{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:49:29Z","timestamp":1793652569145,"version":"4.5.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetics and Genomics"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.jgg.2020.08.001","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T06:21:36Z","timestamp":1598422896000},"page":"451-465","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["The novel male meiosis recombination regulator coordinates the progression of meiosis prophase I"],"prefix":"10.1016","volume":"47","author":[{"given":"Miao","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiwei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexiong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongteng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junshi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond H.W.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest H.Y.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.Y.","family":"Huen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Jeremy","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S.B.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7519-3332","authenticated-orcid":false,"given":"Kui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgg.2020.08.001_bib1","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1128\/MCB.25.3.1041-1053.2005","article-title":"Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis","volume":"25","author":"Baarends","year":"2005","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jgg.2020.08.001_bib2","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/ng0796-336","article-title":"Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over","volume":"13","author":"Baker","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jgg.2020.08.001_bib3","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1126\/science.1183439","article-title":"PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice","volume":"327","author":"Baudat","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.jgg.2020.08.001_bib4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/978-1-4939-0817-2_9","article-title":"Ubiquitin-proteasome system in spermatogenesis","volume":"759","author":"Bose","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jgg.2020.08.001_bib5","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1016\/j.celrep.2019.05.096","article-title":"HSF2BP interacts with a conserved domain of BRCA2 and is required for mouse spermatogenesis","volume":"27","author":"Brandsma","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.jgg.2020.08.001_bib6","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1126\/science.1219379","article-title":"Rad51 is an accessory factor for Dmc1-mediated joint molecule formation during meiosis","volume":"337","author":"Cloud","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.jgg.2020.08.001_bib7","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0092-8674(00)81312-4","article-title":"Meiotic pachytene arrest in MLH1-deficient mice","volume":"85","author":"Edelmann","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.jgg.2020.08.001_bib8","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.fertnstert.2019.08.004","article-title":"Meiotic arrest occurs most frequently at metaphase and is often incomplete in azoospermic men","volume":"112","author":"Enguita-Marruedo","year":"2019","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.jgg.2020.08.001_bib9","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1038\/ncomms2995","article-title":"Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis","volume":"4","author":"Gan","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jgg.2020.08.001_bib10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nrg2723","article-title":"Genetics of mammalian meiosis: regulation, dynamics and impact on fertility","volume":"11","author":"Handel","year":"2010","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jgg.2020.08.001_bib11","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.devcel.2015.01.014","article-title":"SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination","volume":"32","author":"Hasegawa","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jgg.2020.08.001_bib12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/andr.12315","article-title":"Spermatogenesis associated 22 is required for DNA repair and synapsis of homologous chromosomes in mouse germ cells","volume":"5","author":"Hays","year":"2017","journal-title":"Andrology"},{"key":"10.1016\/j.jgg.2020.08.001_bib13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/35056583","article-title":"Protein regulation by monoubiquitin","volume":"2","author":"Hicke","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jgg.2020.08.001_bib14","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.devcel.2018.10.004","article-title":"SETDB1 links the meiotic DNA damage response to sex chromosome silencing in mice","volume":"47","author":"Hirota","year":"2018","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jgg.2020.08.001_bib15","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1101\/gad.2030811","article-title":"MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells","volume":"25","author":"Ichijima","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.jgg.2020.08.001_bib16","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nature09399","article-title":"Purified human BRCA2 stimulates RAD51-mediated recombination","volume":"467","author":"Jensen","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.jgg.2020.08.001_bib17","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1042\/BST0340523","article-title":"Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation","volume":"34","author":"Keeney","year":"2006","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.jgg.2020.08.001_bib18","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1126\/science.184.4139.868","article-title":"Chromatin structure: a repeating unit of histones and DNA","volume":"184","author":"Kornberg","year":"1974","journal-title":"Science"},{"key":"10.1016\/j.jgg.2020.08.001_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1095\/biolreprod.111.095752","article-title":"Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells","volume":"86","author":"La Salle","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jgg.2020.08.001_bib20","doi-asserted-by":"crossref","first-page":"eaax1101","DOI":"10.1126\/sciadv.aax1101","article-title":"The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice","volume":"5","author":"Li","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jgg.2020.08.001_bib21","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1093\/nar\/gkz226","article-title":"SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice","volume":"47","author":"Liu","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jgg.2020.08.001_bib22","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.devcel.2010.01.010","article-title":"RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesis","volume":"18","author":"Lu","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jgg.2020.08.001_bib23","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1038\/ncomms3105","article-title":"Regulation of the