{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:40:48Z","timestamp":1790912448515,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Engineering and Biotechnology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.jgeb.2025.100474","type":"journal-article","created":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T18:59:06Z","timestamp":1741114746000},"page":"100474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Designing of multi-valent epitope vaccine displaying interactions with diverse HLA alleles against Candida auris using immuno-informatics"],"prefix":"10.1016","volume":"23","author":[{"given":"Vaishali","family":"Ahlawat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Sura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4783-1309","authenticated-orcid":false,"given":"Mehak","family":"Dangi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil Kumar","family":"Chhillar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jgeb.2025.100474_b0005","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/j.jiph.2019.05.007","article-title":"Epidemiology and burden of invasive fungal infections in the countries of the Arab League","volume":"13","author":"Kmeid","year":"2020","journal-title":"J Infect Public Health"},{"key":"10.1016\/j.jgeb.2025.100474_b0010","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3389\/fmicb.2019.00214","article-title":"The still underestimated problem of fungal diseases worldwide","volume":"10","author":"Almeida","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1016\/j.jgeb.2025.100474_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2021.104879","article-title":"In-silico design of a multivalent epitope-based vaccine against Candida auris","volume":"155","author":"Akhtar","year":"2021","journal-title":"Microb Pathog"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100474_b0020","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00029-17","article-title":"Candida auris: a review of the literature","volume":"31","author":"Jeffery-Smith","year":"2018","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100474_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/mmy\/myy054","article-title":"Candida auris: The recent emergence of a multidrug-resistant fungal pathogen","volume":"57","author":"Forsberg","year":"2019","journal-title":"Med Mycol"},{"issue":"6","key":"10.1016\/j.jgeb.2025.100474_b0030","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1093\/jac\/dkx034","article-title":"Candida auris candidaemia in Indian ICUs: analysis of risk factors","volume":"72","author":"Rudramurthy","year":"2017","journal-title":"J Antimicrob Chemother"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100474_b0035","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cid\/ciw691","article-title":"Simultaneous emergence of multidrug-resistant candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses","volume":"64","author":"Lockhart","year":"2017","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jgeb.2025.100474_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105462","article-title":"Subtractive proteomics assisted therapeutic targets mining and designing ensemble vaccine against Candida auris for immune response induction","volume":"145","author":"Khan","year":"2022","journal-title":"Comput Biol Med"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100474_b0045","first-page":"43","article-title":"Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris","volume":"7","author":"Rhodes","year":"2018","journal-title":"Emerg Microbes Infect"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100474_b0050","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/cid\/ciy411","article-title":"Molecular epidemiology of candida auris in colombia reveals a highly related, countrywide colonization with regional patterns in amphotericin B resistance","volume":"68","author":"Escandon","year":"2019","journal-title":"Clin Infect Dis"},{"issue":"3","key":"10.1016\/j.jgeb.2025.100474_b0055","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.diagmicrobio.2017.10.021","article-title":"Activity of CD101, a long-acting echinocandin, against clinical isolates of Candida auris","volume":"90","author":"Berkow","year":"2018","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.jgeb.2025.100474_b0060","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s40560-018-0342-4","article-title":"Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris","volume":"6","author":"Cortegiani","year":"2018","journal-title":"J Intensive Care"},{"issue":"10","key":"10.1016\/j.jgeb.2025.100474_b0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008921","article-title":"Candida auris: Epidemiology, biology, antifungal resistance, and virulence","volume":"16","author":"Du","year":"2020","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.jgeb.2025.100474_b0070","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkm259","article-title":"WoLF PSORT: