{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:14:21Z","timestamp":1790194461922,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004071","name":"Khon Kaen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Engineering and Biotechnology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jgeb.2025.100472","type":"journal-article","created":{"date-parts":[[2025,2,17]],"date-time":"2025-02-17T21:02:21Z","timestamp":1739826141000},"page":"100472","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unraveling the mechanisms of benzimidazole resistance in hookworms: A molecular docking and dynamics study"],"prefix":"10.1016","volume":"23","author":[{"given":"Jan Clyden B.","family":"Tenorio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Fikri","family":"Heikal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0048-5699","authenticated-orcid":false,"given":"Alok","family":"Kafle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Andrian B.","family":"Macalalad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredmoore L.","family":"Orosco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasert","family":"Saichua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2323-2344","authenticated-orcid":false,"given":"Sutas","family":"Suttiprapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgeb.2025.100472_b0005","unstructured":"World Health Organization. Soil-transmitted helminth infections. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/soil-transmitted-helminth-infections. Published 2023. Accessed September 16, 2023."},{"key":"10.1016\/j.jgeb.2025.100472_b0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/1756-3305-5-91","article-title":"Pet roundworms and hookworms: A continuing need for global worming","volume":"5","author":"Traversa","year":"2012","journal-title":"Parasit Vectors."},{"issue":"1","key":"10.1016\/j.jgeb.2025.100472_b0015","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1016\/S2666-5247(21)00181-6","article-title":"Global distribution of human hookworm species and differences in their morbidity effects: a systematic review","volume":"3","author":"Clements","year":"2022","journal-title":"Lancet Microbe."},{"issue":"9","key":"10.1016\/j.jgeb.2025.100472_b0020","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.pt.2021.04.013","article-title":"Ancylostoma ceylanicum","volume":"37","author":"Colella","year":"2021","journal-title":"Trends Parasitol."},{"issue":"10159","key":"10.1016\/j.jgeb.2025.100472_b0025","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/S0140-6736(18)32335-3","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Kyu","year":"2018","journal-title":"Lancet."},{"issue":"10117","key":"10.1016\/j.jgeb.2025.100472_b0030","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0140-6736(17)31930-X","article-title":"Soil-transmitted helminth infections","volume":"391","author":"Jourdan","year":"2018","journal-title":"Lancet."},{"issue":"10159","key":"10.1016\/j.jgeb.2025.100472_b0035","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"James","year":"2018","journal-title":"Lancet."},{"issue":"1","key":"10.1016\/j.jgeb.2025.100472_b0040","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4269\/ajtmh.20-0060","article-title":"Zoonotic Ancylostomiasis: An Update of a Continually Neglected Zoonosis","volume":"103","author":"Stracke","year":"2020","journal-title":"Am J Trop Med Hyg."},{"issue":"3","key":"10.1016\/j.jgeb.2025.100472_b0045","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/trstmh\/trz115","article-title":"Insights into hookworm prevalence in Asia: a systematic review and meta-analysis","volume":"114","author":"Zibaei","year":"2020","journal-title":"Trans R Soc Trop Med Hyg."},{"issue":"1","key":"10.1016\/j.jgeb.2025.100472_b0050","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s40249-021-00870-z","article-title":"The control of soil-transmitted helminthiases in the Philippines: the story continues","volume":"10","author":"Mationg","year":"2021","journal-title":"Infect Dis Poverty."},{"key":"10.1016\/j.jgeb.2025.100472_b0055","unstructured":"World Health Organization. Guideline: Preventive Chemotherapy to Control Soil-Transmitted Helminth Infections in at-Risk Population Groups. Geneva: World Health Organization; 2017. https:\/\/apps.who.int\/iris\/handle\/10665\/258983. Accessed August 24, 2023."},{"key":"10.1016\/j.jgeb.2025.100472_b0060","unstructured":"TroCCAP. Guidelines for the Diagnosis, Treatment and Control of Canine Endoparasites in the Tropics. 2nd ed.; 2019. https:\/\/www.troccap.com\/2017press\/wp-content\/uploads\/2019\/05\/TroCCAP_Canine_Endo_Guidelines_English_Ver2.pdf. Accessed August 23, 2023."