{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T16:01:48Z","timestamp":1785168108884,"version":"3.55.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016282","name":"Maharishi Dayanand University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016282","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Engineering and Biotechnology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jgeb.2026.100711","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:02:24Z","timestamp":1779148944000},"page":"100711","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Combating Streptococcus agalactiae infections by designing a multi-epitope vaccine using molecular dynamic simulations"],"prefix":"10.1016","volume":"24","author":[{"given":"Jasmine","family":"Arya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8111-4987","authenticated-orcid":false,"given":"Deepshikha","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhawna","family":"Berwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awadhesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Budhwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1387-2480","authenticated-orcid":false,"given":"Navita","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himanshi","family":"Dahiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirti","family":"Nain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astha","family":"Chhillar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4783-1309","authenticated-orcid":false,"given":"Mehak","family":"Dangi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgeb.2026.100711_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103274","article-title":"Molecular diagnostic assays for the detection of common bacterial meningitis pathogens: a narrative review","volume":"65","author":"Diallo","year":"2021","journal-title":"EBioMedicine"},{"issue":"4","key":"10.1016\/j.jgeb.2026.100711_b0010","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3390\/microorganisms9040771","article-title":"Vaccines to prevent meningitis: historical perspectives and future directions","volume":"9","author":"Alderson","year":"2021","journal-title":"Microorganisms"},{"issue":"12","key":"10.1016\/j.jgeb.2026.100711_b0015","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1086\/340538","article-title":"Streptococcus agalactiae infective endocarditis: analysis of 30 cases and review of the literature, 1962\u20131998","volume":"34","author":"Sambola","year":"2002","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.jgeb.2026.100711_b0020","doi-asserted-by":"crossref","unstructured":"Tavares T, L. Pinho, and E. Bonif\u00e1cio Andrade, Group B streptococcal neonatal meningitis, Clin. Microbiol. Rev., vol. 35, no. 2, pp. e00079-21, Apr. 2022, doi: 10.1128\/cmr.00079-21.","DOI":"10.1128\/cmr.00079-21"},{"issue":"2","key":"10.1016\/j.jgeb.2026.100711_b0025","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00404-004-0705-z","article-title":"Serotype distribution and mother-to-baby transmission rate of Streptococcus agalactiae among expectant mothers in Kuwait","volume":"272","author":"Al-Sweih","year":"2005","journal-title":"Arch Gynecol Obstet"},{"issue":"6","key":"10.1016\/j.jgeb.2026.100711_b0030","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/infdis\/jix395","article-title":"Group B streptococcus and the vaginal microbiota","volume":"216","author":"Rosen","year":"2017","journal-title":"J Infect Dis"},{"key":"10.1016\/j.jgeb.2026.100711_b0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.617925","article-title":"Invasive Group B streptococcus disease with recurrence and in multiples: towards a better understanding of GBS late-onset sepsis","volume":"12","author":"Freudenhammer","year":"2021","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.jgeb.2026.100711_b0040","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.immuni.2010.09.017","article-title":"Reverse vaccinology: developing vaccines in the era of genomics","volume":"33","author":"Sette","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.jgeb.2026.100711_b0045","doi-asserted-by":"crossref","unstructured":"Maria M Silva et al., Distribution and prevalence of serotypes of group B streptococcus isolated from pregnant women in 30 countries: a systematic review, Matern.