{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T16:48:14Z","timestamp":1784566094379,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-001278\\u201301"],"award-info":[{"award-number":["MOH-001278\\u201301"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-000018\\u201300"],"award-info":[{"award-number":["MOH-000018\\u201300"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["CG21APR1011"],"award-info":[{"award-number":["CG21APR1011"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-001168\\u201301"],"award-info":[{"award-number":["MOH-001168\\u201301"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["CG21APR2005"],"award-info":[{"award-number":["CG21APR2005"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001469","name":"Singapore General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001469","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jgar.2025.06.021","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T14:20:31Z","timestamp":1753194031000},"page":"340-346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Comparative in vitro activities of eravacycline and tigecycline against carbapenem-resistant Acinetobacter baumannii: Insights from whole genome sequencing analysis"],"prefix":"10.1016","volume":"44","author":[{"given":"Yang","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn Qi Min","family":"Teo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Yi","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6478-5888","authenticated-orcid":false,"given":"Jiahao","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhua","family":"Thong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihui","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurhayati Binte Monhamed","family":"Yusoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tze Peng","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Lay Hoon","family":"Kwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2025.06.021_bib0001","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1128\/CMR.00058-16","article-title":"Clinical and pathophysiological overview of Acinetobacter infections: a century of challenges","volume":"30","author":"Wong","year":"2017","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jgar.2025.06.021_bib0002","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00661-17","article-title":"Multicenter study of the relationship between carbapenem MIC values and clinical outcome of patients with Acinetobacter bacteremia","volume":"61","author":"Yang","year":"2017","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.jgar.2025.06.021_bib0003","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","article-title":"Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis","volume":"18","author":"Tacconelli","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jgar.2025.06.021_bib0004","doi-asserted-by":"crossref","first-page":"5548","DOI":"10.1128\/AAC.01288-13","article-title":"Antibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogens","volume":"57","author":"Sutcliffe","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.06.021_bib0006","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01002-23","article-title":"Comparative activities of novel therapeutic agents against molecularly characterized clinical carbapenem-resistant enterobacterales isolates","volume":"11","author":"Teo","year":"2023","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jgar.2025.06.021_bib0007","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s40265-016-0545-8","article-title":"Review of eravacycline, a novel fluorocycline antibacterial agent","volume":"76","author":"Zhanel","year":"2016","journal-title":"Drugs"},{"key":"10.1016\/j.jgar.2025.06.021_bib0008","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ijantimicag.2017.06.022","article-title":"In-vitro activity of the novel fluorocycline eravacycline against carbapenem non-susceptible Acinetobacter baumannii","volume":"51","author":"Seifert","year":"2018","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jgar.2025.06.021_bib0009","article-title":"In vitro activity of eravacycline against gram-negative Bacilli isolated in clinical laboratories worldwide from 2013 to 2017","volume":"64","author":"Morrissey","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.06.021_bib0010","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00957-22","article-title":"Genomic surveillance of carbapenem-resistant Klebsiella pneumoniae from a major public health hospital in Singapore","volume":"10","author":"Teo","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jgar.2025.06.021_bib0011","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jgar.2025.06.021_bib0012","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/cmb.2012.0021","article-title":"SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing","volume":"19","author":"Bankevich","year":"2012","journal-title":"J Comput Biol"},{"key":"10.1016\/j.jgar.2025.06.021_bib0013","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.00197-18","article-title":"Kaptive Web: user-friendly capsule and lipopolysaccharide serotype prediction for Klebsiella genomes","volume":"56","author":"Wick","year":"2018","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2025.06.021_bib0014","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104984","article-title":"Solving the problem of comparing whole bacterial genomes across different sequencing platforms","volume":"9","author":"Kaas","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jgar.2025.06.021_bib0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/bioinformatics\/btl529","article-title":"Interactive Tree of Life (iTOL): an online tool for phylogenetic tree display and annotation","volume":"23","author":"Letunic","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jgar.2025.06.021_bib0016","doi-asserted-by":"crossref","first-page":"D690","DOI":"10.1093\/nar\/gkac920","article-title":"CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database","volume":"51","author":"Alcock","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jgar.2025.06.021_bib0017","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1128\/AAC.04809-14","article-title":"Activity of eravacycline against Enterobacteriaceae and Acinetobacter baumannii, including multidrug-resistant isolates, from New York City","volume":"59","author":"Abdallah","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.06.021_bib0018","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01031-21","article-title":"Cryo-EM determination of eravacycline-bound structures of the ribosome and the multidrug efflux pump AdeJ of Acinetobacter baumannii","volume":"12","author":"Zhang","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.jgar.2025.06.021_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2020.104185","article-title":"Mechanism of eravacycline resistance in Acinetobacter baumannii mediated by a deletion mutation in the sensor kinase adeS, leading to elevated expression of the efflux pump AdeABC","volume":"80","author":"Shi","year":"2020","journal-title":"Infect Genet Evol"},{"key":"10.1016\/j.jgar.2025.06.021_bib0020","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1093\/jac\/dkab079","article-title":"Prevalence of RND efflux pump regulator variants associated with tigecycline resistance in carbapenem-resistant Acinetobacter baumannii from a worldwide survey","volume":"76","author":"Luca\u00dfen","year":"2021","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2025.06.021_bib0021","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.1128\/AAC.00436-16","article-title":"In vitro activity of eravacycline against carbapenem-resistant Enterobacteriaceae and Acinetobacter baumannii","volume":"60","author":"Livermore","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.06.021_bib0022","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1128\/AAC.45.12.3375-3380.2001","article-title":"Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454","volume":"45","author":"Magnet","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.06.021_bib0023","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1089\/mdr.2019.0423","article-title":"Activity of omadacycline and other tetracyclines against contemporary gram-negative pathogens from New York City hospitals","volume":"27","author":"Iregui","year":"2021","journal-title":"Microb Drug Resist"},{"key":"10.1016\/j.jgar.2025.06.021_bib0024","doi-asserted-by":"crossref","first-page":"3298","DOI":"10.1128\/AAC.48.9.3298-3304.2004","article-title":"Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system","volume":"48","author":"Marchand","year":"2004","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716525001559?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716525001559?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:19:31Z","timestamp":1777101571000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716525001559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":23,"alternative-id":["S2213716525001559"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2025.06.021","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative in vitro activities of eravacycline and tigecycline against carbapenem-resistant Acinetobacter baumannii: Insights from whole genome sequencing analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2025.06.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}