protein localization predictor","author":"Horton","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100474_b0075","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/protein\/12.2.85","article-title":"Twilight zone of protein sequence alignments","volume":"12","author":"Rost","year":"1999","journal-title":"Protein Eng"},{"key":"10.1016\/j.jgeb.2025.100474_b0080","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-8-4","article-title":"VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines","volume":"8","author":"Doytchinova","year":"2007","journal-title":"BMC Bioinf"},{"issue":"6","key":"10.1016\/j.jgeb.2025.100474_b0085","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1007\/s00894-014-2278-5","article-title":"AllerTOP vol 2\u2013a server for in silico prediction of allergens","volume":"20","author":"Dimitrov","year":"2014","journal-title":"J Mol Model"},{"issue":"11","key":"10.1016\/j.jgeb.2025.100474_b0090","article-title":"Development of a candidate multi-epitope subunit vaccine against klebsiella aerogenes: subtractive proteomics and immuno-informatics approach","volume":"9","author":"Umar","year":"2021","journal-title":"Vaccines (Basel)"},{"issue":"4","key":"10.1016\/j.jgeb.2025.100474_b0095","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/bioinformatics\/btv639","article-title":"Gapped sequence alignment using artificial neural networks: application to the MHC class I system","volume":"32","author":"Andreatta","year":"2016","journal-title":"Bioinformatics"},{"issue":"23\u201324","key":"10.1016\/j.jgeb.2025.100474_b0100","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1016\/j.vaccine.2004.02.005","article-title":"Prediction of CTL epitopes using QM, SVM and ANN techniques","volume":"22","author":"Bhasin","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.jgeb.2025.100474_b0105","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/1471-2105-8-238","article-title":"Prediction of MHC class II binding affinity using SMM-align, a novel stabilization matrix alignment method","volume":"8","author":"Nielsen","year":"2007","journal-title":"BMC Bioinf"},{"key":"10.1016\/j.jgeb.2025.100474_b0110","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/1471-2105-11-568","article-title":"Peptide binding predictions for HLA DR, DP and DQ molecules","volume":"11","author":"Wang","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jgeb.2025.100474_b0115","doi-asserted-by":"crossref","first-page":"42851","DOI":"10.1038\/srep42851","article-title":"Computer-aided designing of immunosuppressive peptides based on IL-10 inducing potential","volume":"7","author":"Nagpal","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jgeb.2025.100474_b0120","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/263952","article-title":"Prediction of IL4 inducing peptides","volume":"2013","author":"Dhanda","year":"2013","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.jgeb.2025.100474_b0125","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1745-6150-8-30","article-title":"Designing of interferon-gamma inducing MHC class-II binders","volume":"8","author":"Dhanda","year":"2013","journal-title":"Biol Direct"},{"key":"10.1016\/j.jgeb.2025.100474_b0130","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1471-2105-7-153","article-title":"Predicting population coverage of T-cell epitope-based diagnostics and vaccines","volume":"7","author":"Bui","year":"2006","journal-title":"BMC Bioinf"},{"issue":"W1","key":"10.1016\/j.jgeb.2025.100474_b0135","doi-asserted-by":"crossref","first-page":"W24","DOI":"10.1093\/nar\/gkx346","article-title":"BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes","volume":"45","author":"Jespersen","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"10.1016\/j.jgeb.2025.100474_b0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062216","article-title":"Improved method for linear B-cell epitope prediction using antigen's primary sequence","volume":"8","author":"Singh","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100474_b0145","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/prot.21078","article-title":"Prediction of continuous B-cell epitopes in an antigen using recurrent neural network","volume":"65","author":"Saha","year":"2006","journal-title":"Proteins"},{"key":"10.1016\/j.jgeb.2025.100474_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2021.104389","article-title":"Designing multi-epitope vaccine against Staphylococcus aureus by employing subtractive proteomics, reverse vaccinology and immuno-informatics approaches","volume":"132","author":"Tahir Ul Qamar","year":"2021","journal-title":"Comput Biol Med"},{"issue":"10225","key":"10.1016\/j.jgeb.2025.100474_b0155","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(20)30260-9","article-title":"Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study","volume":"395","author":"Wu","year":"2020","journal-title":"Lancet"},{"issue":"13","key":"10.1016\/j.jgeb.2025.100474_b0160","doi-asserted-by":"crossref","first-page":"3784","DOI":"10.1093\/nar\/gkg563","article-title":"ExPASy: The proteomics server for in-depth protein knowledge and analysis","volume":"31","author":"Gasteiger","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jgeb.2025.100474_b0165","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1471-2105-9-40","article-title":"I-TASSER server for protein 3D structure prediction","volume":"9","author":"Zhang","year":"2008","journal-title":"BMC Bioinf"},{"issue":"7","key":"10.1016\/j.jgeb.2025.100474_b0170","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2174\/092986607781483912","article-title":"Ramachandran plot on the web (2.0)","volume":"14","author":"Gopalakrishnan","year":"2007","journal-title":"Protein Pept Lett"},{"issue":"9","key":"10.1016\/j.jgeb.2025.100474_b0175","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/pro.5560020916","article-title":"Verification of protein structures: patterns of nonbonded atomic interactions","volume":"2","author":"Colovos","year":"1993","journal-title":"Protein Sci"},{"key":"10.1016\/j.jgeb.2025.100474_b0180","doi-asserted-by":"crossref","unstructured":"M. Wiederstein, M.J. Sippl, ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins. Nucleic Acids Res 2007, 35 (Web Server issue), W407-410. DOI: 10.1093\/nar\/gkm290.","DOI":"10.1093\/nar\/gkm290"},{"issue":"W1","key":"10.1016\/j.jgeb.2025.100474_b0185","doi-asserted-by":"crossref","first-page":"W406","DOI":"10.1093\/nar\/gkw336","article-title":"3Drefine: an interactive web server for efficient protein structure refinement","volume":"44","author":"Bhattacharya","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100474_b0190","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein data bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res"},{"issue":"13","key":"10.1016\/j.jgeb.2025.100474_b0195","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2013a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J Comput Chem"},{"issue":"W1","key":"10.1016\/j.jgeb.2025.100474_b0200","doi-asserted-by":"crossref","first-page":"W363","DOI":"10.1093\/nar\/gky473","article-title":"CASTp 3.0: computed atlas of surface topography of proteins","volume":"46","author":"Tian","year":"2018","journal-title":"Nucleic Acids Res"},{"issue":"13","key":"10.1016\/j.jgeb.2025.100474_b0205","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1093\/bioinformatics\/btt262","article-title":"pyDockWEB: a web server for rigid-body protein-protein docking using electrostatics and desolvation scoring","volume":"29","author":"Jimenez-Garcia","year":"2013","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1016\/j.jgeb.2025.100474_b0210","doi-asserted-by":"crossref","first-page":"e4473","DOI":"10.1002\/pro.4473","article-title":"PDBsum1: A standalone program for generating PDBsum analyses","volume":"31","author":"Laskowski","year":"2022","journal-title":"Protein Sci"},{"issue":"16","key":"10.1016\/j.jgeb.2025.100474_b0215","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26164961","article-title":"Pharmacophore-based virtual screening, quantum mechanics calculations, and molecular dynamics simulation approaches identified potential natural antiviral drug candidates against MERS-CoV S1-NTD","volume":"26","author":"Bouback","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jgeb.2025.100474_b0220","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gki376","article-title":"JCat: a novel tool to adapt codon usage of a target gene to its potential expression host","volume":"33","author":"Grote","year":"2005","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100474_b0225","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1080\/07391102.2020.1816493","article-title":"Design of a multi-epitope peptide vaccine candidate against chandipura virus: an immuno-informatics study","volume":"40","author":"Pavitrakar","year":"2022","journal-title":"J Biomol Struct Dyn"}],"container-title":["Journal of Genetic Engineering and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X25000186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X25000186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T16:35:56Z","timestamp":1741624556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687157X25000186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S1687157X25000186"],"URL":"https:\/\/doi.org\/10.1016\/j.jgeb.2025.100474","relation":{},"ISSN":["1687-157X"],"issn-type":[{"value":"1687-157X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Designing of multi-valent epitope vaccine displaying interactions with diverse HLA alleles against Candida auris using immuno-informatics","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetic Engineering and Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgeb.2025.100474","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of Academy of Scientific Research and Technology.","name":"copyright","label":"Copyright"}],"article-number":"100474"}}