{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:16:03Z","timestamp":1787318163804,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Engineering and Biotechnology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.jgeb.2024.100438","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T04:59:38Z","timestamp":1732078778000},"page":"100438","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adropin a candidate diagnostic biomarker for cardiovascular disease in patients with chronic kidney disease"],"prefix":"10.1016","volume":"22","author":[{"given":"Maha Abd","family":"El Moneem Elfedawy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia Abd","family":"El Sadek Elsebai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hend Mohamed","family":"Tawfik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman Refaat","family":"Youness","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5853-0050","authenticated-orcid":false,"given":"Moushira","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgeb.2024.100438_b0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0272-6386(03)00372-X","article-title":"Cardiovascular complications in chronic kidney disease","volume":"41","author":"Sarnak","year":"2003","journal-title":"Am J Kidney Dis"},{"issue":"9","key":"10.1016\/j.jgeb.2024.100438_b0010","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1515\/CCLM.2009.263","article-title":"Glomerular filtration rate measurement and prediction equations","volume":"47","author":"Soares","year":"2009","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.jgeb.2024.100438_b0015","unstructured":"Vaidya SR, Aeddula NR, Doerr C. Chronic renal failure (nursing). 2021."},{"issue":"6","key":"10.1016\/j.jgeb.2024.100438_b0020","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.kint.2020.02.010","article-title":"Nomenclature for kidney function and disease: Report of a Kidney Disease: Improving Global Outcomes (KDIGO) Consensus Conference","volume":"97","author":"Levey","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.jgeb.2024.100438_b0025","unstructured":"van Doorn KJ. Observational studies on renal impairment in critically ill patients. Universiteit Antwerpen (Belgium); 2016."},{"key":"10.1016\/j.jgeb.2024.100438_b0030","unstructured":"Rajauria G, Nikhat S, Singh R, Kumar MR. ASSESSMENT OF COMPLICATIONS IN PATIENTS WITH CHRONIC KIDNEY DISEASE UNDERGOING HEMODIALYSIS. 2020;."},{"issue":"1","key":"10.1016\/j.jgeb.2024.100438_b0035","article-title":"Epidemiology and risk factors of chronic kidney disease in the El-Sharkia Governorate, Egypt","volume":"27","author":"Ghonemy","year":"2016","journal-title":"Saudi J Kidney Dis Transplant"},{"key":"10.1016\/j.jgeb.2024.100438_b0040","doi-asserted-by":"crossref","unstructured":"Farag YMK, El-Sayed E. Global dialysis perspective: Egypt. Kidney360. 2022;3(7):1263\u20138.","DOI":"10.34067\/KID.0007482021"},{"issue":"4","key":"10.1016\/j.jgeb.2024.100438_b0045","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00000441-200304000-00002","article-title":"Cardiovascular mortality in end-stage renal disease","volume":"325","author":"Collins","year":"2003","journal-title":"Am J Med Sci"},{"issue":"4","key":"10.1016\/j.jgeb.2024.100438_b0050","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.amjms.2020.01.013","article-title":"Type 2 diabetes and chronic conditions disparities in medicare beneficiaries in the state of Michigan","volume":"359","author":"Clements","year":"2020","journal-title":"Am J Med Sci"},{"issue":"6","key":"10.1016\/j.jgeb.2024.100438_b0055","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.3390\/jcm11061584","article-title":"Quality of life in patients with end-stage renal disease undergoing hemodialysis","volume":"11","author":"Dembowska","year":"2022","journal-title":"J Clin Med"},{"issue":"2","key":"10.1016\/j.jgeb.2024.100438_b0060","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2215\/CJN.05260516","article-title":"Diagnosis, treatment, and prevention of hemodialysis emergencies","volume":"12","author":"Saha","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.jgeb.2024.100438_b0065","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1016\/j.kisu.2019.11.010","article-title":"Global