{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:41:26Z","timestamp":1789249286430,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007395","name":"Instituto Nacional de Ci\u00eancia e Tecnologia para Excitotoxicidade e Neuroprote\u00e7\u00e3o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003810","name":"Clinics Hospital of Porto Alegre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018799","name":"Instituto Nacional de Pesquisas em Resist\u00eancia a Antimicrobianos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018799","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jgar.2025.02.020","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T20:00:46Z","timestamp":1741464046000},"page":"214-221","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Plasmidome analyses of Klebsiella pneumoniae co-producing blaKPC-2 and blaNDM-1 in Southern Brazil: characterisation of mobile genetic elements"],"prefix":"10.1016","volume":"42","author":[{"given":"Mayana Kieling Hernandez","family":"Berdichevski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0223-6423","authenticated-orcid":false,"given":"Rafaela R.","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9119-6242","authenticated-orcid":false,"given":"Dariane C.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8083-6171","authenticated-orcid":false,"given":"Camila M.","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0763-1430","authenticated-orcid":false,"given":"Patricia O.","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9281-9272","authenticated-orcid":false,"given":"Melise C.","family":"Silveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5225-2256","authenticated-orcid":false,"given":"Fabiana C.Z.","family":"Volpato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4369-0876","authenticated-orcid":false,"given":"Claudio","family":"Rocha-de-Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8250-084X","authenticated-orcid":false,"given":"Richard M.","family":"Carrassai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7044-4596","authenticated-orcid":false,"given":"Ana Paula","family":"Carvalho-Assef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreza F.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-3908","authenticated-orcid":false,"given":"Afonso Lu\u00eds","family":"Barth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2025.02.020_bib0001","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0213-005X(14)70168-5","article-title":"Carbapenemases in Enterobacteriaceae: types and molecular epidemiology","volume":"32","author":"Martinez","year":"2014","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"10.1016\/j.jgar.2025.02.020_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2022.127249","article-title":"Global spread of carbapenem-resistant Enterobacteriaceae: epidemiological features, resistance mechanisms, detection and therapy","volume":"266","author":"Ma","year":"2023","journal-title":"Microbiol Res"},{"key":"10.1016\/j.jgar.2025.02.020_bib0003","doi-asserted-by":"crossref","DOI":"10.1007\/s11908-018-0617-x","article-title":"The epidemiology, evolution, and treatment of KPC-producing organisms","volume":"20","author":"Porreca","year":"2018","journal-title":"Curr Infect Dis Rep"},{"key":"10.1016\/j.jgar.2025.02.020_bib0004","doi-asserted-by":"crossref","first-page":"5046","DOI":"10.1128\/AAC.00774-09","article-title":"Characterization of a new metallo-\u03b2-lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India","volume":"53","author":"Yong","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.02.020_bib0005","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s42770-020-00412-z","article-title":"Increased frequency of blaNDM in a tertiary care hospital in southern Brazil","volume":"52","author":"Wink","year":"2021","journal-title":"Braz J Microbiol"},{"key":"10.1016\/j.jgar.2025.02.020_bib0006","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.3390\/antibiotics12061063","article-title":"Evaluation of aztreonam and ceftazidime\/avibactam synergism against Klebsiella pneumoniae by MALDI-TOF MS","volume":"12","author":"Wilhelm","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.jgar.2025.02.020_bib0007","unstructured":"ANVISA, BRCAST, CGLAB. Nota T\u00e9cnica No 74\/2022-CGLAB\/DAEVS\/SVS\/MS. 2022;1\u20139."},{"key":"10.1016\/j.jgar.2025.02.020_bib0008","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.3390\/antibiotics12081285","article-title":"Carbapenem-resistant Klebsiella pneumoniae in COVID-19 era\u2014challenges and solutions","volume":"12","author":"Ficik","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.jgar.2025.02.020_bib0009","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1089\/mdr.2014.0171","article-title":"Coproduction of NDM-1 and KPC-2 in Enterobacter hormaechei from Brazil","volume":"21","author":"Pereira","year":"2015","journal-title":"Microb Drug Resist"},{"key":"10.1016\/j.jgar.2025.02.020_bib0010","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-17278-2","article-title":"Pathways for horizontal gene transfer in bacteria revealed by a global map of their plasmids","volume":"11","author":"Redondo-Salvo","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jgar.2025.02.020_bib0011","first-page":"51","article-title":"The transferability and evolution of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae from clinical settings","author":"Gao","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jgar.2025.02.020_bib0012","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1017\/ice.2017.146","article-title":"Characteristics of Enterobacteriaceae isolates coharboring distinct carbapenemase genes","volume":"38","author":"Rozales","year":"2017","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.jgar.2025.02.020_bib0013","doi-asserted-by":"crossref","DOI":"10.1590\/0037-8682-0397-2020","article-title":"High plasmid variability and the presence of IncFIB, IncQ, IncA\/C, IncHI1B, and IncL\/M in clinical isolates of Klebsiella pneumoniae with blaKPC and blaNDM from patients at a public