{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:11:20Z","timestamp":1789560680341,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023174","name":"Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023174","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013375","name":"Universitas Sumatera Utara","doi-asserted-by":"publisher","award":["91\/UN5.2.3.1\/PPM\/KPEP\/2023"],"award-info":[{"award-number":["91\/UN5.2.3.1\/PPM\/KPEP\/2023"]}],"id":[{"id":"10.13039\/501100013375","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013375","name":"Universitas Sumatera Utara","doi-asserted-by":"publisher","award":["EQUITY 2023-2024"],"award-info":[{"award-number":["EQUITY 2023-2024"]}],"id":[{"id":"10.13039\/501100013375","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Engineering and Biotechnology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jgeb.2026.100713","type":"journal-article","created":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T06:28:04Z","timestamp":1780208884000},"page":"100713","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The bioinformatics approach to identifying pathogenic variants for colorectal cancer (CRC)"],"prefix":"10.1016","volume":"24","author":[{"given":"Muhammad","family":"Ma'ruf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalu Muhammad","family":"Irham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wirawan","family":"Adikusuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maulida","family":"Mazaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfian","family":"Mubaraq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didi Nurhadi","family":"Illian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arini Sabilah","family":"Al Mustaqimah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Chiuman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayssam M.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shofiyah Sabilah","family":"Al Mustaniroh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Basyuni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgeb.2026.100713_bb0005","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1200\/GO.20.00155","article-title":"Five-year cancer epidemiology at the National Referral Hospital: hospital-based cancer registry data in Indonesia","volume":"7","author":"Gondhowiardjo","year":"2021","journal-title":"JCO Glob Oncol"},{"key":"10.1016\/j.jgeb.2026.100713_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26164984","article-title":"Current status, distribution, and future directions of natural products against colorectal cancer in Indonesia: a systematic review","author":"Illian","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jgeb.2026.100713_bb0015","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdu253","article-title":"Treatment of colorectal cancer in older patients: International Society of Geriatric Oncology (SIOG) consensus recommendations 2013","author":"Papamichael","year":"2015","journal-title":"Ann Oncol"},{"key":"10.1016\/j.jgeb.2026.100713_bb0020","first-page":"2727","article-title":"Colorectal cancer and inflammatory bowel disease: epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies","volume":"29","author":"Triantafillidis","year":"2009","journal-title":"Anticancer Res"},{"issue":"4","key":"10.1016\/j.jgeb.2026.100713_bb0025","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1136\/gutjnl-2015-310912","article-title":"Global patterns and trends in colorectal cancer incidence and mortality","volume":"66","author":"Arnold","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jgeb.2026.100713_bb0030","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.cgh.2020.02.026","article-title":"Differences in incidence and mortality trends of colorectal cancer worldwide based on sex, age, and anatomic location","volume":"19","author":"Wong","year":"2021","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"11","key":"10.1016\/j.jgeb.2026.100713_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijc.30382","article-title":"A global view on cancer incidence and national levels of the human development index","volume":"139","author":"Fidler","year":"2016","journal-title":"Int J Cancer"},{"issue":"10","key":"10.1016\/j.jgeb.2026.100713_bb0040","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/hep4.1751","article-title":"Association of genetic risk score with NAFLD in an ethnically diverse cohort","volume":"5","author":"Wang","year":"2021","journal-title":"Hepatol Commun"},{"issue":"1 D","key":"10.1016\/j.jgeb.2026.100713_bb0045","doi-asserted-by":"crossref","first-page":"D977","DOI":"10.1093\/nar\/gkac1010","article-title":"The NHGRI-EBI GWAS catalog: knowledgebase and deposition resource","volume":"51","author":"Sollis","year":"2023","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"10.1016\/j.jgeb.2026.100713_bb0050","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkr917","article-title":"HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants","volume":"40","author":"Ward","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"10.1016\/j.jgeb.2026.100713_bb0055","doi-asserted-by":"crossref","first-page":"D891","DOI":"10.1093\/nar\/gkad1049","article-title":"Ensembl 2024","volume":"52","author":"Harrison","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jgeb.2026.100713_bb0060","author":"Aguet"},{"issue":"W1","key":"10.1016\/j.jgeb.2026.100713_bb0065","doi-asserted-by":"crossref","first-page":"W185","DOI":"10.1093\/nar\/gkaa420","article-title":"SNPnexus: a web server for functional annotation of human genome sequence variation (2020 update)","volume":"48","author":"Oscanoa","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jgeb.2026.100713_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2020.00045","article-title":"Identification of core gene expression signature and key