{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:46:53Z","timestamp":1788436013670,"version":"build-2803163510"},"reference-count":83,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T00:00:00Z","timestamp":1681516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172388"],"award-info":[{"award-number":["82172388"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871771"],"award-info":[{"award-number":["81871771"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2022YFA1103500"],"award-info":[{"award-number":["2022YFA1103500"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013290","name":"National Key Research and Development Program of China Stem Cell and Translational Research","doi-asserted-by":"publisher","award":["2022YFA1104100"],"award-info":[{"award-number":["2022YFA1104100"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["L212065"],"award-info":[{"award-number":["L212065"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["7222123"],"award-info":[{"award-number":["7222123"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetics and Genomics"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.jgg.2023.04.004","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T11:56:30Z","timestamp":1681732590000},"page":"702-712","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Single-cell transcriptomic analysis identifies a highly replicating Cd168+ skeletal stem\/progenitor cell population in mouse long bones"],"prefix":"10.1016","volume":"50","author":[{"given":"Rui-Cong","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei-Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Lin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo-Feng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Tong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8408-3821","authenticated-orcid":false,"given":"Heng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgg.2023.04.004_bib1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.devcel.2007.02.004","article-title":"MEF2C transcription factor controls chondrocyte hypertrophy and bone development","volume":"12","author":"Arnold","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jgg.2023.04.004_bib2","doi-asserted-by":"crossref","first-page":"10117","DOI":"10.1073\/pnas.1214100110","article-title":"Hydrogels that mimic developmentally relevant matrix and N-cadherin interactions enhance MSC chondrogenesis","volume":"110","author":"Bian","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jgg.2023.04.004_bib3","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0002-9440(10)63868-0","article-title":"Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells","volume":"162","author":"Bondjers","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jgg.2023.04.004_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00223-014-9931-y","article-title":"Osteocalcin: an osteoblast-derived polypeptide hormone that modulates whole body energy metabolism","volume":"96","author":"Brennan-Speranza","year":"2015","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.jgg.2023.04.004_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2021.153486","article-title":"RHAMM in liver metastases of stage IV colorectal cancer with mismatch-repair proficient status correlates with tumor budding, cytotoxic T-cells and PD-1\/PD-L1","volume":"223","author":"Burren","year":"2021","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.jgg.2023.04.004_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cell.2018.07.029","article-title":"Identification of the human skeletal stem cell","volume":"175","author":"Chan","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jgg.2023.04.004_bib8","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1074\/jbc.270.4.1747","article-title":"A\u00a0COL2A1 mutation in achondrogenesis type II results in the replacement of type II collagen by type I and III collagens in cartilage","volume":"270","author":"Chan","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jgg.2023.04.004_bib7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2014.12.002","article-title":"Identification and specification of the mouse skeletal stem cell","volume":"160","author":"Chan","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jgg.2023.04.004_bib9","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cell.2021.01.010","article-title":"A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells","volume":"184","author":"Cheng","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jgg.2023.04.004_bib10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic Res."},{"key":"10.1016\/j.jgg.2023.04.004_bib11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.matbio.2018.08.002","article-title":"The Receptor for Hyaluronan-Mediated Motility (CD168) promotes inflammation and fibrosis after acute lung injury","volume":"78\u201379","author":"Cui","year":"2019","journal-title":"Matrix Biol."},{"key":"10.1016\/j.jgg.2023.04.004_bib12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41586-018-0554-8","article-title":"Discovery of a periosteal stem cell mediating intramembranous bone formation","volume":"562","author":"Debnath","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jgg.2023.04.004_bib13","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/ng.665","article-title":"Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin","volume":"42","author":"Depianto","year":"2010","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jgg.2023.04.004_bib14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10783","article-title":"Endothelial and perivascular cells maintain haematopoietic stem cells","volume":"481","author":"Ding","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jgg.2023.04.004_bib15","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41574-019-0246-y","article-title":"The role of osteoblasts in energy homeostasis","volume":"15","author":"Dirckx","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jgg.2023.04.004_bib16","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/S0021-9258(17)35257-2","article-title":"Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms","volume":"266","author":"Doege","year":"1991","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jgg.2023.04.004_bib17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/372525a0","article-title":"Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene","volume":"372","author":"Foster","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jgg.2023.04.004_bib18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nature11926","article-title":"CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance","volume":"495","author":"Greenbaum","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jgg.2023.04.004_bib19","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/jbmr.3802","article-title":"The