hospital in Brazil","volume":"53","author":"Oliveira","year":"2020","journal-title":"Rev Soc Bras Med Trop"},{"key":"10.1016\/j.jgar.2025.02.020_bib0014","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3390\/antibiotics12050926","article-title":"Characterization of blaKPC-2 and blaNDM-1 plasmids of a K. pneumoniae ST11 outbreak clone","volume":"12","author":"Boralli","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.jgar.2025.02.020_bib0015","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/bioinformatics\/btu153","article-title":"Prokka: rapid prokaryotic genome annotation","volume":"30","author":"Seemann","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jgar.2025.02.020_bib0016","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1186\/1471-2105-11-595","article-title":"BIGSdb: scalable analysis of bacterial genome variation at the population level","volume":"11","author":"Jolley","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jgar.2025.02.020_bib0017","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/1471-2164-12-402","article-title":"BLAST ring image generator (BRIG): simple prokaryote genome comparisons","volume":"12","author":"Alikhan","year":"2011","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jgar.2025.02.020_bib0018","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1128\/AAC.02412-14","article-title":"In silico detection and typing of plasmids using PlasmidFinder and plasmid multilocus sequence typing","volume":"58","author":"Carattoli","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.02.020_bib0019","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12941-021-00464-5","article-title":"Bloodstream infections caused by Klebsiella pneumoniae and Serratia marcescens isolates co-harboring NDM-1 and KPC-2","volume":"20","author":"Bes","year":"2021","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"10.1016\/j.jgar.2025.02.020_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2807\/1560-7917.ES.2017.22.6.30461","article-title":"Trends in carbapenemase-producing Enterobacteriaceae, France, 2012 to 2014","volume":"22","author":"Dortet","year":"2017","journal-title":"EuroSurveillance"},{"key":"10.1016\/j.jgar.2025.02.020_bib0021","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jiph.2023.04.020","article-title":"Genotypic characterization of a Proteus mirabilis strain harboring blaKPC-2 on the IncN plasmid isolated from a patient with bloodstream infection in China","volume":"16","author":"Sun","year":"2023","journal-title":"J Infect Public Health"},{"key":"10.1016\/j.jgar.2025.02.020_bib0022","article-title":"Emergence of carbapenem-resistant Klebsiella pneumoniae species complex from agrifood systems: detection of ST6326 co-producing KPC-2 and NDM-1","volume":"23","author":"Furlan","year":"2024","journal-title":"J Sci Food Agric"},{"key":"10.1016\/j.jgar.2025.02.020_bib0023","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-28819-2","article-title":"Role of mobile genetic elements in the global dissemination of the carbapenem resistance gene blaNDM","volume":"13","author":"Acman","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.jgar.2025.02.020_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.875116","article-title":"Hybrid plasmids encoding antimicrobial resistance and virulence traits among hypervirulent Klebsiella pneumoniae ST2096 in India","volume":"12","author":"Shankar","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jgar.2025.02.020_bib0025","article-title":"A small KPC-2-producing plasmid in Klebsiella pneumoniae: implications for diversified vehicles of carbapenem resistance","volume":"10","author":"Chen","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jgar.2025.02.020_bib0026","doi-asserted-by":"crossref","first-page":"7387","DOI":"10.1128\/AAC.01458-15","article-title":"Characterization of Tn3000, a transposon responsible for blaNDM-1 dissemination among Enterobacteriaceae in Brazil, Nepal, Morocco, and India","volume":"59","author":"Campos","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.02.020_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.163322","article-title":"Genetic plurality of blaKPC-2-harboring plasmids in high-risk clones of Klebsiella pneumoniae of environmental origin","volume":"881","author":"Furlan","year":"2023","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jgar.2025.02.020_bib0028","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3390\/pathogens11121394","article-title":"A comprehensive genomic analysis of the emergent Klebsiella pneumoniae ST16 lineage: virulence, antimicrobial resistance and a comparison with the clinically relevant ST11 strain","volume":"11","author":"de Sales","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.jgar.2025.02.020_bib0029","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1186920","article-title":"The fitness cost of horizontally transferred and mutational antimicrobial resistance in Escherichia coli","volume":"14","author":"Vanacker","year":"2023","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgar.2025.02.020_bib0030","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41579-021-00534-7","article-title":"Examining horizontal gene transfer in microbial communities","volume":"19","author":"Brito","year":"2021","journal-title":"Nat Rev Microbiol"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716525000542?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716525000542?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T14:00:01Z","timestamp":1762610401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716525000542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":30,"alternative-id":["S2213716525000542"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2025.02.020","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plasmidome analyses of Klebsiella pneumoniae co-producing blaKPC-2 and blaNDM-1 in Southern Brazil: characterisation of mobile genetic elements","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2025.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}