{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:52:07Z","timestamp":1792572727406,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012399","name":"Biomedical Advanced Research and Development Authority","doi-asserted-by":"publisher","award":["HHSO100201600002C"],"award-info":[{"award-number":["HHSO100201600002C"]}],"id":[{"id":"10.13039\/100012399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009930","name":"Basilea Pharmaceutica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009930","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.jgar.2025.07.022","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T15:18:47Z","timestamp":1753456727000},"page":"323-331","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Activity of ceftobiprole against methicillin-resistant Staphylococcus aureus of diverse genetic types"],"prefix":"10.1016","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9785-5034","authenticated-orcid":false,"given":"Marisa L.","family":"Winkler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0457-1543","authenticated-orcid":false,"given":"John H.","family":"Kimbrough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helio S.","family":"Sader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Castanheira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo E.","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2025.07.022_bib0001","series-title":"Antibiotic resistance threats in the United States, 2019","year":"2019"},{"key":"10.1016\/j.jgar.2025.07.022_bib0002","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1080\/1120009X.2023.2259673","article-title":"Oritavancin in vitro activity against Gram-positive organisms from European medical centers: a 10-year longitudinal overview from the SENTRY Antimicrobial Surveillance Program (2010-2019)","volume":"35","author":"Pfaller","year":"2023","journal-title":"J Chemother"},{"issue":"5","key":"10.1016\/j.jgar.2025.07.022_bib0003","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02488-19","article-title":"Surveillance of omadacycline activity tested against clinical isolates from the United States and Europe: report from the SENTRY Antimicrobial Surveillance Program, 2016 to 2018","volume":"64","author":"Pfaller","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.07.022_bib0004","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1093\/cid\/ciq146","article-title":"Clinical practice guidelines by the infectious diseases society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children","volume":"52","author":"Liu","year":"2011","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jgar.2025.07.022_bib0006","unstructured":"Red Book online, on UpToDate, Inc, 2021. Accessed 11 December 2024."},{"key":"10.1016\/j.jgar.2025.07.022_bib0008","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ijantimicag.2011.11.005","article-title":"A randomised, double-blind trial comparing ceftobiprole medocaril with ceftriaxone with or without linezolid for the treatment of patients with community-acquired pneumonia requiring hospitalisation","volume":"39","author":"Nicholson","year":"2012","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jgar.2025.07.022_bib0009","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1086\/526527","article-title":"A randomized, double-blind trial comparing ceftobiprole medocaril with vancomycin plus ceftazidime for the treatment of patients with complicated skin and skin-structure infections","volume":"46","author":"Noel","year":"2008","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jgar.2025.07.022_bib0010","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1056\/NEJMoa2300220","article-title":"Ceftobiprole for treatment of complicated Staphylococcus aureus bacteremia","volume":"389","author":"Holland","year":"2023","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.jgar.2025.07.022_bib0011","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00106-20","article-title":"Structural insights into ceftobiprole inhibition of Pseudomonas aeruginosa penicillin-binding protein 3","volume":"64","author":"Kumar","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"10.1016\/j.jgar.2025.07.022_bib0012","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01566-18","article-title":"Ceftobiprole activity against Gram-positive and -negative pathogens collected from the United States in 2006 and 2016","volume":"63","author":"Pfaller","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.07.022_bib0013","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.diagmicrobio.2019.01.015","article-title":"Ceftobiprole activity when tested against contemporary bacteria causing bloodstream infections in the United States (2016-2017)","volume":"94","author":"Pfaller","year":"2019","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jgar.2025.07.022_bib0014","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01402-24","article-title":"Ceftobiprole activity against multidrug-resistant Staphylococcus aureus clinical isolates collected in the United States from 2016 through 2022","volume":"69","author":"Sader","year":"2025","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.07.022_bib0015","series-title":"Re-Exploring