{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T11:57:39Z","timestamp":1781351859675,"version":"3.54.1"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004844","name":"National Cheng Kung University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004844","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007750","name":"National Cheng Kung University","doi-asserted-by":"publisher","award":["NCKUH-11102022"],"award-info":[{"award-number":["NCKUH-11102022"]}],"id":[{"id":"10.13039\/501100007750","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007750","name":"National Cheng Kung University","doi-asserted-by":"publisher","award":["NSTC 112\\u20132314-B-006 \\u2212022 -MY3"],"award-info":[{"award-number":["NSTC 112\\u20132314-B-006 \\u2212022 -MY3"]}],"id":[{"id":"10.13039\/501100007750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.jgar.2026.01.014","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:35:48Z","timestamp":1770770148000},"page":"44-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Tet(X4)-producing Escherichia coli isolates in Taiwan"],"prefix":"10.1016","volume":"48","author":[{"given":"Wen-Chun","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Tsung","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chien","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-An","family":"Shih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Hao","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9465-8692","authenticated-orcid":false,"given":"Jiun-Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2026.01.014_bib0001","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1038\/s41467-020-18475-9","article-title":"Epidemiological and phylogenetic analysis reveals Flavobacteriaceae as potential ancestral source of tigecycline resistance gene tet(X)","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat Commun"},{"issue":"Suppl 5","key":"10.1016\/j.jgar.2026.01.014_bib0002","doi-asserted-by":"crossref","first-page":"S303","DOI":"10.1086\/431672","article-title":"Tigecycline: a new glycylcycline for treatment of serious infections","volume":"41","author":"Noskin","year":"2005","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jgar.2026.01.014_bib0003","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijantimicag.2012.09.005","article-title":"The emergence of clinical resistance to tigecycline","volume":"41","author":"Sun","year":"2013","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jgar.2026.01.014_bib0004","doi-asserted-by":"crossref","first-page":"1289396","DOI":"10.3389\/fcimb.2024.1289396","article-title":"Molecular mechanisms of tigecycline-resistance among Enterobacterales","volume":"14","author":"Korczak","year":"2024","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jgar.2026.01.014_bib0005","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202000014","article-title":"Emerging high-level tigecycline resistance: novel tetracycline destructases spread via the mobile tet(X)","volume":"42","author":"Fang","year":"2020","journal-title":"Bioessays"},{"key":"10.1016\/j.jgar.2026.01.014_bib0006","doi-asserted-by":"crossref","first-page":"52346","DOI":"10.1074\/jbc.M409573200","article-title":"TetX is a flavin-dependent monooxygenase conferring resistance to tetracycline antibiotics","volume":"279","author":"Yang","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jgar.2026.01.014_bib0007","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1128\/AAC.32.12.1797","article-title":"The cryptic tetracycline resistance determinant on Tn4400 mediates tetracycline degradation as well as tetracycline efflux","volume":"32","author":"Park","year":"1988","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2026.01.014_bib0008","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1128\/jb.170.4.1423-1429.1988","article-title":"Characterization of a novel tetracycline resistance that functions only in aerobically grown Escherichia coli","volume":"170","author":"Speer","year":"1988","journal-title":"J Bacteriol"},{"key":"10.1016\/j.jgar.2026.01.014_bib0009","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/s41564-019-0496-4","article-title":"Plasmid-encoded tet(X) genes that confer high-level tigecycline resistance in Escherichia coli","volume":"4","author":"Sun","year":"2019","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jgar.2026.01.014_bib0010","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/s41564-019-0445-2","article-title":"Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans","volume":"4","author":"He","year":"2019","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jgar.2026.01.014_bib0011","doi-asserted-by":"crossref","first-page":"106930","DOI":"10.1016\/j.ijantimicag.2023.106930","volume":"62","author":"Wang","year":"2023","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jgar.2026.01.014_bib0012","doi-asserted-by":"crossref","first-page":"164148","DOI":"10.1016\/j.scitotenv.2023.164148","article-title":"Global distribution and genomic characteristics of tet(X)-positive Escherichia coli among humans, animals, and the environment","volume":"887","author":"Li","year":"2023","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jgar.2026.01.014_bib0013","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jgar.2021.12.012","article-title":"Broad-host-range IncW plasmid harbouring