"Gauthier","year":"2001","journal-title":"Environ Forensics"},{"key":"10.1016\/j.jgar.2023.04.012_bib0030","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/02626667.2014.968573","article-title":"The distribution of Spearman's rho trend statistic for persistent hydrologic data","volume":"61","author":"Hamed","year":"2016","journal-title":"Hydrol Sci J"},{"key":"10.1016\/j.jgar.2023.04.012_bib0031","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s10393-019-01415-5","article-title":"Critical importance of a One Health approach to antimicrobial resistance","volume":"16","author":"White","year":"2019","journal-title":"Ecohealth"},{"key":"10.1016\/j.jgar.2023.04.012_bib0032","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/trstmh\/trw048","article-title":"Antibiotic resistance is the quintessential One Health issue","volume":"110","author":"Robinson","year":"2016","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.jgar.2023.04.012_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2019.02892","article-title":"Gene transmission in the One Health microbiosphere and the channels of antimicrobial resistance","volume":"10","author":"Baquero","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgar.2023.04.012_bib0034","unstructured":"Corradi C, Heim D, Hardegger M, Zimmermann S. Strategy on antibiotic resistance (StAR). 2018 Report."},{"key":"10.1016\/j.jgar.2023.04.012_bib0035","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/s41586-019-1665-6","article-title":"Chimeric peptidomimetic antibiotics against Gram-negative bacteria","volume":"576","author":"Luther","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jgar.2023.04.012_bib0036","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.watres.2019.06.039","article-title":"Antibiotic resistance genes in treated wastewater and in the receiving water bodies: A pan-European survey of urban settings","volume":"162","author":"Cacace","year":"2019","journal-title":"Water Res"},{"key":"10.1016\/j.jgar.2023.04.012_bib0037","article-title":"Prevalence of antibiotics and antibiotic resistance genes in a wastewater effluent-receiving river in the Netherlands","volume":"8","author":"Sabri","year":"2018","journal-title":"J Environ Chem Eng"},{"key":"10.1016\/j.jgar.2023.04.012_bib0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2019.00688","article-title":"Prevalence and diversity of antibiotic resistance genes in Swedish aquatic environments impacted by household and hospital wastewater","volume":"10","author":"Khan","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgar.2023.04.012_bib0039","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.scitotenv.2013.01.032","article-title":"Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review","volume":"447","author":"Rizzo","year":"2013","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jgar.2023.04.012_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2021.117827","article-title":"Wastewater bypass is a major temporary point-source of antibiotic resistance genes and multi-resistance risk factors in a Swiss river","volume":"208","author":"Lee","year":"2022","journal-title":"Water Res"},{"key":"10.1016\/j.jgar.2023.04.012_bib0041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2012.00106","article-title":"Increased levels of multiresistant bacteria and resistance genes after wastewater treatment and their dissemination into Lake Geneva, Switzerland","volume":"3","author":"Czekalski","year":"2012","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgar.2023.04.012_bib0042","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1021\/es2003588","article-title":"Spatial and temporal presence of a wastewater-derived micropollutant plume in Lake Geneva","volume":"45","author":"Bonvin","year":"2011","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.jgar.2023.04.012_bib0043","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/ismej.2014.8","article-title":"Wastewater as a point source of antibiotic-resistance genes in the sediment of a freshwater lake","volume":"8","author":"Czekalski","year":"2014","journal-title":"ISME J"},{"key":"10.1016\/j.jgar.2023.04.012_bib0044","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.envint.2015.04.005","article-title":"Does human activity impact the natural antibiotic resistance background? Abundance of antibiotic resistance genes in 21 Swiss lakes","volume":"81","author":"Czekalski","year":"2015","journal-title":"Environ Int"},{"key":"10.1016\/j.jgar.2023.04.012_bib0045","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1111\/mec.13293","article-title":"Constitutive presence of antibiotic resistance genes within the bacterial community of a large subalpine lake","volume":"24","author":"Di Cesare","year":"2015","journal-title":"Mol Ecol"},{"key":"10.1016\/j.jgar.2023.04.012_bib0046","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10750-019-04043-w","article-title":"Seasonality of the antibiotic resistance gene bla CTX-M in temperate Lake Maggiore","volume":"843","author":"Eckert","year":"2019","journal-title":"Hydrobiologia"},{"key":"10.1016\/j.jgar.2023.04.012_bib0047","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.envpol.2017.04.036","article-title":"Rainfall increases the abundance of antibiotic resistance genes within a riverine microbial community","volume":"226","author":"Di Cesare","year":"2017","journal-title":"Environ Pollut"},{"key":"10.1016\/j.jgar.2023.04.012_bib0048","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10750-017-3480-0","article-title":"Persistence of antibiotic resistance genes in large subalpine lakes: the role of anthropogenic pollution and ecological interactions","volume":"824","author":"Eckert","year":"2018","journal-title":"Hydrobiologia"},{"key":"10.1016\/j.jgar.2023.04.012_bib0049","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.copbio.2008.05.006","article-title":"Antibiotics and antibiotic resistance in water environments","volume":"19","author":"Baquero","year":"2008","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.jgar.2023.04.012_bib0050","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nrmicro3439","article-title":"Tackling antibiotic resistance: the environmental framework","volume":"13","author":"Berendonk","year":"2015","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jgar.2023.04.012_bib0051","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41579-021-00649-x","article-title":"Antibiotic resistance in the environment","volume":"20","author":"Larsson","year":"2022","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jgar.2023.04.012_bib0052","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1289\/ehp.1206446","article-title":"Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment","volume":"121","author":"Pruden","year":"2013","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jgar.2023.04.012_bib0053","doi-asserted-by":"crossref","DOI":"10.1021\/acs.est.1c08918","article-title":"Antimicrobial resistance monitoring of water environments: a framework for standardized methods and quality control","author":"Liguori","year":"2022","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.jgar.2023.04.012_bib0054","doi-asserted-by":"crossref","first-page":"i5","DOI":"10.1093\/jacamr\/dlab052","article-title":"Antibiotic resistance during and beyond COVID-19","volume":"3","author":"Livermore","year":"2021","journal-title":"JAC Antimicrob Resist"},{"key":"10.1016\/j.jgar.2023.04.012_bib0055","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.cmi.2020.04.024","article-title":"COVID-19: don't neglect antimicrobial stewardship principles!","volume":"26","author":"Huttner","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jgar.2023.04.012_bib0056","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antibiotics11060792","article-title":"Impact of the COVID-19 pandemic on inpatient antibiotic consumption in Switzerland","volume":"11","author":"Friedli","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.jgar.2023.04.012_bib0057","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jacamr\/dlaa051","article-title":"CON: COVID-19 will not result in increased antimicrobial resistance prevalence","volume":"2","author":"Collignon","year":"2020","journal-title":"JAC Antimicrob Resist"},{"key":"10.1016\/j.jgar.2023.04.012_bib0058","doi-asserted-by":"crossref","first-page":"6891","DOI":"10.3390\/ijms22136891","article-title":"COVID-19 lockdowns may reduce resistance genes diversity in the human microbiome and the need for antibiotics","volume":"22","author":"Rebelo","year":"2021","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716523000619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716523000619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T10:02:22Z","timestamp":1761991342000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716523000619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":58,"alternative-id":["S2213716523000619"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2023.04.012","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distribution and quantification of antibiotic resistance genes in a large subalpine lake (Lugano Lake) and tributary rivers","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2023.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}