-Fetal Med., vol. 5, no. 2, pp. 97\u2013103, Apr. 2023, doi: 10.1097\/FM9.0000000000000174.","DOI":"10.1097\/FM9.0000000000000174"},{"key":"10.1016\/j.jgeb.2026.100711_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105507","article-title":"Designing a multi-epitope vaccine against Chlamydia pneumoniae by integrating the core proteomics, subtractive proteomics and reverse vaccinology-based immunoinformatics approaches","volume":"145","author":"Noor","year":"2022","journal-title":"Comput Biol Med"},{"issue":"1","key":"10.1016\/j.jgeb.2026.100711_b0055","doi-asserted-by":"crossref","first-page":"21929","DOI":"10.1038\/s41598-021-01283-6","article-title":"An integrated computational framework to design a multi-epitopes vaccine against Mycobacterium tuberculosis","volume":"11","author":"Albutti","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.jgeb.2026.100711_b0060","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.biologicals.2020.10.002","article-title":"Next-generation vaccines and the impacts of state-of-the-art in-silico technologies","volume":"69","author":"Salemi","year":"2021","journal-title":"Biologicals"},{"issue":"1","key":"10.1016\/j.jgeb.2026.100711_b0065","doi-asserted-by":"crossref","first-page":"9044","DOI":"10.1038\/s41598-018-26689-7","article-title":"Subtractive proteomics to identify novel drug targets and reverse vaccinology for the development of chimeric vaccine against Acinetobacter baumannii","volume":"8","author":"Solanki","year":"2018","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.jgeb.2026.100711_b0070","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/bioinformatics\/btq003","article-title":"CD-HIT Suite: a web server for clustering and comparing biological sequences","volume":"26","author":"Huang","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jgeb.2026.100711_b0075","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.genrep.2017.04.008","article-title":"Identification of plausible drug targets by investigating the druggable genome of MDR Staphylococcus epidermidis","volume":"7","author":"Sanober","year":"2017","journal-title":"Gene Rep"},{"key":"10.1016\/j.jgeb.2026.100711_b0080","doi-asserted-by":"crossref","unstructured":"Gao F, H. Luo, C.-T. Zhang, and R. Zhang, \u201cGene Essentiality Analysis Based on DEG 10, an Updated Database of Essential Genes,\u201d in Gene Essentiality, L. J. Lu, Ed., in Methods in Molecular Biology, vol. 1279. New York, NY: Springer New York, 2015, pp. 219\u2013233. doi: 10.1007\/978-1-4939-2398-4_14.","DOI":"10.1007\/978-1-4939-2398-4_14"},{"issue":"13","key":"10.1016\/j.jgeb.2026.100711_b0085","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/bioinformatics\/btq249","article-title":"PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes","volume":"26","author":"Yu","year":"2010","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.jgeb.2026.100711_b0090","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052773","article-title":"Exoproteome and secretome derived broad spectrum novel drug and vaccine candidates in Vibrio cholerae targeted by piper betel derived compounds","volume":"8","author":"Barh","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jgeb.2026.100711_b0095","doi-asserted-by":"crossref","DOI":"10.1101\/2022.04.08.487609","article-title":"DeepTMHMM predicts alpha and beta transmembrane proteins using deep neural networks","author":"Hallgren","year":"2022","journal-title":"Bioinformatics, Preprint, Apr"},{"key":"10.1016\/j.jgeb.2026.100711_b0100","doi-asserted-by":"crossref","unstructured":"Kall L, A. Krogh, and E. L. L. Sonnhammer, Advantages of combined transmembrane topology and signal peptide prediction--the Phobius web server, Nucleic Acids Res., vol. 35, no. Web Server, pp. W429\u2013W432, May 2007, doi: 10.1093\/nar\/gkm256.","DOI":"10.1093\/nar\/gkm256"},{"key":"10.1016\/j.jgeb.2026.100711_b0105","doi-asserted-by":"crossref","unstructured":"Sharma N, S. Patiyal, A. Dhall, A. Pande, C. Arora, and G. P. S. Raghava, \u201cAlgPred 2.0: an improved