{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T23:05:17Z","timestamp":1770332717737,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007179","name":"University of New Mexico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007179","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetics and Genomics"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.jgg.2015.01.001","type":"journal-article","created":{"date-parts":[[2015,1,10]],"date-time":"2015-01-10T10:31:46Z","timestamp":1420885906000},"page":"49-56","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Association of the Late Cornified Envelope-3 Genes with Psoriasis and Psoriatic Arthritis: A Systematic Review"],"prefix":"10.1016","volume":"42","author":[{"given":"Changbing","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianyong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujun","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangdan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgg.2015.01.001_bib1","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.bbrc.2013.12.128","article-title":"Regulation of late cornified envelope genes relevant to psoriasis risk by plant-derived cyanidin","volume":"443","author":"Austin","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jgg.2015.01.001_bib2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/1471-2164-14-261","article-title":"Worldwide population distribution of the common LCE3C-LCE3B deletion associated with psoriasis and other autoimmune disorders","volume":"14","author":"Bassaganyas","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.jgg.2015.01.001_bib3","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/jid.2010.88","article-title":"Deletion of late cornified envelope 3B and 3C genes is not associated with atopic dermatitis","volume":"130","author":"Bergboer","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jgg.2015.01.001_bib4","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.ajpath.2010.12.017","article-title":"Psoriasis risk genes of the late cornified envelope-3 group are distinctly expressed compared with genes of other LCE groups","volume":"178","author":"Bergboer","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jgg.2015.01.001_bib5","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/j.1365-2133.2012.10992.x","article-title":"Paediatric-onset psoriasis is associated with ERAP1 and IL23R loci, LCE3C_LCE3B deletion and HLA-C*06","volume":"167","author":"Bergboer","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jgg.2015.01.001_bib6","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/jid.2011.336","article-title":"Koebner phenomenon in psoriasis is not associated with deletion of late cornified envelope genes LCE3B and LCE3C","volume":"132","author":"Bergboer","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jgg.2015.01.001_bib7","doi-asserted-by":"crossref","first-page":"e32045","DOI":"10.1371\/journal.pone.0032045","article-title":"A replication study of the association between rheumatoid arthritis and deletion of the late cornified envelope genes LCE3B and LCE3C","volume":"7","author":"Bergboer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jgg.2015.01.001_bib8","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1038\/jid.2012.167","article-title":"Genetics of psoriasis: evidence for epistatic interaction between skin barrier abnormalities and immune deviation","volume":"132","author":"Bergboer","year":"2012","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jgg.2015.01.001_bib9","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1136\/ard.2010.130575","article-title":"Variants in linkage disequilibrium with the late cornified envelope gene cluster deletion are associated with susceptibility to psoriatic arthritis","volume":"69","author":"Bowes","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jgg.2015.01.001_bib10","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1086\/302653","article-title":"Evidence for interaction between psoriasis-susceptibility loci on chromosomes 6p21 and 1q21","volume":"65","author":"Capon","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jgg.2015.01.001_bib11","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1046\/j.1523-1747.2001.01311.x","article-title":"Fine mapping of the PSORS4 psoriasis susceptibility region on chromosome 1q21","volume":"116","author":"Capon","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jgg.2015.01.001_bib12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s12016-012-8303-5","article-title":"The genetics of psoriasis and psoriatic arthritis","volume":"44","author":"Chandran","year":"2013","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jgg.2015.01.001_bib13","doi-asserted-by":"crossref","first-page":"e19454","DOI":"10.1371\/journal.pone.0019454","article-title":"A genetic risk score combining ten psoriasis risk loci improves disease prediction","volume":"6","author":"Chen","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.jgg.2015.01.001_bib14","doi-asserted-by":"crossref","first-page":"41411","DOI":"10.1007\/s11033-014-3285-4","article-title":"Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not associated with psoriatic arthritis in Tunisian patients","volume":"41","author":"Chiraz","year":"2014","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.jgg.2015.01.001_bib15","doi-asserted-by":"crossref","first-page":"i370","DOI":"10.1093\/bioinformatics\/bts379","article-title":"An exome sequencing pipeline for identifying and genotyping common CNVs associated with disease with application to psoriasis","volume":"28","author":"Coin","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jgg.2015.01.001_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1471-2350-11-45","article-title":"Mutation analysis of the LCE3B\/LCE3C genes in Psoriasis","volume":"11","author":"Coto","year":"2010","journal-title":"BMC Med. Genet."