{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:50:50Z","timestamp":1793735450299,"version":"4.6.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007787","name":"National Research Centre","doi-asserted-by":"publisher","award":["12,010,126"],"award-info":[{"award-number":["12,010,126"]}],"id":[{"id":"10.13039\/100007787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007787","name":"National Research Centre","doi-asserted-by":"publisher","award":["TT110801"],"award-info":[{"award-number":["TT110801"]}],"id":[{"id":"10.13039\/100007787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Engineering and Biotechnology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jgeb.2023.100334","type":"journal-article","created":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T14:15:46Z","timestamp":1705932946000},"page":"100334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of potential antiviral compounds from Egyptian sea stars against seasonal influenza A\/H1N1 virus"],"prefix":"10.1016","volume":"22","author":[{"given":"Nadia I.","family":"Okasha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abdel Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"Nafie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noura M.","family":"Abo Shama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia A.","family":"El-Ebeedy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Z.","family":"Abdel Azeiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgeb.2023.100334_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.onehlt.2020.100124","article-title":"From SARS to COVID-19: A previously unknown SARS- related coronavirus (SARS-CoV-2) of pandemic potential infecting humans \u2013 call for a one health approach","volume":"9","author":"El Zowalaty","year":"2020","journal-title":"One Health"},{"key":"10.1016\/j.jgeb.2023.100334_b0010","doi-asserted-by":"crossref","first-page":"E497","DOI":"10.3390\/v10090497","article-title":"Zoonotic potential of influenza a viruses: a comprehensive overview","volume":"10","author":"Mostafa","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.jgeb.2023.100334_b0015","first-page":"96","article-title":"Oseltamivir resistance in swine influenza: a brief discussion","volume":"1","author":"Wiwanitkit","year":"2009","journal-title":"N Am J Med Sci"},{"key":"10.1016\/j.jgeb.2023.100334_b0020","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2147\/IDR.S105473","article-title":"Drug resistance in influenza a virus: the epidemiology and management","volume":"10","author":"Hussain","year":"2017","journal-title":"Infect Drug Resist"},{"key":"10.1016\/j.jgeb.2023.100334_b0025","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1093\/jac\/dky462","article-title":"Combination treatment with the cap-dependent endonuclease inhibitor baloxavir marboxil and a neuraminidase inhibitor in a mouse model of influenza a virus infection","volume":"74","author":"Fukao","year":"2019","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.jgeb.2023.100334_b0030","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/irv.12446","article-title":"Influenza antivirals currently in late-phase clinical trial","volume":"11","author":"Koszalka","year":"2017","journal-title":"Influenza Other Respi Viruses"},{"key":"10.1016\/j.jgeb.2023.100334_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2021.109314","article-title":"Mutations in PB2 and HA are crucial for the increased virulence and transmissibility of H1N1 swine influenza virus in mammalian models","volume":"265","author":"Hu","year":"2022","journal-title":"Vet Microbiol"},{"key":"10.1016\/j.jgeb.2023.100334_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.dci.2020.103912","article-title":"Current progress on identification of virus pathogens and the antiviral effectors in echinoderms","volume":"116","author":"Guo","year":"2021","journal-title":"Dev Comp Immunol"},{"key":"10.1016\/j.jgeb.2023.100334_b0045","series-title":"Virus Infection and Tumorigenesis: Hints from Marine Hosts\u2019 Stress Responses","first-page":"63","article-title":"Marine invertebrate stress responses to virus infection","author":"He","year":"2019"},{"issue":"2","key":"10.1016\/j.jgeb.2023.100334_b0050","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem"},{"key":"10.1016\/j.jgeb.2023.100334_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.steroids.2019.108485","article-title":"Screening of different drug design tools to predict the mode of action of steroidal derivatives as anti-cancer agents","volume":"152","author":"Nafie","year":"2019","journal-title":"Steroids"},{"issue":"13","key":"10.1016\/j.jgeb.2023.100334_b0060","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF chimera\u2014a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J Comput Chem"},{"key":"10.1016\/j.jgeb.2023.100334_b0065","doi-asserted-by":"crossref","DOI":"10.21608\/ejchem.2021.61245.3316","article-title":"Comparative phytochemical and biological studies of lipoidal matter of Ipomoea tricolor (Cav.) and Ipomoea fistulosa (Mart. Ex Choisy) growing in Egypt","author":"Selim","year":"2021","journal-title":"Egypt. J. Chem."