{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:05:14Z","timestamp":1782921914660,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460668"],"award-info":[{"award-number":["82460668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["D17011"],"award-info":[{"award-number":["D17011"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["AA18221001"],"award-info":[{"award-number":["AA18221001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetics and Genomics"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.jgg.2025.11.003","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T02:40:45Z","timestamp":1763347245000},"page":"643-654","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Genome-wide association study of HBV-related hepatocellular carcinoma identifies a functional variant at the FAM114A1 locus"],"prefix":"10.1016","volume":"53","author":[{"given":"Hong-Ping","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bang-De","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuling","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7196-9002","authenticated-orcid":false,"given":"Junjie","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2266-3939","authenticated-orcid":false,"given":"Shicheng","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncheng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuping","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanji","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5424-5248","authenticated-orcid":false,"given":"Tianyi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Ao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3845-9445","authenticated-orcid":false,"given":"Qingyi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangqiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qiang","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-7844","authenticated-orcid":false,"given":"Ruoxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgg.2025.11.003_bib1","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.3748\/wjg.v24.i30.3347","article-title":"Host genetic factors affecting hepatitis B infection outcomes: insights from genome-wide association studies","volume":"24","author":"Akcay","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jgg.2025.11.003_bib2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jgg.2025.11.003_bib3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1111\/j.1471-4159.2006.04093.x","article-title":"Noxp20 and Noxp70, two new markers of early neuronal differentiation, detected in teratocarcinoma-derived neuroectodermic precursor cells","volume":"99","author":"Boucquey","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jgg.2025.11.003_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0028798","article-title":"Genome-wide association study of hepatocellular carcinoma in Southern Chinese patients with chronic hepatitis B virus infection","volume":"6","author":"Chan","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.jgg.2025.11.003_bib6","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/emboj\/17.1.244","article-title":"Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome","volume":"17","author":"Cirillo","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.jgg.2025.11.003_bib7","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1002\/hep.23943","article-title":"Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma","volume":"52","author":"Clifford","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jgg.2025.11.003_bib8","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.3656","article-title":"Next-generation genotype imputation service and methods","volume":"48","author":"Das","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jgg.2025.11.003_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004219","article-title":"MAGMA: generalized gene-set analysis of GWAS data","volume":"11","author":"de Leeuw","year":"2015","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.jgg.2025.11.003_bib10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/ng.2483","article-title":"Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma","volume":"45","author":"Jiang","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jgg.2025.11.003_bib11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1365-2893.2004.00492.x","article-title":"Prevention of hepatitis C virus infection","volume":"11","author":"Kew","year":"2004","journal-title":"J. Viral Hepat."},{"key":"10.1016\/j.jgg.2025.11.003_bib12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jgg.2025.11.003_bib13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/ng.809","article-title":"Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma","volume":"43","author":"Kumar","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jgg.2025.11.003_bib14","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jgg.2025.11.003_bib15","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/hep.29531","article-title":"Human leukocyte antigen variants and risk of hepatocellular carcinoma modified by hepatitis C virus genotypes: a genome-wide association study","volume":"67","author":"Lee","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jgg.2025.11.003_bib16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cell.2011.11.026","article-title":"Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer","volume":"148","author":"Li","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jgg.2025.11.003_bib17","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.jgg.2025.11.003_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002791","article-title":"GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers","volume":"8","author":"Li","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jgg.2025.11.003_bib19","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1002\/cncr.30851","article-title":"Genome-wide association analysis identifies a GLUL haplotype for familial hepatitis B virus-related hepatocellular carcinoma","volume":"123","author":"Lin","year":"2017","journal-title":"Cancer"},{"key":"10.1016\/j.jgg.2025.11.003_bib20","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.jhep.2018.12.001","article-title":"The trends in incidence of primary liver cancer caused by specific etiologies: results from the Global Burden of Disease Study 2016 and implications for liver cancer prevention","volume":"70","author":"Liu","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jgg.2025.11.003_bib21","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1053\/j.gastro.2017.01.041","article-title":"Genome-Wide association study identifies TLL1 variant associated with development of hepatocellular carcinoma after eradication of hepatitis C virus infection","volume":"152","author":"Matsuura","year":"2017","journal-title":"Gastroenterology"},{"issue":"Suppl. 