{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:02:09Z","timestamp":1762542129122,"version":"build-2065373602"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetics and Genomics"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.jgg.2013.01.001","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T21:30:20Z","timestamp":1358803820000},"page":"83-91","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dual Effects of IL-1 Overactivity on the Immune System in a Mouse Model of Arthritis due to Deficiency of IL-1 Receptor Antagonist"],"prefix":"10.1016","volume":"40","author":[{"given":"Jian","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen A.","family":"Hasty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Stuart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weikuan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgg.2013.01.001_bib1","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1172\/JCI115453","article-title":"Interleukin 1 receptor antagonist. A new member of the interleukin 1 family","volume":"88","author":"Arend","year":"1991","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jgg.2013.01.001_bib2","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1182\/blood-2006-05-022988","article-title":"Low SCL\/TAL1 expression reveals its major role in adult hematopoietic myeloid progenitors and stem cells","volume":"108","author":"Brunet de la Grange","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jgg.2013.01.001_bib4","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2003-4-9-r60","article-title":"DAVID: Database for Annotation, Visualization, and Integrated Discovery","volume":"4","author":"Dennis","year":"2003","journal-title":"Genome Biol."},{"key":"10.1016\/j.jgg.2013.01.001_bib5","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/sj.gene.6364132","article-title":"DNA microarray allows molecular profiling of rheumatoid arthritis and identification of pathophysiological targets","volume":"5","author":"Devauchelle","year":"2004","journal-title":"Genes Immun."},{"key":"10.1016\/j.jgg.2013.01.001_bib6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1056\/NEJM199301143280207","article-title":"The role of interleukin-1 in disease","volume":"328","author":"Dinarello","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jgg.2013.01.001_bib7","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1073\/pnas.84.16.5585","article-title":"Detection of neuropeptide Y and its mRNA in megakaryocytes: enhanced levels in certain autoimmune mice","volume":"84","author":"Ericsson","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jgg.2013.01.001_bib8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00439-002-0832-1","article-title":"Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions","volume":"112","author":"Freson","year":"2003","journal-title":"Hum. Genet."},{"key":"10.1016\/j.jgg.2013.01.001_bib9","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1186\/ar1985","article-title":"Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis","volume":"8","author":"Fujikado","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jgg.2013.01.001_bib10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1084\/jem.20062259","article-title":"T cell self-reactivity forms a cytokine milieu for spontaneous development of IL-17+ Th cells that cause autoimmune arthritis","volume":"204","author":"Hirota","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jgg.2013.01.001_bib11","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1172\/JCI20742","article-title":"TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice","volume":"114","author":"Horai","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jgg.2013.01.001_bib12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1084\/jem.191.2.313","article-title":"Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice","volume":"191","author":"Horai","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jgg.2013.01.001_bib13","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/rheumatology\/kel405","article-title":"Down-regulation of leucocyte immunoglobulin-like receptor expression in the synovium of rheumatoid arthritis patients after treatment with disease-modifying anti-rheumatic drugs","volume":"46","author":"Huynh","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jgg.2013.01.001_bib14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/bioinformatics\/btk005","article-title":"EDGE: extraction and analysis of differential gene expression","volume":"22","author":"Leek","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jgg.2013.01.001_bib15","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1084\/jem.20061341","article-title":"Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease","volume":"203","author":"Lohr","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jgg.2013.01.001_bib16","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.1073\/pnas.1035999100","article-title":"IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist","volume":"100","author":"Nakae","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jgg.2013.01.001_bib17","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1172\/JCI11530","article-title":"Macrophage- and neutrophil-dominant arthritis in human IL-1 \u03b1 transgenic mice","volume":"107","author":"Niki","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jgg.2013.01.001_bib18","doi-asserted-by":"crossref","first-page":"5757","DOI":"10.4049\/jimmunol.173.9.5757","article-title":"The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling","volume":"173","author":"Pereira","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.jgg.2013.01.001_bib19","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.coi.2005.09.017","article-title":"Animal models of arthritis caused by systemic alteration of the immune system","volume":"17","author":"Sakaguchi","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.jgg.2013.01.001_bib20","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/art.20382","article-title":"Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis","volume":"50","author":"Sims","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jgg.2013.01.001_bib21","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nri1810","article-title":"Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens","volume":"6","author":"Sternberg","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jgg.2013.01.001_bib22","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.1073\/pnas.012025199","article-title":"Large-scale analysis of the human and mouse transcriptomes","volume":"99","author":"Su","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jgg.2013.01.001_bib23","doi-asserted-by":"crossref","first-page":"R69","DOI":"10.1186\/ar1939","article-title":"The S100A8\/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis","volume":"8","author":"Sunahori","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jgg.2013.01.001_bib24","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1073\/pnas.86.16.6398","article-title":"Intracerebroventricular infusion of interleukin 1 rapidly decreases peripheral cellular immune responses","volume":"86","author":"Sundar","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jgg.2013.01.001_bib25","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1523\/JNEUROSCI.10-11-03701.1990","article-title":"Brain IL-1-induced immunosuppression occurs through activation of both pituitary-adrenal axis and sympathetic nervous system by corticotropin-releasing factor","volume":"10","author":"Sundar","year":"1990","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jgg.2013.01.001_bib26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0065-2776(05)88005-8","article-title":"A novel recognition system for MHC class I molecules constituted by PIR","volume":"88","author":"Takai","year":"2005","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.jgg.2013.01.001_bib27","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1006\/brbi.1995.1027","article-title":"Modulation of interleukin-1 receptors in the brain-endocrine-immune axis by stress and infection","volume":"9","author":"Takao","year":"1995","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jgg.2013.01.001_bib28","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0002-9440(10)64861-4","article-title":"The co-expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium","volume":"160","author":"Tedla","year":"2002","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jgg.2013.01.001_bib29","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1172\/JCI200112195","article-title":"Inhibition of IgE-mediated mast cell activation by the paired Ig-like receptor PIR-B","volume":"108","author":"Uehara","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jgg.2013.01.001_bib30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/sj.gene.6363975","article-title":"Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: evidence for the existence of multiple pathways of tissue destruction and repair","volume":"4","author":"van der Pouw Kraan","year":"2003","journal-title":"Genes Immun."},{"key":"10.1016\/j.jgg.2013.01.001_bib31","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nri1593","article-title":"Heat-shock proteins induce T-cell regulation of chronic inflammation","volume":"5","author":"van Eden","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jgg.2013.01.001_bib32","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1046\/j.1471-4159.2000.740457.x","article-title":"\u201cInflammatory\u201d cytokines: neuromodulators in normal brain?","volume":"74","author":"Vitkovic","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jgg.2013.01.001_bib33","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1084\/jem.20051971","article-title":"A fundamental bimodal role for neuropeptide Y1 receptor in the immune system","volume":"202","author":"Wheway","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jgg.2013.01.001_bib34","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1126\/science.2471266","article-title":"Brefeldin A specifically inhibits presentation of protein antigens to cytotoxic T lymphocytes","volume":"244","author":"Yewdell","year":"1989","journal-title":"Science"}],"container-title":["Journal of Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1673852713000209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1673852713000209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T11:24:38Z","timestamp":1761650678000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1673852713000209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S1673852713000209"],"URL":"https:\/\/doi.org\/10.1016\/j.jgg.2013.01.001","relation":{},"ISSN":["1673-8527"],"issn-type":[{"type":"print","value":"1673-8527"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual Effects of IL-1 Overactivity on the Immune System in a Mouse Model of Arthritis due to Deficiency of IL-1 Receptor Antagonist","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetics and Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgg.2013.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}