{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:13:57Z","timestamp":1790954037607,"version":"4.1.0"},"reference-count":80,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetics and Genomics"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.jgg.2024.08.009","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T17:16:27Z","timestamp":1725642987000},"page":"1237-1251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nicotine-induced transcriptional changes and mitochondrial dysfunction in the ventral tegmental area revealed by single-nucleus transcriptomics"],"prefix":"10.1016","volume":"51","author":[{"given":"Lei","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjie","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgg.2024.08.009_bib1","doi-asserted-by":"crossref","first-page":"eaax7031","DOI":"10.1126\/sciadv.aax7031","article-title":"Microglia morphology and proinflammatory signaling in the nucleus accumbens during nicotine withdrawal","volume":"5","author":"Adeluyi","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jgg.2024.08.009_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1360-0443.95.1s1.6.x","article-title":"Policy interventions to reduce the harm from smoking","volume":"95","author":"Anderson","year":"2000","journal-title":"Addiction"},{"key":"10.1016\/j.jgg.2024.08.009_bib3","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1002\/glia.24011","article-title":"Nicotine induces morphological and functional changes in astrocytes via nicotinic receptor activity","volume":"69","author":"Aryal","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.jgg.2024.08.009_bib4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrm.2017.27","article-title":"Alternative splicing as a regulator of development and tissue identity","volume":"18","author":"Baralle","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jgg.2024.08.009_bib5","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1111\/jnc.13779","article-title":"Ventral tegmental area subcircuits process rewarding and aversive experiences","volume":"139","author":"Bariselli","year":"2016","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.jgg.2024.08.009_bib6","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0140-6736(19)31884-7","article-title":"Nicotine without smoke: fighting the tobacco epidemic with harm reduction","volume":"394","author":"Beaglehole","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.jgg.2024.08.009_bib7","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1056\/NEJMra0809890","article-title":"Nicotine addiction","volume":"362","author":"Benowitz","year":"2010","journal-title":"New Engl. J. Med."},{"key":"10.1016\/j.jgg.2024.08.009_bib8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/npp.2010.151","article-title":"Opponency revisited: competition and cooperation between dopamine and serotonin","volume":"36","author":"Boureau","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jgg.2024.08.009_bib9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3390\/brainsci11020172","article-title":"Systematic review of nicotine exposure's effects on neural stem and progenitor cells","volume":"11","author":"Brooks","year":"2021","journal-title":"Brain Sci."},{"key":"10.1016\/j.jgg.2024.08.009_bib10","doi-asserted-by":"crossref","DOI":"10.1042\/AN20100019","article-title":"Mitochondria and neuroplasticity","volume":"2","author":"Cheng","year":"2010","journal-title":"ASN Neuro"},{"key":"10.1016\/j.jgg.2024.08.009_bib11","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.tcb.2018.02.009","article-title":"Endoplasmic reticulum\u2013mitochondrial contactology: structure and signaling functions","volume":"28","author":"Csord\u00e1s","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.jgg.2024.08.009_bib12","article-title":"Cocaine perturbs mitovesicle biology in the brain","volume":"12","author":"D\u2019Acunzo","year":"2023","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.jgg.2024.08.009_bib13","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2017.06.020","article-title":"Local cues establish and maintain region-specific phenotypes of basal ganglia microglia","volume":"95","author":"De Biase","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.jgg.2024.08.009_bib14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev-neuro-110920-011929","article-title":"Mesoaccumbal dopamine heterogeneity: what do dopamine firing and release have to do with it?","volume":"45","author":"de Jong","year":"2022","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.jgg.2024.08.009_bib15","series-title":"Synapse Development and Maturation","first-page":"383","article-title":"Neurotransmitter phenotype plasticity: from calcium signaling to functional consequences","author":"Demarque","year":"2020"},{"key":"10.1016\/j.jgg.2024.08.009_bib16","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1038\/nn1104","article-title":"Lmx1b is essential for the development of serotonergic neurons","volume":"6","author":"Ding","year":"2003","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jgg.2024.08.009_bib17","doi-asserted-by":"crossref","first-page":"10330","DOI":"10.1523\/JNEUROSCI.2644-08.2008","article-title":"Neuroprotective effect of apolipoprotein D against human coronavirus OC43-induced encephalitis in mice","volume":"28","author":"Do Carmo","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jgg.2024.08.009_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.48788","article-title":"Lmx1b is required at multiple stages to build expansive serotonergic axon architectures","volume":"8","author":"Donovan","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jgg.2024.08.009_bib19","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1016\/j.febslet.2015.10.020","article-title":"Cell fate determination, neuronal maintenance and disease state: the emerging role of transcription factors Lmx1a and