{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:08:11Z","timestamp":1790179691440,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Global Antimicrobial Resistance"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jgar.2026.06.022","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:41:15Z","timestamp":1783525275000},"page":"195-203","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["FPI-1523, a novel \u03b2-lactamase inhibitor, enhances imipenem activity against carbapenemase-producing Enterobacterales"],"prefix":"10.1016","volume":"50","author":[{"given":"Zeyong","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingchun","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchun","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8174-2580","authenticated-orcid":false,"given":"Jianzhong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgar.2026.06.022_bib0001","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S1473-3099(19)30755-8","article-title":"Molecular and clinical epidemiology of carbapenem-resistant Enterobacterales in the USA (CRACKLE-2): a prospective cohort study","volume":"20","author":"van Duin","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.jgar.2026.06.022_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2022.127249","article-title":"Global spread of carbapenem-resistant Enterobacteriaceae: epidemiological features, resistance mechanisms, detection and therapy","volume":"266","author":"Ma","year":"2023","journal-title":"Microbiol Res"},{"key":"10.1016\/j.jgar.2026.06.022_bib0003","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1007\/s10096-021-04296-1","article-title":"Treatment for carbapenem-resistant Enterobacterales infections: recent advances and future directions","volume":"40","author":"Tompkins","year":"2021","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"10.1016\/j.jgar.2026.06.022_bib0004","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1080\/21505594.2016.1222343","article-title":"The global epidemiology of carbapenemase-producing Enterobacteriaceae","volume":"8","author":"van Duin","year":"2017","journal-title":"Virulence"},{"key":"10.1016\/j.jgar.2026.06.022_bib0005","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40560-020-0429-6","article-title":"Molecular diversity of extended-spectrum \u03b2-lactamases and carbapenemases, and antimicrobial resistance","volume":"8","author":"Sawa","year":"2020","journal-title":"J Intensive Care"},{"key":"10.1016\/j.jgar.2026.06.022_bib0006","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1093\/jac\/dkac037","article-title":"Synergistic effect of the novel \u03b2-lactamase inhibitor BLI-489 combined with imipenem or meropenem against diverse carbapenemase-producing carbapenem-resistant Enterobacterales","volume":"77","author":"Shi","year":"2022","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgar.2026.06.022_bib0007","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1021\/acschembio.5b00944","article-title":"Structural and kinetic characterization of diazabicyclooctanes as dual inhibitors of both serine-\u03b2-lactamases and penicillin-binding proteins","volume":"11","author":"King","year":"2016","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.jgar.2026.06.022_bib0008","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/s41564-023-01369-z","article-title":"Inhibiting fatty acid synthesis overcomes colistin resistance","volume":"8","author":"Carfrae","year":"2023","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jgar.2026.06.022_bib0009","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1153868","article-title":"Synergistic effect and antibiofilm activity of the antimicrobial peptide K11 with conventional antibiotics against multidrug-resistant and extensively drug-resistant Klebsiella pneumoniae","volume":"13","author":"Chatupheeraphat","year":"2023","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jgar.2026.06.022_bib0010","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00107-24","article-title":"Effect of ceftazidime-avibactam combined with different antimicrobials against carbapenem-resistant Klebsiella pneumoniae","volume":"12","author":"Wu","year":"2024","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jgar.2026.06.022_bib0011","article-title":"Population pharmacokinetics and dosing optimization of imipenem in Chinese elderly patients","volume":"15","author":"Wang","year":"2024","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jgar.2026.06.022_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.782733","article-title":"Galleria mellonella as a suitable model of bacterial infection: past, present and future","volume":"11","author":"M\u00e9nard","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.jgar.2026.06.022_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2024.107285","article-title":"Immunomodulator AS101 restores colistin susceptibility of clinical colistin-resistant Escherichia coli and Klebsiella pneumoniae in vitro and in vivo","volume":"64","author":"Liu","year":"2024","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.jgar.2026.06.022_bib0014","article-title":"In vitro and in vivo synergistic effect of chrysin in combination with colistin against Acinetobacter baumannii","volume":"13","author":"Zhao","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgar.2026.06.022_bib0015","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s13756-020-00840-4","article-title":"Detection of CMY-type beta-lactamases in Escherichia coli isolates from paediatric patients in a tertiary care hospital in Mexico","volume":"9","author":"Merida-Vieyra","year":"2020","journal-title":"Antimicrob Resist Infect Control"},{"key":"10.1016\/j.jgar.2026.06.022_bib0016","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12866-024-03214-7","article-title":"Phenotypic, molecular, and in silico characterization of coumarin as carbapenemase inhibitor to fight carbapenem-resistant Klebsiella pneumoniae","volume":"24","author":"Abdel-Halim","year":"2024","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jgar.2026.06.022_bib0017","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.diagmicrobio.2012.05.021","article-title":"Spectrophotometry-based detection of carbapenemase producers among Enterobacteriaceae","volume":"74","author":"Bernabeu","year":"2012","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jgar.2026.06.022_bib0018","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00102-19","article-title":"The global ascendency of OXA-48-type carbapenemases","volume":"33","author":"Pitout","year":"2019","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jgar.2026.06.022_bib0019","doi-asserted-by":"crossref","DOI":"10.1128\/cmr.00008-23","article-title":"Klebsiella pneumoniae carbapenemase variants: the new threat to global public health","volume":"36","author":"Ding","year":"2023","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.jgar.2026.06.022_bib0020","article-title":"Comparative genomics of an emerging multidrug-resistant blaNDM-carrying ST182 lineage in Enterobacter cloacae complex","volume":"13","author":"Mavroidi","year":"2024","journal-title":"Antibiot (Basel)"},{"key":"10.1016\/j.jgar.2026.06.022_bib0021","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.02511-22","article-title":"An emerging lineage of uropathogenic extended spectrum \u03b2-lactamase Escherichia coli ST127","volume":"10","author":"Cave","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jgar.2026.06.022_bib0022","article-title":"Resveratrol increases sensitivity of clinical colistin-resistant Pseudomonas aeruginosa to colistin in vitro and in vivo","volume":"11","author":"Wang","year":"2023","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.jgar.2026.06.022_bib0023","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.2147\/IDR.S337611","article-title":"Emerging carbapenem-resistant Enterobacteriaceae infection, its epidemiology and novel treatment options: a review","volume":"14","author":"Tilahun","year":"2021","journal-title":"Infect Drug Resist"},{"key":"10.1016\/j.jgar.2026.06.022_bib0024","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-64992-8","article-title":"Carbapenem-resistant Enterobacteriaceae in the livestock, humans and environmental samples around the globe: a systematic review and meta-analysis","volume":"14","author":"Tuhamize","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.jgar.2026.06.022_bib0025","doi-asserted-by":"crossref","first-page":"S565","DOI":"10.1093\/cid\/ciz830","article-title":"Treatment options for carbapenem-resistant gram-negative bacterial infections","volume":"69","author":"Doi","year":"2019","journal-title":"Clin Infect Dis"}],"container-title":["Journal of Global Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716526001049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2213716526001049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T15:47:54Z","timestamp":1790178474000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2213716526001049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":25,"alternative-id":["S2213716526001049"],"URL":"https:\/\/doi.org\/10.1016\/j.jgar.2026.06.022","relation":{},"ISSN":["2213-7165"],"issn-type":[{"value":"2213-7165","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FPI-1523, a novel \u03b2-lactamase inhibitor, enhances imipenem activity against carbapenemase-producing Enterobacterales","name":"articletitle","label":"Article Title"},{"value":"Journal of Global Antimicrobial Resistance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgar.2026.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.","name":"copyright","label":"Copyright"}]}}