the intermediate interpretive category","author":"Humphries","year":"2021"},{"key":"10.1016\/j.jgar.2025.07.022_bib0017","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1086\/675283","article-title":"Continued emergence of USA300 methicillin-resistant Staphylococcus aureus in the United States: results from a nationwide surveillance study","volume":"35","author":"Diekema","year":"2014","journal-title":"Infect Control Hosp Epidemiol"},{"key":"10.1016\/j.jgar.2025.07.022_bib0018","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.3201\/eid2111.150452","article-title":"USA300 Methicillin-resistant Staphylococcus aureus, United States, 2000-2013","volume":"21","author":"Carrel","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.jgar.2025.07.022_bib0019","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jgar.2016.04.004","article-title":"Genomic insights into the emergence and spread of international clones of healthcare-, community- and livestock-associated meticillin-resistant Staphylococcus aureus: blurring of the traditional definitions","volume":"6","author":"Bal","year":"2016","journal-title":"J Glob Antimicrob Resist"},{"issue":"3","key":"10.1016\/j.jgar.2025.07.022_bib0020","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00464-17","article-title":"Improved subtyping of Staphylococcus aureus clonal complex 8 strains based on whole-genome phylogenetic analysis","volume":"3","author":"Bowers","year":"2018","journal-title":"mSphere"},{"key":"10.1016\/j.jgar.2025.07.022_bib0021","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1469-0691.2006.01573.x","article-title":"The molecular evolution of methicillin-resistant Staphylococcus aureus","volume":"13","author":"Deurenberg","year":"2007","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jgar.2025.07.022_bib0022","series-title":"Antibacterial susceptibility test interpretive criteria","year":"2025"},{"key":"10.1016\/j.jgar.2025.07.022_bib0024","series-title":"M100Ed34. performance standards for antimicrobial susceptibility testing: 34th informational supplement","year":"2024"},{"key":"10.1016\/j.jgar.2025.07.022_bib0025","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/cmb.2012.0021","article-title":"SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing","volume":"19","author":"Bankevich","year":"2012","journal-title":"J Comput Biol"},{"key":"10.1016\/j.jgar.2025.07.022_bib0026","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1128\/JCM.41.12.5442-5448.2003","article-title":"Typing of methicillin-resistant Staphylococcus aureus in a university hospital setting by using novel software for spa repeat determination and database management","volume":"41","author":"Harmsen","year":"2003","journal-title":"J Clin Microbiol"},{"issue":"1","key":"10.1016\/j.jgar.2025.07.022_bib0027","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00612-17","article-title":"SCCmecFinder, a web-based tool for typing of staphylococcal cassette chromosome mec in Staphylococcus aureus using whole-genome sequence data","volume":"3","author":"Kaya","year":"2018","journal-title":"mSphere"},{"key":"10.1016\/j.jgar.2025.07.022_bib0028","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1128\/JCM.03617-13","article-title":"Real-time whole-genome sequencing for routine typing, surveillance, and outbreak detection of verotoxigenic Escherichia coli","volume":"52","author":"Joensen","year":"2014","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2025.07.022_bib0029","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/bioinformatics\/btw582","article-title":"PHYLOViZ 2.0: providing scalable data integration and visualization for multiple phylogenetic inference methods","volume":"33","author":"Nascimento","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jgar.2025.07.022_bib0030","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1471-2105-10-152","article-title":"Global optimal eBURST analysis of multilocus typing data using a graphic matroid approach","volume":"10","author":"Francisco","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jgar.2025.07.022_bib0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017936","article-title":"A field guide to pandemic, epidemic and sporadic clones of methicillin-resistant Staphylococcus aureus","volume":"6","author":"Monecke","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jgar.2025.07.022_bib0032","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1128\/JCM.01708-13","article-title":"Diversity of methicillin-resistant Staphylococcus aureus strains isolated from residents of 26 nursing homes in Orange County, California","volume":"51","author":"Hudson","year":"2013","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2025.07.022_bib0033","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1128\/JCM.00511-07","article-title":"Changing molecular epidemiology of methicillin-resistant Staphylococcus aureus in a small geographic area over an eight-year period","volume":"45","author":"Blanc","year":"2007","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2025.07.022_bib0034","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1128\/AAC.01287-09","article-title":"Differentiation of clonal complex 59 