Lmx1b","volume":"589","author":"Doucet-Beaupr\u00e9","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jgg.2024.08.009_bib20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/1471-2105-7-191","article-title":"STEM: a tool for the analysis of short time series gene expression data","volume":"7","author":"Ernst","year":"2006","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.jgg.2024.08.009_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2022.173510","article-title":"ERK signaling is required for nicotine-induced conditional place preference by regulating neuroplasticity genes expression in male mice","volume":"222","author":"Fan","year":"2023","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jgg.2024.08.009_bib22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0079-6123(08)00918-7","article-title":"Serotonin receptors as potential targets for modulation of nicotine use and dependence","volume":"172","author":"Fletcher","year":"2008","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.jgg.2024.08.009_bib23","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuropharm.2011.05.012","article-title":"Intravenous nicotine self-administration and cue-induced reinstatement in mice: effects of nicotine dose, rate of drug infusion and prior instrumental training","volume":"61","author":"Fowler","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jgg.2024.08.009_bib24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.biocel.2014.01.001","article-title":"\u03b17 nicotinic acetylcholine receptors control cytochrome c release from isolated mitochondria through kinase-mediated pathways","volume":"49","author":"Gergalova","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.jgg.2024.08.009_bib25","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.1007\/s12035-018-1034-8","article-title":"Nicotine modulates mitochondrial dynamics in hippocampal neurons","volume":"55","author":"Godoy","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jgg.2024.08.009_bib26","doi-asserted-by":"crossref","first-page":"25968","DOI":"10.1073\/pnas.1908724116","article-title":"\u03b22\u2217 nAChRs on VTA dopamine and GABA neurons separately mediate nicotine aversion and reward","volume":"116","author":"Grieder","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jgg.2024.08.009_bib27","series-title":"Endocannabinoids and Lipid Mediators in Brain Functions","first-page":"211","article-title":"Cannabinoids and mitochondria","author":"Hebert-Chatelain","year":"2017"},{"key":"10.1016\/j.jgg.2024.08.009_bib28","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s41048-018-0066-y","article-title":"PTB\/nPTB: master regulators of neuronal fate in mammals","volume":"4","author":"Hu","year":"2018","journal-title":"Biophys. Rep."},{"key":"10.1016\/j.jgg.2024.08.009_bib29","doi-asserted-by":"crossref","first-page":"15923","DOI":"10.1523\/JNEUROSCI.3910-09.2009","article-title":"Nurr1 is required for maintenance of maturing and adult midbrain dopamine neurons","volume":"29","author":"Kadkhodaei","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jgg.2024.08.009_bib30","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.lfs.2012.02.005","article-title":"Intracellular localization of nicotinic acetylcholine receptors in human cell lines","volume":"91","author":"Kalashnyk","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.jgg.2024.08.009_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1223354","article-title":"The role of mitochondrial endoplasmic reticulum contact sites in human health and disease","volume":"10","author":"Katti","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.jgg.2024.08.009_bib32","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3390\/ijms23020975","article-title":"New insights and potential therapeutic targeting of CB2 cannabinoid receptors in CNS disorders","volume":"23","author":"Kibret","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jgg.2024.08.009_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108157","article-title":"Glial cells as therapeutic targets for smoking cessation","volume":"175","author":"Kumar","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jgg.2024.08.009_bib34","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.3390\/ijms24044204","article-title":"Nicotine-mediated recruitment of GABAergic neurons to a dopaminergic phenotype attenuates motor deficits in an alpha-synuclein Parkinson's model","volume":"24","author":"Lai","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jgg.2024.08.009_bib35","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.neuropharm.2013.03.019","article-title":"Reward and aversion in a heterogeneous midbrain dopamine system","volume":"76 Pt B","author":"Lammel","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.jgg.2024.08.009_bib36","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.jgg.2024.08.009_bib37","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41572-022-00346-w","article-title":"Tobacco and nicotine use","volume":"8","author":"Le Foll","year":"2022","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.jgg.2024.08.009_bib38","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1016\/j.neuron.2022.07.003","article-title":"An inhibitory brainstem input to dopamine neurons encodes nicotine aversion","volume":"110","author":"Liu","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.jgg.2024.08.009_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-17796-y","article-title":"Cannabinoid type 2 receptors in dopamine neurons inhibits psychomotor behaviors, alters anxiety, depression and alcohol preference","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jgg.2024.08.009_bib40","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fncel.2017.00282","article-title":"Nicotinic acetylcholine receptor \u03b19 and \u03b110 subunits are expressed in the brain of mice","volume":"11","author":"Lykhmus","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jgg.2024.08.009_bib41","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s10863-019-09800-z","article-title":"Mitochondria