unmixing problem: a guide to applying single-cell RNA sequencing to bone","volume":"34","author":"Greenblatt","year":"2019","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.jgg.2023.04.004_bib20","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/nprot.2018.041","article-title":"Isolation and functional assessment of mouse skeletal stem cell lineage","volume":"13","author":"Gulati","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jgg.2023.04.004_bib21","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.4049\/jimmunol.141.8.2781","article-title":"Complete exon-intron organization of the human leukocyte common antigen (CD45) gene","volume":"141","author":"Hall","year":"1988","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jgg.2023.04.004_bib22","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/s41422-021-00467-z","article-title":"Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses","volume":"31","author":"He","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.jgg.2023.04.004_bib23","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.2741\/2296","article-title":"Signaling and transcriptional regulation in osteoblast commitment and differentiation","volume":"12","author":"Huang","year":"2007","journal-title":"Front. Biosci."},{"key":"10.1016\/j.jgg.2023.04.004_bib25","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.stem.2022.10.002","article-title":"Bone marrow and periosteal skeletal stem\/progenitor cells make distinct contributions to bone maintenance and repair","volume":"29","author":"Jeffery","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jgg.2023.04.004_bib26","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bbrc.2009.06.059","article-title":"Mice expressing GFP and CreER in osteochondro progenitor cells in the periosteum","volume":"386","author":"Kawanami","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jgg.2023.04.004_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.matbio.2019.12.004","article-title":"Single cell RNA-sequencing reveals cellular heterogeneity and trajectories of lineage specification during murine embryonic limb development","volume":"89","author":"Kelly","year":"2020","journal-title":"Matrix Biol."},{"key":"10.1016\/j.jgg.2023.04.004_bib28","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s13104-015-1136-6","article-title":"Transcriptional profiling of PRKG2-null growth plate identifies putative down-stream targets of PRKG2","volume":"8","author":"Koltes","year":"2015","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.jgg.2023.04.004_bib29","doi-asserted-by":"crossref","DOI":"10.1242\/dev.199607","article-title":"Skeletal stem cell fate defects caused by Pdgfrb activating mutation","volume":"148","author":"Kwon","year":"2021","journal-title":"Development"},{"key":"10.1016\/j.jgg.2023.04.004_bib30","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0925-4773(95)00389-I","article-title":"Expression patterns of the paired-related homeobox genes MHox\/Prx1 and S8\/Prx2 suggest roles in development of the heart and the forebrain","volume":"52","author":"Leussink","year":"1995","journal-title":"Mech. Dev."},{"key":"10.1016\/j.jgg.2023.04.004_bib31","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/82609","article-title":"Fgf8 signalling from the AER is essential for normal limb development","volume":"26","author":"Lewandoski","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jgg.2023.04.004_bib32","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/01.RES.78.2.188","article-title":"SM22 alpha, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis","volume":"78","author":"Li","year":"1996","journal-title":"Circ. Res."},{"key":"10.1016\/j.jgg.2023.04.004_bib33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41368-021-00146-0","article-title":"From bulk, single-cell to spatial RNA sequencing","volume":"13","author":"Li","year":"2021","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.jgg.2023.04.004_bib34","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1038\/s41588-022-01227-4","article-title":"Prrx1 marks stem cells for bone, white adipose tissue and dermis in adult mice","volume":"54","author":"Liu","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jgg.2023.04.004_bib35","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nrm3254","article-title":"Building strong bones: molecular regulation of the osteoblast lineage","volume":"13","author":"Long","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jgg.2023.04.004_bib36","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/(SICI)1097-4652(199711)173:2<271::AID-JCP34>3.0.CO;2-G","article-title":"E-cadherin\/catenin\/cytoskeleton complex: a regulator of cancer invasion","volume":"173","author":"Mareel","year":"1997","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.jgg.2023.04.004_bib37","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41390-020-0873-y","article-title":"CD44 and RHAMM expression patterns in the human developing lung","volume":"89","author":"Markasz","year":"2021","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.jgg.2023.04.004_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb4416","article-title":"BMPR1A maintains skeletal stem cell properties in craniofacial development and craniosynostosis","volume":"13","author":"Maruyama","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jgg.2023.04.004_bib39","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41467-019-14029-w","article-title":"A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration","volume":"11","author":"Matsushita","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jgg.2023.04.004_bib40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-1-0716-1425-9_7","article-title":"Flow cytometry-based analysis of the mouse bone marrow stromal and perivascular compartment","volume":"2308","author":"Matsushita","year":"2021","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jgg.2023.04.004_bib41","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/sctm.20-0378","article-title":"A\u00a0replicating stem-like cell that contributes to bone morphogenetic protein 2-induced heterotopic bone