{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:13:54Z","timestamp":1778825634011,"version":"3.51.4"},"reference-count":138,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018434","name":"Asian Institute of Medicine, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004386","name":"Universiti Malaya","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"Malaysia Ministry of Higher Education","doi-asserted-by":"publisher","award":["FRGS\/1\/2023\/WAB13\/AIMST\/01\/1"],"award-info":[{"award-number":["FRGS\/1\/2023\/WAB13\/AIMST\/01\/1"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Engineering and Biotechnology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.jgeb.2025.100561","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T18:29:34Z","timestamp":1756232974000},"page":"100561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploration of Canarium odontophyllum fruit phytoconstituents as potential candidates against epilepsy using in silico studies"],"prefix":"10.1016","volume":"23","author":[{"given":"Lim Joe","family":"Siang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamini","family":"Vijeepallam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arunachalam","family":"Muthuraman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parasuraman","family":"Pavadai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiruventhan","family":"Karunakaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veerasamy","family":"Ravichandran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.jgeb.2025.100561_b0005","doi-asserted-by":"crossref","first-page":"785","DOI":"10.3390\/brainsci14080785","article-title":"Recent advances in pathophysiology and therapeutic approaches in epilepsy","volume":"14","author":"Prakash","year":"2024","journal-title":"Brain Sci"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0010","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jn\/129.1.5","article-title":"Beta-carotene, carotenoids and the prevention of coronary heart disease","volume":"129","author":"Kritchevsky","year":"1999","journal-title":"J Nutr"},{"issue":"12","key":"10.1016\/j.jgeb.2025.100561_b0015","doi-asserted-by":"crossref","first-page":"3840","DOI":"10.3390\/molecules27123840","article-title":"Fatty acid profile and antioxidant capacity of dabai (Canarium odontophyllum L.): effect of origin and fruit component","volume":"27","author":"Salleh","year":"2022","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.jgeb.2025.100561_b0020","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.phrs.2007.01.012","article-title":"Carotenoids and human health","volume":"55","author":"Rao","year":"2007","journal-title":"Pharmacol Res"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0025","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.foodchem.2005.07.011","article-title":"Antioxidative and prooxidative effects of extracts made from cherry liqueur pomace","volume":"99","author":"R\u00f8dtjer","year":"2006","journal-title":"Food Chem"},{"key":"10.1016\/j.jgeb.2025.100561_b0030","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9999340","article-title":"Phenotypic screening of molecular docking enriched chemical libraries from targets identified in ischemic stroke genome data by network-based method","volume":"2021","author":"Peng","year":"2021","journal-title":"J Healthc Eng"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0035","article-title":"Design of inhibitors that target the menin\u2013mixed-lineage leukemia interaction","volume":"12","author":"Arthur","year":"2024","journal-title":"Computation (Basel, Switzerland)"},{"issue":"3","key":"10.1016\/j.jgeb.2025.100561_b0040","doi-asserted-by":"crossref","first-page":"281","DOI":"10.30574\/wjarr.2023.17.3.0373","article-title":"Conceptual and molecular docking study of newly developed antiepileptic drug cenobamate","volume":"17","author":"Ilyas","year":"2023","journal-title":"World J Adv Res Rev"},{"issue":"3","key":"10.1016\/j.jgeb.2025.100561_b0045","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/ajprhc.ajprhc_59_23","article-title":"Computational insights into the epilepsy-related phytoconstituents of Acacia farnesiana: In silico analysis, molecular modeling, and ADMET profiling","volume":"15","author":"Gupta","year":"2023","journal-title":"Asian J Pharm Res Health Care"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0050","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s43141-021-00273-5","article-title":"Molecular docking and pharmacokinetic studies of phytocompounds from Nigerian medicinal plants as promising inhibitory agents against SARS-CoV-2 methyltransferase (nsp16)","volume":"19","author":"Saliu","year":"2021","journal-title":"J Gen Eng Biotech"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0055","first-page":"21","article-title":"Mushroom derived compounds unveiled naringin as a potential multi-targeted anti-breast cancer compound - an in-silico approach","volume":"49","author":"Veerasamy","year":"2025","journal-title":"Ankara Ecz Fak Derg"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0060","doi-asserted-by":"crossref","first-page":"12547","DOI":"10.1038\/s41598-022-16102-9","article-title":"Molecular docking analysis and evaluation of the antimicrobial properties of the constituents of Geranium wallichianum D. Don ex Sweet from Kashmir Himalaya","volume":"12","author":"Mir","year":"2022","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0065","first-page":"381","article-title":"In silico docking, drug-likeness and toxicity prediction studies of bioactive compounds of Eurycoma longifolia as