{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:46:19Z","timestamp":1786992379347,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jgar.2025.04.009","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T12:08:12Z","timestamp":1745928492000},"page":"143-154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effects of in vitro combination therapy with polymyxin B on delaying resistance in Klebsiella pneumoniae and insights into the mechanisms of polymyxin-induced resistance"],"prefix":"10.1016","volume":"43","author":[{"given":"Huanhuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengjun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6418-5993","authenticated-orcid":false,"given":"Yan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2025.04.009_bib0001","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S1473-3099(17)30489-9","article-title":"A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study","volume":"18","author":"Gu","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jgar.2025.04.009_bib0002","first-page":"62","article-title":"The characteristic of virulence, biofilm and antibiotic resistance of Klebsiella pneumoniae","volume":"17","author":"Wang","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jgar.2025.04.009_bib0003","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jgar.2014.02.007","article-title":"High burden of antimicrobial drug resistance in Asia","volume":"2","author":"Lai","year":"2014","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.jgar.2025.04.009_bib0004","doi-asserted-by":"crossref","first-page":"dlae052","DOI":"10.1093\/jacamr\/dlae052","article-title":"Antimicrobial resistance of clinical bacterial isolates in China: current status and trends","volume":"6","author":"Qin","year":"2024","journal-title":"JAC-Antimicrob Resist"},{"key":"10.1016\/j.jgar.2025.04.009_bib0005","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1093\/cid\/ciy702","article-title":"Antimicrobial resistance in China: challenges and actions","volume":"67","author":"Wang","year":"2018","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jgar.2025.04.009_bib0006","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.mib.2010.09.002","article-title":"Polymyxins and their novel derivatives","volume":"13","author":"Vaara","year":"2010","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.jgar.2025.04.009_bib0007","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ijantimicag.2006.07.008","article-title":"Colistin as a salvage therapy for nosocomial infections caused by multidrug-resistant bacteria in the ICU","volume":"28","author":"Kallel","year":"2006","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jgar.2025.04.009_bib0008","doi-asserted-by":"crossref","first-page":"S128","DOI":"10.1093\/cid\/ciy657","article-title":"Current status and trends of antibacterial resistance in China","volume":"67","author":"Hu","year":"2018","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jgar.2025.04.009_bib0009","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1128\/AAC.01733-10","article-title":"Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients","volume":"55","author":"Garonzik","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.04.009_bib0010","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1093\/cid\/cit334","article-title":"Population pharmacokinetics of intravenous polymyxin B in critically ill patients: implications for selection of dosage regimens","volume":"57","author":"Sandri","year":"2013","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jgar.2025.04.009_bib0011","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.1128\/AAC.01009-12","article-title":"Breakthrough bacteremia due to extended-spectrum-\u03b2-lactamase-producing Klebsiella pneumoniae during combination therapy with colistin and tigecycline","volume":"56","author":"Cho","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.04.009_bib0012","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jgar.2020.04.014","article-title":"In vitro activity of polymyxin B in combination with meropenem, amikacin and gentamicin against Klebsiella pneumoniae clinical isolates co-harbouring aminoglycoside-modifying enzymes, bla(NDM-1) and bla(KPC-2)","volume":"22","author":"Firmo","year":"2020","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.jgar.2025.04.009_bib0013","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s10096-011-1360-5","article-title":"Synergy of fosfomycin with carbapenems, colistin, netilmicin, and tigecycline against multidrug-resistant Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa clinical isolates","volume":"31","author":"Samonis","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"2","key":"10.1016\/j.jgar.2025.04.009_bib0014","doi-asserted-by":"crossref","first-page":"e01815","DOI":"10.1128\/AAC.01815-17","article-title":"Evaluation of activity and emergence of resistance of polymyxin B and ZTI-01 (fosfomycin for injection) against KPC-producing Klebsiella pneumoniae","volume":"62","author":"Diep","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.04.009_bib0015","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/1469-0691.12697","article-title":"Treating infections caused by carbapenemase-producing Enterobacteriaceae","volume":"20","author":"Tzouvelekis","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jgar.2025.04.009_bib0016","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1128\/AAC.02166-13","article-title":"Carbapenemase-producing Klebsiella pneumoniae bloodstream infections: lowering mortality by antibiotic combination schemes and the role of carbapenems","volume":"58","author":"Daikos","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.04.009_bib0017","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/cid\/cis588","article-title":"Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy","volume":"55","author":"Tumbarello","year":"2012","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jgar.2025.04.009_bib0018","series-title":"Performance standards for antimicrobial susceptibility testing","year":"2018"},{"key":"10.1016\/j.jgar.2025.04.009_bib0019","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.00213-21","article-title":"Overview of changes to the clinical and laboratory standards institute performance standards for antimicrobial susceptibility testing, M100, 31st edition","volume":"59","author":"Humphries","year":"2021","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2025.04.009_bib0020","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jgar.2020.04.014","article-title":"In vitro activity