{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T20:59:03Z","timestamp":1784667543764,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012990","name":"Universit\u00e0 degli Studi di Siena","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jgar.2025.06.006","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T19:34:00Z","timestamp":1749670440000},"page":"116-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Urinary tract infections caused by Gram-negative bacteria in elderly hospitalized patients: Epidemiology, clinical features and outcomes in the era of antimicrobial resistance"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-630X","authenticated-orcid":false,"given":"Gabriele","family":"Giuliano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Hankache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5669-5294","authenticated-orcid":false,"given":"Margherita","family":"Sambo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8869-8164","authenticated-orcid":false,"given":"Maria Grazia","family":"Cusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro Enea","family":"Lazzerini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Gennari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1343-812X","authenticated-orcid":false,"given":"Massimiliano","family":"Fabbiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2267-1337","authenticated-orcid":false,"given":"Francesca","family":"Montagnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-8552","authenticated-orcid":false,"given":"Mario","family":"Tumbarello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2025.06.006_bib0001","doi-asserted-by":"crossref","first-page":"5333","DOI":"10.3390\/ijerph18105333","article-title":"Epidemiology and prevention of Healthcare-associated infections in geriatric patients: a narrative review","volume":"18","author":"Cristina","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jgar.2025.06.006_bib0002","doi-asserted-by":"crossref","first-page":"afac155","DOI":"10.1093\/ageing\/afac155","article-title":"Association between multimorbidity and hospitalization in older adults: systematic review and meta-analysis","volume":"51","author":"Rodrigues","year":"2022","journal-title":"Age Ageing"},{"key":"10.1016\/j.jgar.2025.06.006_bib0003","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000516677","article-title":"Geriatric patients and symptomatic urinary tract infections: analysis of bacterial range and resistance rates at a 3rd level of care hospital in Germany","volume":"106","author":"Manseck","year":"2022","journal-title":"Urol Int"},{"key":"10.1016\/j.jgar.2025.06.006_bib0004","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1186\/s12879-023-08711-0","article-title":"7295 elderly hospitalized patients with catheter-associated urinary tract infection: a case-control study","volume":"23","author":"Shen","year":"2023","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jgar.2025.06.006_bib0005","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.medmal.2019.01.012","article-title":"Multifactorial immunodeficiency in frail elderly patients: contributing factors and management","volume":"49","author":"Tannou","year":"2019","journal-title":"Med Mal Infect"},{"key":"10.1016\/j.jgar.2025.06.006_bib0006","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ijantimicag.2011.09.009","article-title":"Critical review of current definitions of urinary tract infections and proposal of an EAU\/ESIU classification system","volume":"38 Suppl","author":"Johansen","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jgar.2025.06.006_bib0007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.idc.2013.09.003","article-title":"Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden","volume":"28","author":"Foxman","year":"2014","journal-title":"Infect Dis Clin North Am"},{"key":"10.1016\/j.jgar.2025.06.006_bib0008","doi-asserted-by":"crossref","first-page":"477","DOI":"10.21037\/atm.2020.03.95","article-title":"Risk factors for uroseptic shock in hospitalized patients aged over 80 years with urinary tract infection","volume":"8","author":"Hsiao","year":"2020","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.jgar.2025.06.006_bib0009","doi-asserted-by":"crossref","first-page":"5S","DOI":"10.1016\/S0002-9343(02)01054-9","article-title":"Epidemiology of urinary tract infections: incidence, morbidity, and economic costs","volume":"113","author":"Foxman","year":"2002","journal-title":"Am J Med"},{"key":"10.1016\/j.jgar.2025.06.006_bib0010","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/oxfordjournals.aje.a117402","article-title":"Clinical infections in the noninstitutionalized geriatric age group: methods utilized and incidence of infections. The Pittsburgh Good Health Study","volume":"141","author":"Ruben","year":"1995","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jgar.2025.06.006_bib0011","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/14737167.2017.1358618","article-title":"Clinical and economic implications of urinary tract infections","volume":"17","author":"Steiger","year":"2017","journal-title":"Expert Rev Pharmacoecon Outcomes