{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:21:51Z","timestamp":1783167711668,"version":"3.54.6"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031910","name":"Changping Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031910","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82430012"],"award-info":[{"award-number":["82430012"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341208"],"award-info":[{"award-number":["82341208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetics and Genomics"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.jgg.2026.05.014","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:43:35Z","timestamp":1780641815000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The TNFR2M196R germline variant confers dual impact on CAR-T cell immunotherapy by enhancing T-cell survival and tumor proliferation"],"prefix":"10.1016","author":[{"given":"Nan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7708-4064","authenticated-orcid":false,"given":"Qi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-9889","authenticated-orcid":false,"given":"Zhiqiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8716-570X","authenticated-orcid":false,"given":"Jianshu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgg.2026.05.014_bib1","first-page":"1850","article-title":"Relapses after CAR-T therapy","volume":"320","author":"Abbasi","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.jgg.2026.05.014_bib2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1189\/jlb.0303112","article-title":"Regulation of TCR-mediated T cell activation by TNF-RII","volume":"74","author":"Aspalter","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jgg.2026.05.014_bib3","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00438-021-01805-x","article-title":"Classifying single nucleotide polymorphisms in humans","volume":"296","author":"Azizzadeh-Roodpish","year":"2021","journal-title":"Mol. Genet. Genomics"},{"key":"10.1016\/j.jgg.2026.05.014_bib4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.critrevonc.2008.01.002","article-title":"Concepts of activated T cell death","volume":"66","author":"Brenner","year":"2008","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.jgg.2026.05.014_bib5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.intimp.2015.05.049","article-title":"The tumor necrosis factor receptor superfamily member 1B polymorphisms predict response to anti-TNF therapy in patients with autoimmune disease: a meta-analysis","volume":"28","author":"Chen","year":"2015","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.jgg.2026.05.014_bib6","doi-asserted-by":"crossref","first-page":"6467","DOI":"10.4049\/jimmunol.180.10.6467","article-title":"Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells","volume":"180","author":"Chen","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jgg.2026.05.014_bib7","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.3389\/fonc.2019.01237","article-title":"Understanding the mechanisms of resistance to CAR T-cell therapy in malignancies","volume":"9","author":"Cheng","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.jgg.2026.05.014_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-47076-w","article-title":"Locating potentially lethal genes using the abnormal distributions of genotypes","volume":"9","author":"Ding","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jgg.2026.05.014_bib9","article-title":"Genetic variants in the TNF pathway impact TNFi response in a mixed population with rheumatoid arthritis","volume":"928","author":"Dos Santos Rodrigues","year":"2024","journal-title":"Gene"},{"key":"10.1016\/j.jgg.2026.05.014_bib10","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1056\/NEJMra2026131","article-title":"Cytokine storm","volume":"383","author":"Fajgenbaum","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jgg.2026.05.014_bib11","article-title":"IL-2-inducible T cell kinase deficiency sustains chimeric antigen receptor T cell therapy against tumor cells","volume":"135","author":"Fu","year":"2024","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jgg.2026.05.014_bib12","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1182\/blood.2021014497","article-title":"Impact of CD19 CAR T-cell product type on outcomes in relapsed or refractory aggressive B-NHL","volume":"139","author":"Gauthier","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.jgg.2026.05.014_bib13","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00403-014-1533-z","article-title":"The TNFRSF1B rs1061622 polymorphism (p.M196R) is associated with biological drug outcome in psoriasis patients","volume":"307","author":"Gonz\u00e1lez-Lara","year":"2015","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jgg.2026.05.014_bib14","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1002\/ajh.70281","article-title":"Five-year follow-up: tandem CD19\/CD20 CAR T therapy enduring impact on refractory\/relapsed non-Hodgkin lymphoma","volume":"101","author":"Han","year":"2026","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.jgg.2026.05.014_bib15","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1136\/ard.2006.058917","article-title":"A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis","volume":"66","author":"Horiuchi","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jgg.2026.05.014_bib16","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/s41423-023-01071-4","article-title":"The