},{"key":"10.1016\/j.jgeb.2023.100334_b0070","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.1099\/ijsem.0.004403","article-title":"Actinomadura rubteroloni sp. nov. and Actinomadura macrotermitis sp. nov., isolated from the gut of the fungus growing-termite Macrotermes natalensis","volume":"70","author":"Benndorf","year":"2020","journal-title":"Int J Syst Evol Microbiol"},{"key":"10.1016\/j.jgeb.2023.100334_b0075","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/0091270003260336","article-title":"Human liver aldehyde oxidase: Inhibition by 239 drugs","volume":"44","author":"Obach","year":"2004","journal-title":"J Clin Pharmacol"},{"key":"10.1016\/j.jgeb.2023.100334_b0080","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0163-7827(01)00008-X","article-title":"The biologically active isomers of conjugated linoleic acid","volume":"40","author":"Pariza","year":"2001","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.jgeb.2023.100334_b0085","article-title":"Biodiesel from flowering plants","author":"Raj","year":"2022","journal-title":"Springer Nature"},{"key":"10.1016\/j.jgeb.2023.100334_b0090","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ejar.2019.06.006","article-title":"Characterization of some fungal strains isolated from the Eastern coast of Alexandria, Egypt, and some applications of Penicillium crustosum","volume":"45","author":"Amer","year":"2019","journal-title":"Egypt J Aquat Res"},{"key":"10.1016\/j.jgeb.2023.100334_b0095","first-page":"780","article-title":"Ethyl iso-allocholate from a medicinal rice karungkavuni inhibits dihydropteroate synthase in Escherichia coli: a molecular docking and dynamics study","volume":"78","author":"Malathi","year":"2017","journal-title":"Indian J Pharm Sci"},{"key":"10.1016\/j.jgeb.2023.100334_b0100","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jfda.2018.05.001","article-title":"A steroidal derivative from trigonella foenum graecum L. that induces apoptosis in vitro and in vivo","volume":"27","author":"Thakur","year":"2019","journal-title":"J Food Drug Anal"},{"key":"10.1016\/j.jgeb.2023.100334_b0105","unstructured":"Nesnow DS. Characterization of phytophthora capsici erg3 through complementation of a yeast erg3 null mutant, 2013, 80."},{"key":"10.1016\/j.jgeb.2023.100334_b0110","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bej.2013.04.003","article-title":"Evaluation of FAME production from wet marine and freshwater microalgae by in situ transesterification","volume":"76","author":"Velasquez-Orta","year":"2013","journal-title":"Biochem Eng J"},{"key":"10.1016\/j.jgeb.2023.100334_b0115","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.algal.2013.04.003","article-title":"Fatty acids profiling: a selective criterion for screening microalgae strains for biodiesel production","volume":"2","author":"Talebi","year":"2013","journal-title":"Algal Res"},{"key":"10.1016\/j.jgeb.2023.100334_b0120","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.5958\/0974-360X.2015.00292.9","article-title":"Phytochemical profiling of the leaves of chenopodium and polygonum using GC-MS","volume":"8","author":"Kumar","year":"2015","journal-title":"Res J Pharm Technol"},{"issue":"2","key":"10.1016\/j.jgeb.2023.100334_b0125","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1128\/JVI.79.2.732-744.2005","article-title":"Involvement of influenza virus PA subunit in assembly of functional RNA polymerase complexes","volume":"79","author":"Kawaguchi","year":"2005","journal-title":"J Virol"},{"issue":"8","key":"10.1016\/j.jgeb.2023.100334_b0130","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/emboj\/20.8.2078","article-title":"The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits","volume":"20","author":"Li","year":"2001","journal-title":"EMBO J"},{"issue":"4","key":"10.1016\/j.jgeb.2023.100334_b0135","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.tim.2019.12.006","article-title":"The cap-snatching mechanism of bunyaviruses","volume":"28","author":"Olschewski","year":"2020","journal-title":"Trends Microbiol"},{"issue":"17","key":"10.1016\/j.jgeb.2023.100334_b0140","doi-asserted-by":"crossref","first-page":"8433","DOI":"10.1128\/JVI.00879-10","article-title":"The PB2 subunit of the influenza virus RNA polymerase affects virulence by interacting with the mitochondrial antiviral signaling protein and inhibiting expression of beta interferon","volume":"84","author":"Graef","year":"2010","journal-title":"J Virol"},{"issue":"10","key":"10.1016\/j.jgeb.2023.100334_b0145","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/ni1243","article-title":"IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction","volume":"6","author":"Kawai","year":"2005","journal-title":"Nat Immunol"},{"issue":"7062","key":"10.1016\/j.jgeb.2023.100334_b0150","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/nature04193","article-title":"Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus","volume":"437","author":"Meylan","year":"2005","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.jgeb.2023.100334_b0155","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.cell.2005.08.012","article-title":"Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-\u03baB and IRF3","volume":"122","author":"Seth","year":"2005","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.jgeb.2023.100334_b0160","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.molcel.2005.08.014","article-title":"VISA is an adapter protein required for virus-triggered IFN-beta signaling","volume":"19","author":"Xu","year":"2005","journal-title":"Mol Cell"},{"issue":"5","key":"10.1016\/j.jgeb.2023.100334_b0165","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3390\/v11050458","article-title":"Competitive cooperation of hemagglutinin and neuraminidase during influenza a virus