tet(X) in Escherichia coli isolated from pigs in Japan","volume":"28","author":"Usui","year":"2022","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.jgar.2026.01.014_bib0014","doi-asserted-by":"crossref","first-page":"e03969","DOI":"10.1128\/spectrum.03969-23","article-title":"Comparison of tet(X4)-containing contigs assembled from metagenomic sequencing data with plasmid sequences of isolates from a cohort of healthy subjects","volume":"12","author":"Ding","year":"2024","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jgar.2026.01.014_bib0015","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.3390\/foods11142010","article-title":"International spread of tet(X4)-producing Escherichia coli isolates","volume":"11","author":"Zhang","year":"2022","journal-title":"Foods"},{"key":"10.1016\/j.jgar.2026.01.014_bib0016","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1128\/AAC.06053-11","article-title":"Trends in the susceptibility of clinically important resistant bacteria to tigecycline: results from the Tigecycline In Vitro Surveillance in Taiwan study, 2006 to 2010","volume":"56","author":"Chen","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2026.01.014_bib0017","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jmii.2022.09.009","article-title":"In vitro susceptibility of common enterobacterales to eravacycline in Taiwan","volume":"56","author":"Huang","year":"2023","journal-title":"J Microbiol Immunol Infect"},{"key":"10.1016\/j.jgar.2026.01.014_bib0018","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.3389\/fmicb.2020.01967","article-title":"Molecular evidence for intra- and inter-farm spread of porcine mcr-1-carrying Escherichia coli in Taiwan","volume":"11","author":"Hsueh","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgar.2026.01.014_bib0019","doi-asserted-by":"crossref","first-page":"864209","DOI":"10.3389\/fmicb.2022.864209","article-title":"Antimicrobial-resistant Escherichia coli distribution and whole-genome analysis of sequence type 131 Escherichia coli isolates in public restrooms in Taiwan","volume":"13","author":"Chang","year":"2022","journal-title":"Front Microbiol"},{"issue":"Suppl 1","key":"10.1016\/j.jgar.2026.01.014_bib0020","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jac\/48.suppl_1.5","article-title":"Determination of minimum inhibitory concentrations","volume":"48","author":"Andrews","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2026.01.014_bib0021","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3390\/antibiotics10101239","article-title":"An outbreak of tet(X6)-carrying tigecycline-resistant Acinetobacter baumannii isolates with a new capsular type at a hospital in Taiwan","volume":"10","author":"Hsieh","year":"2021","journal-title":"Antibiotics"},{"key":"10.1016\/j.jgar.2026.01.014_bib0022","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1093\/jac\/dkab182","article-title":"Characterization of novel ISAba1-bounded tet(X15)-bearing composite transposon Tn6866 in Acinetobacter variabilis","volume":"76","author":"Li","year":"2021","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"10.1016\/j.jgar.2026.01.014_bib0023","doi-asserted-by":"crossref","DOI":"10.1128\/Spectrum.01164-21","article-title":"Source tracking and Global distribution of the Tigecycline Non-susceptible tet(X)","volume":"9","author":"Zhang","year":"2021","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jgar.2026.01.014_bib0024","doi-asserted-by":"crossref","first-page":"586214","DOI":"10.3389\/fmicb.2020.586214","article-title":"Peptidoglycan endopeptidase spr of uropathogenic Escherichia coli contributes to kidney infections and competitive fitness during bladder colonization","volume":"11","author":"Huang","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgar.2026.01.014_bib0025","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1089\/mdr.2024.0212","article-title":"Comprehensive Genomic analysis of Antimicrobial resistance in Aeromonas dhakensis","volume":"31","author":"Chen","year":"2025","journal-title":"Microb Drug Resist"},{"issue":"14","key":"10.1016\/j.jgar.2026.01.014_bib0026","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1093\/nar\/gkw569","article-title":"NCBI prokaryotic genome annotation pipeline","volume":"44","author":"Tatusova","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jgar.2026.01.014_bib0027","doi-asserted-by":"crossref","first-page":"D535","DOI":"10.1093\/nar\/gkw1017","article-title":"Improvements to PATRIC, the All-Bacterial Bioinformatics Database and Analysis Resource Center","volume":"45","author":"Wattam","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"Web Server issue","key":"10.1016\/j.jgar.2026.01.014_bib0028","doi-asserted-by":"crossref","first-page":"W475","DOI":"10.1093\/nar\/gkr201","article-title":"Interactive Tree of Life v2: online annotation and display of phylogenetic trees made easy","volume":"39","author":"Letunic","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jgar.2026.01.014_bib0029","doi-asserted-by":"crossref","first-page":"124","DOI":"10.12688\/wellcomeopenres.14826.1","article-title":"Maiden MCJ.Open-access bacterial population genomics: bIGSdb software, the PubMLST.Org website and their applications","volume":"3","author":"Jolley","year":"2018","journal-title":"Wellcome Open