potential multi-targeted antiviral agents against SARS-CoV-2","volume":"13","author":"Veerasamy","year":"2025","journal-title":"Mor J Chem"},{"key":"10.1016\/j.jgeb.2025.100561_b0070","article-title":"Microwave-assisted synthesis of (6-((1-(4-aminophenyl)-1H-1,2,3-triazol-4-yl)methoxy)substituted benzofuran-2-yl)(phenyl)methanones, evaluation of in vitro anticancer, antimicrobial activities and molecular docking on COVID-19","volume":"4","author":"Dharavath","year":"2022","journal-title":"Res Chem"},{"key":"10.1016\/j.jgeb.2025.100561_b0075","first-page":"7661","article-title":"In silico design of novel pyrazole derivatives containing thiourea skeleton as anti-cancer agents using: 3D QSAR, drug-likeness studies, ADMET prediction and molecular docking","volume":"45","author":"El Mchichi","year":"2021","journal-title":"Mat Today: Proc"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100561_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1145\/1273440.1250664","article-title":"Anton, a special-purpose machine for molecular dynamics simulation","volume":"35","author":"Shaw","year":"2007","journal-title":"SIGARCH Comput Archit News"},{"issue":"43","key":"10.1016\/j.jgeb.2025.100561_b0085","first-page":"9954","article-title":"Structure and dynamics of the TIP3P, SPC, and SPC\/E water models at 298 K","volume":"105","author":"Mark","year":"2001","journal-title":"Chem A Eur J"},{"issue":"45","key":"10.1016\/j.jgeb.2025.100561_b0090","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1021\/ja9621760","article-title":"Development and testing of the OPLS all-atom force field on conformational energetics and properties of organic liquids","volume":"118","author":"Jorgensen","year":"1996","journal-title":"J Am Chem Soc"},{"issue":"5","key":"10.1016\/j.jgeb.2025.100561_b0095","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1021\/jp951968y","article-title":"Application of the Nos\u00e9\u2212Hoover chain algorithm to the study of protein dynamics","volume":"100","author":"Cheng","year":"1996","journal-title":"J Phys Chem"},{"issue":"3","key":"10.1016\/j.jgeb.2025.100561_b0100","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1063\/1.463137","article-title":"Reversible multiple time scale molecular dynamics","volume":"97","author":"Tuckerman","year":"1992","journal-title":"J Chem Phys"},{"issue":"6","key":"10.1016\/j.jgeb.2025.100561_b0105","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1080\/0026897021000044025","article-title":"Constant pressure-constant temperature molecular dynamics: a correct constrained NPT ensemble using the molecular virial","volume":"101","author":"Kalibaeva","year":"2003","journal-title":"Mol Phys"},{"issue":"4","key":"10.1016\/j.jgeb.2025.100561_b0110","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1007\/s11030-022-10512-7","article-title":"Design, synthesis, graph theoretical analysis and molecular modelling studies of novel substituted quinoline analogues as promising anti-breast cancer agents","volume":"27","author":"Dessai","year":"2023","journal-title":"Mol Divers"},{"key":"10.1016\/j.jgeb.2025.100561_b0115","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13065-017-0285-1","article-title":"Effects of temperature, time, and solvent ratio on the extraction of phenolic compounds and the anti-radical activity of Clinacanthus nutans Lindau leaves by response surface methodology","volume":"11","author":"Che Sulaiman","year":"2017","journal-title":"Chem Cent J"},{"key":"10.1016\/j.jgeb.2025.100561_b0120","first-page":"51","article-title":"Effect of extraction process parameters on the yield of bioactive compounds from the roots of Eurycoma longifolia","volume":"60","author":"Mohamad","year":"2013","journal-title":"Jurnal Teknologi (Sci Eng)"},{"issue":"4","key":"10.1016\/j.jgeb.2025.100561_b0125","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jfoodeng.2009.02.015","article-title":"Subcritical water extraction of mannitol from olive leaves","volume":"93","author":"Ghoreishi","year":"2009","journal-title":"J Food Eng"},{"issue":"6","key":"10.1016\/j.jgeb.2025.100561_b0130","doi-asserted-by":"crossref","DOI":"10.1002\/ptr.6617","article-title":"Natural polyphenols in preclinical models of epilepsy","volume":"34","author":"Dhir","year":"2020","journal-title":"Phytother Res: PTR"},{"key":"10.1016\/j.jgeb.2025.100561_b0135","first-page":"90","article-title":"Stigmasterol can be new steroidal drug for neurological disorders: evidence of the GABAergic mechanism via receptor modulation","author":"Karim","year":"2021","journal-title":"Phytomed: Inter J Phytother Phytopharm"},{"issue":"3","key":"10.1016\/j.jgeb.2025.100561_b0140","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jep.2010.07.031","article-title":"Evaluation of the effects of Astragalus mongholicus Bunge saponin extract on central nervous system functions","volume":"131","author":"Jalsrai","year":"2010","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"10.1016\/j.jgeb.2025.100561_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2010.03.007","article-title":"Anticonvulsant activity of berberine, an isoquinoline alkaloid in mice","volume":"18","author":"Bhutada","year":"2010","journal-title":"Epilepsy & Behavior : e&b"},{"issue":"5","key":"10.1016\/j.jgeb.2025.100561_b0150","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41401-019-0327-4","article-title":"Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels","volume":"41","author":"Qing","year":"2020","journal-title":"Acta Pharmacol Sin"},{"issue":"5","key":"10.1016\/j.jgeb.2025.100561_b0155","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/19336950.2015.1092836","article-title":"Anticonvulsant