{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:12:29Z","timestamp":1793913149888,"version":"4.8.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jgar.2023.07.002","type":"journal-article","created":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T17:35:18Z","timestamp":1688924118000},"page":"127-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Surveillance of Helicobacter pylori resistance over 22 Years (2000-2021) in Northern Spain"],"prefix":"10.1016","volume":"34","author":[{"given":"Marta","family":"G\u00f3mez-Ruiz de Arbulo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4185-1210","authenticated-orcid":false,"given":"Esther","family":"Tamayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Bujanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire","family":"Mendibil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josune","family":"Mendiola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7285-3107","authenticated-orcid":false,"given":"Gustavo","family":"Cilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6554-4912","authenticated-orcid":false,"given":"Milagrosa","family":"Montes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2023.07.002_bib0001","first-page":"420","article-title":"Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis","volume":"153","author":"Hooi","year":"2017","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jgar.2023.07.002_bib0002","first-page":"529","article-title":"Review \u2013 Helicobacter pylori: and extragastric diseases","volume":"3","author":"Gesualdo","year":"2021","journal-title":"Microbiota Health Dis"},{"key":"10.1016\/j.jgar.2023.07.002_bib0003","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","article-title":"Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis","volume":"18","author":"Tacconelli","year":"2018","journal-title":"Lancet Infect Dis Mar"},{"key":"10.1016\/j.jgar.2023.07.002_bib0004","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1136\/gutjnl-2015-309252","article-title":"Kyoto global consensus report on Helicobacter pylori gastritis","volume":"64","author":"Sugano","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.jgar.2023.07.002_bib0005","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1136\/gutjnl-2022-327745","article-title":"Management of Helicobacter pylori infection: the Maastricht VI\/Florence consensus report","volume":"71","author":"Malfertheiner","year":"2022","journal-title":"Gut Sep"},{"key":"10.1016\/j.jgar.2023.07.002_bib0006","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/ajg.2016.563","article-title":"Clinical Guideline: treatment of Helicobacter pylori Infection","volume":"112","author":"Chey","year":"2017","journal-title":"Off J Am Coll Gastroenterol ACG"},{"key":"10.1016\/j.jgar.2023.07.002_bib0007","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1097\/MPG.0000000000001594","article-title":"Joint ESPGHAN\/NASPGHAN guidelines for the management of Helicobacter pylori in children and adolescents (update 2016)","volume":"64","author":"Jones","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1016\/j.jgar.2023.07.002_bib0008","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.gastrohep.2021.07.011","article-title":"Conferencia Espa\u00f1ola de Consenso sobre el tratamiento de la infecci\u00f3n por Helicobacter pylori","volume":"45","author":"Gisbert","year":"2022","journal-title":"Gastroenterol Hepatol"},{"key":"10.1016\/j.jgar.2023.07.002_bib0009","doi-asserted-by":"crossref","unstructured":"Fallone CA, Chiba N, van Zanten SV, Fischbach L, Gisbert JP, Hunt RH, et\u00a0al. The Toronto Consensus for the Treatment of Helicobacter pylori infection in adults. Gastroenterology 2016;151:51\u201369. e14. doi: 10.1053\/j.gastro.2016.04.006.","DOI":"10.1053\/j.gastro.2016.04.006"},{"key":"10.1016\/j.jgar.2023.07.002_bib0010","first-page":"325","article-title":"The fourth Mexican consensus on Helicobacter pylori","volume":"83","author":"Bosques-Padilla","year":"2018","journal-title":"Rev Gastroenterol Mex Engl Sep"},{"key":"10.1016\/j.jgar.2023.07.002_bib0011","doi-asserted-by":"crossref","first-page":"11221","DOI":"10.3748\/wjg.v21.i40.11221","article-title":"Diagnosis of Helicobacter pylori infection: current options and developments","volume":"21","author":"Wang","year":"2015","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jgar.2023.07.002_bib0012","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0140-6736(95)90524-3","article-title":"Non-endoscopic method to obtain Helicobacter pylori for culture","volume":"345","author":"Perez-Trallero","year":"1995","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.jgar.2023.07.002_bib0013","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1111\/j.1572-0241.1999.3075_e.x","article-title":"How long for the routine Helicobacter pylori antimicrobial susceptibility testing? The usefulness of the string test to obtain helicobacter for culture","volume":"94","author":"Perez-Trallero","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jgar.2023.07.002_bib0014","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1128\/AAC.46.4.1156-1157.2002","article-title":"PCR-restriction fragment length polymorphism can also detect point mutation A2142C in the 23S rRNA gene, associated with Helicobacter pylori resistance to clarithromycin","volume":"46","author":"M\u00e9nard","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2023.07.002_bib0015","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jgar.2016.12.019","article-title":"Clarithromycin resistance in Helicobacter pylori and its molecular determinants in Northern Spain, 2013-2015","volume":"9","author":"Tamayo","year":"2017","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.jgar.2023.07.002_bib0016","series-title":"Performance standards for antimicrobial susceptibility testing; ninth informational supplement","year":"1999"},{"key":"10.1016\/j.jgar.2023.07.002_bib0017","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1136\/gutjnl-2020-322368","article-title":"Screening and eradication of Helicobacter pylori for gastric cancer prevention: the Taipei global consensus","volume":"69","author":"Liou","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.jgar.2023.07.002_bib0018","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1111\/j.1469-0691.2012.03844.x","article-title":"Usefulness of antimicrobial susceptibility in the eradication of Helicobacter