{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T02:12:59Z","timestamp":1774059179230,"version":"3.50.1"},"reference-count":88,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","geriatriconcology.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Geriatric Oncology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.jgo.2025.102840","type":"journal-article","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T13:04:02Z","timestamp":1766235842000},"page":"102840","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of surgically resectable colorectal liver metastases in older patients"],"prefix":"10.1016","volume":"17","author":[{"given":"Sara","family":"Myers","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ponnandai","family":"Somasundar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clark","family":"DuMontier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jgo.2025.102840_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0230914","article-title":"Surgical and regional treatments for colorectal cancer metastases in older patients: a systematic review and meta-analysis","volume":"15","author":"De\u2019Angelis","year":"2020","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.jgo.2025.102840_bb0010","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1001\/jamaoncol.2015.2943","article-title":"Management and outcome of colorectal cancer liver metastases in elderly patients: a population-based study","volume":"1","author":"Booth","year":"2015","journal-title":"JAMA Oncol"},{"issue":"1","key":"10.1016\/j.jgo.2025.102840_bb0015","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12885-020-6710-1","article-title":"Population-based SEER analysis of survival in colorectal cancer patients with or without resection of lung and liver metastases","volume":"20","author":"Siebenh\u00fcner","year":"2020","journal-title":"BMC Cancer"},{"issue":"2","key":"10.1016\/j.jgo.2025.102840_bb0020","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.hpb.2016.09.009","article-title":"Operative morbidity and survival following hepatectomy for colorectal liver metastasis in octogenarians: a contemporary case matched series","volume":"19","author":"Leal","year":"2017","journal-title":"HPB"},{"issue":"4","key":"10.1016\/j.jgo.2025.102840_bb0025","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1001\/jamasurg.2014.1819","article-title":"Development of a list of high-risk operations for patients 65 years and older","volume":"150","author":"Schwarze","year":"2015","journal-title":"JAMA Surg"},{"key":"10.1016\/j.jgo.2025.102840_bb0030","first-page":"9","article-title":"Understanding the unique microenvironment in the aging liver","author":"Zhao","year":"2022","journal-title":"Front Med"},{"issue":"2","key":"10.1016\/j.jgo.2025.102840_bb0035","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1006\/jsre.2002.6462","article-title":"Evaluation of the effect of age on functioning hepatocyte mass and liver blood flow using liver scintigraphy in preoperative estimations for surgical patients: comparison with CT volumetry","volume":"106","author":"Wakabayashi","year":"2002","journal-title":"J Surg Res"},{"issue":"8","key":"10.1016\/j.jgo.2025.102840_bb0040","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.exger.2005.06.009","article-title":"Age-related changes in liver structure and function: implications for disease\u00a0?","volume":"40","author":"Schmucker","year":"2005","journal-title":"Exp Gerontol"},{"issue":"8","key":"10.1016\/j.jgo.2025.102840_bb0045","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.hpb.2016.05.011","article-title":"Liver function declines with increased age","volume":"18","author":"Cieslak","year":"2016","journal-title":"HPB"},{"key":"10.1016\/j.jgo.2025.102840_bb0050","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.csbj.2019.07.021","article-title":"Hallmarks of aging in the liver","volume":"17","author":"Hunt","year":"2019","journal-title":"Comput Struct Biotechnol J"},{"key":"10.1016\/j.jgo.2025.102840_bb0055","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13530","article-title":"Aging reduces liver resiliency by dysregulating Hedgehog signaling","volume":"21","author":"Maeso-D\u00edaz","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.jgo.2025.102840_bb0060","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1055\/s-0040-1715446","article-title":"Aging and chronic liver disease","volume":"40","author":"Maeso-D\u00edaz","year":"2020","journal-title":"Semin