mechanisms of piperine, a piperidine alkaloid","volume":"9","author":"Mishra","year":"2015","journal-title":"Channels (Austin)"},{"issue":"6\u20137","key":"10.1016\/j.jgeb.2025.100561_b0160","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1078\/094471103322331557","article-title":"Nantenine alkaloid presents anticonvulsant effect on two classical animal models","volume":"10","author":"Riberio","year":"2003","journal-title":"Phytomedicine: Inter J Phytother & Amp; Phytopharmacol"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/epi.12463","article-title":"Medicinal compounds with antiepileptic\/anticonvulsant activities","volume":"55","author":"Zhu","year":"2014","journal-title":"Epilepsia"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100561_b0170","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1747-0285.2012.01400.x","article-title":"Neuroprotective effects of vitexin, a flavonoid, on pentylenetetrazole-induced seizure in rats","volume":"80","author":"Abbasi","year":"2012","journal-title":"Chem Biol Drug Des"},{"issue":"8","key":"10.1016\/j.jgeb.2025.100561_b0175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042920","article-title":"Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children","volume":"7","author":"Hino","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jgeb.2025.100561_b0180","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s12906-016-1269-8","article-title":"Anticonvulsant effects of iridoid glycosides fraction purified from Feretia apodanthera Del. (Rubiaceae) in experimental mice models of generalized tonic-clonic seizures","volume":"16","author":"Taiwe","year":"2016","journal-title":"BMC Complement Altern Med"},{"issue":"1\u20132","key":"10.1016\/j.jgeb.2025.100561_b0185","doi-asserted-by":"crossref","first-page":"63","DOI":"10.25040\/aml2021.01-02.063","article-title":"Anticonvulsive potential of cardiac glycosides under conditions of pentilentetrazole-induced seizures in mice: comparative study. 1","volume":"27","author":"Tsyvunin","year":"2021","journal-title":"Acta Medica Leopoliensia"},{"key":"10.1016\/j.jgeb.2025.100561_b0190","article-title":"A comparative brain toxico-pharmacokinetics study of a developed tannic acid nanoparticles in the treatment of epilepsy","volume":"76","author":"Ahmad","year":"2022","journal-title":"J Drug Del Sci Tech"},{"issue":"4","key":"10.1016\/j.jgeb.2025.100561_b0195","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s13659-021-00298-w","article-title":"Hinokiflavone and related C\u2013O\u2013C-type biflavonoids as anti-cancer compounds: Properties and mechanism of action","volume":"11","author":"Goossens","year":"2021","journal-title":"Nat Prod Bioprospect"},{"key":"10.1016\/j.jgeb.2025.100561_b0200","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2174\/1573401319666230602121227","article-title":"Biological potential and therapeutic effectiveness of hinokiflavone in medicine: the effective components of herbal medicines for treatment of cancers and associated complications","volume":"20","author":"Patel","year":"2024","journal-title":"Curr Nutr Food Sci"},{"issue":"3","key":"10.1016\/j.jgeb.2025.100561_b0205","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.jep.2012.05.062","article-title":"Vitexin and isovitexin from the leaves of Ficus deltoidea with in-vivo \u03b1-glucosidase inhibition","volume":"142","author":"Choo","year":"2012","journal-title":"J Ethnopharmacol"},{"issue":"6","key":"10.1016\/j.jgeb.2025.100561_b0210","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/fsn3.1567","article-title":"Review of the effects of vitexin in oxidative stress\u2010related diseases","volume":"8","author":"Babaei","year":"2020","journal-title":"Food Sci Nutr"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100561_b0215","doi-asserted-by":"crossref","first-page":"8","DOI":"10.21315\/mjms2023.30.2.2","article-title":"Beneficial role of vitexin in Parkinson\u2019s disease","volume":"30","author":"Mustapha","year":"2023","journal-title":"Malays J Med Sci"},{"issue":"s3","key":"10.1016\/j.jgeb.2025.100561_b0220","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1046\/j.1528-1157.2001.042suppl.3008.x","article-title":"GABAergic mechanisms in epilepsy","volume":"42","author":"Treiman","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.jgeb.2025.100561_b0225","series-title":"StatPearls","article-title":"Biochemistry, gamma aminobutyric acid","author":"de Leon","year":"2024"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100561_b0230","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.3390\/molecules16021471","article-title":"Flavonoids and the CNS","volume":"16","author":"J\u00e4ger","year":"2011","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100561_b0235","article-title":"Flavonoid modulation of GABA(A) receptors","volume":"163","author":"Jr","year":"2011","journal-title":"Brit J Pharmacol"},{"key":"10.1016\/j.jgeb.2025.100561_b0240","unstructured":"Nilsson J, Sterner O. Modulation of GABAA receptors by natural products and the development of novel synthetic ligands for the benzodiazepine binding site. http:\/\/www.eurekaselect.com. Accessed July 10, 2024. https:\/\/www.eurekaselect.com\/article\/20047."