case studies for chronic kidney disease\/end-stage kidney disease care","volume":"10","author":"Yang","year":"2020","journal-title":"KidneyInt Suppl"},{"issue":"3","key":"10.1016\/j.jgeb.2024.100438_b0070","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.krcp.2015.08.004","article-title":"Lessons from 30 years\u2019 data of Korean end-stage renal disease registry, 1985\u20132015","volume":"34","author":"Jin","year":"2015","journal-title":"Kidney Res Clin Pract"},{"issue":"24","key":"10.1016\/j.jgeb.2024.100438_b0075","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.2174\/1381612822666160429121934","article-title":"Are the myokines the mediators of physical activity-induced health benefits?","volume":"22","author":"Di Raimondo","year":"2016","journal-title":"Curr Pharm Des"},{"issue":"3","key":"10.1016\/j.jgeb.2024.100438_b0080","doi-asserted-by":"crossref","first-page":"e0192895","DOI":"10.1371\/journal.pone.0192895","article-title":"Cardiovascular disease risk factors in chronic kidney disease: A systematic review and meta-analysis","volume":"13","author":"Major","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jgeb.2024.100438_b0085","doi-asserted-by":"crossref","unstructured":"Hsu C yuan, McCulloch CE, Iribarren C, Darbinian J, Go AS. Body mass index and risk for end-stage renal disease. Ann Intern Med. 2006;144(1):21\u20138.","DOI":"10.7326\/0003-4819-144-1-200601030-00006"},{"issue":"12","key":"10.1016\/j.jgeb.2024.100438_b0090","doi-asserted-by":"crossref","first-page":"e14204","DOI":"10.2196\/14204","article-title":"Detecting lifestyle risk factors for chronic kidney disease with comorbidities: Association rule mining analysis of web-based survey data","volume":"21","author":"Peng","year":"2019","journal-title":"J Med Internet Res"},{"issue":"3","key":"10.1016\/j.jgeb.2024.100438_b0095","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1053\/j.ajkd.2018.02.363","article-title":"Evolution of echocardiographic measures of cardiac disease from CKD to ESRD and risk of all-cause mortality: Findings from the CRIC study","volume":"72","author":"Bansal","year":"2018","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jgeb.2024.100438_b0100","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-981-32-9131-7_9","article-title":"Cardiovascular disease in chronic kidney disease","author":"Wu","year":"2020","journal-title":"Chronic Kidney Dis Diagnosis Treat"},{"issue":"2","key":"10.1016\/j.jgeb.2024.100438_b0105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1136\/heartasia-2016-010809","article-title":"Cardiovascular disease in patients with chronic kidney disease: A neglected subgroup","volume":"8","author":"Subbiah","year":"2016","journal-title":"Heart Asia"},{"issue":"3","key":"10.1016\/j.jgeb.2024.100438_b0110","first-page":"353","article-title":"Adropin and irisin: New biomarkers of cardiac status in patients with end-stage renal disease? A preliminary study","volume":"28","author":"Ka\u0142u\u017cna","year":"2019","journal-title":"Adv Clin Exp Med"},{"issue":"15","key":"10.1016\/j.jgeb.2024.100438_b0115","doi-asserted-by":"crossref","first-page":"8318","DOI":"10.3390\/ijms23158318","article-title":"Adropin\u2019s role in energy homeostasis and metabolic disorders","volume":"23","author":"Ali","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jgeb.2024.100438_b0120","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3892\/ijmm.2024.5414","article-title":"Unveiling the multifaceted role of adropin in various diseases","volume":"54","author":"Chen","year":"2024","journal-title":"Int J Mol Med"},{"issue":"25","key":"10.1016\/j.jgeb.2024.100438_b0125","doi-asserted-by":"crossref","first-page":"9706","DOI":"10.1074\/jbc.RA119.007528","article-title":"Low plasma adropin concentrations increase risks of weight gain and metabolic dysregulation in response to a high-sugar diet in male nonhuman primates","volume":"294","author":"Butler","year":"2019","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jgeb.2024.100438_b0130","doi-asserted-by":"crossref","unstructured":"Rooban S, Senghor KAA, Vinodhini VM, Kumar JS. Adropin: A crucial regulator of cardiovascular health and