Liver Dis"},{"issue":"10","key":"10.1016\/j.jgo.2025.102840_bb0065","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1089\/ars.2021.0048","article-title":"The aging liver: redox biology and liver regeneration","volume":"35","author":"Bellanti","year":"2021","journal-title":"Antioxid Redox Signal"},{"issue":"5","key":"10.1016\/j.jgo.2025.102840_bb0070","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13811","article-title":"Age-dependent loss of hepatic SIRT1 enhances NLRP3 inflammasome signaling and impairs capacity for liver fibrosis resolution","volume":"22","author":"Adjei-Mosi","year":"2023","journal-title":"Aging Cell"},{"issue":"7","key":"10.1016\/j.jgo.2025.102840_bb0075","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/hep4.1725","article-title":"Impact of aging on liver cells and liver disease: focus on the biliary and vascular compartments","volume":"5","author":"Baiocchi","year":"2021","journal-title":"Hepatol Commun"},{"issue":"3","key":"10.1016\/j.jgo.2025.102840_bb0080","doi-asserted-by":"crossref","first-page":"C508","DOI":"10.1152\/ajpcell.00408.2021","article-title":"Intravital imaging reveals inflammation as a dominant pathophysiology of age-related hepatovascular changes","volume":"322","author":"Vats","year":"2022","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"10.1016\/j.jgo.2025.102840_bb0085","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101426R","article-title":"Endothelial dysfunction in pathological processes of chronic liver disease during aging","volume":"36","author":"Wan","year":"2022","journal-title":"FASEB J"},{"key":"10.1016\/j.jgo.2025.102840_bb0090","first-page":"283","article-title":"Survival after liver resection in metastatic colorectal cancer: review and meta-analysis of prognostic factors","volume":"4","author":"Kanas","year":"2012","journal-title":"Clin Epidemiol"},{"issue":"3","key":"10.1016\/j.jgo.2025.102840_bb0095","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/SLA.0b013e3181b4539b","article-title":"Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients","volume":"250","author":"de Jong","year":"2009","journal-title":"Ann Surg"},{"issue":"2","key":"10.1016\/j.jgo.2025.102840_bb0100","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/SLA.0000000000002353","article-title":"Laparoscopic versus open resection for colorectal liver metastases: the OSLO-COMET randomized controlled trial","volume":"267","author":"Fretland","year":"2018","journal-title":"Ann Surg"},{"issue":"6","key":"10.1016\/j.jgo.2025.102840_bb0105","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1007\/s11605-017-3397-y","article-title":"Parenchymal-sparing versus anatomic liver resection for colorectal liver metastases: a systematic review","volume":"21","author":"Moris","year":"2017","journal-title":"J Gastrointest Surg Off J Soc Surg Aliment Tract"},{"issue":"11","key":"10.1016\/j.jgo.2025.102840_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejso.2024.108660","article-title":"Impact of the future liver remnant volume before major hepatectomy","volume":"50","author":"Reese","year":"2024","journal-title":"Eur J Surg Oncol"},{"issue":"6","key":"10.1016\/j.jgo.2025.102840_bb0115","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/j.1478-3231.2008.01777.x","article-title":"Liver failure after partial hepatic resection: definition, pathophysiology, risk factors and treatment","volume":"28","author":"Van Den Broek","year":"2008","journal-title":"Liver Int"},{"issue":"2","key":"10.1016\/j.jgo.2025.102840_bb0120","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jamcollsurg.2012.10.018","article-title":"Kinetic growth rate after portal vein embolization predicts posthepatectomy outcomes: toward zero liver-related mortality in patients with colorectal liver metastases and small future liver remnant","volume":"216","author":"Shindoh","year":"2013","journal-title":"J Am Coll Surg"},{"issue":"2","key":"10.1016\/j.jgo.2025.102840_bb0125","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/0003134820951451","article-title":"The future liver remnant: definition, evaluation, and management","volume":"87","author":"Dixon","year":"2021","journal-title":"Am Surg"},{"issue":"8","key":"10.1016\/j.jgo.2025.102840_bb0130","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1245\/s10434-012-2864-7","article-title":"Optimal future liver remnant in patients treated with extensive preoperative chemotherapy