},{"issue":"2","key":"10.1016\/j.jgeb.2025.100561_b0245","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4236\/abc.2014.42019","article-title":"gabaa receptor modulation by compounds isolated from Salvia triloba L","volume":"4","author":"Abdelhalim","year":"2014","journal-title":"Adv Biol Chem"},{"issue":"7","key":"10.1016\/j.jgeb.2025.100561_b0250","article-title":"Design and mechanism of GABA aminotransferase inactivators. Treatments for epilepsies and addictions","volume":"118","author":"Rb","year":"2018","journal-title":"Chem Rev"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0255","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.15769","article-title":"Fundamental neurochemistry review: GABAA receptor neurotransmission and epilepsy: Principles, disease mechanisms and pharmacotherapy","volume":"165","author":"Bryson","year":"2023","journal-title":"J Neurochem"},{"key":"10.1016\/j.jgeb.2025.100561_b0260","doi-asserted-by":"crossref","DOI":"10.1590\/s2175-97902019000100249","article-title":"Anticonvulsant evaluation of 2-pyrazolines carrying naphthyl moiety: an insight into synthesis and molecular docking study","volume":"55","author":"Nusrat","year":"2019","journal-title":"Braz J Pharm Sci"},{"key":"10.1016\/j.jgeb.2025.100561_b0265","doi-asserted-by":"crossref","first-page":"202","DOI":"10.5530\/001954641727","article-title":"Synthesis, anticonvulsant, and molecular docking studies of (3,5-disubstituted-4,5-dihydro-1H-pyrazol-1-yl)(4-chlorophenyl) methanone derivatives","volume":"57","author":"Ray","year":"2023","journal-title":"Indian J Pharm Edu"},{"key":"10.1016\/j.jgeb.2025.100561_b0270","first-page":"6","article-title":"Expression of mitochondrial branched-chain aminotransferase and \u03b1-keto-acid dehydrogenase in rat brain: implications for neurotransmitter metabolism","author":"Cole","year":"2012","journal-title":"Front Neuroanat"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0275","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuroscience.2009.12.011","article-title":"Differential expression of exon 5 splice variants of sodium channel alpha subunit mRNAs in the developing mouse brain","volume":"166","author":"Gazina","year":"2010","journal-title":"Neurosci"},{"issue":"7397","key":"10.1016\/j.jgeb.2025.100561_b0280","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature10945","article-title":"De novo mutations revealed by whole exome sequencing are strongly associated with autism","volume":"485","author":"Sanders","year":"2012","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.jgeb.2025.100561_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109495","article-title":"Severe deficiency of the voltage-gated sodium channel NaV1.2 elevates neuronal excitability in adult mice","volume":"36","author":"Zhang","year":"2021","journal-title":"Cell Rep"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100561_b0290","doi-asserted-by":"crossref","first-page":"56","DOI":"10.5698\/1535-7511-11.2.56","article-title":"Revisiting AMPA receptors as an antiepileptic drug target","volume":"11","author":"Rogawski","year":"2011","journal-title":"Epilepsy Curr"},{"issue":"9","key":"10.1016\/j.jgeb.2025.100561_b0295","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0166-2236(93)90093-2","article-title":"The TINS\/TiPS Lecture. The molecular biology of mammalian glutamate receptor channels","volume":"16","author":"Seeburg","year":"1993","journal-title":"Trends Neurosci"},{"issue":"Pt 10","key":"10.1016\/j.jgeb.2025.100561_b0300","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1093\/brain\/awr202","article-title":"Interictal-like network activity and receptor expression in the epileptic human lateral amygdala","volume":"134","author":"Graebenitz","year":"2011","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100561_b0305","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1523\/JNEUROSCI.11-02-00428.1991","article-title":"Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus","volume":"11","author":"Hosford","year":"1991","journal-title":"J Neurosci"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100561_b0310","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0920-1211(94)90016-7","article-title":"The effect of the non-NMDA receptor antagonist GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizures","volume":"17","author":"D\u00fcrm\u00fcller","year":"1994","journal-title":"Epilepsy Res"},{"issue":"1\u20132","key":"10.1016\/j.jgeb.2025.100561_b0315","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0006-8993(94)90630-0","article-title":"Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy","volume":"638","author":"Namba","year":"1994","journal-title":"Brain Res"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100561_b0320","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S0022-3565(25)11359-1","article-title":"Relief of experimental spasticity and anxiolytic\/anticonvulsant actions of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline","volume":"260","author":"Turski","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.jgeb.2025.100561_b0325","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2017.00229","article-title":"Amyloid \u03b21-42 (A\u03b21-42) induces the CDK2-mediated phosphorylation of Tau through the activation of the mTORC1 signaling pathway while promoting neuronal cell death","volume":"10","author":"Lee","year":"2017","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0330","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s10020-023-00742-2","article-title":"Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator","volume":"29","author":"Ali","year":"2023","journal-title":"Mol Med"},{"issue":"10","key":"10.1016\/j.jgeb.2025.100561_b0335","first-page":"182","article-title":"Progress of autophagy in epilepsy research","volume":"10","author":"Mo","year":"2022","journal-title":"J Biosci