formation","volume":"10","author":"Mejia","year":"2021","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.jgg.2023.04.004_bib42","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.devcel.2014.03.013","article-title":"Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development","volume":"29","author":"Mizoguchi","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.jgg.2023.04.004_bib43","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41586-018-0662-5","article-title":"Resting zone of the growth plate houses a unique class of skeletal stem cells","volume":"563","author":"Mizuhashi","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jgg.2023.04.004_bib44","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108415","article-title":"Single-cell transcriptomics of LepR-positive skeletal cells reveals heterogeneous stress-dependent stem and progenitor pools","volume":"41","author":"Mo","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.jgg.2023.04.004_bib45","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1084\/jem.20091046","article-title":"Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow","volume":"206","author":"Morikawa","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jgg.2023.04.004_bib46","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12984","article-title":"The bone marrow niche for haematopoietic stem cells","volume":"505","author":"Morrison","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jgg.2023.04.004_bib47","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0945-053X(99)00042-6","article-title":"Distribution of cartilage molecules in the developing mouse joint","volume":"18","author":"Murphy","year":"1999","journal-title":"Matrix Biol."},{"key":"10.1016\/j.jgg.2023.04.004_bib48","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/s41591-020-1013-2","article-title":"Articular cartilage regeneration by activated skeletal stem cells","volume":"26","author":"Murphy","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.jgg.2023.04.004_bib49","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1038\/s41467-022-30247-1","article-title":"A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury","volume":"13","author":"Muruganandan","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jgg.2023.04.004_bib50","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1369\/jhc.2010.955393","article-title":"Localization of Thy-1-positive cells in the perichondrium during endochondral ossification","volume":"58","author":"Nakamura","year":"2010","journal-title":"J.\u00a0Histochem. Cytochem."},{"key":"10.1016\/j.jgg.2023.04.004_bib51","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(01)00622-5","article-title":"The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation","volume":"108","author":"Nakashima","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.jgg.2023.04.004_bib52","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.stem.2019.11.003","article-title":"Identification of functionally distinct Mx1+\u03b1SMA+ periosteal skeletal stem cells","volume":"25","author":"Ortinau","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jgg.2023.04.004_bib53","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature17040","article-title":"Angiocrine functions of organ-specific endothelial cells","volume":"529","author":"Rafii","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jgg.2023.04.004_bib54","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1172\/JCI200522263","article-title":"The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth","volume":"115","author":"Rhee","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jgg.2023.04.004_bib55","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1038\/s41580-020-00279-w","article-title":"Mechanisms of bone development and repair","volume":"21","author":"Salhotra","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jgg.2023.04.004_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108715","article-title":"Identification and validation of Osteopontin and receptor for hyaluronic acid-mediated motility (RHAMM, CD168) for potential immunotherapeutic significance of in lung squamous cell carcinoma","volume":"107","author":"Shan","year":"2022","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jgg.2023.04.004_bib57","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev-physiol-021119-034425","article-title":"Osteoclasts provide coupling signals to osteoblast lineage cells through multiple mechanisms","volume":"82","author":"Sims","year":"2020","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.jgg.2023.04.004_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109352","article-title":"Regional specialization and fate specification of bone stromal cells in skeletal development","volume":"36","author":"Sivaraj","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.jgg.2023.04.004_bib59","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41467-022-28142-w","article-title":"Mesenchymal stromal cell-derived septoclasts resorb cartilage during developmental ossification and fracture healing","volume":"13","author":"Sivaraj","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jgg.2023.04.004_bib60","first-page":"e126","article-title":"Targeting hyaluronic acid and peritoneal dissemination in colorectal cancer","volume":"21","author":"Soliman","year":"2022","journal-title":"Clin. Colorectal Cancer"},{"key":"10.1016\/j.jgg.2023.04.004_bib61","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1089\/scd.2011.0154","article-title":"Odd-skipped related genes regulate differentiation of embryonic limb mesenchyme and bone marrow mesenchymal stromal cells","volume":"21","author":"Stricker","year":"2012","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.jgg.2023.04.004_bib62","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1242\/dev.01874","article-title":"The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription","volume":"132","author":"Tapscott","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.jgg.2023.04.004_bib63","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.stem.2018.09.006","article-title":"Human skeletal stem cells: the markers provide some clues in the hunt for hidden treasure","volume":"23","author":"Tichy","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jgg.2023.04.004_bib64","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41586-019-1104-8","article-title":"The bone marrow microenvironment at single-cell resolution","volume":"569","author":"Tikhonova","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jgg.2023.04.004_bib65","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41584-021-00682-3","article-title":"The