{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:14:45Z","timestamp":1778832885615,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["1720150"],"award-info":[{"award-number":["1720150"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006293","name":"American Society of Clinical Oncology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006293","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","geriatriconcology.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Geriatric Oncology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.jgo.2019.03.015","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T09:16:36Z","timestamp":1554196596000},"page":"749-756","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Serum biomarkers for predicting overall survival and early mortality in older patients with metastatic solid tumors"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2292-906X","authenticated-orcid":false,"given":"Se Hyun","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7461-0333","authenticated-orcid":false,"given":"In Gyu","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joung Soon","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soojung","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Yong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5068-5891","authenticated-orcid":false,"given":"Ji Yeon","family":"Baek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5745-560X","authenticated-orcid":false,"given":"Seong Hoon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Der Sheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-Sik","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong Sang","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Sook","family":"Woo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju-Hyun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jee Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jgo.2019.03.015_bb0005","first-page":"9","article-title":"Cancer statistics, 2014","volume":"64","author":"Siegel","year":"2014","journal-title":"CA Cancer J Clin"},{"issue":"17","key":"10.1016\/j.jgo.2019.03.015_bb0010","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1200\/JCO.2008.20.8983","article-title":"Future of cancer incidence in the United States: burdens upon an aging, changing nation","volume":"27","author":"Smith","year":"2009","journal-title":"J Clin Oncol"},{"issue":"11","key":"10.1016\/j.jgo.2019.03.015_bb0015","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1038\/bjc.2011.430","article-title":"Cancer incidence in the United Kingdom: projections to the year 2030","volume":"105","author":"Mistry","year":"2011","journal-title":"Br J Cancer"},{"issue":"12","key":"10.1016\/j.jgo.2019.03.015_bb0020","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1002\/cncr.22726","article-title":"The impact of chronic illnesses on the use and effectiveness of adjuvant chemotherapy for colon cancer","volume":"109","author":"Gross","year":"2007","journal-title":"Cancer"},{"issue":"15","key":"10.1016\/j.jgo.2019.03.015_bb0025","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1056\/NEJMoa010957","article-title":"A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients","volume":"345","author":"Sargent","year":"2001","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.jgo.2019.03.015_bb0030","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1001\/jama.293.9.1073","article-title":"Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer","volume":"293","author":"Muss","year":"2005","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.jgo.2019.03.015_bb0035","first-page":"120","article-title":"Evaluating the older patient with cancer: understanding frailty and the geriatric assessment","volume":"60","author":"Pal","year":"2010","journal-title":"CA Cancer J Clin"},{"issue":"24","key":"10.1016\/j.jgo.2019.03.015_bb0040","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1200\/JCO.2014.55.4261","article-title":"Incorporating biomarkers into cancer and aging research","volume":"32","author":"Hubbard","year":"2014","journal-title":"J Clin Oncol"},{"issue":"12","key":"10.1016\/j.jgo.2019.03.015_bb0045","doi-asserted-by":"crossref","first-page":"e301","DOI":"10.1371\/journal.pbio.0060301","article-title":"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor","volume":"6","author":"Copp\u00e9","year":"2008","journal-title":"PLoS Biol"},{"issue":"9B","key":"10.1016\/j.jgo.2019.03.015_bb0050","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1111\/j.1582-4934.2009.00733.x","article-title":"Inflammation and frailty measures in older people","volume":"13","author":"Hubbard","year":"2009","journal-title":"J Cell Mol Med"},{"issue":"1","key":"10.1016\/j.jgo.2019.03.015_bb0055","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mad.2006.11.015","article-title":"Inflammatory networks in ageing, age-related diseases and longevity","volume":"128","author":"Vasto","year":"2007","journal-title":"Mech Ageing Dev"},{"issue":"5","key":"10.1016\/j.jgo.2019.03.015_bb0060","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1111\/j.1532-5415.2008.01677.x","article-title":"Biomarkers of inflammation and malnutrition associated with early death in healthy elderly people","volume":"56","author":"Carriere","year":"2008","journal-title":"J Am Geriatr Soc"},{"issue":"8","key":"10.1016\/j.jgo.2019.03.015_bb0065","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1007\/s12603-009-0201-z","article-title":"Epidemiology and consequences of sarcopenia","volume":"13","author":"Van Kan","year":"2009","journal-title":"JNHA J Nutr Health Aging"},{"issue":"1","key":"10.1016\/j.jgo.2019.03.015_bb0070","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s12603-013-0369-0","article-title":"The impact of sarcopenia on a physical activity intervention: the lifestyle interventions and Independence for elders pilot study (LIFE-P)","volume":"18","author":"Liu","year":"2014","journal-title":"J Nutr Health Aging"},{"issue":"3","key":"10.1016\/j.jgo.2019.03.015_bb0075","first-page":"687","article-title":"Effect of muscle mass on toxicity and survival in patients with colon cancer undergoing adjuvant chemotherapy","volume":"23","author":"Jung","year":"2015","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.jgo.2019.03.015_bb0080","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.arr.2015.05.001","article-title":"Sarcopenia\u2013the search for emerging biomarkers","volume":"22","author":"Kalinkovich","year":"2015","journal-title":"Ageing Res Rev"},{"issue":"5","key":"10.1016\/j.jgo.2019.03.015_bb0085","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1210\/jc.2014-4318","article-title":"Role of Activin a and myostatin in human cancer