of polymyxin B in combination with meropenem, amikacin and gentamicin against Klebsiella pneumoniae clinical isolates co-harbouring aminoglycoside-modifying enzymes, blaNDM-1 and blaKPC-2","volume":"22","author":"Firmo","year":"2020","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.jgar.2025.04.009_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/dkg301","article-title":"Synergy, antagonism, and what the chequerboard puts between them","volume":"52","author":"Odds","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2025.04.009_bib0022","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12941-022-00520-8","article-title":"Prevalence of colistin resistance of Klebsiella pneumoniae isolates in Iran: a systematic review and meta-analysis","volume":"21","author":"Narimisa","year":"2022","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"10.1016\/j.jgar.2025.04.009_bib0023","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1080\/14787210.2022.2142118","article-title":"A narrative review on drug development for the management of antimicrobial-resistant infection crisis in Japan: the past, present, and future","volume":"20","author":"Ohashi","year":"2022","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.jgar.2025.04.009_bib0024","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.cmi.2020.03.035","article-title":"Colistin plus meropenem for carbapenem-resistant Gram-negative infections: in vitro synergism is not associated with better clinical outcomes","volume":"26","author":"Nutman","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jgar.2025.04.009_bib0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijantimicag.2014.02.016","article-title":"Colistin resistance in Klebsiella pneumoniae","volume":"44","author":"Ah","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jgar.2025.04.009_bib0026","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3389\/fmicb.2014.00643","article-title":"Mechanisms of polymyxin resistance: acquired and intrinsic resistance in bacteria","volume":"5","author":"Olaitan","year":"2014","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgar.2025.04.009_bib0027","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1128\/AAC.00009-16","article-title":"Amino acid substitutions of CrrB responsible for resistance to Colistin through CrrC in Klebsiella pneumoniae","volume":"60","author":"Cheng","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"10.1016\/j.jgar.2025.04.009_bib0028","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00618-19","article-title":"A stress response monitoring lipoprotein trafficking to the outer membrane","volume":"10","author":"May","year":"2019","journal-title":"mBio"},{"key":"10.1016\/j.jgar.2025.04.009_bib0029","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1073\/pnas.042521699","article-title":"Surface sensing and adhesion of Escherichia coli controlled by the cpx-signaling pathway","volume":"99","author":"Otto","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"10.1016\/j.jgar.2025.04.009_bib0030","doi-asserted-by":"crossref","DOI":"10.1128\/JB.00611-18","article-title":"The lipoprotein NlpE is a cpx sensor that serves as a sentinel for protein sorting and folding defects in the Escherichia coli envelope","volume":"201","author":"Delhaye","year":"2019","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jgar.2025.04.009_bib0031","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1021\/pr060372s","article-title":"Global comparison of the membrane subproteomes between a multidrug-resistant Acinetobacter baumannii strain and a reference strain","volume":"5","author":"Siroy","year":"2006","journal-title":"J Proteome Res"},{"key":"10.1016\/j.jgar.2025.04.009_bib0032","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1128\/AAC.01677-09","article-title":"Effect of NlpE overproduction on multidrug resistance in Escherichia coli","volume":"54","author":"Nishino","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.04.009_bib0033","doi-asserted-by":"crossref","first-page":"26652","DOI":"10.1074\/jbc.M203487200","article-title":"Genome-wide profiling of promoter recognition by the two-component response regulator CpxR-P in Escherichia coli","volume":"277","author":"De Wulf","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jgar.2025.04.009_bib0034","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1128\/jb.177.15.4216-4223.1995","article-title":"Overproduction of NlpE, a new outer membrane lipoprotein, suppresses the toxicity of periplasmic LacZ by activation of the Cpx signal transduction pathway","volume":"177","author":"Snyder","year":"1995","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jgar.2025.04.009_bib0035","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1128\/AAC.00715-09","article-title":"Klebsiella pneumoniae AcrAB efflux pump contributes to antimicrobial resistance and virulence","volume":"54","author":"Padilla","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.04.009_bib0036","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1101\/gad.11.15.2012","article-title":"The response to extracytoplasmic stress in Escherichia coli is controlled by partially overlapping pathways","volume":"11","author":"Connolly","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/j.jgar.2025.04.009_bib0037","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1128\/JB.185.8.2432-2440.2003","article-title":"Signal detection and target gene induction by the CpxRA two-component system","volume":"185","author":"DiGiuseppe","year":"2003","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jgar.2025.04.009_bib0038","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1073\/pnas.1702248114","article-title":"Redefining the essential trafficking pathway for outer membrane lipoproteins","volume":"114","author":"Grabowicz","year":"2017","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716525000840?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716525000840?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T14:00:38Z","timestamp":1762610438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716525000840"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":38,"alternative-id":["S2213716525000840"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2025.04.009","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of in vitro combination therapy with polymyxin B on delaying resistance in Klebsiella pneumoniae and insights into the mechanisms of polymyxin-induced resistance","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2025.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}