},{"key":"10.1016\/j.jgg.2015.01.001_bib17","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/jid.2011.14","article-title":"New psoriasis susceptibility genes: momentum for skin-barrier disruption","volume":"131","author":"Coto","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jgg.2015.01.001_bib18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/ng.313","article-title":"Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis","volume":"41","author":"de Cid","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jgg.2015.01.001_bib19","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/hmg\/ddq019","article-title":"A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis","volume":"19","author":"de Guzman Strong","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jgg.2015.01.001_bib20","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/j.1365-2133.2012.10885.x","article-title":"Expression profile of cornified envelope structural proteins and keratinocyte differentiation-regulating proteins during skin barrier repair","volume":"166","author":"de Koning","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jgg.2015.01.001_bib21","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1002\/art.27381","article-title":"Deletion of the late cornified envelope genes, LCE3C and LCE3B, is associated with rheumatoid arthritis","volume":"62","author":"Docampo","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jgg.2015.01.001_bib22","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1002\/art.30340","article-title":"Deletion of LCE3C and LCE3B is a susceptibility factor for psoriatic arthritis: a study in Spanish and Italian populations and meta-analysis","volume":"63","author":"Docampo","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jgg.2015.01.001_bib23","first-page":"1449","article-title":"Genetics of psoriasis and psoriatic arthritis: update and future direction","volume":"35","author":"Duffin","year":"2008","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.jgg.2015.01.001_bib24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00281-007-0060-9","article-title":"The skin barrier as an innate immune element","volume":"29","author":"Elias","year":"2007","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.jgg.2015.01.001_bib25","doi-asserted-by":"crossref","first-page":"1000993","DOI":"10.1371\/journal.pgen.1000993","article-title":"Web-based, participant-driven studies yield novel genetic associations for common traits","volume":"6","author":"Eriksson","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jgg.2015.01.001_bib26","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1586\/eci.09.13","article-title":"Current understanding of the genetic basis of psoriasis","volume":"5","author":"Gudjonsson","year":"2009","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.jgg.2015.01.001_bib27","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/jid.2009.385","article-title":"Replication of LCE3C\u2013LCE3B CNV as a risk factor for psoriasis and analysis of interaction with other genetic risk factors","volume":"130","author":"H\u00fcffmeier","year":"2010","journal-title":"J. Invest. Dermatol."},{"issue":"Suppl. 2","key":"10.1016\/j.jgg.2015.01.001_bib28","doi-asserted-by":"crossref","first-page":"ii3","DOI":"10.1136\/ard.2004.032318","article-title":"Classification and diagnostic criteria for psoriatic arthritis","volume":"64","author":"Helliwell","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jgg.2015.01.001_bib29","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00403-013-1390-1","article-title":"Control of late cornified envelope genes relevant to psoriasis risk: upregulation by 1,25-dihydroxyvitamin D3 and plant-derived delphinidin","volume":"305","author":"Hoss","year":"2013","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jgg.2015.01.001_bib30","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.0022-202X.2005.23699.x","article-title":"Late cornified envelope family in differentiating epithelia\u2013response to calcium and ultraviolet irradiation","volume":"124","author":"Jackson","year":"2005","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jgg.2015.01.001_bib31","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1093\/hmg\/dds295","article-title":"Risk variants for psoriasis vulgaris in a large case-control collection and association with clinical subphenotypes","volume":"21","author":"Julia","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jgg.2015.01.001_bib32","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/jid.2011.86","article-title":"Deletion