as a possible target for nicotine action","volume":"51","author":"Mali\u0144ska","year":"2019","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.jgg.2024.08.009_bib43","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00213-006-0441-0","article-title":"Guidelines on nicotine dose selection for in vivo research","volume":"190","author":"Matta","year":"2007","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jgg.2024.08.009_bib44","series-title":"NeuroPsychopharmacotherapy","first-page":"1","article-title":"The endocannabinoid system in the central nervous system: emphasis on the role of the mitochondrial cannabinoid receptor 1 (mtCB1R)","author":"Maya-L\u00f3pez","year":"2020"},{"key":"10.1016\/j.jgg.2024.08.009_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm0972","article-title":"Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad","volume":"8","author":"May\u00e8re","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jgg.2024.08.009_bib46","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","article-title":"DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors","volume":"8","author":"McGinnis","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/j.jgg.2024.08.009_bib47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nrn.2016.165","article-title":"Ventral tegmental area: cellular heterogeneity, connectivity and behaviour","volume":"18","author":"Morales","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.jgg.2024.08.009_bib48","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.3390\/ijms21062160","article-title":"The role of dorsal raphe serotonin neurons in the balance between reward and aversion","volume":"21","author":"Nagai","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jgg.2024.08.009_bib49","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1007\/s12035-016-9920-4","article-title":"Apolipoprotein D overexpression protects against kainate-induced neurotoxicity in mice","volume":"54","author":"Najyb","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.jgg.2024.08.009_bib50","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0091-3057(01)00673-6","article-title":"Involvement of serotonin in nicotine dependence: processes relevant to positive and negative regulation of drug intake","volume":"71","author":"Olausson","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.jgg.2024.08.009_bib51","doi-asserted-by":"crossref","first-page":"eabf1970","DOI":"10.1126\/science.abf1970","article-title":"Single-cell RNA-seq reveals cell type-specific molecular and genetic associations to lupus","volume":"376","author":"Perez","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.jgg.2024.08.009_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110616","article-title":"An atlas of transcriptionally defined cell populations in the rat ventral tegmental area","volume":"39","author":"Phillips","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.jgg.2024.08.009_bib53","series-title":"Nicotinic Receptors","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/978-1-4939-1167-7_14","article-title":"Role of central serotonin receptors in nicotine addiction","author":"Pierucci","year":"2014"},{"key":"10.1016\/j.jgg.2024.08.009_bib54","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/jnr.23858","article-title":"Sex differences in nicotine preference","volume":"95","author":"Pogun","year":"2017","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.jgg.2024.08.009_bib55","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3390\/biom13040692","article-title":"Large-scale integration of single-cell RNA-seq data reveals astrocyte diversity and transcriptomic modules across six central nervous system disorders","volume":"13","author":"Qian","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.jgg.2024.08.009_bib56","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1038\/sj.npp.1301671","article-title":"Mitochondrially mediated plasticity in the pathophysiology and treatment of bipolar disorder","volume":"33","author":"Quiroz","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jgg.2024.08.009_bib57","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.biopsych.2015.11.009","article-title":"Effects of smoking cessation on presynaptic dopamine function of addicted male smokers","volume":"80","author":"Rademacher","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jgg.2024.08.009_bib58","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.freeradbiomed.2016.11.045","article-title":"Adaptive responses of neuronal mitochondria to bioenergetic challenges: roles in neuroplasticity and disease resistance","volume":"102","author":"Raefsky","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jgg.2024.08.009_bib59","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s002130050411","article-title":"Nicotine withdrawal leads to increased sensitivity of serotonergic neurons to the 5-HT1A agonist 8-OH-DPAT","volume":"133","author":"Rasmussen","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jgg.2024.08.009_bib60","doi-asserted-by":"crossref","first-page":"e472","DOI":"10.1016\/S2468-2667(21)00102-X","article-title":"Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and initiation among young people in 204 countries and territories, 1990-2019","volume":"6","author":"Reitsma","year":"2021","journal-title":"Lancet Public Health"},{"key":"10.1016\/j.jgg.2024.08.009_bib61","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0006-8993(93)90121-3","article-title":"Effects of systemic nicotine on serotonin release in rat brain","volume":"621","author":"Ribeiro","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.jgg.2024.08.009_bib62","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.biopsych.2019.04.019","article-title":"Neonatal nicotine exposure primes midbrain neurons to a dopaminergic phenotype and increases adult drug consumption","volume":"86","author":"Romoli","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jgg.2024.08.009_bib63","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/bmj.2.5968.414","article-title":"Plasma nicotine levels after smoking cigarettes with high, medium, and low nicotine yields","volume":"2","author":"Russell","year":"1975","journal-title":"Br. Med. J."