for colorectal liver metastases","volume":"20","author":"Shindoh","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"10.1016\/j.jgo.2025.102840_bb0135","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3748\/wjg.v22.i2.567","article-title":"Preoperative selection of patients with colorectal cancer liver metastasis for hepatic resection","volume":"22","author":"Mattar","year":"2016","journal-title":"World J Gastroenterol"},{"issue":"10","key":"10.1016\/j.jgo.2025.102840_bb0140","doi-asserted-by":"crossref","first-page":"761","DOI":"10.5306\/wjco.v11.i10.761","article-title":"Colorectal liver metastases: current management and future perspectives","volume":"11","author":"Martin","year":"2020","journal-title":"World J Clin Oncol"},{"issue":"8","key":"10.1016\/j.jgo.2025.102840_bb0145","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1002\/bjs.7084","article-title":"Value of indocyanine green clearance of the future liver remnant in predicting outcome after resection for biliary cancer","volume":"97","author":"Yokoyama","year":"2010","journal-title":"Br J Surg"},{"key":"10.1016\/j.jgo.2025.102840_bb0150","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/757052","article-title":"Assessment of liver remnant using ICG clearance intraoperatively during vascular exclusion: early experience with the ALIIVE technique","volume":"2015","author":"Lau","year":"2015","journal-title":"HPB Surg"},{"issue":"13","key":"10.1016\/j.jgo.2025.102840_bb0155","doi-asserted-by":"crossref","first-page":"9205","DOI":"10.1245\/s10434-024-16108-9","article-title":"Comprehensive review of future liver remnant (FLR) assessment and hypertrophy techniques before major hepatectomy: how to assess and manage the FLR","volume":"31","author":"Boubaddi","year":"2024","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"10.1016\/j.jgo.2025.102840_bb0160","first-page":"965","article-title":"Preoperative assessment of postoperative remnant liver function using hepatobiliary scintigraphy","volume":"45","author":"Bennink","year":"2004","journal-title":"J Nucl Med Off Publ Soc Nucl Med"},{"issue":"6","key":"10.1016\/j.jgo.2025.102840_bb0165","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.ejso.2021.12.028","article-title":"Liver resection in elderly patients with extensive CRLM: are we offering an adequate treatment? A propensity score matched analysis","volume":"48","author":"Di Martino","year":"2022","journal-title":"Eur J Surg Oncol"},{"issue":"4","key":"10.1016\/j.jgo.2025.102840_bb0170","doi-asserted-by":"crossref","first-page":"234","DOI":"10.21037\/hbsn.2017.09.03","article-title":"Survival after resection of colorectal liver metastases in octogenarians and sexagenarians compared to their respective age-matched national population","volume":"7","author":"Brudvik","year":"2018","journal-title":"Hepatobiliary Surg Nutr"},{"key":"10.1016\/j.jgo.2025.102840_bb0175","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12957-024-03316-6","article-title":"Mortality and morbidity after colorectal cancer resection surgery in elderly patients: a retrospective population-based study in Sweden","volume":"22","author":"Normann","year":"2024","journal-title":"World J Surg Oncol"},{"issue":"6","key":"10.1016\/j.jgo.2025.102840_bb0180","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1097\/SLA.0000000000002147","article-title":"Laparoscopic versus open liver resection for colorectal metastases in elderly and octogenarian patients: a multicenter propensity score based analysis of short- and long-term outcomes","volume":"265","author":"Mart\u00ednez-Cecilia","year":"2017","journal-title":"Ann Surg"},{"issue":"2","key":"10.1016\/j.jgo.2025.102840_bb0185","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s10353-020-00685-6","article-title":"Liver resections for colorectal liver metastases in elderly patients","volume":"53","author":"Treska","year":"2021","journal-title":"Eur Surg"},{"issue":"2","key":"10.1016\/j.jgo.2025.102840_bb0190","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1001\/jamasurg.2023.6083","article-title":"Liver transplant as a treatment of primary and secondary liver neoplasms","volume":"159","author":"Gorji","year":"2024","journal-title":"JAMA Surg"},{"issue":"11","key":"10.1016\/j.jgo.2025.102840_bb0195","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S2468-1253(21)00219-3","article-title":"Liver transplantation for non-resectable colorectal liver metastases: the international