Res"},{"key":"10.1016\/j.jgar.2025.06.006_bib0012","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.cmi.2022.09.004","article-title":"Excess length of stay and readmission following hospital-acquired bacteraemia: a population-based cohort study applying a multi-state model approach","volume":"29","author":"Mortensen","year":"2023","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jgar.2025.06.006_bib0013","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41579-024-01092-4","article-title":"Urinary tract infections: pathogenesis, host susceptibility and emerging therapeutics","volume":"23","author":"Timm","year":"2025","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jgar.2025.06.006_bib0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178178","article-title":"Pseudomonas aeruginosa urinary tract infections in hospitalized patients: mortality and prognostic factors","volume":"12","author":"Lamas Ferreiro","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jgar.2025.06.006_bib0015","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/1120009X.2017.1380395","article-title":"Multi-drug-resistant Gram-negative bacteria causing urinary tract infections: a review","volume":"29","author":"Mazzariol","year":"2017","journal-title":"J Chemother"},{"key":"10.1016\/j.jgar.2025.06.006_bib0016","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/5584_2020_566","article-title":"The role of Gram-negative bacteria in urinary tract infections: current concepts and therapeutic options","volume":"1323","author":"Behzadi","year":"2021","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.jgar.2025.06.006_bib0017","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3390\/antibiotics11070832","article-title":"Spread of multidrug-resistant microorganisms","volume":"11","author":"Di Lodovico","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.jgar.2025.06.006_bib0018","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3390\/pathogens12040623","article-title":"Urinary tract infections: the current scenario and future prospects","volume":"12","author":"Mancuso","year":"2023","journal-title":"Pathogens"},{"key":"10.1016\/j.jgar.2025.06.006_bib0019","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/ggi.14080","article-title":"Characteristics of urinary tract infections in older patients in a tertiary hospital in Greece","volume":"20","author":"Ioannou","year":"2020","journal-title":"Geriatr Gerontol Int"},{"key":"10.1016\/j.jgar.2025.06.006_bib0020","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1007\/s00345-020-03159-2","article-title":"Treatment of urinary tract infections in the old and fragile","volume":"38","author":"Zeng","year":"2020","journal-title":"World J Urol"},{"key":"10.1016\/j.jgar.2025.06.006_bib0021","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.amjms.2020.06.016","article-title":"On the subject of urinary tract infections in the elderly","volume":"360","author":"Higuita","year":"2020","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.jgar.2025.06.006_bib0022","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.3390\/antibiotics10091098","article-title":"Urinary tract infections in elderly patients: a 10-year study on their epidemiology and antibiotic resistance based on the WHO access, watch, reserve (AWaRe) classification","volume":"10","author":"Gajd\u00e1cs","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.jgar.2025.06.006_bib0023","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"10.1016\/j.jgar.2025.06.006_bib0024","series-title":"Breakpoint tables for interpretation of MICs and zone diameters. Version 15.0","year":"2025"},{"key":"10.1016\/j.jgar.2025.06.006_bib0025","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jamda.2013.02.016","article-title":"Carbapenem resistance and mortality in institutionalized elderly with urinary infection","volume":"14","author":"Marinosci","year":"2013","journal-title":"J Am Med Dir Assoc"},{"key":"10.1016\/j.jgar.2025.06.006_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinf.2024.106167","article-title":"Population incidence and associated mortality of urinary tract infection in people living with dementia","volume":"88","author":"Lai","year":"2024","journal-title":"J Infect"},{"key":"10.1016\/j.jgar.2025.06.006_bib0027","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1186\/s12879-024-09319-8","article-title":"Nomogram predictive model for in-hospital mortality risk in elderly ICU patients with urosepsis","volume":"24","author":"Wei","year":"2024","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jgar.2025.06.006_bib0028","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1016\/j.archger.2010.05.011","article-title":"Risk factors of all-cause in-hospital mortality among Korean elderly bacteremic urinary tract infection (UTI) patients","volume":"52","author":"Chin","year":"2011","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.jgar.2025.06.006_bib0029","doi-asserted-by":"crossref","first-page":"681","DOI":"10.4140\/TCP.n.2021.681","article-title":"Admissions and mortality related to urinary tract infections in male veterans with dementia","volume":"36","author":"DeRosa","year":"2021","journal-title":"Sr Care Pharm"},{"key":"10.1016\/j.jgar.2025.06.006_bib0030","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3390\/diagnostics11030523","article-title":"Atypical