DNA damage response on male meiotic sex chromosomes","volume":"4","author":"Lu","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jgg.2020.08.001_bib24","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1038\/ncomms3788","article-title":"MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination","volume":"4","author":"Luo","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jgg.2020.08.001_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004954","article-title":"Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis","volume":"11","author":"Luo","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jgg.2020.08.001_bib26","doi-asserted-by":"crossref","first-page":"jcs217125","DOI":"10.1242\/jcs.217125","article-title":"SCML2 promotes heterochromatin organization in late spermatogenesis","volume":"131","author":"Maezawa","year":"2018","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.jgg.2020.08.001_bib27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41586-020-2034-1","article-title":"Gene expression and cell identity controlled by anaphase-promoting complex","volume":"579","author":"Oh","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jgg.2020.08.001_bib28","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1023\/A:1018445520117","article-title":"A\u00a0drying-down technique for the spreading of mammalian meiocytes from the male and female germline","volume":"5","author":"Peters","year":"1997","journal-title":"Chromosome Res."},{"key":"10.1016\/j.jgg.2020.08.001_bib29","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/ng.2858","article-title":"Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination","volume":"46","author":"Qiao","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jgg.2020.08.001_bib30","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1126\/science.aaf6407","article-title":"A\u00a0SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination","volume":"355","author":"Rao","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.jgg.2020.08.001_bib31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/ng.2541","article-title":"RNF212 is a dosage-sensitive regulator of crossing-over during mammalian meiosis","volume":"45","author":"Reynolds","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jgg.2020.08.001_bib32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00412-015-0552-7","article-title":"RPA homologs and ssDNA processing during meiotic recombination","volume":"125","author":"Ribeiro","year":"2016","journal-title":"Chromosoma"},{"key":"10.1016\/j.jgg.2020.08.001_bib33","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1128\/MCB.01566-07","article-title":"The mouse polyubiquitin gene Ubb is essential for meiotic progression","volume":"28","author":"Ryu","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jgg.2020.08.001_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007952","article-title":"Dual functions for the ssDNA-binding protein RPA in meiotic recombination","volume":"15","author":"Shi","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jgg.2020.08.001_bib35","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/mrd.21318","article-title":"Altered testicular gene expression patterns in mice lacking the polyubiquitin gene Ubb","volume":"78","author":"Sinnar","year":"2011","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.jgg.2020.08.001_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005531","article-title":"A gene regulatory program for meiotic prophase in the fetal ovary","volume":"11","author":"Soh","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jgg.2020.08.001_bib37","doi-asserted-by":"crossref","first-page":"107686","DOI":"10.1016\/j.celrep.2020.107686","article-title":"Meiosis-specific C19orf57\/4930432K21Rik\/BRME1 modulates localization of RAD51 and DMC1 to DSBs in mouse meiotic recombination","volume":"31","author":"Takemoto","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.jgg.2020.08.001_bib38","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1038\/sj.emboj.7601739","article-title":"Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1","volume":"26","author":"Thorslund","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.jgg.2020.08.001_bib39","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1242\/dev.000018","article-title":"Meiotic sex chromosome inactivation","volume":"134","author":"Turner","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.jgg.2020.08.001_bib40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.dnarep.2017.06.011","article-title":"Histone ubiquitination in the DNA damage response","volume":"56","author":"Uckelmann","year":"2017","journal-title":"DNA Repair"},{"key":"10.1016\/j.jgg.2020.08.001_bib41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1146\/annurev.biochem.66.1.61","article-title":"Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism","volume":"66","author":"Wold","year":"1997","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jgg.2020.08.001_bib42","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/biolre\/iox040","article-title":"Meiosis-specific proteins MEIOB and SPATA22 cooperatively associate with the single-stranded DNA-binding replication protein A complex and DNA double-strand breaks","volume":"96","author":"Xu","year":"2017","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.jgg.2020.08.001_bib43","first-page":"9681","article-title":"H2B ubiquitination regulates meiotic recombination by promoting chromatin relaxation","volume":"44","author":"Xu","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jgg.2020.08.001_bib44","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1038\/s41467-020-15954-x","article-title":"The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells","volume":"11","author":"Zhang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jgg.2020.08.001_bib45","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1146\/annurev.genet.33.1.603","article-title":"Meiotic chromosomes: integrating structure and function","volume":"33","author":"Zickler","year":"1999","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.jgg.2020.08.001_bib46","doi-asserted-by":"crossref","first-page":"a016626","DOI":"10.1101\/cshperspect.a016626","article-title":"Recombination, pairing, and synapsis of homologs during meiosis","volume":"7","author":"Zickler","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."}],"container-title":["Journal of Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1673852720301272?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1673852720301272?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T11:33:45Z","timestamp":1761651225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1673852720301272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S1673852720301272"],"URL":"https:\/\/doi.org\/10.1016\/j.jgg.2020.08.001","relation":{},"ISSN":["1673-8527"],"issn-type":[{"value":"1673-8527","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The novel male meiosis recombination regulator coordinates the progression of meiosis prophase I","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetics and Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgg.2020.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press.","name":"copyright","label":"Copyright"}]}}