Hepato-Pancreato-biliary association consensus guidelines","volume":"6","author":"Bonney","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.jgo.2025.102840_bb0200","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/SLA.0000000000003404","article-title":"Survival following liver transplantation for patients with nonresectable liver-only colorectal metastases","volume":"271","author":"Dueland","year":"2020","journal-title":"Ann Surg"},{"issue":"9","key":"10.1016\/j.jgo.2025.102840_bb0205","doi-asserted-by":"crossref","DOI":"10.1001\/jamasurg.2023.2932","article-title":"Long-term survival, prognostic factors, and selection of patients with colorectal cancer for liver transplant: a nonrandomized controlled trial","volume":"158","author":"Dueland","year":"2023","journal-title":"JAMA Surg"},{"issue":"10458","key":"10.1016\/j.jgo.2025.102840_bb0210","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0140-6736(24)01595-2","article-title":"Liver transplantation plus chemotherapy versus chemotherapy alone in patients with permanently unresectable colorectal liver metastases (TransMet): results from a multicentre, open-label, prospective, randomised controlled trial","volume":"404","author":"Adam","year":"2024","journal-title":"Lancet Lond Engl"},{"issue":"12","key":"10.1016\/j.jgo.2025.102840_bb0215","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/S1470-2045(13)70447-9","article-title":"Perioperative FOLFOX4 chemotherapy and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC 40983): long-term results of a randomised, controlled, phase 3 trial","volume":"14","author":"Nordlinger","year":"2013","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.jgo.2025.102840_bb0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.sla.0000193603.26265.c3","article-title":"Influence of preoperative chemotherapy on the risk of major hepatectomy for colorectal liver metastases","volume":"243","author":"Karoui","year":"2006","journal-title":"Ann Surg"},{"issue":"9","key":"10.1016\/j.jgo.2025.102840_bb0225","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1007\/s00261-019-02110-3","article-title":"5-fluorouracil induced liver toxicity in patients with colorectal cancer: role of computed tomography texture analysis as a potential biomarker","volume":"44","author":"Alessandrino","year":"2019","journal-title":"Abdom Radiol N Y"},{"issue":"13","key":"10.1016\/j.jgo.2025.102840_bb0230","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1200\/JCO.2005.05.3074","article-title":"Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases","volume":"24","author":"Vauthey","year":"2006","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"issue":"3","key":"10.1016\/j.jgo.2025.102840_bb0235","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/annonc\/mdh095","article-title":"Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer","volume":"15","author":"Rubbia-Brandt","year":"2004","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"key":"10.1016\/j.jgo.2025.102840_bb0240","series-title":"LiverTox: clinical and research information on drug-induced liver injury","article-title":"Sinusoidal obstruction syndrome (veno-occlusive disease)","author":"National Institute of Diabetes and Digestive and Kidney Diseases","year":"2012"},{"issue":"11","key":"10.1016\/j.jgo.2025.102840_bb0245","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/hpb.12292","article-title":"Optimal management of colorectal liver metastases in older patients: a decision analysis","volume":"16","author":"Yang","year":"2014","journal-title":"HPB"},{"issue":"9","key":"10.1016\/j.jgo.2025.102840_bb0250","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djx015","article-title":"Local treatment of unresectable colorectal liver metastases: results of a randomized phase II trial. JNCI","volume":"109","author":"Ruers","year":"2017","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.jgo.2025.102840_bb0255","article-title":"Surgery versus thermal ablation for small-size colorectal liver metastases (COLLISION): an international, multicenter, phase III randomized controlled trial","author":"van der Lei","year":"2024","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jgo.2025.102840_bb0260","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1186\/s12885-018-4716-8","article-title":"Colorectal liver metastases: surgery versus thermal ablation (COLLISION) \u2013 a phase III single-blind prospective randomized controlled