{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:59:59Z","timestamp":1785945599744,"version":"3.56.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","geriatriconcology.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Geriatric Oncology"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.jgo.2023.101689","type":"journal-article","created":{"date-parts":[[2024,1,13]],"date-time":"2024-01-13T12:43:24Z","timestamp":1705149804000},"page":"101689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of age, comorbidity, and polypharmacy on receipt of systemic therapy in advanced cancers: A retrospective population-based study"],"prefix":"10.1016","volume":"15","author":[{"given":"Rebekah","family":"Rittberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Decker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"St. John","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Czaykowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Dawe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgo.2023.101689_bb0005","series-title":"Canadian cancer statistics 2021","year":"2021"},{"issue":"6","key":"10.1016\/j.jgo.2023.101689_bb0010","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"10.1016\/j.jgo.2023.101689_bb0015","first-page":"7","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jgo.2023.101689_bb0020","author":"American Cancer Society"},{"issue":"5","key":"10.1016\/j.jgo.2023.101689_bb0025","first-page":"363","article-title":"Cancer treatment and survivorship statistics, 2019","volume":"69","author":"Miller","year":"2019","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"10.1016\/j.jgo.2023.101689_bb0030","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jgo.2017.07.013","article-title":"Chemotherapy and radiation treatment decision-making experiences of older adults with cancer: a qualitative study","volume":"9","author":"Sattar","year":"2018","journal-title":"J Geriatr Oncol"},{"issue":"5","key":"10.1016\/j.jgo.2023.101689_bb0035","first-page":"362","article-title":"Frailty and cancer: implications for oncology surgery, medical oncology, and radiation oncology","volume":"67","author":"Ethun","year":"2017","journal-title":"CA Cancer J Clin"},{"issue":"7","key":"10.1016\/j.jgo.2023.101689_bb0040","doi-asserted-by":"crossref","DOI":"10.1001\/jamasurg.2021.1425","article-title":"All-cause and cancer-specific death of older adults following surgery for cancer","volume":"156","author":"Chesney","year":"2021","journal-title":"JAMA Surg"},{"issue":"5","key":"10.1016\/j.jgo.2023.101689_bb0045","first-page":"1","article-title":"Factors influencing general practitioners in the referral of elderly cancer patients","volume":"11","author":"Delva","year":"2011","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jgo.2023.101689_bb0050","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.lungcan.2016.07.016","article-title":"Chemoradiotherapy versus radiotherapy alone in elderly patients with stage III non-small cell lung cancer: a systematic review and meta-analysis","volume":"99","author":"Dawe","year":"2016","journal-title":"Lung Cancer"},{"issue":"27","key":"10.1016\/j.jgo.2023.101689_bb0055","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1200\/JCO.2006.06.7835","article-title":"Elderly patients benefit from second-line cytotoxic chemotherapy: a subset analysis of a randomized phase III trial of pemetrexed compared with docetaxel in patients with previously treated advanced non-small-cell lung cancer","volume":"24","author":"Weiss","year":"2006","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.jgo.2023.101689_bb0060","first-page":"120","article-title":"Evaluating the older patient with cancer: understanding frailty and the geriatric assessment","volume":"60","author":"Pal","year":"2010","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jgo.2023.101689_bb0065","first-page":"1","article-title":"Guiding principles for the care of older adults with multimorbidity: an approach for clinicians","volume":"60","author":"American Geriatrics Society Expert Panel","year":"2012","journal-title":"J Am Geriatr Soc"},{"issue":"3","key":"10.1016\/j.jgo.2023.101689_bb0070","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1634\/theoncologist.10-3-198","article-title":"Never too old? Age should not be a barrier to enrollment in cancer clinical trials","volume":"10","author":"Aapro","year":"2005","journal-title":"Oncologist"},{"issue":"4","key":"10.1016\/j.jgo.2023.101689_bb0075","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s11606-007-0104-9","article-title":"Changes in preferences for life-sustaining treatment among older persons with advanced illness","volume":"22","author":"Fried","year":"2007","journal-title":"J Gen Intern Med"},{"issue":"4","key":"10.1016\/j.jgo.2023.101689_bb0080","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/ibd.20341","article-title":"Survival in Danish patients with breast cancer and inflammatory bowel disease: a nationwide cohort study","volume":"14","author":"S\u00f8gaard","year":"2008","journal-title":"Inflamm Bowel Dis"},{"issue":"13","key":"10.1016\/j.jgo.2023.101689_bb0085","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1200\/JCO.2011.39.5269","article-title":"Impact