of the late cornified envelope genes LCE3C and LCE3B is associated with psoriasis in a Chinese population","volume":"131","author":"Li","year":"2011","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jgg.2015.01.001_bib33","doi-asserted-by":"crossref","first-page":"e1000041","DOI":"10.1371\/journal.pgen.1000041","article-title":"A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci","volume":"4","author":"Liu","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jgg.2015.01.001_bib34","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/nature05663","article-title":"Pathogenesis and therapy of psoriasis","volume":"445","author":"Lowes","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jgg.2015.01.001_bib35","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1136\/ard.2010.148072","article-title":"Deletion of LCE3C_LCE3B is associated with rheumatoid arthritis and systemic lupus erythematosus in the Chinese Han population","volume":"70","author":"Lu","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jgg.2015.01.001_bib36","doi-asserted-by":"crossref","first-page":"13031","DOI":"10.1073\/pnas.231489198","article-title":"Differentially expressed late constituents of the epidermal cornified envelope","volume":"98","author":"Marshall","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jgg.2015.01.001_bib37","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2340\/00015555-1810","article-title":"Genotype-phenotype correlations in a prospective cohort study of paediatric plaque psoriasis: lack of correlation between HLA-C*06 and family history of psoriasis","volume":"94","author":"Oostveen","year":"2014","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.jgg.2015.01.001_bib38","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/jid.2012.339","article-title":"Global epidemiology of psoriasis: a systematic review of incidence and prevalence","volume":"133","author":"Parisi","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jgg.2015.01.001_bib39","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/jid.2010.350","article-title":"Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6","volume":"131","author":"Riveira-Munoz","year":"2010","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jgg.2015.01.001_bib40","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/bjd.12331","article-title":"Pharmacogenetics of psoriasis: HLA-Cw6 but not LCE3B\/3C deletion nor TNFAIP3 polymorphism predisposes to clinical response to interleukin 12\/23 blocker ustekinumab","volume":"169","author":"Talamonti","year":"2013","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jgg.2015.01.001_bib41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ng.2827","article-title":"A large-scale screen for coding variants predisposing to psoriasis","volume":"46","author":"Tang","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jgg.2015.01.001_bib42","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5603\/FHC.2014.0018","article-title":"Epidermal differentiation complex (locus 1q21) gene expression in head and neck cancer and normal mucosa","volume":"52","author":"Tyszkiewicz","year":"2014","journal-title":"Folia Histochem. Cytobiol."},{"key":"10.1016\/j.jgg.2015.01.001_bib43","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1111\/j.1365-2133.2011.10485.x","article-title":"Deletion of LCE3C and LCE3B genes is associated with psoriasis in a northern Chinese population","volume":"165","author":"Xu","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jgg.2015.01.001_bib44","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.cell.2010.03.003","article-title":"Unraveling the genetics of autoimmunity","volume":"140","author":"Zenewicz","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jgg.2015.01.001_bib45","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/ng.310","article-title":"Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21","volume":"41","author":"Zhang","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jgg.2015.01.001_bib46","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jdermsci.2010.12.001","article-title":"Variants in MHC, LCE and IL12B have epistatic effects on psoriasis risk in Chinese population","volume":"61","author":"Zheng","year":"2011","journal-title":"J. Dermatol. Sci."}],"container-title":["Journal of Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1673852715000041?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1673852715000041?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T11:27:05Z","timestamp":1761650825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1673852715000041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S1673852715000041"],"URL":"https:\/\/doi.org\/10.1016\/j.jgg.2015.01.001","relation":{},"ISSN":["1673-8527"],"issn-type":[{"value":"1673-8527","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of the Late Cornified Envelope-3 Genes with Psoriasis and Psoriatic Arthritis: A Systematic Review","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetics and Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgg.2015.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}