{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:55:54Z","timestamp":1781510154988,"version":"3.54.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2023KY195"],"award-info":[{"award-number":["2023KY195"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.jgar.2025.12.016","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T16:16:00Z","timestamp":1767802560000},"page":"246-253","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Evaluating the performance of the InnowaveDx MTB\/RIF\/INH for simultaneous detection of Mycobacterium tuberculosis and resistance to rifampicin and isoniazid"],"prefix":"10.1016","volume":"46","author":[{"given":"Dapeng","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechai","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaofen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongning","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6585-2448","authenticated-orcid":false,"given":"Long","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2025.12.016_bib0001","series-title":"Global tuberculosis report 2024","year":"2024"},{"key":"10.1016\/j.jgar.2025.12.016_bib0002","series-title":"WHO consolidated guidelines on tuberculosis. Module 3: diagnosis \u2013 rapid diagnostics for tuberculosis detection","year":"2020"},{"key":"10.1016\/j.jgar.2025.12.016_bib0003","doi-asserted-by":"crossref","first-page":"e121","DOI":"10.1016\/S1473-3099(21)00613-7","article-title":"Can the GeneXpert MTB\/XDR deliver on the promise of expanded, near-patient tuberculosis drug-susceptibility testing?","volume":"22","author":"Naidoo","year":"2022","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jgar.2025.12.016_bib0004","unstructured":"World Health Organization. The end TB strategy, https:\/\/www.who.int\/publications\/i\/item\/WHO-HTM-TB-2015.19; 2017 [accessed 4.01.23]."},{"key":"10.1016\/j.jgar.2025.12.016_bib0005","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1128\/JCM.38.4.1498-1501.2000","article-title":"New agar medium for testing susceptibility of mycobacterium tuberculosis to pyrazinamide","volume":"38","author":"Heifets","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2025.12.016_bib0006","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1148\/92.1.154","article-title":"Early detection of bacterial growth, with carbon-14-labeled glucose","volume":"92","author":"DeLand","year":"1969","journal-title":"Radiology"},{"key":"10.1016\/j.jgar.2025.12.016_bib0007","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1056\/NEJMoa0907847","article-title":"Rapid molecular detection of tuberculosis and rifampin resistance","volume":"363","author":"Boehme","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jgar.2025.12.016_bib0008","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1089\/mdr.2017.0114","article-title":"Rifampicin resistance and multidrug-resistant tuberculosis detection using Xpert MTB\/RIF in Wuhan, China: a retrospective study","volume":"24","author":"Huang","year":"2018","journal-title":"Microb Drug Resist"},{"key":"10.1016\/j.jgar.2025.12.016_bib0009","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/s12879-020-4871-9","article-title":"Effect of the Xpert MTB\/RIF on the detection of pulmonary tuberculosis cases and rifampicin resistance in Shanghai, China","volume":"20","author":"Wu","year":"2020","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jgar.2025.12.016_bib0010","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jinf.2019.08.004","article-title":"Is rifampin resistance a reliable predictive marker of multidrug-resistant tuberculosis in China: a meta-analysis of findings","volume":"79","author":"Liu","year":"2019","journal-title":"J Infect"},{"key":"10.1016\/j.jgar.2025.12.016_bib0011","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1128\/AAC.00077-13","article-title":"Epidemiology of isoniazid resistance mutations and their effect on tuberculosis treatment outcomes","volume":"57","author":"Huyen","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2025.12.016_bib0012","series-title":"Systematic screening for active tuberculosis: principles and recommendations","year":"2013"},{"key":"10.1016\/j.jgar.2025.12.016_bib0013","series-title":"Technical guidelines for tuberculosis prevention and control in China","author":"Zhao","year":"2021"},{"key":"10.1016\/j.jgar.2025.12.016_bib0014","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1128\/JCM.37.11.3578-3582.1999","article-title":"Use of BACTEC MGIT 960 for recovery of mycobacteria from clinical specimens: multicenter study","volume":"37","author":"Tortoli","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2025.12.016_bib0015","series-title":"Guidelines for the implementation of China\u2019s tuberculosis control program","year":"2008"},{"key":"10.1016\/j.jgar.2025.12.016_bib0016","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3343\/alm.2012.32.4.264","article-title":"Rapid