Med"},{"issue":"11","key":"10.1016\/j.jgeb.2025.100561_b0340","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.5215-08.2009","article-title":"Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy","volume":"29","author":"Minkeviciene","year":"2009","journal-title":"J Neurosci Off J Soc Neurosci"},{"issue":"9","key":"10.1016\/j.jgeb.2025.100561_b0345","first-page":"1360","article-title":"Mechanisms of apoptosis in drug-resistant epilepsy","volume":"52","author":"Bazhanova","year":"2022","journal-title":"Neurosci Behav Physi"},{"key":"10.1016\/j.jgeb.2025.100561_b0350","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2123748","article-title":"Seizure-induced regulations of amyloid-\u03b2, STEP61, and STEP61 substrates involved in hippocampal synaptic plasticity","author":"Jang","year":"2016","journal-title":"Neural Plast"},{"key":"10.1016\/j.jgeb.2025.100561_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577268","article-title":"LGI1-antibody associated epilepsy successfully treated in the outpatient setting","volume":"345","author":"Uribe-San-Mart\u00edn","year":"2020","journal-title":"J Neuroimmunol"},{"issue":"30","key":"10.1016\/j.jgeb.2025.100561_b0360","doi-asserted-by":"crossref","first-page":"E4129","DOI":"10.1073\/pnas.1511910112","article-title":"The LGI1\u2013ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function","volume":"112","author":"Lovero","year":"2015","journal-title":"Proc Natl Acad Sci"},{"issue":"11","key":"10.1016\/j.jgeb.2025.100561_b0365","first-page":"3144","article-title":"LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory","volume":"141","author":"Petit-Pedrol","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.jgeb.2025.100561_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105537","article-title":"Role of LGI1 protein in synaptic transmission: from physiology to pathology","volume":"160","author":"Fels","year":"2021","journal-title":"Neurobiol Dis"},{"issue":"6","key":"10.1016\/j.jgeb.2025.100561_b0375","article-title":"Arginase 1 deficiency presenting as complicated hereditary spastic paraplegia","volume":"8","author":"Freua","year":"2022","journal-title":"Cold Spring Harb Mol Case Stud"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0380","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/mdc3.13612","article-title":"Arginase 1 Deficiency in patients initially diagnosed with hereditary spastic paraplegia","volume":"10","author":"McNutt","year":"2022","journal-title":"Mov Disord Clin Pract"},{"issue":"1\u20132","key":"10.1016\/j.jgeb.2025.100561_b0385","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.eplepsyres.2005.05.001","article-title":"Sequential changes of nitric oxide levels in the temporal lobes of kainic acid-treated mice following application of nitric oxide synthase inhibitors and phenobarbital","volume":"65","author":"Kato","year":"2005","journal-title":"Epilepsy Res"},{"issue":"26","key":"10.1016\/j.jgeb.2025.100561_b0390","doi-asserted-by":"crossref","first-page":"8565","DOI":"10.1523\/JNEUROSCI.5698-08.2009","article-title":"Endogenous nitric oxide is a key promoting factor for initiation of seizure-like events in hippocampal and entorhinal cortex slices","volume":"29","author":"Kov\u00e1cs","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.jgeb.2025.100561_b0395","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1590\/S0100-879X1997000800010","article-title":"Anticonvulsant and proconvulsant roles of nitric oxide in experimental epilepsy models","volume":"30","author":"Del-Bel","year":"1997","journal-title":"Braz J Med Biol Res"},{"issue":"7","key":"10.1016\/j.jgeb.2025.100561_b0400","doi-asserted-by":"crossref","DOI":"10.2174\/187152711798072347","article-title":"Nitric oxide, epileptic seizures, and action of antiepileptic drugs","volume":"10","author":"Banach","year":"2011","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"24","key":"10.1016\/j.jgeb.2025.100561_b0405","doi-asserted-by":"crossref","first-page":"15339","DOI":"10.1080\/07391102.2023.2188945","article-title":"Ensemble-based molecular docking and spectrofluorometric analysis of interaction between cytotoxin and tumor necrosis factor receptor 1","volume":"41","author":"Misuan","year":"2023","journal-title":"J Biomol Struc Dyn"},{"issue":"4","key":"10.1016\/j.jgeb.2025.100561_b0410","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3390\/cancers12040875","article-title":"Structure-activity relationships and molecular docking analysis of Mcl-1 targeting renieramycin T analogues in patient-derived lung cancer cells","volume":"12","author":"Petsri","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0415","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40781-015-0077-x","article-title":"In silico characterisation, homology modelling and structure-based functional annotation of blunt snout bream (Megalobrama amblycephala) Hsp70 and Hsc70 proteins","volume":"57","author":"Tran","year":"2015","journal-title":"J Anim Sci Technol"},{"issue":"9","key":"10.1016\/j.jgeb.2025.100561_b0420","article-title":"Verification of protein structures: patterns of nonbonded atomic interactions. Protein Science\u00a0: a publication of the Protein","volume":"2","author":"Colovos","year":"1993","journal-title":"Society"},{"issue":"4","key":"10.1016\/j.jgeb.2025.100561_b0425","doi-asserted-by":"crossref","first-page":"6797","DOI":"10.3390\/ijms15046797","article-title":"Modeling and docking studies on novel mutants (K71L and T204V) of the ATPase domain of human heat shock 70 kDa protein 1","volume":"15","author":"Elengoe","year":"2014","journal-title":"Inter J Mol Sci"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100561_b0430","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1107\/S0021889892009944","article-title":"PROCHECK: a program to check the stereochemical quality of protein structures","volume":"26","author":"Laskowski","year":"1993","journal-title":"J Appl Cryst"},{"issue":"suppl_2","key":"10.1016\/j.jgeb.2025.100561_b0435","doi-asserted-by":"crossref","first-page":"W407","DOI":"10.1093\/nar\/gkm290","article-title":"Interactive web service for the recognition of errors in three-dimensional structures of proteins","volume":"35","author":"Wiederstein","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"10.1016\/j.jgeb.2025.100561_b0440","article-title":"In silico structural modeling and quality assessment of Plasmodium knowlesi apical membrane antigen 1 using comparative protein models","volume":"39","author":"Haron","year":"2022","journal-title":"Trop Biomed"},{"issue":"7","key":"10.1016\/j.jgeb.2025.100561_b0445","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00706-023-03076-1","article-title":"Molecular docking in organic, inorganic, and hybrid systems: a tutorial review","volume":"154","author":"Mohanty","year":"2023","journal-title":"Monatsh Chem"},{"key":"10.1016\/j.jgeb.2025.100561_b0450","first-page":"54","article-title":"Introducing a two-dimensional graph of docking score difference vs. similarity of ligand-receptor interactions. Indonesian","volume":"26","author":"Pratama","year":"2021","journal-title":"J Biotech"},{"issue":"5","key":"10.1016\/j.jgeb.2025.100561_b0455","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.3390\/molecules23051038","article-title":"Is it reliable to take the molecular docking top scoring position as the best solution without considering available structural data?","volume":"23","author":"Ram\u00edrez","year":"2018","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100561_b0460","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.3390\/molecules19021672","article-title":"Docking studies in target proteins involved in antibacterial action mechanisms: Extending the knowledge on standard antibiotics to antimicrobial mushroom compounds","volume":"19","author":"Alves","year":"2014","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100561_b0465","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1021\/ci300399w","article-title":"Consensus docking: improving the reliability of docking in a virtual screening context","volume":"53","author":"Houston","year":"2013","journal-title":"J Chem Inf Model"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0470","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1038\/s41598-022-07320-2","article-title":"GC\u2013MS and molecular docking analyses of phytochemicals from the underutilized plant, Parkia timoriana revealed candidate anti-cancerous and anti-inflammatory agents","volume":"12","author":"Ralte","year":"2022","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.jgeb.2025.100561_b0475","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1124\/pr.108.00505","article-title":"International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update","volume":"60","author":"Olsen","year":"2008","journal-title":"Pharmacol Rev"},{"issue":"7","key":"10.1016\/j.jgeb.2025.100561_b0480","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.tips.2018.03.006","article-title":"The benzodiazepine binding sites of GABAA receptors","volume":"39","author":"Sigel","year":"2018","journal-title":"Trends Pharmacol Sci"},{"issue":"2","key":"10.1016\/j.jgeb.2025.100561_b0485","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1021\/jm201650r","article-title":"The 2011 E. B. Hershberg award for important discoveries in medicinally active substances: (1S,3S)-3-Amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a GABA aminotransferase inactivator and new treatment for drug addiction and infantile spasms","volume":"55","author":"Silverman","year":"2012","journal-title":"J Med Chem"},{"issue":"7","key":"10.1016\/j.jgeb.2025.100561_b0490","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrn1430","article-title":"The neurobiology of antiepileptic drugs","volume":"5","author":"Rogawski","year":"2004","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"10.1016\/j.jgeb.2025.100561_b0495","doi-asserted-by":"crossref","DOI":"10.1093\/oxfordjournals.jbchem.a021879","article-title":"Mutation of arginine 98, which serves as a substrate-recognition site of D-amino acid aminotransferase, can be partly compensated for by mutation of tyrosine 88 to an arginyl residue","volume":"122","author":"Kishimoto","year":"1997","journal-title":"J Biochem"},{"issue":"6","key":"10.1016\/j.jgeb.2025.100561_b0500","doi-asserted-by":"crossref","DOI":"10.1080\/19336950.2015.1079674","article-title":"Voltage gated sodium channels as drug discovery targets","volume":"9","author":"Bagal","year":"2015","journal-title":"Channels (Austin)"},{"issue":"4","key":"10.1016\/j.jgeb.2025.100561_b0505","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1124\/pr.57.4.4","article-title":"International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels","volume":"57","author":"Catterall","year":"2005","journal-title":"Pharmacol Rev"},{"issue":"5","key":"10.1016\/j.jgeb.2025.100561_b0510","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1039\/C9NP00056A","article-title":"Contributions of natural products to ion channel pharmacology","volume":"37","author":"Bajaj","year":"2020","journal-title":"Nat Prod Rep"},{"issue":"6","key":"10.1016\/j.jgeb.2025.100561_b0515","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/jat.1556","article-title":"Ion channels in toxicology","volume":"30","author":"Restrepo-Angulo","year":"2010","journal-title":"J