trial","volume":"18","author":"Puijk","year":"2018","journal-title":"BMC Cancer"},{"issue":"9","key":"10.1016\/j.jgo.2025.102840_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045493","article-title":"Radiofrequency ablation versus resection for colorectal Cancer liver metastases: a meta-analysis","volume":"7","author":"Weng","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jgo.2025.102840_bb0270","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.3390\/cancers14061503","article-title":"The role of conventional TACE (cTACE) and DEBIRI-TACE in colorectal cancer liver metastases","volume":"14","author":"Vogl","year":"2022","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.jgo.2025.102840_bb0275","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.suronc.2017.05.003","article-title":"Hepatic intra-arterial injection of irinotecan drug eluting beads (DEBIRI) for patients with unresectable colorectal liver metastases: a systematic review","volume":"26","author":"Akinwande","year":"2017","journal-title":"Surg Oncol"},{"issue":"1","key":"10.1016\/j.jgo.2025.102840_bb0280","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jvir.2012.09.010","article-title":"Transcatheter arterial chemoembolization using cisplatin powder mixed with degradable starch microspheres for colorectal liver metastases after FOLFOX failure: results of a phase I\/II study","volume":"24","author":"Nishiofuku","year":"2013","journal-title":"J Vasc Interv Radiol JVIR"},{"issue":"20","key":"10.1016\/j.jgo.2025.102840_bb0285","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1002\/cncr.29534","article-title":"Randomized controlled trial of irinotecan drug-eluting beads with simultaneous FOLFOX and bevacizumab for patients with unresectable colorectal liver-limited metastasis","volume":"121","author":"Martin","year":"2015","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.jgo.2025.102840_bb0290","first-page":"1387","article-title":"Intra-arterial infusion of irinotecan-loaded drug-eluting beads (DEBIRI) versus intravenous therapy (FOLFIRI) for hepatic metastases from colorectal cancer: final results of a phase III study","volume":"32","author":"Fiorentini","year":"2012","journal-title":"Anticancer Res"},{"issue":"17","key":"10.1016\/j.jgo.2025.102840_bb0295","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1200\/JCO.2016.71.8346","article-title":"Perioperative hepatic arterial infusion pump chemotherapy is associated with longer survival after resection of colorectal liver metastases: a propensity score analysis","volume":"35","author":"Groot Koerkamp","year":"2017","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jgo.2025.102840_bb0300","article-title":"Perioperative and oncologic outcomes of hepatic arterial infusion (HAI) pump chemotherapy for patients with unresectable colorectal liver metastases at an expanding HAI program","author":"Liu","year":"2024","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"10.1016\/j.jgo.2025.102840_bb0305","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.surg.2023.03.026","article-title":"Starting a successful hepatic artery infusion pump program: a practical guide","volume":"174","author":"McDonald","year":"2023","journal-title":"Surgery"},{"issue":"4","key":"10.1016\/j.jgo.2025.102840_bb0310","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.21037\/jgo-22-1183","article-title":"Stereotactic body radiation therapy for colorectal cancer liver metastases","volume":"15","author":"Lukovic","year":"2024","journal-title":"J Gastrointest Oncol"},{"issue":"3","key":"10.1016\/j.jgo.2025.102840_bb0315","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.radonc.2018.06.035","article-title":"Stereotactic body radiotherapy for colorectal cancer liver metastases: a systematic review","volume":"129","author":"Petrelli","year":"2018","journal-title":"Radiother Oncol"},{"issue":"9","key":"10.1016\/j.jgo.2025.102840_bb0320","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S1470-2045(17)30457-6","article-title":"First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-global): a combined analysis of three multicentre, randomised, phase 3 trials","volume":"18","author":"Wasan","year":"2017","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jgo.2025.102840_bb0325","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ctrv.2016.09.007","article-title":"Selective internal radiation therapy for liver metastases from colorectal