metabolic balance. Metab Open. 2024;100299.","DOI":"10.1016\/j.metop.2024.100299"},{"issue":"17","key":"10.1016\/j.jgeb.2024.100438_b0135","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1177\/15353702211012417","article-title":"Inflammatory response and matrix metalloproteinases in chronic kidney failure: Modulation by adropin and spexin","volume":"246","author":"Yazgan","year":"2021","journal-title":"Exp Biol Med"},{"key":"10.1016\/j.jgeb.2024.100438_b0140","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.peptides.2014.03.021","article-title":"Three new players in energy regulation: preptin, adropin and irisin","volume":"56","author":"Aydin","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.jgeb.2024.100438_b0145","doi-asserted-by":"crossref","unstructured":"Kaluzna M, Schwermer K, Hoppe K, Czlapka-Matyasik M, Sawicka-Gutaj N, Yusuf IA, et al. Adropin as a potential biomarker of nutrition status and cardiac function in hemodialyzed patients. In: Endocrine Abstracts. Bioscientifica; 2016.","DOI":"10.1530\/endoabs.41.EP202"},{"issue":"1","key":"10.1016\/j.jgeb.2024.100438_b0150","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12902-023-01327-0","article-title":"Circulating levels of adropin and diabetes: A systematic review and meta-analysis of observational studies","volume":"23","author":"Soltani","year":"2023","journal-title":"BMC Endocr Disord"},{"issue":"1","key":"10.1016\/j.jgeb.2024.100438_b0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s42000-021-00331-0","article-title":"Circulating levels of adropin and overweight\/obesity: A systematic review and meta-analysis of observational studies","volume":"21","author":"Soltani","year":"2022","journal-title":"Hormones"},{"issue":"7","key":"10.1016\/j.jgeb.2024.100438_b0160","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/oby.2012.31","article-title":"Adropin deficiency is associated with increased adiposity and insulin resistance","volume":"20","author":"Ganesh-Kumar","year":"2012","journal-title":"Obesity"},{"key":"10.1016\/j.jgeb.2024.100438_b0165","doi-asserted-by":"crossref","unstructured":"Liu F, Cui B, Zhao X, Wu Y, Qin H, Guo Y, et al. Correlation of Serum Adropin Levels with Risk Factors of Cardiovascular Disease in Hemodialysis Patients. Metab Syndr Relat Disord [Internet]. 2021 May 26;19(7):401\u20138. Available from: https:\/\/doi.org\/10.1089\/met.2021.0015.","DOI":"10.1089\/met.2021.0015"},{"issue":"3","key":"10.1016\/j.jgeb.2024.100438_b0170","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/j.ajkd.2020.05.006","article-title":"KDOQI clinical practice guideline for nutrition in CKD: 2020 update","volume":"76","author":"Ikizler","year":"2020","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jgeb.2024.100438_b0175","unstructured":"Vaidya SR, Aeddula NR. Chronic renal failure. 2018;."},{"issue":"10075","key":"10.1016\/j.jgeb.2024.100438_b0180","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic kidney disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jgeb.2024.100438_b0185","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1161\/CIRCULATIONAHA.115.018713","article-title":"Epidemiology and mechanisms of uremia-related cardiovascular disease","volume":"133","author":"Tonelli","year":"2016","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jgeb.2024.100438_b0190","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3390\/toxins12030161","article-title":"Cardiac remodeling in chronic kidney disease","volume":"12","author":"Kaesler","year":"2020","journal-title":"Toxins (Basel)"},{"issue":"10","key":"10.1016\/j.jgeb.2024.100438_b0195","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.ekir.2020.07.029","article-title":"Impact of CKD progression on cardiovascular disease risk in a contemporary UK cohort of individuals with diabetes","volume":"5","author":"Cabrera","year":"2020","journal-title":"Kidney Int Reports"},{"key":"10.1016\/j.jgeb.2024.100438_b0200","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/2175-8239-jbn-2018-0120","article-title":"Demographic, clinical characteristics and cardiovascular disease burden in a Portuguese cohort of older chronic kidney disease patients","volume":"41","author":"Lascasas","year":"2019","journal-title":"Brazilian J Nephrol"},{"key":"10.1016\/j.jgeb.2024.100438_b0205","unstructured":"Rao DC. Adropin: An endocrine link between the biological clock and cholesterol homeostasis. 