Appl Toxicol"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0520","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0896-6273(00)00094-5","article-title":"Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: Crystal structures of the GluR2 ligand binding core","volume":"28","author":"Armstrong","year":"2000","journal-title":"Neuron"},{"issue":"7274","key":"10.1016\/j.jgeb.2025.100561_b0525","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nature08624","article-title":"X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor","volume":"462","author":"Sobolevsky","year":"2009","journal-title":"Nature"},{"issue":"Pt 2","key":"10.1016\/j.jgeb.2025.100561_b0530","first-page":"249","article-title":"Structure and function of AMPA receptors","volume":"554","author":"Gouaux","year":"2003","journal-title":"J Physiol"},{"issue":"8","key":"10.1016\/j.jgeb.2025.100561_b0535","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0896-6273(88)90162-6","article-title":"Glutamate neurotoxicity and diseases of the nervous system","volume":"1","author":"Choi","year":"1988","journal-title":"Neuron"},{"key":"10.1016\/j.jgeb.2025.100561_b0540","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/ane.12099","article-title":"AMPA receptors as a molecular target in epilepsy therapy","volume":"127","author":"Rogawski","year":"2013","journal-title":"Acta Neurol Scand"},{"issue":"5","key":"10.1016\/j.jgeb.2025.100561_b0545","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.3390\/ph3051426","article-title":"Natural products in epilepsy-the present situation and perspectives for the future","volume":"3","author":"Ekstein","year":"2010","journal-title":"Pharmaceuticals"},{"issue":"5","key":"10.1016\/j.jgeb.2025.100561_b0550","doi-asserted-by":"crossref","DOI":"10.1006\/jmbi.1999.2640","article-title":"Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors","volume":"287","author":"Pavletich","year":"1999","journal-title":"J Mol Biol"},{"issue":"11","key":"10.1016\/j.jgeb.2025.100561_b0555","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0969-2126(01)00259-3","article-title":"The crystal structure of cyclin a","volume":"3","author":"Brown","year":"1995","journal-title":"Structure"},{"key":"10.1016\/j.jgeb.2025.100561_b0560","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.1030639","article-title":"Focusing on cyclin-dependent kinases 5: a potential target for neurological disorders","volume":"15","author":"Tian","year":"2022","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0565","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-025-02179-x","article-title":"Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery","volume":"10","author":"Wu","year":"2025","journal-title":"Sig Transduct Target Ther"},{"issue":"3","key":"10.1016\/j.jgeb.2025.100561_b0570","doi-asserted-by":"crossref","DOI":"10.1111\/j.1460-9568.2012.08129.x","article-title":"Leucine-rich glioma inactivated 1 (Lgi1), an epilepsy-related secreted protein, has a nuclear localization signal and localizes to both the cytoplasm and the nucleus of the caudal ganglionic eminence neurons","volume":"36","author":"Kusuzawa","year":"2012","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.jgeb.2025.100561_b0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108628","article-title":"Trans-synaptic LGI1-ADAM22-MAGUK in AMPA and NMDA receptor regulation","volume":"194","author":"Fukata","year":"2021","journal-title":"Neuropharmacol"},{"issue":"10 Suppl","key":"10.1016\/j.jgeb.2025.100561_b0580","article-title":"Structure and function of arginases","volume":"134","author":"De","year":"2004","journal-title":"J Nutr"},{"issue":"1\u20132","key":"10.1016\/j.jgeb.2025.100561_b0585","article-title":"Nitric oxide and neurological disorders","volume":"26","author":"Duncan","year":"2005","journal-title":"Mol Aspects Medicine"},{"issue":"12","key":"10.1016\/j.jgeb.2025.100561_b0590","doi-asserted-by":"crossref","first-page":"2579S","DOI":"10.3945\/jn.115.226621","article-title":"Arginine metabolism revisited","volume":"146","author":"Morris","year":"2016","journal-title":"J Nutr"},{"key":"10.1016\/j.jgeb.2025.100561_b0595","first-page":"51","article-title":"Molecular docking, drug-likeness and SwissADME evaluations of the interactions of 2\u2019-substituted triclosan derivatives with Plasmodium falciparum enoyl-acyl carrier protein reductase","volume":"20","author":"Ibrahim","year":"2022","journal-title":"Mal J Pharm Sci"},{"issue":"4","key":"10.1016\/j.jgeb.2025.100561_b0600","article-title":"Lead- and drug-like compounds: the rule-of-five revolution","volume":"1","author":"Christopher","year":"2004","journal-title":"Drug Discov Today Technol"},{"issue":"1\u20133","key":"10.1016\/j.jgeb.2025.100561_b0605","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv Drug Deliv Rev"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0610","doi-asserted-by":"crossref","DOI":"10.1002\/0471141755.ph0912s49","article-title":"Overview on the rule of five","volume":"49","author":"Pollastri","year":"2010","journal-title":"Curr Protocols Pharmacol"},{"issue":"12","key":"10.1016\/j.jgeb.2025.100561_b0615","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","article-title":"Molecular properties that influence the oral bioavailability of drug candidates","volume":"45","author":"Veber","year":"2002","journal-title":"J Med Chem"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0620","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s13721-020-00276-1","article-title":"Estimation of drug-likeness properties of GC\u2013MS separated bioactive