Res"},{"key":"10.1016\/j.jgar.2026.01.014_bib0030","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/1758-2229.12019","article-title":"The Clermont Escherichia coli phylo-typing method revisited: improvement of specificity and detection of new phylo-groups","volume":"5","author":"Clermont","year":"2013","journal-title":"Environ Microbiol Rep"},{"key":"10.1016\/j.jgar.2026.01.014_bib0031","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/978-1-4939-9877-7_20","article-title":"PlasmidFinder and In Silico pMLST: identification and typing of plasmid replicons in whole-genome sequencing (WGS)","volume":"2075","author":"Carattoli","year":"2020","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.jgar.2026.01.014_bib0032","doi-asserted-by":"crossref","first-page":"D690","DOI":"10.1093\/nar\/gkac920","article-title":"CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database","volume":"51","author":"Alcock","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jgar.2026.01.014_bib0033","doi-asserted-by":"crossref","first-page":"e00079","DOI":"10.1128\/CMR.00079-17","article-title":"Treatment of infections caused by extended-spectrum-beta-lactamase-, AmpC-, and carbapenemase-producing Enterobacteriaceae","volume":"31","author":"Rodriguez-Bano","year":"2018","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jgar.2026.01.014_bib0034","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01633-21","article-title":"Comprehensive genomic investigation of tigecycline resistance gene tet(X4)-bearing strains expanding among different settings","volume":"9","author":"Li","year":"2021","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jgar.2026.01.014_bib0035","first-page":"58","article-title":"Contributions of mutations in acrR and marR genes to organic solvent tolerance in Escherichia coli","volume":"2","author":"Watanabe","year":"2012"},{"key":"10.1016\/j.jgar.2026.01.014_bib0036","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1128\/MMBR.66.4.671-701.2002","article-title":"Regulation of bacterial drug export systems","volume":"66","author":"Grkovic","year":"2002","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.jgar.2026.01.014_bib0037","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s42003-020-01148-0","article-title":"Genomic epidemiology of animal-derived tigecycline-resistant Escherichia coli across China reveals recent endemic plasmid-encoded tet(X4) gene","volume":"3","author":"Sun","year":"2020","journal-title":"Commun Biol"},{"key":"10.1016\/j.jgar.2026.01.014_bib0038","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00488-21","article-title":"Extended-spectrum beta-lactamase-producing and mcr-1-positive Escherichia coli from the gut microbiota of healthy Singaporeans","volume":"87","author":"Ding","year":"2021","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.jgar.2026.01.014_bib0039","doi-asserted-by":"crossref","first-page":"1582851","DOI":"10.3389\/fmicb.2025.1582851","article-title":"Epidemiology and resistance mechanisms of tigecycline- and carbapenem-resistant Enterobacteriaceae in China: a multicentre genome-based study","volume":"16","author":"Yan","year":"2025","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgar.2026.01.014_bib0040","doi-asserted-by":"crossref","first-page":"e01118","DOI":"10.1128\/AAC.01118-20","article-title":"Escherichia coli sequence type 457 is an emerging extended-spectrum-beta-lactam-resistant lineage with reservoirs in wildlife and food-producing animals","volume":"65","author":"Nesporova","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2026.01.014_bib0041","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1093\/jac\/dkt263","article-title":"Mechanisms and fitness costs of tigecycline resistance in Escherichia coli","volume":"68","author":"Linkevicius","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2026.01.014_bib0042","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.3390\/biomedicines11112937","article-title":"Extended-spectrum beta-lactamases (ESBL): challenges and opportunities","volume":"11","author":"Husna","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.jgar.2026.01.014_bib0043","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.femsre.2004.04.001","article-title":"Molecular basis of bacterial resistance to chloramphenicol and florfenicol","volume":"28","author":"Schwarz","year":"2004","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.jgar.2026.01.014_bib0044","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1093\/jac\/dkaa205","article-title":"Epidemiology of mobile colistin resistance genes mcr-1 to mcr-9","volume":"75","author":"Ling","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2026.01.014_bib0045","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3390\/microorganisms9040722","article-title":"A large spatial survey of colistin-resistant gene mcr-1-carrying E. coli in rivers across Taiwan","volume":"9","author":"Teng","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.jgar.2026.01.014_bib0046","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.bbrc.2007.10.174","article-title":"Transcriptome of Escherichia coli K1 bound to human brain microvascular endothelial cells","volume":"365","author":"Xie","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jgar.2026.01.014_bib0047","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.mcp.2010.07.004","article-title":"Comparison of phenotypic