method for predicting allergenic proteins and mapping of IgE epitopes,\u201d Brief. Bioinform., vol. 22, no. 4, p. bbaa294, Jul. 2021, doi: 10.1093\/bib\/bbaa294.","DOI":"10.1093\/bib\/bbaa294"},{"issue":"1","key":"10.1016\/j.jgeb.2026.100711_b0110","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-8-4","article-title":"VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines","volume":"8","author":"Doytchinova","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jgeb.2026.100711_b0115","doi-asserted-by":"crossref","unstructured":"L. Chen, \u201cVFDB: a reference database for bacterial virulence factors,\u201d Nucleic Acids Res., vol. 33, no. Database issue, pp. D325\u2013D328, Dec. 2004, doi: 10.1093\/nar\/gki008.","DOI":"10.1093\/nar\/gki008"},{"issue":"D1","key":"10.1016\/j.jgeb.2026.100711_b0120","doi-asserted-by":"crossref","first-page":"D8","DOI":"10.1093\/nar\/gks1189","article-title":"Database resources of the National Center for Biotechnology Information","volume":"41","author":"NCBI Resource Coordinators","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"10.1016\/j.jgeb.2026.100711_b0125","first-page":"74","article-title":"MFPPI \u2013 Multi FASTA ProtParam Interface","volume":"12","author":"Garg","year":"2016","journal-title":"Biomed Inform"},{"key":"10.1016\/j.jgeb.2026.100711_b0130","doi-asserted-by":"crossref","unstructured":"Kiefer F, K. Arnold, M. Kunzli, L. Bordoli, and T. Schwede, \u201cThe SWISS-MODEL Repository and associated resources,\u201d Nucleic Acids Res., vol. 37, no. Database, pp. D387\u2013D392, Jan. 2009, doi: 10.1093\/nar\/gkn750.","DOI":"10.1093\/nar\/gkn750"},{"issue":"9","key":"10.1016\/j.jgeb.2026.100711_b0135","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/pro.5560020916","article-title":"Verification of protein structures: patterns of nonbonded atomic interactions","volume":"2","author":"Colovos","year":"1993","journal-title":"Protein Sci"},{"issue":"11","key":"10.1016\/j.jgeb.2026.100711_b0140","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1002\/eji.1830271111","article-title":"Control of self-reactive cytotoxic T lymphocytes expressing \u03b3\u03b4 T cell receptors by natural killer inhibitory receptors","volume":"27","author":"Halary","year":"1997","journal-title":"Eur J Immunol"},{"issue":"D1","key":"10.1016\/j.jgeb.2026.100711_b0145","doi-asserted-by":"crossref","first-page":"D405","DOI":"10.1093\/nar\/gku938","article-title":"The immune epitope database (IEDB) 3.0","volume":"43","author":"Vita","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"10.1016\/j.jgeb.2026.100711_b0150","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1007\/s00894-014-2278-5","article-title":"AllerTOP vol 2\u2014a server for in silico prediction of allergens","volume":"20","author":"Dimitrov","year":"2014","journal-title":"J Mol Model"},{"issue":"9","key":"10.1016\/j.jgeb.2026.100711_b0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073957","article-title":"In silico approach for predicting toxicity of peptides and proteins","volume":"8","author":"Gupta","year":"2013","journal-title":"PLoS ONE"},{"issue":"10","key":"10.1016\/j.jgeb.2026.100711_b0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003266","article-title":"Properties of MHC class I presented peptides that enhance immunogenicity","volume":"9","author":"Calis","year":"2013","journal-title":"PLoS Comput Biol"},{"issue":"5","key":"10.1016\/j.jgeb.2026.100711_b0165","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1182\/blood-2008-05-078154","article-title":"CD4 T cells: fates, functions, and faults","volume":"112","author":"Zhu","year":"2008","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.jgeb.2026.100711_b0170","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/1471-2105-11-568","article-title":"Peptide binding predictions for HLA DR, DP and DQ molecules","volume":"11","author":"Wang","year":"2010","journal-title":"BMC Bioinformatics"},{"issue":"1","key":"10.1016\/j.jgeb.2026.100711_b0175","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1745-6150-8-30","article-title":"Designing of interferon-gamma inducing MHC class-II binders","volume":"8","author":"Dhanda","year":"2013","journal-title":"Biol