pathways in colorectal cancer","volume":"11","author":"Ding","year":"2020","journal-title":"Front Genet"},{"issue":"15","key":"10.1016\/j.jgeb.2026.100713_bb0075","first-page":"4352","article-title":"Gene expression in colorectal cancer","volume":"62","author":"Birkenkamp-Demtroder","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.jgeb.2026.100713_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.606527","article-title":"SH2B3, transcribed by STAT1, promotes glioblastoma progression through transducing IL-6\/gp130 signaling to activate STAT3 signaling","volume":"9","author":"Cai","year":"2021","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"10.1016\/j.jgeb.2026.100713_bb0085","first-page":"6071","article-title":"Gene expression profile comparison between colorectal cancer and adjacent normal tissues","volume":"14","author":"Yang","year":"2017","journal-title":"Oncol Lett"},{"issue":"8","key":"10.1016\/j.jgeb.2026.100713_bb0090","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.7150\/ijbs.40834","article-title":"Transcription factor RREB1: from target genes toward biological functions","volume":"16","author":"Deng","year":"2020","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.jgeb.2026.100713_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2021.08.017","article-title":"miR-26a enhances colorectal cancer cell growth by targeting RREB1 deacetylation to activate AKT-mediated glycolysis","volume":"521","author":"Chen","year":"2021","journal-title":"Cancer Lett"},{"issue":"11","key":"10.1016\/j.jgeb.2026.100713_bb0100","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1093\/hmg\/ddw087","article-title":"Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease","volume":"25","author":"Orlando","year":"2016","journal-title":"Hum Mol Genet"},{"issue":"5","key":"10.1016\/j.jgeb.2026.100713_bb0105","first-page":"681","article-title":"m7G-lncRNAs are potential biomarkers for prognosis and tumor microenvironment in patients with colon cancer","volume":"42","author":"Chen","year":"2022","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"issue":"4","key":"10.1016\/j.jgeb.2026.100713_bb0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196245","article-title":"Genetic susceptibility markers for a breast-colorectal cancer phenotype: exploratory results from genome-wide association studies","volume":"13","author":"Pande","year":"2018","journal-title":"PloS One"},{"issue":"19","key":"10.1016\/j.jgeb.2026.100713_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15194688","article-title":"Genetic variants as predictors of the success of colorectal cancer treatments","volume":"15","author":"Garcia-Etxebarria","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.jgeb.2026.100713_bb0120","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41588-022-01222-9","article-title":"Deciphering colorectal cancer genetics through multiomic analysis of 100,204 cases and 154,587 controls of European and East Asian ancestries","volume":"55","author":"Fernandez-Rozadilla","year":"2023","journal-title":"Nat Genet"},{"issue":"APR","key":"10.1016\/j.jgeb.2026.100713_bb0125","article-title":"Prognosis prediction of colorectal cancer using gene expression profiles","volume":"9","author":"Pan","year":"2019","journal-title":"Front Oncol"},{"issue":"21","key":"10.1016\/j.jgeb.2026.100713_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21218150","article-title":"Genotype-based gene expression in colon tissue\u2014prediction accuracy and relationship with the prognosis of colorectal cancer patients","volume":"21","author":"Deutelmoser","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jgeb.2026.100713_bb0135","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-11-238","article-title":"COX-2 gene expression in colon cancer tissue related to regulating factors and promoter methylation status","volume":"11","author":"Asting","year":"2011","journal-title":"BMC Cancer"},{"issue":"4","key":"10.1016\/j.jgeb.2026.100713_bb0140","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.ijrobp.2010.06.023","article-title":"A gene expression signature for chemoradiosensitivity of colorectal cancer cells","volume":"78","author":"Spitzner","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"12","key":"10.1016\/j.jgeb.2026.100713_bb0145","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.31557\/APJCP.2018.19.12.3393","article-title":"Cytotoxic and antiproliferative activity of polyisoprenoids in seventeen mangroves species against WiDr colon cancer cells","volume":"19","author":"Sari","year":"2018","journal-title":"Asian Pac J Cancer Prev"},{"issue":"1","key":"10.1016\/j.jgeb.2026.100713_bb0150","article-title":"Bioinformatics analysis of the oxidosqualene cyclase gene and the amino acid sequence in mangrove plants","volume":"801","author":"Basyuni","year":"2017","journal-title":"J Phys Conf Ser"}],"container-title":["Journal of Genetic Engineering and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X26000570?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X26000570?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:55:43Z","timestamp":1789559743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687157X26000570"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1687157X26000570"],"URL":"https:\/\/doi.org\/10.1016\/j.jgeb.2026.100713","relation":{},"ISSN":["1687-157X"],"issn-type":[{"value":"1687-157X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The bioinformatics approach to identifying pathogenic variants for colorectal cancer (CRC)","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetic Engineering and Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgeb.2026.100713","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Academy of Scientific Research and Technology.","name":"copyright","label":"Copyright"}],"article-number":"100713"}}