cachexia","volume":"100","author":"Loumaye","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.jgo.2019.03.015_bb0090","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/jcsm.12209","article-title":"Circulating activin a predicts survival in cancer patients","volume":"8","author":"Loumaye","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"4","key":"10.1016\/j.jgo.2019.03.015_bb0095","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1359\/jbmr.060104","article-title":"High bone turnover is an independent predictor of mortality in the frail elderly","volume":"21","author":"Sambrook","year":"2006","journal-title":"J Bone Miner Res"},{"issue":"11","key":"10.1016\/j.jgo.2019.03.015_bb0100","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1001\/archinte.167.11.1159","article-title":"Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the third National Health and nutrition examination survey","volume":"167","author":"Martins","year":"2007","journal-title":"Arch Intern Med"},{"issue":"1","key":"10.1016\/j.jgo.2019.03.015_bb0105","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/gerona\/gln007","article-title":"Association of low vitamin D levels with the frailty syndrome in men and women","volume":"64","author":"Shardell","year":"2009","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"3","key":"10.1016\/j.jgo.2019.03.015_bb0110","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1001\/jamaoncol.2016.4188","article-title":"Association of serum level of vitamin D at diagnosis with breast cancer survival: a case-cohort analysis in the pathways study","volume":"3","author":"Yao","year":"2017","journal-title":"JAMA Oncol"},{"issue":"23","key":"10.1016\/j.jgo.2019.03.015_bb0115","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMra1100831","article-title":"Epstein lecture: sirtuins, aging, and medicine","volume":"364","author":"Guarente","year":"2011","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jgo.2019.03.015_bb0120","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1111\/acel.12260","article-title":"Identification of serum sirtuins as novel noninvasive protein markers for frailty","volume":"13","author":"Kumar","year":"2014","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.jgo.2019.03.015_bb0125","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrd.2015.9","article-title":"Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23","volume":"15","author":"Degirolamo","year":"2016","journal-title":"Nat Rev Drug Discov"},{"issue":"6655","key":"10.1016\/j.jgo.2019.03.015_bb0130","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-o","year":"1997","journal-title":"nature"},{"issue":"9","key":"10.1016\/j.jgo.2019.03.015_bb0135","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1038\/s41416-018-0037-6","article-title":"Predicting cumulative incidence of adverse events in older patients with cancer undergoing first-line palliative chemotherapy: Korean Cancer study group (KCSG) multicentre prospective study","volume":"118","author":"Kim","year":"2018","journal-title":"Br J Cancer"},{"issue":"9","key":"10.1016\/j.jgo.2019.03.015_bb0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138304","article-title":"A novel geriatric screening tool in older patients with cancer: the Korean cancer study group geriatric score (KG)-7","volume":"10","author":"Kim","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.jgo.2019.03.015_bb0145","doi-asserted-by":"crossref","first-page":"e437","DOI":"10.1016\/S1470-2045(12)70259-0","article-title":"Frailty screening methods for predicting outcome of a comprehensive geriatric assessment in elderly patients with cancer: a systematic review","volume":"13","author":"Hamaker","year":"2012","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.jgo.2019.03.015_bb0150","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/widm.8","article-title":"Classification and regression trees","volume":"1","author":"Loh","year":"2011","journal-title":"Wiley Interdiscip Rev Data Min Knowl Disc"},{"issue":"4","key":"10.1016\/j.jgo.2019.03.015_bb0155","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.cell.2010.07.011","article-title":"Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival","volume":"142","author":"Zhou","year":"2010","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.jgo.2019.03.015_bb0160","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1111\/jgs.14927","article-title":"Treatment of sarcopenia with bimagrumab: results from a phase II, randomized, controlled, proof-of-concept study","volume":"65","author":"Rooks","year":"2017","journal-title":"J Am Geriatr Soc"},{"issue":"5","key":"10.1016\/j.jgo.2019.03.015_bb0165","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1530\/eje.0.1480559","article-title":"Serum concentrations of activin and follistatin are elevated and run in parallel in patients with septicemia","volume":"148","author":"Michel","year":"2003","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"10.1016\/j.jgo.2019.03.015_bb0170","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/resp.12751","article-title":"Serum activin-a as a predictive and prognostic marker in critically ill patients with sepsis","volume":"21","author":"Lee","year":"2016","journal-title":"Respirology"},{"issue":"10","key":"10.1016\/j.jgo.2019.03.015_bb0175","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1210\/jc.2016-2215","article-title":"Fibroblast growth factor 23 and cause-specific mortality in the general population: the northern Manhattan study","volume":"101","author":"Souma","year":"2016","journal-title":"J Clin Endocrinol Metabol"},{"issue":"8","key":"10.1016\/j.jgo.2019.03.015_bb0180","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/ncb1909","article-title":"Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion","volume":"11","author":"Rodier","year":"2009","journal-title":"Nat Cell Biol"}],"container-title":["Journal of Geriatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879406818303862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879406818303862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T08:01:54Z","timestamp":1778832114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879406818303862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S1879406818303862"],"URL":"https:\/\/doi.org\/10.1016\/j.jgo.2019.03.015","relation":{},"ISSN":["1879-4068"],"issn-type":[{"value":"1879-4068","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum biomarkers for predicting overall survival and early mortality in older patients with metastatic solid tumors","name":"articletitle","label":"Article Title"},{"value":"Journal of Geriatric Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgo.2019.03.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}