Direct"},{"key":"10.1016\/j.jgeb.2026.100711_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/263952","article-title":"Prediction of IL4 Inducing Peptides","volume":"2013","author":"Dhanda","year":"2013","journal-title":"Clin Dev Immunol"},{"issue":"1","key":"10.1016\/j.jgeb.2026.100711_b0185","doi-asserted-by":"crossref","first-page":"42851","DOI":"10.1038\/srep42851","article-title":"Computer-aided designing of immunosuppressive peptides based on IL-10 inducing potential","volume":"7","author":"Nagpal","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.jgeb.2026.100711_b0190","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/prot.21078","article-title":"Prediction of continuous B-cell epitopes in an antigen using recurrent neural network","volume":"65","author":"Saha","year":"2006","journal-title":"Proteins Struct Funct Bioinforma"},{"key":"10.1016\/j.jgeb.2026.100711_b0195","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.meegid.2017.10.022","article-title":"Overlapping CD8 + and CD4 + T-cell epitopes identification for the progression of epitope-based peptide vaccine from nucleocapsid and glycoprotein of emerging Rift Valley fever virus using immunoinformatics approach","volume":"56","author":"Adhikari","year":"2017","journal-title":"Infect Genet Evol"},{"issue":"4","key":"10.1016\/j.jgeb.2026.100711_b0200","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1007\/s10989-019-10003-8","article-title":"Exploring lassa virus proteome to design a multi-epitope vaccine through immunoinformatics and immune simulation analyses","volume":"26","author":"Sayed","year":"2020","journal-title":"Int J Pept Res Ther"},{"issue":"7","key":"10.1016\/j.jgeb.2026.100711_b0205","doi-asserted-by":"crossref","first-page":"255","DOI":"10.6026\/97320630006255","article-title":"Population coverage analysis of T-Cell epitopes of Neisseria meningitidis serogroup B from Iron acquisition proteins for vaccine design","volume":"6","author":"Misra","year":"2011","journal-title":"Bioinformation"},{"issue":"8","key":"10.1016\/j.jgeb.2026.100711_b0210","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/protein\/14.8.529","article-title":"Design of the linkers which effectively separate domains of a bifunctional fusion protein","volume":"14","author":"Arai","year":"2001","journal-title":"Protein Eng Des Sel"},{"key":"10.1016\/j.jgeb.2026.100711_b0215","series-title":"The Proteomics Protocols Handbook","first-page":"571","article-title":"Protein identification and analysis tools on the ExPASy Server","author":"Gasteiger","year":"2005"},{"issue":"6","key":"10.1016\/j.jgeb.2026.100711_b0220","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/bioinformatics\/11.6.681","article-title":"SOPMA: significant improvements in protein secondary structure prediction by consensus prediction from multiple alignments","volume":"11","author":"Geourjon","year":"1995","journal-title":"Bioinformatics"},{"issue":"8016","key":"10.1016\/j.jgeb.2026.100711_b0225","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.jgeb.2026.100711_b0230","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/pro.5560020916","article-title":"Verification of protein structures: patterns of nonbonded atomic interactions","volume":"2","author":"Colovos","year":"1993","journal-title":"Protein Science"},{"key":"10.1016\/j.jgeb.2026.100711_b0235","doi-asserted-by":"crossref","unstructured":"M. Wiederstein and M. J. Sippl, \u201cProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins,\u201d Nucleic Acids Res., vol. 35, no. Web Server, pp. W407\u2013W410, May 2007, doi: 10.1093\/nar\/gkm290.","DOI":"10.1093\/nar\/gkm290"},{"issue":"3","key":"10.1016\/j.jgeb.2026.100711_b0240","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/prot.10286","article-title":"Structure validation by C\u03b1 geometry: \u03d5,\u03c8 and C\u03b2 deviation","volume":"50","author":"Lovell","year":"2003","journal-title":"Proteins Struct Funct Bioinforma"},{"issue":"W1","key":"10.1016\/j.jgeb.2026.100711_b0245","doi-asserted-by":"crossref","first-page":"W502","DOI":"10.1093\/nar\/gkz452","article-title":"IEDB-AR: immune epitope database\u2014analysis