},{"key":"10.1016\/j.jgeb.2025.100472_b0065","unstructured":"TroCCAP. Guidelines for the Diagnosis, Treatment and Control of Feline Endoparasites in the Tropics. 2nd ed.; 2019. https:\/\/www.troccap.com\/2017press\/wp-content\/uploads\/2019\/06\/TroCCAP_Feline_Endo_Guidelines_English_Ver2.pdf. Accessed September 15, 2023."},{"key":"10.1016\/j.jgeb.2025.100472_b0070","doi-asserted-by":"crossref","unstructured":"Montresor A, Mupfasoni D, Mikhailov A, et al. The global progress of soil-transmitted helminthiases control in 2020 and World Health Organization targets for 2030. Babu S, ed. PLoS Negl Trop Dis. 2020;14(8):e0008505. doi:10.1371\/journal.pntd.0008505.","DOI":"10.1371\/journal.pntd.0008505"},{"key":"10.1016\/j.jgeb.2025.100472_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.onehlt.2019.100106","article-title":"Preventive chemotherapy and anthelmintic resistance of soil-transmitted helminths \u2013 Can we learn nothing from veterinary medicine?","volume":"9","author":"Tinkler","year":"2020","journal-title":"One Health."},{"issue":"1","key":"10.1016\/j.jgeb.2025.100472_b0080","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s44149-024-00117-y","article-title":"Ancylostoma ceylanicum and other zoonotic canine hookworms: neglected public and animal health risks in the Asia\u2013Pacific region","volume":"4","author":"Tenorio","year":"2024","journal-title":"Anim Dis."},{"key":"10.1016\/j.jgeb.2025.100472_b0085","doi-asserted-by":"crossref","unstructured":"Tenorio JCB, Belizario VYJ, Furtado LFV, Suttiprapa S. Can Benzimidazole Resistance Undermine the Philippines\u2019 Success in Controlling and Eliminating Soil-Transmitted Helminth Infections? A Mini-Review. Infectious Microbes & Diseases. 2024:10.1097\/IM9.0000000000000163. doi:10.1097\/IM9.0000000000000163.","DOI":"10.1097\/IM9.0000000000000163"},{"issue":"8","key":"10.1016\/j.jgeb.2025.100472_b0090","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1017\/S0031182007000054","article-title":"Single nucleotide polymorphism (SNP) markers for benzimidazole resistance in veterinary nematodes","volume":"134","author":"Von Samson-Himmelstjerna","year":"2007","journal-title":"Parasitology."},{"issue":"8","key":"10.1016\/j.jgeb.2025.100472_b0095","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1017\/S003118200700008X","article-title":"Markers for benzimidazole resistance in human parasitic nematodes?","volume":"134","author":"Prichard","year":"2007","journal-title":"Parasitology."},{"key":"10.1016\/j.jgeb.2025.100472_b0100","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.actatropica.2016.06.021","article-title":"Benzimidazole resistance in helminths: From problem to diagnosis","volume":"162","author":"Furtado","year":"2016","journal-title":"Acta Trop."},{"issue":"3","key":"10.1016\/j.jgeb.2025.100472_b0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011146","article-title":"Molecular evidence of widespread benzimidazole drug resistance in Ancylostoma caninum from domestic dogs throughout the USA and discovery of a novel \u03b2-tubulin benzimidazole resistance mutation","volume":"19","author":"Venkatesan","year":"2023","journal-title":"PLoS Pathog."},{"issue":"9","key":"10.1016\/j.jgeb.2025.100472_b0110","article-title":"Emergence of canine hookworm treatment resistance: Novel detection of Ancylostoma caninum anthelmintic resistance markers by fecal PCR in 11 dogs from Canada","volume":"84","author":"Evason","year":"2023","journal-title":"Am J Vet Res."},{"issue":"3","key":"10.1016\/j.jgeb.2025.100472_b0115","doi-asserted-by":"crossref","first-page":"342","DOI":"10.2460\/javma.22.08.0377","article-title":"Multiple anthelmintic drug resistance in hookworms (Ancylostoma caninum) in a Labrador breeding and training kennel in Georgia, USA","volume":"261","author":"Castro","year":"2023","journal-title":"J Am Vet Med Assoc."},{"key":"10.1016\/j.jgeb.2025.100472_b0120","doi-asserted-by":"crossref","unstructured":"Stocker T, Scott I, \u0160lapeta J. Unambiguous identification of Ancylostoma caninum and Uncinaria stenocephala in Australian and New Zealand dogs from faecal samples. Aust Veterinary J. August 2023:avj.13272. doi:10.1111\/avj.13272.","DOI":"10.1111\/avj.13272"},{"key":"10.1016\/j.jgeb.2025.100472_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2022.106533","article-title":"Moving beyond the state of the art of understanding resistance mechanisms in hookworms: confirming old and suggesting new associated SNPs","volume":"233","author":"Medeiros","year":"2022","journal-title":"Acta Trop."