of age and comorbidity on non-small-cell lung cancer treatment in older veterans","volume":"30","author":"Wang","year":"2012","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.jgo.2023.101689_bb0090","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1200\/JCO.2010.31.3049","article-title":"Impact of comorbidity on chemotherapy use and outcomes in solid tumors: a systematic review","volume":"29","author":"Lee","year":"2011","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.jgo.2023.101689_bb0095","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jgo.2012.02.005","article-title":"Patient characteristics associated with polypharmacy and inappropriate prescribing of medications among older adults with cancer","volume":"3","author":"Prithviraj","year":"2012","journal-title":"J Geriatr Oncol"},{"issue":"3","key":"10.1016\/j.jgo.2023.101689_bb0100","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/(SICI)1097-0142(20000201)88:3<653::AID-CNCR24>3.0.CO;2-1","article-title":"Cancer and comorbidity: redefining chronic diseases","volume":"88","author":"Ogle","year":"2000","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.jgo.2023.101689_bb0105","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/MLR.0000000000000113","article-title":"Prostate cancer treatment and survival: evidence for men with prevalent comorbid conditions","volume":"52","author":"Bradley","year":"2014","journal-title":"Med Care"},{"issue":"5","key":"10.1016\/j.jgo.2023.101689_bb0110","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/bjs.4913","article-title":"Co-morbidity leads to altered treatment and worse survival of elderly patients with colorectal cancer","volume":"92","author":"Lemmens","year":"2005","journal-title":"Br J Surg"},{"issue":"1","key":"10.1016\/j.jgo.2023.101689_bb0115","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1634\/theoncologist.2019-0406","article-title":"Associations of polypharmacy and inappropriate medications with adverse outcomes in older adults with cancer: a systematic review and meta-analysis","volume":"25","author":"Mohamed","year":"2020","journal-title":"Oncologist"},{"key":"10.1016\/j.jgo.2023.101689_bb0120","series-title":"Manitoba population report","year":"2020"},{"issue":"3","key":"10.1016\/j.jgo.2023.101689_bb0125","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/00005650-199303000-00002","article-title":"Registries and administrative data: organization and accuracy","volume":"31","author":"Roos","year":"1993","journal-title":"Med Care"},{"issue":"9","key":"10.1016\/j.jgo.2023.101689_bb0130","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1097\/00005650-199709000-00006","article-title":"Estimating the burden of disease. Comparing administrative data and self-reports","volume":"35","author":"Robinson","year":"1997","journal-title":"Med Care"},{"issue":"2","key":"10.1016\/j.jgo.2023.101689_bb0135","first-page":"1","article-title":"Population data centre profile: the Manitoba centre for health policy","volume":"4","author":"Katz","year":"2020","journal-title":"Int J Popul Data Sci"},{"key":"10.1016\/j.jgo.2023.101689_bb0140","series-title":"Collaborative staging task force of the American joint committee on cancer","year":"2004"},{"issue":"11","key":"10.1016\/j.jgo.2023.101689_bb0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11912-017-0632-3","article-title":"Polypharmacy in the geriatric oncology population","volume":"19","author":"Hersh","year":"2017","journal-title":"Curr Oncol Rep"},{"issue":"5","key":"10.1016\/j.jgo.2023.101689_bb0150","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"issue":"8","key":"10.1016\/j.jgo.2023.101689_bb0155","first-page":"1","article-title":"Risk adjustment performance of Charlson and Elixhauser comorbidities in ICD-9 and ICD-10 administrative databases","volume":"14","author":"Li","year":"2008","journal-title":"BMC Health Serv Res"},{"issue":"12","key":"10.1016\/j.jgo.2023.101689_bb0160","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1097\/MLR.0b013e3181484347","article-title":"Cross-national comparative performance of three versions of the ICD-10 charlson index","volume":"45","author":"Sundararajan","year":"2007","journal-title":"Med Care"},{"issue":"1","key":"10.1016\/j.jgo.2023.101689_bb0165","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/00005650-200101000-00010","article-title":"Performance of the ACG case-mix system in two Canadian provinces","volume":"39","author":"Reid","year":"2001","journal-title":"Med Care"},{"key":"10.1016\/j.jgo.2023.101689_bb0170","series-title":"Clinical prediction models: a practical approach to development, validation, and updating","author":"Steyerberg","year":"2009"},{"issue":"5","key":"10.1016\/j.jgo.2023.101689_bb0175","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0735-1097(85)80005-X","article-title":"Prognostic value of a coronary artery jeopardy score","volume":"5","author":"Califf","year":"1985","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1016\/j.jgo.2023.101689_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1175\/1520-0493(1950)078<0001:VOFEIT>2.0.CO;2","article-title":"Verification of forecasts expressed