cancer","volume":"50","author":"Townsend","year":"2016","journal-title":"Cancer Treat Rev"},{"issue":"23","key":"10.1016\/j.jgo.2025.102840_bb0330","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1200\/JCO.2010.28.5643","article-title":"Phase III trial comparing protracted intravenous fluorouracil infusion alone or with yttrium-90 resin microspheres radioembolization for liver-limited metastatic colorectal cancer refractory to standard chemotherapy","volume":"28","author":"Hendlisz","year":"2010","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"issue":"6","key":"10.1016\/j.jgo.2025.102840_bb0335","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1093\/ageing\/afab160","article-title":"\u2018What matters to you?\u2019 Health outcome prioritisation in treatment decision-making for older patients","volume":"50","author":"Festen","year":"2021","journal-title":"Age Ageing"},{"issue":"5","key":"10.1016\/j.jgo.2025.102840_bb0340","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1007\/s11605-015-3069-8","article-title":"Permanent loss of preoperative Independence in elderly patients undergoing hepatectomy: key factor in the informed consent process","volume":"20","author":"Shutt","year":"2016","journal-title":"J Gastrointest Surg"},{"issue":"1606","key":"10.1016\/j.jgo.2025.102840_bb0345","first-page":"40","article-title":"Outcomes following the introduction of an interdisciplinary shared decision-making clinic for older patients with colorectal cancer","volume":"137","author":"Jackson","year":"2024","journal-title":"N Z Med J"},{"issue":"3","key":"10.1016\/j.jgo.2025.102840_bb0350","doi-asserted-by":"crossref","DOI":"10.1097\/SLA.0000000000003585","article-title":"Preoperative risk assessment for loss of Independence following hepatic resection in elderly patients: a prospective multicenter study","volume":"274","author":"Tanaka","year":"2021","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.jgo.2025.102840_bb0355","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jss.2013.01.021","article-title":"Accumulating deficits model of frailty and postoperative mortality and morbidity: its application to a national database","volume":"183","author":"Velanovich","year":"2013","journal-title":"J Surg Res"},{"issue":"6","key":"10.1016\/j.jgo.2025.102840_bb0360","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1097\/SLA.0000000000003276","article-title":"Recalibration and external validation of the risk analysis index: a surgical frailty assessment tool","volume":"272","author":"Arya","year":"2020","journal-title":"Ann Surg"},{"issue":"2","key":"10.1016\/j.jgo.2025.102840_bb0365","article-title":"Accumulation of deficits as a proxy measure of aging","volume":"1","author":"Mitnitski","year":"2001","journal-title":"Sci World J"},{"issue":"5","key":"10.1016\/j.jgo.2025.102840_bb0370","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1001\/jamasurg.2022.0089","article-title":"Evaluation of quality of life after nonoperative or operative Management of Proximal Femoral Fractures in frail institutionalized patients: the FRAIL-HIP study","volume":"157","author":"Loggers","year":"2022","journal-title":"JAMA Surg"},{"issue":"9","key":"10.1016\/j.jgo.2025.102840_bb0375","doi-asserted-by":"crossref","first-page":"5476","DOI":"10.1245\/s10434-022-11830-8","article-title":"Increased morbidity and mortality after hepatectomy for colorectal liver metastases in frail patients is largely driven by worse outcomes after minor hepatectomy: it\u2019s not \u201cjust a wedge\u201d","volume":"29","author":"Leigh","year":"2022","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"10.1016\/j.jgo.2025.102840_bb0380","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/0003134820949511","article-title":"Frailty as a predictor of postoperative morbidity and mortality following liver resection","volume":"87","author":"McKechnie","year":"2021","journal-title":"Am Surg"},{"issue":"24","key":"10.1016\/j.jgo.2025.102840_bb0385","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1200\/JCO.2013.54.8347","article-title":"International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer","volume":"32","author":"Wildiers","year":"2014","journal-title":"J Clin Oncol Off J Am Soc Clin Oncol"},{"issue":"1","key":"10.1016\/j.jgo.2025.102840_bb0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/SLA.0000000000001491","article-title":"Recommendations for best communication practices to facilitate goal-concordant care for seriously ill older