community-associated methicillin-resistant Staphylococcus aureus in Western Australia","volume":"54","author":"Coombs","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.07.022_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042864","article-title":"A typical hospital-acquired methicillin-resistant Staphylococcus aureus clone is widespread in the community in the Gaza strip","volume":"7","author":"Biber","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jgar.2025.07.022_bib0036","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S1438-4221(01)80006-0","article-title":"Characteristics of a new epidemic MRSA in Germany ancestral to United Kingdom EMRSA 15","volume":"290","author":"Witte","year":"2001","journal-title":"Int J Med Microbiol"},{"key":"10.1016\/j.jgar.2025.07.022_bib0037","doi-asserted-by":"crossref","first-page":"571","DOI":"10.5578\/mb.5770","article-title":"[t030 is the most common spa type among methicillin-resistant Staphylococcus aureus strains isolated from Turkish hospitals]","volume":"47","author":"Bozdogan","year":"2013","journal-title":"Mikrobiyol Bul"},{"key":"10.1016\/j.jgar.2025.07.022_bib0038","doi-asserted-by":"crossref","first-page":"3454","DOI":"10.1128\/JCM.01050-08","article-title":"Epidemiology of invasive methicillin-resistant Staphylococcus aureus clones collected in France in 2006 and 2007","volume":"46","author":"Dauwalder","year":"2008","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2025.07.022_bib0039","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1128\/JCM.01967-12","article-title":"Diversification of clonal complex 5 methicillin-resistant Staphylococcus aureus strains (Rhine-Hesse clone) within Germany","volume":"51","author":"Schulte","year":"2013","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2025.07.022_bib0040","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/zph.12034","article-title":"Colonization of butchers with livestock-associated methicillin-resistant Staphylococcus aureus","volume":"60","author":"Boost","year":"2013","journal-title":"Zoonoses Public Health"},{"key":"10.1016\/j.jgar.2025.07.022_bib0041","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1128\/AAC.01689-12","article-title":"Emergence of sequence type 779 methicillin-resistant Staphylococcus aureus harboring a novel pseudo staphylococcal cassette chromosome mec (SCCmec)-SCC-SCCCRISPR composite element in Irish hospitals","volume":"57","author":"Kinnevey","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.07.022_bib0042","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41579-018-0147-4","article-title":"Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research","volume":"17","author":"Turner","year":"2019","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.jgar.2025.07.022_bib0043","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tim.2016.09.009","article-title":"Architecture of a species: phylogenomics of Staphylococcus aureus","volume":"25","author":"Planet","year":"2017","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.jgar.2025.07.022_bib0044","doi-asserted-by":"crossref","first-page":"e1063","DOI":"10.1097\/CCM.0000000000005337","article-title":"Surviving sepsis campaign: international Guidelines for management of sepsis and Septic Shock 2021","volume":"49","author":"Evans","year":"2021","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jgar.2025.07.022_bib0045","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1089\/mdr.2014.0307","article-title":"Genotypic characterization of methicillin-resistant Staphylococcus aureus recovered at baseline from phase 3 pneumonia clinical trials for ceftobiprole","volume":"22","author":"Mendes","year":"2016","journal-title":"Microb Drug Resist"},{"key":"10.1016\/j.jgar.2025.07.022_bib0046","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ijantimicag.2013.11.005","article-title":"Activity of ceftobiprole against methicillin-resistant Staphylococcus aureus strains with reduced susceptibility to daptomycin, linezolid or vancomycin, and strains with defined SCCmec types","volume":"43","author":"Farrell","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jgar.2025.07.022_bib0047","doi-asserted-by":"crossref","first-page":"ofaf282","DOI":"10.1093\/ofid\/ofaf282","article-title":"Trends in incidence and epidemiology of methicillin-resistant Staphylococcus aureus bacteremia, six emerging infections program surveillance sites, 2005-2022","volume":"12","author":"Biggs","year":"2025","journal-title":"Open Forum Infect Dis"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716525001754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716525001754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:19:42Z","timestamp":1777101582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716525001754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":43,"alternative-id":["S2213716525001754"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2025.07.022","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activity of ceftobiprole against methicillin-resistant Staphylococcus aureus of diverse genetic types","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2025.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}