presentation of bacteremic urinary tract infection in older patients: frequency and prognostic impact","volume":"11","author":"Laborde","year":"2021","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.jgar.2025.06.006_bib0031","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.amjms.2016.05.031","article-title":"Effect of bacteremia in elderly patients with urinary tract infection","volume":"352","author":"Artero","year":"2016","journal-title":"Am J Med Sci"},{"key":"10.1016\/j.jgar.2025.06.006_bib0032","series-title":"Antimicrobial resistance surveillance in Europe 2015. Annual report of the European antimicrobial resistance surveillance network (EARS-Net)","year":"2017"},{"key":"10.1016\/j.jgar.2025.06.006_bib0033","doi-asserted-by":"crossref","first-page":"l525","DOI":"10.1136\/bmj.l525","article-title":"Antibiotic management of urinary tract infection in elderly patients in primary care and its association with bloodstream infections and all cause mortality: population based cohort study","volume":"364","author":"Gharbi","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.jgar.2025.06.006_bib0034","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ejim.2014.04.009","article-title":"Influence of inadequate antimicrobial therapy on prognosis in elderly patients with severe urinary tract infections","volume":"25","author":"Esparcia","year":"2014","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.jgar.2025.06.006_bib0035","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/21548331.2016.1133214","article-title":"Epidemiology and economics of adult patients hospitalized with urinary tract infections","volume":"44","author":"Cardwell","year":"2016","journal-title":"Hosp Pract (1995)"},{"key":"10.1016\/j.jgar.2025.06.006_bib0036","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1186\/s12879-021-06229-x","article-title":"Burden of illness in US hospitals due to carbapenem-resistant Gram-negative urinary tract infections in patients with or without bacteraemia","volume":"21","author":"Shields","year":"2021","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jgar.2025.06.006_bib0037","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/cid\/ciad725","article-title":"Clinical features and outcomes of infections caused by metallo-\u03b2-lactamase-producing Enterobacterales: a 3-year prospective study from an endemic area","volume":"78","author":"Falcone","year":"2024","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jgar.2025.06.006_bib0038","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ejim.2024.01.009","article-title":"ESCMID study group of infections in the elderly (ESGIE). Challenges of antimicrobial stewardship among older adults","volume":"124","author":"Alves","year":"2024","journal-title":"Eur J Intern Med"},{"key":"10.1016\/j.jgar.2025.06.006_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2024.1433597","article-title":"Assessment of community-acquired urinary tract infections treatment in the emergency department: a retrospective study","volume":"14","author":"Ghaleb","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jgar.2025.06.006_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.105900","article-title":"Characterisation and risk factor profiling of Pseudomonas aeruginosa urinary tract infections: pinpointing those likely to be caused by multidrug-resistant strains","volume":"55","author":"Tumbarello","year":"2020","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jgar.2025.06.006_bib0041","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1001\/jama.2024.6259","article-title":"Stewardship prompts to improve antibiotic selection for urinary tract infection: the INSPIRE randomized clinical trial","volume":"331","author":"Gohil","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.jgar.2025.06.006_bib0042","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/jac\/dkh047","article-title":"ESBL-producing multidrug-resistant Providencia stuartii infections in a university hospital","volume":"53","author":"Tumbarello","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2025.06.006_bib0043","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.3390\/microorganisms12102085","article-title":"Clinical and drug resistance characteristics of Providencia infections","volume":"12","author":"Malviya","year":"2024","journal-title":"Microorganisms"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716525001389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716525001389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:16:09Z","timestamp":1777101369000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716525001389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":43,"alternative-id":["S2213716525001389"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2025.06.006","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urinary tract infections caused by Gram-negative bacteria in elderly hospitalized patients: Epidemiology, clinical features and outcomes in the era of antimicrobial resistance","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2025.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}