TNF\u03b1\/TNFR2 axis mediates natural killer cell proliferation by promoting aerobic glycolysis","volume":"20","author":"Khan","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jgg.2026.05.014_bib17","doi-asserted-by":"crossref","first-page":"6051","DOI":"10.4049\/jimmunol.0803482","article-title":"TNFR2-deficient memory CD8 T cells provide superior protection against tumor cell growth","volume":"183","author":"Kim","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jgg.2026.05.014_bib18","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.immuni.2025.02.012","article-title":"Splenic TNF-\u03b1 signaling potentiates the innate-to-adaptive transition of antiviral NK cells","volume":"58","author":"Mujal","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.jgg.2026.05.014_bib19","first-page":"340","article-title":"Influence of FCGR3A-V212F and TNFRSF1B-M196R genotypes in patients with rheumatoid arthritis treated with infliximab therapy","volume":"26","author":"Rooryck","year":"2008","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.jgg.2026.05.014_bib20","first-page":"22","article-title":"Impact of human CD95 mutations on cell death and autoimmunity: a model. Trends","volume":"43","author":"Seyrek","year":"2022","journal-title":"Immunol. Ser."},{"key":"10.1016\/j.jgg.2026.05.014_bib21","first-page":"372","article-title":"Mechanisms of resistance to CAR T cell therapy","volume":"16","author":"Shah","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.jgg.2026.05.014_bib22","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adj5948","article-title":"Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells","volume":"9","author":"Staniek","year":"2024","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.jgg.2026.05.014_bib23","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/0092-8674(93)90464-2","article-title":"A novel domain within the 55 kd TNF receptor signals cell death","volume":"74","author":"Tartaglia","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.jgg.2026.05.014_bib24","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/eji.201040639","article-title":"TNFR1 delivers pro-survival signals that are required for limiting TNFR2-dependent activation-induced cell death (AICD) in CD8+ T cells","volume":"41","author":"Twu","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jgg.2026.05.014_bib25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.cdd.4401189","article-title":"Tumor necrosis factor signaling","volume":"10","author":"Wajant","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jgg.2026.05.014_bib26","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1742-4658.2011.08015.x","article-title":"TNFR1-induced activation of the classical NF-\u03baB pathway","volume":"278","author":"Wajant","year":"2011","journal-title":"FEBS J."},{"key":"10.1016\/j.jgg.2026.05.014_bib27","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s13577-024-01088-5","article-title":"Synergistic effect of chimeric antigen receptor modified with Bcl-2 on enhanced solid tumour targeting","volume":"37","author":"Wang","year":"2024","journal-title":"Hum. Cell"},{"key":"10.1016\/j.jgg.2026.05.014_bib28","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41392-020-00256-x","article-title":"The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma","volume":"5","author":"Wei","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.jgg.2026.05.014_bib29","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1182\/blood.2024026401","article-title":"A phase 1 trial of prizloncabtagene autoleucel, a CD19\/CD20 CAR T-cell therapy for relapsed\/refractory B-cell non-Hodgkin lymphoma","volume":"145","author":"Yu","year":"2025","journal-title":"Blood"},{"key":"10.1016\/j.jgg.2026.05.014_bib30","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41586-022-05140-y","article-title":"Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL","volume":"609","author":"Zhang","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jgg.2026.05.014_bib31","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/377348a0","article-title":"Induction of apoptosis in mature T cells by tumour necrosis factor","volume":"377","author":"Zheng","year":"1995","journal-title":"Nature"}],"container-title":["Journal of Genetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1673852726001888?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1673852726001888?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T12:09:39Z","timestamp":1783166979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1673852726001888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":31,"alternative-id":["S1673852726001888"],"URL":"https:\/\/doi.org\/10.1016\/j.jgg.2026.05.014","relation":{},"ISSN":["1673-8527"],"issn-type":[{"value":"1673-8527","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The TNFR2M196R germline variant confers dual impact on CAR-T cell immunotherapy by enhancing T-cell survival and tumor proliferation","name":"articletitle","label":"Article Title"},{"value":"Journal of Genetics and Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgg.2026.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press.","name":"copyright","label":"Copyright"}]}}