endothelium-bone axis in development, homeostasis and bone and joint disease","volume":"17","author":"Tuckermann","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jgg.2023.04.004_bib66","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41586-020-2050-1","article-title":"Lipid availability determines fate of skeletal progenitor cells via SOX9","volume":"579","author":"van Gastel","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jgg.2023.04.004_bib67","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev-pathmechdis-031521-040919","article-title":"Osteoclasts, master sculptors of bone","volume":"18","author":"Veis","year":"2023","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.jgg.2023.04.004_bib68","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1126\/science.273.5275.613","article-title":"Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein","volume":"273","author":"Vortkamp","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jgg.2023.04.004_bib69","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.3892\/ol.2016.4974","article-title":"Prognostic significance of CD168 overexpression in colorectal cancer","volume":"12","author":"Wang","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jgg.2023.04.004_bib70","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12885-021-09150-3","article-title":"Secretion of BMP-2 by tumor-associated macrophages (TAM) promotes microcalcifications in breast cancer","volume":"22","author":"Wang","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jgg.2023.04.004_bib71","doi-asserted-by":"crossref","first-page":"a031559","DOI":"10.1101\/cshperspect.a031559","article-title":"Biology of bone: the vasculature of the skeletal system","volume":"8","author":"Watson","year":"2018","journal-title":"Cold Spring Harb Perspect. Med."},{"key":"10.1016\/j.jgg.2023.04.004_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2016.01.006","article-title":"TNNT1, TNNT2, and TNNT3: isoform genes, regulation, and structure-function relationships","volume":"582","author":"Wei","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.jgg.2023.04.004_bib73","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1750-1326-5-32","article-title":"Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling","volume":"5","author":"Winkler","year":"2010","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.jgg.2023.04.004_bib74","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.celrep.2019.06.031","article-title":"Mapping distinct bone marrow niche populations and their differentiation paths","volume":"28","author":"Wolock","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.jgg.2023.04.004_bib75","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.cell.2014.11.042","article-title":"Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential","volume":"160","author":"Worthley","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.jgg.2023.04.004_bib76","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1002\/eji.1830210714","article-title":"Characterization of the CAMPATH-1 (CDw52) antigen: biochemical analysis and cDNA cloning reveal an unusually small peptide backbone","volume":"21","author":"Xia","year":"1991","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jgg.2023.04.004_bib77","doi-asserted-by":"crossref","first-page":"119247","DOI":"10.1016\/j.biomaterials.2019.119247","article-title":"Reversing tumor stemness via orally targeted nanoparticles achieves efficient colon cancer treatment","volume":"216","author":"Xu","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.jgg.2023.04.004_bib78","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.7150\/thno.18340","article-title":"Redox responsive hyaluronic acid nanogels for treating RHAMM (CD168) over-expressive cancer, both primary and metastatic tumors","volume":"7","author":"Yang","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.jgg.2023.04.004_bib79","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/bs.mcb.2022.04.009","article-title":"Isolation of murine bone marrow hematopoietic stem and progenitor cell populations via flow cytometry","volume":"171","author":"Yu","year":"2022","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.jgg.2023.04.004_bib80","doi-asserted-by":"crossref","first-page":"7295","DOI":"10.1038\/s41467-022-35010-0","article-title":"Creb5 coordinates synovial joint formation with the genesis of articular cartilage","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jgg.2023.04.004_bib81","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1038\/s41467-022-32868-y","article-title":"Msx1+ stem cells recruited by bioactive tissue engineering graft for bone regeneration","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jgg.2023.04.004_bib82","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.stem.2014.06.008","article-title":"Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow","volume":"15","author":"Zhou","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jgg.2023.04.004_bib83","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.gene.2013.09.028","article-title":"Effects of myogenin on muscle fiber types and key metabolic enzymes in gene transfer mice and C2C12 myoblasts","volume":"532","author":"Zhu","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.jgg.2023.04.004_bib84","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/odi.13766","article-title":"Overexpression of CD168 is related to poor prognosis in oral squamous cell carcinoma","volume":"28","author":"Zhu","year":"2022","journal-title":"Oral Dis."}],"container-title":["Journal of Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1673852723000917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1673852723000917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T11:38:42Z","timestamp":1761651522000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1673852723000917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":83,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S1673852723000917"],"URL":"https:\/\/doi.org\/10.1016\/j.jgg.2023.04.004","relation":{},"ISSN":["1673-8527"],"issn-type":[{"value":"1673-8527","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell transcriptomic analysis identifies a highly replicating Cd168+ skeletal stem\/progenitor cell population in mouse long bones","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetics and Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgg.2023.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press.","name":"copyright","label":"Copyright"}]}}