2018;."},{"key":"10.1016\/j.jgeb.2024.100438_b0210","first-page":"981","article-title":"Adropin\u2013physiological and pathophysiological role","volume":"70","author":"Marczuk","year":"2016","journal-title":"Adv Hyg Exp Med"},{"key":"10.1016\/j.jgeb.2024.100438_b0215","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.regpep.2014.04.002","article-title":"Adropin: A new regulatory peptide in cardiovascular endocrinology","volume":"190","author":"Goetze","year":"2014","journal-title":"Regul Pept"},{"key":"10.1016\/j.jgeb.2024.100438_b0220","doi-asserted-by":"crossref","unstructured":"de Oliveira dos Santos AR, de Oliveira Zanuso B, Miola VFB, Barbalho SM, Santos Bueno PC, Flato UAP, et al. Adipokines, myokines, and hepatokines: crosstalk and metabolic repercussions. Int J Mol Sci. 2021;22(5):2639.","DOI":"10.3390\/ijms22052639"},{"issue":"1","key":"10.1016\/j.jgeb.2024.100438_b0225","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/ntr\/ntaa071","article-title":"Smoking, smoking cessation, and progression of chronic kidney disease: Results from KNOW-CKD study","volume":"23","author":"Lee","year":"2021","journal-title":"Nicotine Tob Res"},{"issue":"2","key":"10.1016\/j.jgeb.2024.100438_b0230","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000488816","article-title":"Disorders of lipid metabolism in chronic kidney disease","volume":"46","author":"Bulbul","year":"2018","journal-title":"Blood Purif"},{"issue":"8","key":"10.1016\/j.jgeb.2024.100438_b0235","doi-asserted-by":"crossref","first-page":"752","DOI":"10.3390\/antiox9080752","article-title":"Chronic kidney disease as oxidative stress-and inflammatory-mediated cardiovascular disease","volume":"9","author":"Podkowi\u0144ska","year":"2020","journal-title":"Antioxidants"},{"issue":"3","key":"10.1016\/j.jgeb.2024.100438_b0240","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3390\/molecules25030549","article-title":"Adropin as a fat-burning hormone with multiple functions\u2014Review of a decade of research","volume":"25","author":"Jasaszwili","year":"2020","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.jgeb.2024.100438_b0245","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.3390\/biomedicines12081857","article-title":"Low levels of adropin predict adverse clinical outcomes in outpatients with newly diagnosed prediabetes after acute myocardial infarction","volume":"12","author":"Berezina","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.jgeb.2024.100438_b0250","unstructured":"Scimeca G. ADROPIN IN PATIENTS WITH HEART FAILURE. University of Split. School of Medicine. Pathophysiology; 2020."},{"issue":"14","key":"10.1016\/j.jgeb.2024.100438_b0255","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.jacc.2024.06.041","article-title":"Relationship between control of cardiovascular risk factors and chronic kidney disease progression, cardiovascular disease events, and mortality in Chinese adults","volume":"84","author":"Geng","year":"2024","journal-title":"J Am Coll Cardiol"}],"container-title":["Journal of Genetic Engineering and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X24001410?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X24001410?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T10:49:10Z","timestamp":1734000550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687157X24001410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S1687157X24001410"],"URL":"https:\/\/doi.org\/10.1016\/j.jgeb.2024.100438","relation":{},"ISSN":["1687-157X"],"issn-type":[{"value":"1687-157X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adropin a candidate diagnostic biomarker for cardiovascular disease in patients with chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetic Engineering and Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgeb.2024.100438","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc. on behalf of Academy of Scientific Research and Technology.","name":"copyright","label":"Copyright"}],"article-number":"100438"}}