pylori","volume":"19","author":"Cosme","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jgar.2023.07.002_bib0019","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1136\/gutjnl-2021-324032","article-title":"Helicobacter pylori resistance to antibiotics in Europe in 2018 and its relationship to antibiotic consumption in the community","volume":"70","author":"Megraud","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jgar.2023.07.002_bib0020","first-page":"1372","article-title":"Prevalence of antibiotic resistance in Helicobacter pylori: a systematic review and meta-analysis in World Health Organization Regions","volume":"155","author":"Savoldi","year":"2018","journal-title":"J Gastroenterol"},{"key":"10.1016\/j.jgar.2023.07.002_bib0021","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S2468-1253(17)30219-4","article-title":"Primary antibiotic resistance in Helicobacter pylori in the Asia-Pacific region: a systematic review and meta-analysis","volume":"2","author":"Kuo","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jgar.2023.07.002_bib0022","doi-asserted-by":"crossref","first-page":"786","DOI":"10.3390\/pathogens11070786","article-title":"Primary antibiotic resistance of Helicobacter pylori in different regions of China: a systematic review and meta-analysis","volume":"11","author":"Chen","year":"2022","journal-title":"Pathog Basel Switz"},{"key":"10.1016\/j.jgar.2023.07.002_bib0023","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.2147\/IDR.S250200","article-title":"Desta DM Primary resistance pattern of Helicobacter pylori to antibiotics in adult population: a systematic review","volume":"13","author":"Kasahun","year":"2020","journal-title":"Infect Drug Resist"},{"key":"10.1016\/j.jgar.2023.07.002_bib0024","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.2169\/internalmedicine.49.3031","article-title":"Is antimicrobial susceptibility testing necessary before first-line treatment for Helicobacter pylori infection? -meta-analysis of randomized controlled trials-","volume":"49","author":"Wenzhen","year":"2010","journal-title":"Intern Med"},{"key":"10.1016\/j.jgar.2023.07.002_bib0025","doi-asserted-by":"crossref","first-page":"913436","DOI":"10.3389\/fmicb.2022.913436","article-title":"Empirical vs. susceptibility-guided treatment of Helicobacter pylori infection: a systematic review and meta-analysis","volume":"13","author":"Nyssen","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgar.2023.07.002_bib0026","doi-asserted-by":"crossref","first-page":"723","DOI":"10.3390\/antibiotics9100723","article-title":"Helicobacter pylori primary and secondary genotypic resistance to clarithromycin and levofloxacin detection in stools: a 4-year scenario in Southern Italy","volume":"9","author":"Losurdo","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.jgar.2023.07.002_bib0027","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jgar.2018.06.016","article-title":"Antimicrobial resistance among Helicobacter pylori isolates in Alaska, 2000\u20132016","volume":"15","author":"Mosites","year":"2018","journal-title":"J Glob Antimicrob Resist"},{"issue":"20","key":"10.1016\/j.jgar.2023.07.002_bib0028","first-page":"30502","article-title":"Mu\u00f1oz Egea MDC, la Orden Izquierdo E Impact of the use of molecular techniques (PCR) on detection and eradication success against Helicobacter pylori","volume":"S1695\u20134033","author":"Gallardo Padilla","year":"2021","journal-title":"An Pediatr"},{"key":"10.1016\/j.jgar.2023.07.002_bib0029","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1136\/gut.50.3.285","article-title":"Molecular testing for antibiotic resistance in Helicobacter pylori","volume":"50","author":"Owen","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.jgar.2023.07.002_bib0030","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1128\/JCM.00744-09","article-title":"Evaluation of a new test, genotype HelicoDR, for molecular detection of antibiotic resistance in Helicobacter pylori","volume":"47","author":"Cambau","year":"2009","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2023.07.002_bib0031","doi-asserted-by":"crossref","first-page":"962063","DOI":"10.3389\/fmicb.2022.962063","article-title":"Alarc\u00f3n T Are molecular methods helpful for the diagnosis of Helicobacter pylori infection and for the prediction of its antimicrobial resistance?","volume":"13","author":"Fernandez-Caso","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgar.2023.07.002_bib0032","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/jgh.15751","article-title":"Prevalence of Helicobacter pylori infection in China: a systematic review and meta-analysis","volume":"37","author":"Ren","year":"2022","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.jgar.2023.07.002_bib0033","doi-asserted-by":"crossref","unstructured":"Hulten KG, Genta RM, Kalfus IN, Zhou Y, Zhang H, Graham DY Comparison of culture with antibiogram to next-generation sequencing using bacterial isolates and formalin-fixed, paraffin-embedded gastric biopsies. J Gastroenterol 2021;161:1433\u20131442. e2. DOI: 10.1053\/j.gastro.2021.07.012.","DOI":"10.1053\/j.gastro.2021.07.012"},{"key":"10.1016\/j.jgar.2023.07.002_bib0034","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1128\/JCM.02583-12","article-title":"Helicobacter pylori virulence genes detected by string PCR in children from an urban community in Northeastern Brazil","volume":"51","author":"Goncalves","year":"2013","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2023.07.002_bib0035","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13150","article-title":"Helicobacter pylori pathogenicity and primary antimicrobial resistance in Northern Spain","volume":"49","author":"Fern\u00e1ndez-Reyes","year":"2019","journal-title":"Eur J Clin Invest"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716523001078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716523001078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:59:46Z","timestamp":1761991186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716523001078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":35,"alternative-id":["S2213716523001078"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2023.07.002","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surveillance of Helicobacter pylori resistance over 22 Years (2000-2021) in Northern Spain","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2023.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}