resource in 2019","volume":"47","author":"Dhanda","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"10.1016\/j.jgeb.2026.100711_b0250","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/prot.25184","article-title":"pyDock scoring for the new modeling challenges in docking: Protein-peptide, homo-multimers, and domain-domain interactions: new modeling challenges in docking","volume":"85","author":"Pallara","year":"2017","journal-title":"Proteins Struct Funct Bioinforma"},{"issue":"12","key":"10.1016\/j.jgeb.2026.100711_b0255","doi-asserted-by":"crossref","DOI":"10.1093\/bioinformatics\/btaf606","article-title":"COCOMAPS 2.0: a web server for identifying, analyzing, and visualizing atomic interactions at the interface of biomolecular complexes","volume":"41","author":"Chawla","year":"2025","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jgeb.2026.100711_b0260","doi-asserted-by":"crossref","unstructured":"Yuan S, H. C. S. Chan, and Z. Hu, \u201cUsing PyMOL as a platform for computational drug design,\u201d WIREs Comput. Mol. Sci., vol. 7, no. 2, Mar. 2017, doi: 10.1002\/wcms.1298.","DOI":"10.1002\/wcms.1298"},{"key":"10.1016\/j.jgeb.2026.100711_b0265","doi-asserted-by":"crossref","unstructured":"Berendsen HJ. et al.\u201cGROMACS: A message-passing parallel molecular dynamics implementation,\u201dComputer physics communications,vol. 91 no. 1-3, Sep. 1995, doi:10.1016\/0010-4655(95)00042-E.","DOI":"10.1016\/0010-4655(95)00042-E"},{"key":"10.1016\/j.jgeb.2026.100711_b0270","doi-asserted-by":"crossref","unstructured":"H.J. Berendsen, et al. \u201cMolecular dynamics with coupling to an external bath,\u201dThe Journal of chemical physics, vol.81 no.8, Oct. 1984, doi: https:\/\/doi.org\/10.1063\/1.448118.","DOI":"10.1063\/1.448118"},{"key":"10.1016\/j.jgeb.2026.100711_b0275","doi-asserted-by":"crossref","unstructured":"Kaushik V, P. Jain, N. Akhtar, et al., Immunoinformatics-aided design andin vivovalidation of a peptide-based multiepitope vaccine targeting canine circovirus, ACS Pharmacol Transl Sci, 5(8), 679-691, Aug 2022, DOI: 10.1021\/acsptsci.2c00130.","DOI":"10.1021\/acsptsci.2c00130"},{"key":"10.1016\/j.jgeb.2026.100711_b0280","doi-asserted-by":"crossref","first-page":"11879","DOI":"10.1038\/s41598-025-95256-8","article-title":"Immunoinformatics-driven design of a multi-epitope vaccine targeting neonatal rotavirus with focus on outer capsid proteins VP4 and VP7 and non structural proteins NSP2 and NSP5","volume":"15","author":"Sharma","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.jgeb.2026.100711_b0285","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3390\/vaccines11020364","article-title":"Secreted aspartyl proteinases targeted multi-epitope vaccine design forCandida dubliniensisusing immunoinformatics","volume":"11","author":"Akhtar","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.jgeb.2026.100711_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2022.105398","article-title":"Comparative genome analysis of Streptococcus strains to identify virulent genes causing neonatal meningitis","volume":"107","author":"Arya","year":"2023","journal-title":"Infect Genet Evol"}],"container-title":["Journal of Genetic Engineering and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X26000557?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X26000557?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T15:43:57Z","timestamp":1785167037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687157X26000557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S1687157X26000557"],"URL":"https:\/\/doi.org\/10.1016\/j.jgeb.2026.100711","relation":{},"ISSN":["1687-157X"],"issn-type":[{"value":"1687-157X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combating Streptococcus agalactiae infections by designing a multi-epitope vaccine using molecular dynamic simulations","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetic Engineering and Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgeb.2026.100711","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Academy of Scientific Research and Technology.","name":"copyright","label":"Copyright"}],"article-number":"100711"}}