{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:39:27Z","timestamp":1793176767855,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017577","name":"Zhejiang Province Basic Public Welfare Research Program","doi-asserted-by":"publisher","award":["LQ24H080004"],"award-info":[{"award-number":["LQ24H080004"]}],"id":[{"id":"10.13039\/501100017577","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008990","name":"Zhejiang Province Science and Technology Department","doi-asserted-by":"publisher","award":["2025C02247 (SD2)"],"award-info":[{"award-number":["2025C02247 (SD2)"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","geriatriconcology.net","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Geriatric Oncology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.jgo.2026.103084","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T03:26:58Z","timestamp":1787196418000},"page":"103084","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disease burden trends of older adult acute myeloid leukemia (1990\u20132021): A population-based study"],"prefix":"10.1016","volume":"17","author":[{"given":"Zhijuan","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongcheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zanzan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanhao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guifang","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgo.2026.103084_bb0005","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1002\/cncr.33477","article-title":"Acute myeloid leukemia: treatment and research outlook for 2021 and the MD anderson approach","volume":"127","author":"Kantarjian","year":"2021","journal-title":"Cancer"},{"key":"10.1016\/j.jgo.2026.103084_bb0010","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s40364-024-00649-y","article-title":"Global, regional, and national burden of acute myeloid leukemia, 1990-2021: a systematic analysis for the global burden of disease study 2021","volume":"12","author":"Zhou","year":"2024","journal-title":"Biomark Res"},{"key":"10.1016\/j.jgo.2026.103084_bb0015","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jgo.2026.103084_bb0020","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/joim.13293","article-title":"Acute myeloid leukaemia in patients we judge as being older and\/or unfit","volume":"290","author":"Lazarevic","year":"2021","journal-title":"J Intern Med"},{"key":"10.1016\/j.jgo.2026.103084_bb0025","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1080\/10428194.2017.1330956","article-title":"Acute myeloid leukemia in the elderly: therapeutic options and choice","volume":"59","author":"Webster","year":"2018","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.jgo.2026.103084_bb0030","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1007\/s11912-024-01604-8","article-title":"AML in the elderly - when less may be more","volume":"26","author":"Winer","year":"2024","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.jgo.2026.103084_bb0035","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2025.2557507","article-title":"Global, regional and national epidemiology of acute myeloid leukemia (1990-2021): a statistical analysis of incidence, mortality, and DALYs","volume":"57","author":"Wu","year":"2025","journal-title":"Ann Med"},{"key":"10.1016\/j.jgo.2026.103084_bb0040","article-title":"Global, national, and regional burden of acute myeloid leukemia among 60-89years-old individuals: insights from a study covering the period 1990 to 2019","volume":"11","author":"Chen","year":"2023","journal-title":"Front Public Health"},{"key":"10.1016\/j.jgo.2026.103084_bb0045","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","article-title":"Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the global burden of disease study 2021","volume":"402","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.jgo.2026.103084_bb0050","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0140-6736(20)30925-9","article-title":"Global burden of 369 diseases and injuries in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.jgo.2026.103084_bb0055","first-page":"2101","article-title":"Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the global burden of disease study 2021","volume":"403","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jgo.2026.103084_bb0060","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.jhep.2018.12.001","article-title":"The trends in incidence of primary liver cancer caused by specific etiologies: results from the global burden of disease study 2016 and implications for liver cancer prevention","volume":"70","author":"Liu","year":"2019","journal-title":"J Hepatol"},{"key":"10.1016\/j.jgo.2026.103084_bb0065","doi-asserted-by":"crossref","first-page":"e1388","DOI":"10.1016\/S2214-109X(19)30360-2","article-title":"Rheumatic heart disease burden, trends, and inequalities in the americas, 1990-2017: a population-based study","volume":"7","author":"Ordunez","year":"2019","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.jgo.2026.103084_bb0070","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/1536867X1601600112","article-title":"Conindex: estimation of concentration indices","volume":"16","author":"O\u2019Donnell","year":"2016","journal-title":"Stata J"},{"key":"10.1016\/j.jgo.2026.103084_bb0075","doi-asserted-by":"crossref","DOI":"10.3402\/gha.v8.29034","article-title":"Promoting health