entry","volume":"11","author":"Du","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.jgeb.2023.100334_b0170","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0042-6822(74)90276-1","article-title":"Characterization of temperature sensitive influenza virus mutants defective in neuraminidase","volume":"61","author":"Palese","year":"1974","journal-title":"Virology"},{"issue":"6","key":"10.1016\/j.jgeb.2023.100334_b0175","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1038\/mi.2017.16","article-title":"The cell surface mucin Muc1 limits the severity of influenza a virus infection","volume":"10","author":"McAuley","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.jgeb.2023.100334_b0180","doi-asserted-by":"crossref","first-page":"12665","DOI":"10.1128\/JVI.78.22.12665-12667.2004","article-title":"Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium","volume":"78","author":"Matrosovich","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.jgeb.2023.100334_b0185","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.micinf.2005.12.008","article-title":"Roles of neuraminidase in the initial stage of influenza virus infection","volume":"8","author":"Ohuchi","year":"2006","journal-title":"Microbes Infect"},{"key":"10.1016\/j.jgeb.2023.100334_b0190","doi-asserted-by":"crossref","first-page":"e8495","DOI":"10.1371\/journal.pone.0008495","article-title":"Enhancement of the influenza a hemagglutinin (HA)-mediated cell-cell fusion and virus entry by the viral neuraminidase (NA)","volume":"4","author":"Su","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jgeb.2023.100334_b0195","doi-asserted-by":"crossref","first-page":"e66325","DOI":"10.1371\/journal.pone.0066325","article-title":"Human H3N2 influenza viruses isolated from 1968 to 2012 show varying preference for receptor substructures with no apparent consequences for disease or spread","volume":"8","author":"Gulati","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jgeb.2023.100334_b0200","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.ejmech.2012.06.025","article-title":"Synthesis, antidepressant and antimicrobial activities of some novel stearic acid analogues","volume":"54","author":"Jubie","year":"2012","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.jgeb.2023.100334_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e07962","article-title":"Telaprevir is a potential drug for repurposing against SARS-CoV-2: computational and in vitro studies","volume":"7","author":"Mahmoud","year":"2021","journal-title":"Heliyon"},{"key":"10.1016\/j.jgeb.2023.100334_b0210","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.sjbs.2014.09.009","article-title":"Screening of ethnic medicinal plants of South India against influenza (H1N1) and their antioxidant activity","volume":"22","author":"Maria John","year":"2015","journal-title":"Saudi J Biol Sci"},{"key":"10.1016\/j.jgeb.2023.100334_b0215","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fmicb.2019.00039","article-title":"Influenza virus neuraminidase structure and functions","volume":"10","author":"McAuley","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgeb.2023.100334_b0220","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3390\/ph13120443","article-title":"FDA-approved drugs with potent in vitro antiviral activity against severe acute respiratory syndrome coronavirus 2","volume":"13","author":"Mostafa","year":"2020","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.jgeb.2023.100334_b0225","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1248\/cpb.58.856","article-title":"Polyhydroxy steroids and saponins from China Sea starfish Asterina pectinifera and their biological activities","volume":"58","author":"Peng","year":"2010","journal-title":"Chem Pharm Bull"},{"key":"10.1016\/j.jgeb.2023.100334_b0230","article-title":"Repurposing siddha mercurial drug for mild to moderate COVID-19 \u2013 case series and exploration of its chemical profile","volume":"13","author":"Shiva","year":"2022","journal-title":"J Ayurveda Integrat Med"},{"key":"10.1016\/j.jgeb.2023.100334_b0240","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jcma.2017.11.007","article-title":"Anti-pandemic influenza a (H1N1) virus potential of catechin and gallic acid","volume":"81","author":"You","year":"2018","journal-title":"J Chin Med Assoc"},{"key":"10.1016\/j.jgeb.2023.100334_b0235","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1515\/znc-2004-1-221","article-title":"Analysis of insecticidal Azadirachta indica A. Juss. fractions","volume":"59","author":"Siddiqui","year":"2004","journal-title":"Z Naturforsch C J Biosci"}],"container-title":["Journal of Genetic Engineering and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X23015056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X23015056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:48:31Z","timestamp":1778824111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687157X23015056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1687157X23015056"],"URL":"https:\/\/doi.org\/10.1016\/j.jgeb.2023.100334","relation":{},"ISSN":["1687-157X"],"issn-type":[{"value":"1687-157X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of potential antiviral compounds from Egyptian sea stars against seasonal influenza A\/H1N1 virus","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetic Engineering and Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgeb.2023.100334","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V. on behalf of Academy of Scientific Research and Technology.","name":"copyright","label":"Copyright"}],"article-number":"100334"}}