diagnosis of tuberculosis and multidrug resistance using a MGIT 960 system","volume":"32","author":"Koh","year":"2012","journal-title":"Ann Lab Med"},{"key":"10.1016\/j.jgar.2025.12.016_bib0017","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1128\/JCM.03395-13","article-title":"Rapid detection of isoniazid resistance in Mycobacterium tuberculosis isolates by use of real-time-PCR-based melting curve analysis","volume":"52","author":"Hu","year":"2014","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2025.12.016_bib0018","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/S0140-6736(11)60438-8","article-title":"Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB\/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study","volume":"377","author":"Boehme","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jgar.2025.12.016_bib0019","doi-asserted-by":"crossref","DOI":"10.1080\/22221751.2022.2151382","article-title":"Accuracy of the InnowaveDX MTB\/RIF test for detection of mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre study","volume":"12","author":"Deng","year":"2023","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.jgar.2025.12.016_bib0020","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S1473-3099(17)30691-6","article-title":"Xpert MTB\/RIF Ultra for detection of mycobacterium tuberculosis and rifampicin resistance: a prospective multicentre diagnostic accuracy study","volume":"18","author":"Dorman","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jgar.2025.12.016_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090569","article-title":"Correlation between genotypic and phenotypic testing for resistance to rifampin in Mycobacterium tuberculosis clinical isolates in Haiti: investigation of cases with discrepant susceptibility results","volume":"9","author":"Ocheretina","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jgar.2025.12.016_bib0022","series-title":"Technical report on critical concentrations for drug susceptibility testing of isoniazid and the rifamycins (rifampicin, rifabutin and rifapentine)","year":"2021"},{"key":"10.1016\/j.jgar.2025.12.016_bib0023","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1128\/JCM.01662-16","article-title":"FIND tuberculosis strain bank: a resource for researchers and developers working on tests to detect mycobacterium tuberculosis and related drug resistance","volume":"55","author":"Tessema","year":"2017","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.jgar.2025.12.016_bib0024","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.diagmicrobio.2016.01.019","article-title":"Rifabutin and rifampin resistance levels and associated rpoB mutations in clinical isolates of Mycobacterium tuberculosis complex","volume":"85","author":"Berrada","year":"2016","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jgar.2025.12.016_bib0025","doi-asserted-by":"crossref","first-page":"781.e1","DOI":"10.1016\/j.cmi.2017.11.021","article-title":"Absence of hybridization with the wild-type and mutant rpoB probes in the Genotype MTBDR plus assay detects \u2018disputed\u2019 rifampicin mutations","volume":"24","author":"Abanda","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.jgar.2025.12.016_bib0026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0198091","article-title":"Prevalence and patterns of rifampicin and isoniazid resistance conferring mutations in Mycobacterium tuberculosis isolates from Uganda","volume":"13","author":"Kigozi","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jgar.2025.12.016_bib0027","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1183\/09031936.00089808","article-title":"Mechanisms of heteroresistance to isoniazid and rifampin of mycobacterium tuberculosis in Tashkent, Uzbekistan","volume":"33","author":"Hofmann-Thiel","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.jgar.2025.12.016_bib0028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1574-695X.2011.00831.x","article-title":"Efflux as a mechanism for drug resistance in Mycobacterium tuberculosis","volume":"63","author":"da Silva","year":"2011","journal-title":"FEMS Immunol Med Microbiol"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716525002838?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716525002838?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T07:47:01Z","timestamp":1781509621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716525002838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":28,"alternative-id":["S2213716525002838"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2025.12.016","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating the performance of the InnowaveDx MTB\/RIF\/INH for simultaneous detection of Mycobacterium tuberculosis and resistance to rifampicin and isoniazid","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2025.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}