},{"issue":"3","key":"10.1016\/j.jgeb.2025.100472_b0130","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s00436-019-06218-9","article-title":"Albendazole resistance induced in Ancylostoma ceylanicum is not due to single-nucleotide polymorphisms (SNPs) at codons 167, 198, or 200 of the beta-tubulin gene, indicating another resistance mechanism","volume":"118","author":"Furtado","year":"2019","journal-title":"Parasitol Res."},{"key":"10.1016\/j.jgeb.2025.100472_b0135","doi-asserted-by":"crossref","unstructured":"Jones BP, van Vliet AHM, LaCourse EJ, Betson M. In Silico Docking of Nematode \u03b2-Tubulins With Benzimidazoles Points to Gene Expression and Orthologue Variation as Factors in Anthelmintic Resistance. Frontiers in Tropical Diseases. 2022;3. https:\/\/www.frontiersin.org\/articles\/10.3389\/fitd.2022.898814. Accessed October 26, 2023.","DOI":"10.3389\/fitd.2022.898814"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100472_b0140","doi-asserted-by":"crossref","first-page":"13725","DOI":"10.1038\/s41598-022-16765-4","article-title":"Identification of key interactions of benzimidazole resistance-associated amino acid mutations in Ascaris \u03b2-tubulins by molecular docking simulations","volume":"12","author":"Jones","year":"2022","journal-title":"Sci Rep."},{"key":"10.1016\/j.jgeb.2025.100472_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2020.109167","article-title":"TroCCAP recommendations for the diagnosis, prevention and treatment of parasitic infections in dogs and cats in the tropics","volume":"283","author":"Dantas-Torres","year":"2020","journal-title":"Vet Parasitol."},{"key":"10.1016\/j.jgeb.2025.100472_b0150","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.molbiopara.2016.11.005","article-title":"WormBase ParaSite \u2212 a comprehensive resource for helminth genomics","volume":"215","author":"Howe","year":"2017","journal-title":"Mol Biochem Parasitol."},{"issue":"D1","key":"10.1016\/j.jgeb.2025.100472_b0155","doi-asserted-by":"crossref","first-page":"D506","DOI":"10.1093\/nar\/gky1049","article-title":"UniProt: a worldwide hub of protein knowledge","volume":"47","author":"The UniProt Consortium","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"41","key":"10.1016\/j.jgeb.2025.100472_b0160","first-page":"95","article-title":"BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT","volume":"41","author":"Hall","year":"1999","journal-title":"Nucleic Acids Symp Ser."},{"issue":"22","key":"10.1016\/j.jgeb.2025.100472_b0165","doi-asserted-by":"crossref","first-page":"4673","DOI":"10.1093\/nar\/22.22.4673","article-title":"CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice","volume":"22","author":"Thompson","year":"1994","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.jgeb.2025.100472_b0170","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/molbev\/msab120","article-title":"MEGA11: Molecular Evolutionary Genetics Analysis Version 11","volume":"38","author":"Tamura","year":"2021","journal-title":"Mol Biol Evol."},{"issue":"13","key":"10.1016\/j.jgeb.2025.100472_b0175","doi-asserted-by":"crossref","first-page":"3381","DOI":"10.1093\/nar\/gkg520","article-title":"SWISS-MODEL: an automated protein homology-modeling server","volume":"31","author":"Schwede","year":"2003","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.jgeb.2025.100472_b0180","doi-asserted-by":"crossref","first-page":"4242","DOI":"10.1038\/s41598-018-22382-x","article-title":"High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design","volume":"8","author":"Bueno","year":"2018","journal-title":"Sci Rep."},{"issue":"3","key":"10.1016\/j.jgeb.2025.100472_b0185","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jmgm.2004.08.001","article-title":"A possible model of benzimidazole binding to \u03b2-tubulin disclosed by invoking an inter-domain movement","volume":"23","author":"Robinson","year":"2004","journal-title":"J Mol Graph Model."},{"issue":"1","key":"10.1016\/j.jgeb.2025.100472_b0190","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s00436-023-08088-8","article-title":"Anthelmintic resistance in soil-transmitted helminths: One-Health considerations","volume":"123","author":"Ng\u2019etich","year":"2023","journal-title":"Parasitol Res."},{"issue":"12","key":"10.1016\/j.jgeb.2025.100472_b0195","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00436-024-08432-6","article-title":"Benzimidazole Resistance-Associated Mutations in the \u03b2-tubulin Gene of Hookworms: A Systematic Review","volume":"123","author":"Tenorio","year":"2024","journal-title":"Parasitol Res."},{"issue":"2","key":"10.1016\/j.jgeb.2025.100472_b0200","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem."},{"issue":"D1","key":"10.1016\/j.jgeb.2025.100472_b0205","doi-asserted-by":"crossref","first-page":"D1202","DOI":"10.1093\/nar\/gkv951","article-title":"PubChem Substance and Compound databases","volume":"44","author":"Kim","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jgeb.2025.100472_b0210","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jmgm.2013.07.008","article-title":"Molecular basis for benzimidazole resistance from a novel \u03b2-tubulin binding site model","volume":"45","author":"Aguayo-Ortiz","year":"2013","journal-title":"J Mol Graph Model."},{"issue":"3","key":"10.1016\/j.jgeb.2025.100472_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111522","article-title":"Genomic landscape of drug response reveals mediators of anthelmintic resistance","volume":"41","author":"Doyle","year":"2022","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.jgeb.2025.100472_b0220","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ijpara.2012.12.011","article-title":"Characterization and comparative analysis of the complete Haemonchus contortus \u03b2-tubulin gene family and implications for benzimidazole resistance in strongylid nematodes","volume":"43","author":"Saunders","year":"2013","journal-title":"Int J Parasitol."},{"key":"10.1016\/j.jgeb.2025.100472_b0225","article-title":"Prevalence of gastrointestinal parasites and molecular identification of beta-tubulin mutations associated with benzimidazole resistance in Haemonchus contortus in goats from selected districts of Uganda","volume":"42","author":"Kalule","year":"2023","journal-title":"Veterinary Parasitol: Reg Stud Rep."},{"issue":"8","key":"10.1016\/j.jgeb.2025.100472_b0230","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/ps.3680","article-title":"Detection and dynamics of different carbendazim-resistance conferring \u03b2-tubulin variants of Gibberella zeae collected from infected wheat heads and rice stubble in China","volume":"70","author":"Liu","year":"2014","journal-title":"Pest Manag Sci."},{"key":"10.1016\/j.jgeb.2025.100472_b0235","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jmgm.2013.01.007","article-title":"Towards the identification of the binding site of benzimidazoles to \u03b2-tubulin of Trichinella spiralis: Insights from computational and experimental data","volume":"41","author":"Aguayo-Ortiz","year":"2013","journal-title":"J Mol Graph Model."},{"issue":"16","key":"10.1016\/j.jgeb.2025.100472_b0240","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1080\/07391102.2020.1796811","article-title":"Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: an in silico study for drug development","volume":"39","author":"Pandey","year":"2021","journal-title":"J Biomol Struct Dyn."},{"key":"10.1016\/j.jgeb.2025.100472_b0245","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ijpddr.2021.09.006","article-title":"Newly identified parasitic nematode beta-tubulin alleles confer resistance to benzimidazoles","volume":"17","author":"Dilks","year":"2021","journal-title":"Int J Parasitol Drugs Drug Resist."},{"key":"10.1016\/j.jgeb.2025.100472_b0250","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijpddr.2020.08.003","article-title":"Quantitative benzimidazole resistance and fitness effects of parasitic nematode beta-tubulin alleles","volume":"14","author":"Dilks","year":"2020","journal-title":"Int J Parasitol Drugs Drug Resist."},{"issue":"12","key":"10.1016\/j.jgeb.2025.100472_b0255","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.14202\/vetworld.2024.2736-2746","article-title":"Benzimidazole resistance-associated mutations improve the in silico dimerization of hookworm tubulin: An additional resistance mechanism","volume":"17","author":"Tenorio","year":"2024","journal-title":"Vet World."}],"container-title":["Journal of Genetic Engineering and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X25000162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X25000162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T16:35:59Z","timestamp":1741624559000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687157X25000162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S1687157X25000162"],"URL":"https:\/\/doi.org\/10.1016\/j.jgeb.2025.100472","relation":{},"ISSN":["1687-157X"],"issn-type":[{"value":"1687-157X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unraveling the mechanisms of benzimidazole resistance in hookworms: A molecular docking and dynamics study","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetic Engineering and Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgeb.2025.100472","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of Academy of Scientific Research and Technology.","name":"copyright","label":"Copyright"}],"article-number":"100472"}}