and genotypic antimicrobial profiles in Escherichia coli and Salmonella enterica from the same dairy cattle farms","volume":"24","author":"Scaria","year":"2010","journal-title":"Mol Cell Probes"},{"key":"10.1016\/j.jgar.2026.01.014_bib0048","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1016\/j.vaccine.2011.01.110","article-title":"Immunostimulatory and antigen delivery properties of liposomes made up of total polar lipids from non-pathogenic bacteria leads to efficient induction of both innate and adaptive immune responses","volume":"29","author":"Faisal","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.jgar.2026.01.014_bib0049","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045608","article-title":"Temporal differential proteomes of Clostridium difficile in the pig ileal-ligated loop model","volume":"7","author":"Janvilisri","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jgar.2026.01.014_bib0050","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1093\/jac\/dkac121","article-title":"Co-transfer of last-line antibiotic resistance and virulence operons by an IncFIBk-FII-X3-ColKP3 hybrid plasmid in Klebsiella pneumoniae","volume":"77","author":"Liu","year":"2022","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2026.01.014_bib0051","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/03079457.2010.507761","article-title":"Prevalence and molecular characterization of chloramphenicol resistance in Riemerella anatipestifer isolated from ducks and geese in Taiwan","volume":"39","author":"Chen","year":"2010","journal-title":"Avian Pathol"},{"key":"10.1016\/j.jgar.2026.01.014_bib0052","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1093\/jac\/dkab409","article-title":"Phenotypic and genomic analysis reveals Riemerella anatipestifer as the potential reservoir of tet(X) variants","volume":"77","author":"Li","year":"2021","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2026.01.014_bib0053","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1093\/jac\/dkz510","article-title":"Co-existence of tet(X4) and mcr-1 in two porcine Escherichia coli isolates","volume":"75","author":"He","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2026.01.014_bib0054","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/jac\/dkm397","article-title":"Bradford PA.MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli","volume":"61","author":"Keeney","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2026.01.014_bib0055","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1093\/jac\/dkx270","article-title":"Hughes D.Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli","volume":"72","author":"Praski Alzrigat","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2026.01.014_bib0056","doi-asserted-by":"crossref","first-page":"e01654","DOI":"10.1128\/AAC.01654-16","article-title":"Tigecycline nonsusceptibility occurs exclusively in fluoroquinolone-resistant Escherichia coli clinical isolates, including the major multidrug-resistant lineages O25b:H4-ST131-H30R and O1-ST648","volume":"61","author":"Sato","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2026.01.014_bib0057","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1186\/s12879-025-11778-6","article-title":"Expression of multidrug efflux pump gene acrAB in Escherichia coli: a systematic review and meta analysis","volume":"25","author":"Bahaj","year":"2025","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.jgar.2026.01.014_bib0058","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1128\/AAC.42.8.2089","article-title":"Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coli","volume":"42","author":"Oethinger","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.jgar.2026.01.014_bib0059","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0315847","article-title":"Tetracycline and chloramphenicol exposure induce decreased susceptibility to tigecycline and genetic alterations in AcrAB-TolC efflux pump regulators in Escherichia coli and Klebsiella pneumoniae","volume":"20","author":"Nasralddin","year":"2025","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jgar.2026.01.014_bib0060","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13756-018-0415-0","article-title":"Spread of the florfenicol resistance floR gene among clinical Klebsiella pneumoniae isolates in China","volume":"7","author":"Lu","year":"2018","journal-title":"Antimicrob Resist Infect Control"},{"key":"10.1016\/j.jgar.2026.01.014_bib0061","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/bioinformatics\/btr039","article-title":"Easyfig: a genome comparison visualizer","volume":"27","author":"Sullivan","year":"2011","journal-title":"Bioinformatics"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716526000159?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716526000159?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T11:27:49Z","timestamp":1781350069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716526000159"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":61,"alternative-id":["S2213716526000159"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2026.01.014","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tet(X4)-producing Escherichia coli isolates in Taiwan","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2026.01.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}