},{"key":"10.1016\/j.jgg.2024.08.009_bib64","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nm.4397","article-title":"Microglia emerge as central players in brain disease","volume":"23","author":"Salter","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.jgg.2024.08.009_bib65","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.jgg.2024.08.009_bib66","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3390\/ijms20020250","article-title":"Dysregulation of dopaminergic regulatory factors TH, Nurr1, and Pitx3 in the ventral tegmental area associated with neuronal injury induced by chronic morphine dependence","volume":"20","author":"Shi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jgg.2024.08.009_bib67","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.jgg.2024.08.009_bib68","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s00213-015-4183-8","article-title":"Sex differences in the acquisition and maintenance of cocaine and nicotine self-administration in rats","volume":"233","author":"Swalve","year":"2016","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jgg.2024.08.009_bib69","doi-asserted-by":"crossref","first-page":"7693","DOI":"10.3390\/ijms24097693","article-title":"Remodeling of mitochondria in cancer and other diseases","volume":"24","author":"Teng","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jgg.2024.08.009_bib70","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1042\/BCJ20200615","article-title":"The role of mitochondria in cocaine addiction","volume":"478","author":"Thornton","year":"2021","journal-title":"Biochem. J."},{"key":"10.1016\/j.jgg.2024.08.009_bib71","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41467-019-08453-1","article-title":"Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development","volume":"10","author":"Tiklov\u00e1","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jgg.2024.08.009_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3831\/KPI.2020.23.001","article-title":"Nicotine addiction: neurobiology and mechanism","volume":"23","author":"Tiwari","year":"2020","journal-title":"J.\u00a0Pharmacopuncture"},{"key":"10.1016\/j.jgg.2024.08.009_bib73","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jgg.2024.08.009_bib74","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1111\/adb.12437","article-title":"Nicotine self-administration remodels perineuronal nets in ventral tegmental area and orbitofrontal cortex in adult male rats","volume":"22","author":"Vazquez-Sanroman","year":"2017","journal-title":"Addict. Biol."},{"key":"10.1016\/j.jgg.2024.08.009_bib75","doi-asserted-by":"crossref","first-page":"32405","DOI":"10.1074\/jbc.M504664200","article-title":"Investigating the receptor-independent neuroprotective mechanisms of nicotine in mitochondria","volume":"280","author":"Xie","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jgg.2024.08.009_bib76","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/s41386-018-0151-4","article-title":"Ventral midbrain astrocytes display unique physiological features and sensitivity to dopamine D2 receptor signaling","volume":"44","author":"Xin","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.jgg.2024.08.009_bib77","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/ntr\/nty249","article-title":"Rewarding effects of nicotine in adolescent and adult male and female rats as measured using intracranial self-stimulation","volume":"22","author":"Xue","year":"2020","journal-title":"Nicotine Tob. Res."},{"key":"10.1016\/j.jgg.2024.08.009_bib78","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/s41467-023-36543-8","article-title":"Nicotine rebalances NAD+ homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity","volume":"14","author":"Yang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jgg.2024.08.009_bib79","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.1523\/JNEUROSCI.0271-19.2019","article-title":"Topography of reward and aversion encoding in the mesolimbic dopaminergic system","volume":"39","author":"Yuan","year":"2019","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.jgg.2024.08.009_bib80","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/ntr\/nts159","article-title":"Nicotinic regulation of energy homeostasis","volume":"14","author":"Zoli","year":"2012","journal-title":"Nicotine Tob. Res."},{"key":"10.1016\/j.jgg.2024.08.009_bib42","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/s41586-019-0924-x","article-title":"Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution","volume":"566","author":"Masuda","year":"2019","journal-title":"Nature"}],"container-title":["Journal of Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1673852724002327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1673852724002327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T04:23:17Z","timestamp":1731644597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1673852724002327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":80,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S1673852724002327"],"URL":"https:\/\/doi.org\/10.1016\/j.jgg.2024.08.009","relation":{},"ISSN":["1673-8527"],"issn-type":[{"value":"1673-8527","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicotine-induced transcriptional changes and mitochondrial dysfunction in the ventral tegmental area revealed by single-nucleus transcriptomics","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetics and Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgg.2024.08.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press.","name":"copyright","label":"Copyright"}]}}