in terms of probability","volume":"78","author":"Brier","year":"1950","journal-title":"Mon Weather Rev"},{"issue":"3","key":"10.1016\/j.jgo.2023.101689_bb0185","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jgo.2018.10.005","article-title":"Impact of age on receipt of curative treatment for cervical cancer: an analysis of patterns of care and survival in a large, national cohort","volume":"10","author":"Albert","year":"2019","journal-title":"J Geriatr Oncol"},{"issue":"2","key":"10.1016\/j.jgo.2023.101689_bb0190","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/MPA.0000000000001486","article-title":"The influence of patients\u2019 age on the outcome of treatment for pancreatic ductal adenocarcinoma","volume":"49","author":"Malik","year":"2020","journal-title":"Pancreas"},{"key":"10.1016\/j.jgo.2023.101689_bb0195","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.lungcan.2016.11.002","article-title":"Impact of age and comorbidity on treatment of non-small cell lung cancer recurrence following complete resection: a nationally representative cohort study Melisa","volume":"102","author":"Wong","year":"2016","journal-title":"Lung Cancer"},{"issue":"7","key":"10.1016\/j.jgo.2023.101689_bb0200","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1182\/blood-2018-11-877795","article-title":"Introduction to a review series on advances in multiple myeloma","volume":"133","author":"Avet-Loiseau","year":"2019","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.jgo.2023.101689_bb0205","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMoa1916623","article-title":"The effect of advances in lung-cancer treatment on population mortality","volume":"383","author":"Howlader","year":"2020","journal-title":"NEJM"},{"key":"10.1016\/j.jgo.2023.101689_bb0210","author":"Lix"},{"issue":"2","key":"10.1016\/j.jgo.2023.101689_bb0215","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1370\/afm.1363","article-title":"Measures of multimorbidity and morbidity burden for use in primary care and community settings: a systematic review and guide","volume":"10","author":"Huntley","year":"2012","journal-title":"Ann Fam Med"},{"issue":"10","key":"10.1016\/j.jgo.2023.101689_bb0220","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.jclinepi.2004.03.002","article-title":"Common comorbidity scales were similar in their ability to predict health care costs and mortality","volume":"57","author":"Perkins","year":"2004","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jgo.2023.101689_bb0225","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jclinepi.2020.04.019","article-title":"Measuring multimorbidity series\u2014an overlooked complexity comparison of self-report vs. administrative data in community-living adults: paper 2. Prevalence estimates depend on the data source","volume":"124","author":"Griffith","year":"2020","journal-title":"J Clin Epidemiol"},{"key":"10.1016\/j.jgo.2023.101689_bb0230","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jclinepi.2020.04.018","article-title":"Measuring multimorbidity series. An overlooked complexity - comparison of self-report vs. administrative data in community-living adults: paper 3. Agreement across data sources and implications for estimating associations with health service use","volume":"124","author":"Gruneir","year":"2020","journal-title":"J Clin Epidemiol"},{"issue":"7","key":"10.1016\/j.jgo.2023.101689_bb0235","first-page":"1727","article-title":"Prevalence and factors associated with polypharmacy in older people with cancer","volume":"22","author":"Turner","year":"2014","journal-title":"Support Care Cancer"},{"issue":"6","key":"10.1016\/j.jgo.2023.101689_bb0240","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.annepidem.2005.09.006","article-title":"Estimating the incidence of dementia: the impact of adjusting for subject attrition using health care utilization data","volume":"16","author":"Tyas","year":"2006","journal-title":"Ann Epidemiol"},{"issue":"2","key":"10.1016\/j.jgo.2023.101689_bb0245","first-page":"E56","article-title":"Multimorbidity predicts functional decline in community-dwelling older adults","volume":"65","author":"St John","year":"2019","journal-title":"Can Fam Physician"},{"key":"10.1016\/j.jgo.2023.101689_bb0250","author":"Doupe"}],"container-title":["Journal of Geriatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879406823005866?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879406823005866?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T09:58:40Z","timestamp":1761818320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879406823005866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1879406823005866"],"URL":"https:\/\/doi.org\/10.1016\/j.jgo.2023.101689","relation":{},"ISSN":["1879-4068"],"issn-type":[{"value":"1879-4068","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of age, comorbidity, and polypharmacy on receipt of systemic therapy in advanced cancers: A retrospective population-based study","name":"articletitle","label":"Article Title"},{"value":"Journal of Geriatric Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgo.2023.101689","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101689"}}