compounds in rare medicinal Pleione maculata using molecular docking technique and SwissADME in silico tools","volume":"10","author":"Sympli","year":"2021","journal-title":"Netw Model Anal Health Inform Bioinforma"},{"key":"10.1016\/j.jgeb.2025.100561_b0625","first-page":"16","article-title":"Influence of logBB cut-off on the prediction of blood-brain barrier permeability","volume":"1","author":"Kunwittaya","year":"2013","journal-title":"Biomed Appl Technol J"},{"issue":"5","key":"10.1016\/j.jgeb.2025.100561_b0630","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.3390\/molecules25051135","article-title":"A Supramolecular approach to structure-based design with a focus on synthons hierarchy in ornithine-derived ligands: Review, synthesis, experimental and in silico studies","volume":"25","author":"Bojarska","year":"2020","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.jgeb.2025.100561_b0635","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1021\/jm0492002","article-title":"A Bioavailability score","volume":"48","author":"Martin","year":"2005","journal-title":"J Med Chem"},{"key":"10.1016\/j.jgeb.2025.100561_b0640","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00089","article-title":"The role of cytochromes P450 in infection","volume":"9","author":"Stavropoulou","year":"2018","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.jgeb.2025.100561_b0645","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cccn.2005.05.047","article-title":"Genetic testing for pharmacogenetics and its clinical application in drug therapy","volume":"363","author":"Hiratsuka","year":"2006","journal-title":"Clin Chim Acta"},{"issue":"11","key":"10.1016\/j.jgeb.2025.100561_b0650","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1002\/cmdc.201600182","article-title":"A BOILED-Egg to predict gastrointestinal absorption and brain penetration of small molecules","volume":"11","author":"Daina","year":"2016","journal-title":"ChemMedChem"},{"issue":"11","key":"10.1016\/j.jgeb.2025.100561_b0655","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1021\/acsomega.9b04398","article-title":"Physicochemical and pharmacokinetic analysis of anacardic acid derivatives","volume":"5","author":"Zafar","year":"2020","journal-title":"ACS Omega"},{"issue":"4","key":"10.1016\/j.jgeb.2025.100561_b0660","doi-asserted-by":"crossref","first-page":"599","DOI":"10.4103\/1673-5374.155434","article-title":"Short-term use of antiepileptic drugs is neurotoxic to the immature brain","volume":"10","author":"Liu","year":"2015","journal-title":"Neural Regen Res"},{"issue":"23","key":"10.1016\/j.jgeb.2025.100561_b0665","doi-asserted-by":"crossref","first-page":"15089","DOI":"10.1073\/pnas.222550499","article-title":"Antiepileptic drugs and apoptotic neurodegeneration in the developing brain","volume":"99","author":"Bittigau","year":"2002","journal-title":"Proc Natl Acad Sci"},{"issue":"9","key":"10.1016\/j.jgeb.2025.100561_b0670","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1080\/17512433.2017.1353418","article-title":"The effect of antiepileptic drugs on the kidney function and structure","volume":"10","author":"Hamed","year":"2017","journal-title":"Exp Rev Clin Pharmacol"},{"key":"10.1016\/j.jgeb.2025.100561_b0675","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.seizure.2020.02.006","article-title":"Managing the patient with epilepsy and renal impairment","volume":"76","author":"Mahmoud","year":"2020","journal-title":"Seizure - Eur J Epilepsy"},{"key":"10.1016\/j.jgeb.2025.100561_b0680","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1178228","article-title":"Molecular dynamics simulation of ligands from Anredera cordifolia (Binahong) to the main protease (Mpro) of SARS-CoV-2","volume":"2022","author":"Fatriansyah","year":"2022","journal-title":"J Trop Med"},{"issue":"17","key":"10.1016\/j.jgeb.2025.100561_b0685","doi-asserted-by":"crossref","first-page":"10027","DOI":"10.1039\/D0RA10674G","article-title":"Revisiting activity of some glucocorticoids as a potential inhibitor of SARS-CoV-2 main protease: Theoretical study","volume":"11","author":"Elmaaty","year":"2021","journal-title":"RSC Adv"},{"key":"10.1016\/j.jgeb.2025.100561_b0690","doi-asserted-by":"crossref","DOI":"10.1177\/11779322221125605","article-title":"Molecular docking, validation, dynamics simulations, and pharmacokinetic prediction of phytochemicals isolated from Croton dichogamus against the HIV-1 reverse transcriptase","volume":"16","author":"Terefe","year":"2022","journal-title":"Bioinf Biol Insights"}],"container-title":["Journal of Genetic Engineering and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X25001052?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X25001052?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T05:54:51Z","timestamp":1778824491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687157X25001052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":138,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1687157X25001052"],"URL":"https:\/\/doi.org\/10.1016\/j.jgeb.2025.100561","relation":{},"ISSN":["1687-157X"],"issn-type":[{"value":"1687-157X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploration of Canarium odontophyllum fruit phytoconstituents as potential candidates against epilepsy using in silico studies","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetic Engineering and Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgeb.2025.100561","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of Academy of Scientific Research and Technology.","name":"copyright","label":"Copyright"}],"article-number":"100561"}}