equity: WHO health inequality monitoring at global and national levels","volume":"8","author":"Hosseinpoor","year":"2015","journal-title":"Glob Health Action"},{"key":"10.1016\/j.jgo.2026.103084_bb0080","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0140-6736(17)30818-8","article-title":"Healthcare access and quality index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990-2015: a novel analysis from the global burden of disease study 2015","volume":"390","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jgo.2026.103084_bb0085","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2024.2403645","article-title":"Epidemiological analysis of chronic kidney disease from 1990 to 2019 and predictions to 2030 by bayesian age-period-cohort analysis","volume":"46","author":"Dong","year":"2024","journal-title":"Ren Fail"},{"key":"10.1016\/j.jgo.2026.103084_bb0090","doi-asserted-by":"crossref","first-page":"17998","DOI":"10.1038\/s41598-017-18278-x","article-title":"Influence of body mass index on incidence and prognosis of acute myeloid leukemia and acute promyelocytic leukemia: a meta-analysis","volume":"7","author":"Li","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jgo.2026.103084_bb0095","first-page":"10049","article-title":"Association between cigarette smoking and the susceptibility of acute myeloid leukemia: a systematic review and meta-analysis","volume":"23","author":"Shi","year":"2019","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.jgo.2026.103084_bb0100","first-page":"31","article-title":"Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis","volume":"9","author":"Khalade","year":"2010","journal-title":"Environ Health Glob Access Sci Source"},{"key":"10.1016\/j.jgo.2026.103084_bb0105","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.mrrev.2008.07.002","article-title":"Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms","volume":"681","author":"Zhang","year":"2009","journal-title":"Mutat Res"},{"key":"10.1016\/j.jgo.2026.103084_bb0110","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1016\/S0140-6736(24)00933-4","article-title":"Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990\u20132021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"403","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jgo.2026.103084_bb0115","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1001\/jamaoncol.2016.5688","article-title":"Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study","volume":"3","author":"Fitzmaurice","year":"2017","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.jgo.2026.103084_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2024.102873","article-title":"The global, regional, and national patterns of change in the burden of congenital birth defects, 1990-2021: an analysis of the global burden of disease study 2021 and forecast to 2040","volume":"77","author":"Bai","year":"2024","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.jgo.2026.103084_bb0125","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1186\/s12889-022-14274-7","article-title":"The global, regional, and national early-onset colorectal cancer burden and trends from 1990 to 2019: results from the global burden of disease study 2019","volume":"22","author":"Pan","year":"2022","journal-title":"BMC Public Health"},{"key":"10.1016\/j.jgo.2026.103084_bb0130","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1007\/s13524-013-0243-z","article-title":"Assessing validity and application scope of the intrinsic estimator approach to the age-period-cohort problem","volume":"50","author":"Luo","year":"2013","journal-title":"Demography"},{"key":"10.1016\/j.jgo.2026.103084_bb0135","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.puhe.2022.04.015","article-title":"Global disease burden of COPD from 1990 to 2019 and prediction of future disease burden trend in China","volume":"208","author":"Hu","year":"2022","journal-title":"Public Health"},{"key":"10.1016\/j.jgo.2026.103084_bb0140","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/ejh.13752","article-title":"Incidence and socioeconomic factors in older adults with acute myeloid leukaemia: real-world outcomes from a population-based cohort","volume":"108","author":"Stubbins","year":"2022","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.jgo.2026.103084_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.leukres.2023.107353","article-title":"Economic burden during remission and after relapse among older patients with newly diagnosed acute myeloid leukemia without hematopoietic stem cell transplant: a retrospective study using the SEER-medicare database","volume":"132","author":"Brunner","year":"2023","journal-title":"Leuk Res"},{"key":"10.1016\/j.jgo.2026.103084_bb0150","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1158\/2159-8290.CD-19-1011","article-title":"Advances in the treatment of acute myeloid leukemia: new drugs and new challenges","volume":"10","author":"Short","year":"2020","journal-title":"Cancer Discov"},{"key":"10.1016\/j.jgo.2026.103084_bb0155","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1159\/000531628","article-title":"Acute myeloid leukemia treatment in the elderly: a comprehensive review of the present and future","volume":"146","author":"Choi","year":"2023","journal-title":"Acta Haematol"},{"key":"10.1016\/j.jgo.2026.103084_bb0160","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13045-023-01424-6","article-title":"Recent