patients with emergency surgical conditions","volume":"263","author":"Cooper","year":"2016","journal-title":"Ann Surg"},{"issue":"10","key":"10.1016\/j.jgo.2025.102840_bb0395","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.pec.2019.07.020","article-title":"Purposeful SDM: a problem-based approach to caring for patients with shared decision making","volume":"102","author":"Hargraves","year":"2019","journal-title":"Patient Educ Couns"},{"issue":"12","key":"10.1016\/j.jgo.2025.102840_bb0400","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-031763","article-title":"Key components of shared decision making models: a systematic review","volume":"9","author":"Bomhof-Roordink","year":"2019","journal-title":"BMJ Open"},{"issue":"5","key":"10.1016\/j.jgo.2025.102840_bb0405","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1001\/jamasurg.2022.0290","article-title":"Surgeon use of shared decision-making for older adults considering major surgery: a secondary analysis of a randomized clinical trial","volume":"157","author":"Baggett","year":"2022","journal-title":"JAMA Surg"},{"issue":"10","key":"10.1016\/j.jgo.2025.102840_bb0410","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.pec.2018.06.005","article-title":"Shared decision-making in older patients with colorectal or pancreatic cancer: determinants of patients\u2019 and observers\u2019 perceptions","volume":"101","author":"Geessink","year":"2018","journal-title":"Patient Educ Couns"},{"issue":"1","key":"10.1016\/j.jgo.2025.102840_bb0415","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00423-023-03031-y","article-title":"Surgical outcome improvement by shared decision-making: value of a preoperative multidisciplinary target clinic for the elderly in colorectal surgery","volume":"408","author":"Staiger","year":"2023","journal-title":"Langenbeck\u2019s Arch Surg"},{"issue":"9","key":"10.1016\/j.jgo.2025.102840_bb0420","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1007\/s00268-013-2084-8","article-title":"Patients\u2019 preferences on information and involvement in decision making for gastrointestinal surgery","volume":"37","author":"Uldry","year":"2013","journal-title":"World J Surg"},{"issue":"1","key":"10.1016\/j.jgo.2025.102840_bb0425","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12913-023-09120-4","article-title":"Patients\u2019 and healthcare professionals\u2019 perceived facilitators and barriers for shared decision-making for frail and elderly patients in perioperative care: a scoping review","volume":"23","author":"Vogel","year":"2023","journal-title":"BMC Health Serv Res"},{"issue":"5","key":"10.1016\/j.jgo.2025.102840_bb0430","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.jamcollsurg.2013.07.385","article-title":"Development and evaluation of the universal ACS NSQIP surgical risk calculator: a decision aid and informed consent tool for patients and surgeons","volume":"217","author":"Bilimoria","year":"2013","journal-title":"J Am Coll Surg"},{"issue":"1","key":"10.1016\/j.jgo.2025.102840_bb0435","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jamcollsurg.2019.09.017","article-title":"Enhancing the American College of Surgeons NSQIP surgical risk calculator to predict geriatric outcomes","volume":"230","author":"Hornor","year":"2020","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.jgo.2025.102840_bb0440","series-title":"Liver cancer","article-title":"Non-alcoholic fatty liver disease progression to non-alcoholic steatohepatitis-related primary liver cancer","author":"Udoh","year":"2021"}],"container-title":["Journal of Geriatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879406825006563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879406825006563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T01:35:55Z","timestamp":1774056955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879406825006563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":88,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1879406825006563"],"URL":"https:\/\/doi.org\/10.1016\/j.jgo.2025.102840","relation":{},"ISSN":["1879-4068"],"issn-type":[{"value":"1879-4068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of surgically resectable colorectal liver metastases in older patients","name":"articletitle","label":"Article Title"},{"value":"Journal of Geriatric Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgo.2025.102840","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102840"}}