{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:13:09Z","timestamp":1789560789226,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Engineering and Biotechnology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jgeb.2026.100769","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:23:12Z","timestamp":1784575392000},"page":"100769","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular study of KIT gene that is related to drug resistance in chronic myeloid leukemia patients"],"prefix":"10.1016","volume":"24","author":[{"given":"Asrar K.","family":"Salman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed E.","family":"Dhamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jgeb.2026.100769_bb0005","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41419-022-04531-3","article-title":"HucMSC exosomes promoted imatinib-induced apoptosis in K562-R cells via a miR-145a-5p\/USP6\/GLS1 axis","volume":"13","author":"Chen","year":"2022","journal-title":"Cell Death Dis"},{"issue":"24","key":"10.1016\/j.jgeb.2026.100769_bb0010","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1200\/JCO.2015.66.2866","article-title":"Life expectancy of patients with chronic myeloid leukemia approaches the life expectancy of the general population","volume":"34","author":"Bower","year":"2016","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.jgeb.2026.100769_bb0015","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s11011-021-00883-5","article-title":"The association of stem cell factor and soluble c-kit (s-cKit) receptor serum concentrations with the severity and risk prediction of autism spectrum disorders","volume":"37","author":"Mashayekhi","year":"2022","journal-title":"Metab Brain Dis"},{"issue":"5","key":"10.1016\/j.jgeb.2026.100769_bb0025","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3390\/pharmaceutics14050999","article-title":"Pharmacogenetic interventions improve the clinical outcome of treatment-resistant autistic spectrum disorder sufferers","volume":"14","author":"Arranz","year":"2022","journal-title":"Pharmaceutics"},{"issue":"7","key":"10.1016\/j.jgeb.2026.100769_bb0030","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.3390\/cancers15072074","article-title":"Molecular-tailored therapeutic options for advanced gastrointestinal stromal tumors (GISTs): current practice and future perspectives","volume":"15","author":"Catalano","year":"2023","journal-title":"Cancers"},{"issue":"5","key":"10.1016\/j.jgeb.2026.100769_bb0035","first-page":"683","article-title":"Role and significance of c-KIT receptor tyrosine kinase in cancer: a review","volume":"22","author":"Sheikh","year":"2022","journal-title":"Bosn J Basic Med Sci"},{"issue":"22","key":"10.1016\/j.jgeb.2026.100769_bb0040","doi-asserted-by":"crossref","first-page":"5354","DOI":"10.3390\/cancers15225354","article-title":"Unraveling the mechanisms of sensitivity to anti-FGF therapies in imatinib-resistant gastrointestinal stromal tumors (GIST) lacking secondary KIT mutations","volume":"15","author":"Boichuk","year":"2023","journal-title":"Cancers"},{"issue":"2","key":"10.1016\/j.jgeb.2026.100769_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/biom15020215","article-title":"Autophagy and cancer: insights into molecular mechanisms and therapeutic approaches for chronic myeloid leukaemia","volume":"15","author":"Kausar","year":"2025","journal-title":"Biomolecules"},{"issue":"38","key":"10.1016\/j.jgeb.2026.100769_bb0055","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1080\/14796694.2024.2402680","article-title":"Dose-escalation of second-line and first-line asciminib in chronic myeloid leukemia in chronic phase: the ASC2ESCALATE phase II trial","volume":"20","author":"Atallah","year":"2024","journal-title":"Future Oncol"},{"issue":"3","key":"10.1016\/j.jgeb.2026.100769_bb0060","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.clml.2023.10.005","article-title":"Real-world effectiveness of dasatinib versus imatinib in newly diagnosed patients with chronic myeloid leukemia","volume":"24","author":"Klink","year":"2024","journal-title":"Clin Lymphoma Myeloma Leuk"},{"issue":"4","key":"10.1016\/j.jgeb.2026.100769_bb0045","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1182\/blood-2007-06-097253","article-title":"RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia","volume":"111","author":"Tyner","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jgeb.2026.100769_bb0050","series-title":"Antipsychotic drugs: probable agents for additional cancer therapy","author":"Mishra","year":"2022"},{"issue":"8","key":"10.1016\/j.jgeb.2026.100769_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/bies.202200242","article-title":"The current status and trends of DNA extraction","volume":"45","author":"Ye","year":"2023","journal-title":"Bioessays"},{"issue":"1","key":"10.1016\/j.jgeb.2026.100769_bb0070","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2144\/btn-2022-0061","article-title":"DNA extraction from clotted blood for genotyping quality","volume":"74","author":"Stanzick","year":"2023","journal-title":"Biotechniques"},{"issue":"9","key":"10.1016\/j.jgeb.2026.100769_bb0080","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/ajh.26642","article-title":"Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring","volume":"97","author":"Jabbour","year":"2022","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jgeb.2026.100769_bb0090","article-title":"Unifying genomics and transcriptomics in single cells with ResolveOME amplification chemistry to illuminate oncogenic and drug resistance mechanisms","volume":"2022","author":"Zawistowski","year":"2022","journal-title":"bioRxiv"},{"issue":"2","key":"10.1016\/j.jgeb.2026.100769_bb0095","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000521751","article-title":"KIT exon 9-mutated gastrointestinal stromal tumours: biology and treatment","volume":"67","author":"Napolitano","year":"2022","journal-title":"Chemotherapy"},{"key":"10.1016\/j.jgeb.2026.100769_bb0100","author":"Abayie"},{"issue":"5","key":"10.1016\/j.jgeb.2026.100769_bb0105","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1073\/pnas.0812413106","article-title":"KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients","volume":"106","author":"Gajiwala","year":"2009","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"10.1016\/j.jgeb.2026.100769_bb0110","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1152\/physrev.00046.2011","article-title":"Stem cell factor receptor\/c-kit: from basic science to clinical implications","volume":"92","author":"Lennartsson","year":"2012","journal-title":"Physiol Rev"},{"key":"10.1016\/j.jgeb.2026.100769_bb0115","first-page":"1609","article-title":"Recent FDA-approved kinase inhibitors for cancer therapy in 2025: a comprehensive review and perspectives","volume":"24","author":"Abbas","year":"2025","journal-title":"EXCLI J"},{"issue":"11","key":"10.1016\/j.jgeb.2026.100769_bb0120","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/S1470-2045(07)70342-X","article-title":"Part I: mechanisms of resistance to imatinib in chronic myeloid leukaemia","volume":"8","author":"Apperley","year":"2007","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jgeb.2026.100769_bb0155","unstructured":"Calculator.net. (n.d.). BMI calculator. Retrieved February 24, 2026, from https:\/\/www.calculator.net\/bmi-calculator.html."}],"container-title":["Journal of Genetic Engineering and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X26001137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1687157X26001137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:01:12Z","timestamp":1789560072000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1687157X26001137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1687157X26001137"],"URL":"https:\/\/doi.org\/10.1016\/j.jgeb.2026.100769","relation":{},"ISSN":["1687-157X"],"issn-type":[{"value":"1687-157X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular study of KIT gene that is related to drug resistance in chronic myeloid leukemia patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetic Engineering and Biotechnology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgeb.2026.100769","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Academy of Scientific Research and Technology.","name":"copyright","label":"Copyright"}],"article-number":"100769"}}