advances in targeted therapies in acute myeloid leukemia","volume":"16","author":"Bhansali","year":"2023","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.jgo.2026.103084_bb0165","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S1470-2045(18)30010-X","article-title":"Safety and preliminary efficacy of venetoclax with decitabine or azacitidine in elderly patients with previously untreated acute myeloid leukaemia: a non-randomised, open-label, phase 1b study","volume":"19","author":"DiNardo","year":"2018","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jgo.2026.103084_bb0170","first-page":"46","article-title":"Acute myeloid leukemia management and research in 2025","volume":"75","author":"Kantarjian","year":"2025","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.jgo.2026.103084_bb0175","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41571-022-00700-7","article-title":"Barriers in access to oncology drugs - a global crisis","volume":"20","author":"Barrios","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.jgo.2026.103084_bb0180","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.3390\/ijms26094005","article-title":"From chemotherapy to targeted therapy: unraveling resistance in acute myeloid leukemia through genetic and non-genetic insights","volume":"26","author":"Cao","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jgo.2026.103084_bb0185","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1182\/hematology.2024000541","article-title":"Mutations and MRD: clinical implications of clonal ontogeny","volume":"2024","author":"Radich","year":"2024","journal-title":"Hematology (Amsterdam)"},{"key":"10.1016\/j.jgo.2026.103084_bb0190","article-title":"Global and Chinese trends in acute myeloid leukemia burden (1990-2021): a comprehensive analysis based on the GBD study","volume":"12","author":"Lu","year":"2025","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.jgo.2026.103084_bb0195","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.stem.2014.11.002","article-title":"Estrogen signaling selectively induces apoptosis of hematopoietic progenitors and myeloid neoplasms without harming steady-state hematopoiesis","volume":"15","author":"S\u00e1nchez-Aguilera","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.jgo.2026.103084_bb0200","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41375-020-0935-5","article-title":"Male predominance in AML is associated with specific preleukemic mutations","volume":"35","author":"De-Morgan","year":"2021","journal-title":"Leukemia"},{"key":"10.1016\/j.jgo.2026.103084_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2020.100736","article-title":"A clandestine culprit with critical consequences: benzene and acute myeloid leukemia","volume":"47","author":"Shallis","year":"2021","journal-title":"Blood Rev"},{"key":"10.1016\/j.jgo.2026.103084_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2023.1272118","article-title":"Sex and gender affect immune aging","volume":"4","author":"Calabr\u00f2","year":"2023","journal-title":"Front Aging"},{"key":"10.1016\/j.jgo.2026.103084_bb0215","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41556-022-00842-x","article-title":"Telomere dysfunction in ageing and age-related diseases","volume":"24","author":"Rossiello","year":"2022","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jgo.2026.103084_bb0220","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41392-022-01251-0","article-title":"Aging and aging-related diseases: from molecular mechanisms to interventions and treatments","volume":"7","author":"Guo","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jgo.2026.103084_bb0225","doi-asserted-by":"crossref","DOI":"10.1172\/JCI180065","article-title":"Clonal hematopoiesis and hematological malignancy","volume":"134","author":"Dunn","year":"2024","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jgo.2026.103084_bb0230","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2024.1490302","article-title":"The 3 i\u2019s of immunity and aging: immunosenescence, inflammaging, and immune resilience","volume":"5","author":"Wrona","year":"2024","journal-title":"Front Aging"},{"key":"10.1016\/j.jgo.2026.103084_bb0235","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/S0140-6736(24)00476-8","volume":"403","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.jgo.2026.103084_bb0240","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/S0140-6736(24)00757-8","volume":"403","year":"2024","journal-title":"Lancet"}],"container-title":["Journal of Geriatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879406826002389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1879406826002389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:25:20Z","timestamp":1793175920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1879406826002389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S1879406826002389"],"URL":"https:\/\/doi.org\/10.1016\/j.jgo.2026.103084","relation":{},"ISSN":["1879-4068"],"issn-type":[{"value":"1879-4068","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disease burden trends of older adult acute myeloid leukemia (1990\u20132021): A population-based study","name":"articletitle","label":"Article Title"},{"value":"Journal of Geriatric Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgo.2026.103084","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103084"}}