1","key":"10.1016\/j.jgg.2025.11.003_bib22","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/hep.31288","article-title":"Epidemiology of hepatocellular carcinoma","volume":"73","author":"McGlynn","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.jgg.2025.11.003_bib23","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/ng.876","article-title":"Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers","volume":"43","author":"Miki","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jgg.2025.11.003_bib24","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ijc.2910620308","article-title":"Characterization of cell lines established from human hepatocellular carcinoma","volume":"62","author":"Park","year":"1995","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jgg.2025.11.003_bib25","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/ijc.21731","article-title":"The global health burden of infection-associated cancers in the year 2002","volume":"118","author":"Parkin","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.jgg.2025.11.003_bib26","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jhep.2006.05.013","article-title":"The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide","volume":"45","author":"Perz","year":"2006","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jgg.2025.11.003_bib27","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"Price","year":"2006","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jgg.2025.11.003_bib28","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1093\/bioinformatics\/btq419","article-title":"LocusZoom: regional visualization of genome-wide association scan results","volume":"26","author":"Pruim","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jgg.2025.11.003_bib29","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jgg.2025.11.003_bib30","first-page":"141","article-title":"Update in global trends and aetiology of hepatocellular carcinoma","volume":"22","author":"Rawla","year":"2018","journal-title":"Contemp. Oncol. (Pozn)"},{"key":"10.1016\/j.jgg.2025.11.003_bib42","doi-asserted-by":"crossref","unstructured":"Rauluseviciute, I., Riudavets-Puig, R., Blanc-Mathieu, R, Castro-Mondragon, J.A., Ferenc, K., Kumar, V., Lemma, R.B., Lucas, J., Ch\u00e8neby, J., Baranasic, D., et al., 2024. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 52, D174\u2013D182.","DOI":"10.1093\/nar\/gkad1059"},{"key":"10.1016\/j.jgg.2025.11.003_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/npjgenmed.2016.8","article-title":"Exome-wide study of ankylosing spondylitis demonstrates additional shared genetic background with inflammatory bowel disease","volume":"1","author":"Robinson","year":"2016","journal-title":"NPJ Genom. Med."},{"key":"10.1016\/j.jgg.2025.11.003_bib32","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.jhep.2022.08.021","article-title":"Global burden of primary liver cancer in 2020 and predictions to 2040","volume":"77","author":"Rumgay","year":"2022","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jgg.2025.11.003_bib33","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.1038\/s41598-018-26217-7","article-title":"Genome-wide association study identified new susceptible genetic variants in HLA class I region for hepatitis B virus-related hepatocellular carcinoma","volume":"8","author":"Sawai","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jgg.2025.11.003_bib34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.eururo.2020.07.038","article-title":"Two-stage study of familial prostate cancer by whole-exome sequencing and custom capture identifies 10 novel genes associated with the risk of prostate cancer","volume":"79","author":"Schaid","year":"2021","journal-title":"Eur. Urol."},{"key":"10.1016\/j.jgg.2025.11.003_bib35","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.jgg.2025.11.003_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/science.adj4301","article-title":"Metabolic inflexibility promotes mitochondrial health during liver regeneration","volume":"384","author":"Wang","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.jgg.2025.11.003_bib37","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1053\/jhep.2000.19349","article-title":"A comprehensive karyotypic study on human hepatocellular carcinoma by spectral karyotyping","volume":"32","author":"Wong","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.jgg.2025.11.003_bib38","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000365307","article-title":"Hepatitis B virus-related hepatocellular carcinoma: pathogenic mechanisms and novel therapeutic interventions","volume":"1","author":"Xu","year":"2014","journal-title":"Gastrointest. Tumors"},{"key":"10.1016\/j.jgg.2025.11.003_bib39","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1158\/1055-9965.EPI-09-1001","article-title":"Distribution and hepatocellular carcinoma-related viral properties of hepatitis B virus genotypes in Mainland China: a community-based study","volume":"19","author":"Yin","year":"2010","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.jgg.2025.11.003_bib40","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1111\/j.1440-1746.2007.05215.x","article-title":"The association between the genetic polymorphism of HLA-DQA1, DQB1, and DRB1 and serum alanine aminotransferase levels in chronic hepatitis C in the Chinese population","volume":"23","author":"Yu","year":"2008","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jgg.2025.11.003_bib41","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00109-015-1377-9","article-title":"Glycogen metabolism has a key role in the cancer microenvironment and provides new targets for cancer therapy","volume":"94","author":"Zois","year":"2016","journal-title":"J. Mol. Med. (Berl.)"}],"container-title":["Journal of Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1673852725002930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1673852725002930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:30:40Z","timestamp":1777620640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1673852725002930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1673852725002930"],"URL":"https:\/\/doi.org\/10.1016\/j.jgg.2025.11.003","relation":{},"ISSN":["1673-8527"],"issn-type":[{"value":"1673-8527","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genome-wide association study of HBV-related hepatocellular carcinoma identifies a functional variant at the FAM114A1 locus","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetics and Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgg.2025.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press.","name":"copyright","label":"Copyright"}]}}