{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T01:25:34Z","timestamp":1768094734418,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,10]],"date-time":"2021-07-10T00:00:00Z","timestamp":1625875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["2020R1A2C1004397"],"award-info":[{"award-number":["2020R1A2C1004397"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015826","name":"Korean Society of Ginseng","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI20C0253"],"award-info":[{"award-number":["HI20C0253"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ginseng Research"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.jgr.2021.07.003","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T01:41:29Z","timestamp":1626054089000},"page":"408-417","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prophylactic role of Korean Red Ginseng in astrocytic mitochondrial biogenesis through HIF-1\u03b1"],"prefix":"10.1016","volume":"46","author":[{"given":"Jinhong","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minjae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minsu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunhong","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seunghee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1969-8528","authenticated-orcid":false,"given":"Sueun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong-Ho","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Myeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0242-9612","authenticated-orcid":false,"given":"Yoon Kyung","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jgr.2021.07.003_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5142\/jgr.2013.37.8","article-title":"A\u00a0comprehensive review of the therapeutic and pharmacological effects of ginseng and ginsenosides in central nervous system","volume":"37","author":"Kim","year":"2013","journal-title":"J\u00a0Ginseng Res"},{"issue":"1","key":"10.1016\/j.jgr.2021.07.003_bib2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nature Reviews Neuroscience"},{"issue":"7613","key":"10.1016\/j.jgr.2021.07.003_bib3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nature18928","article-title":"Transfer of mitochondria from astrocytes to neurons after stroke","volume":"535","author":"Hayakawa","year":"2016","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.jgr.2021.07.003_bib4","doi-asserted-by":"crossref","first-page":"3276","DOI":"10.1523\/JNEUROSCI.4707-08.2009","article-title":"Uniquely hominid features of adult human astrocytes","volume":"29","author":"Oberheim","year":"2009","journal-title":"J\u00a0Neurosci"},{"issue":"6","key":"10.1016\/j.jgr.2021.07.003_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.276","article-title":"Heme oxygenase-1 derived carbon monoxide suppresses Abeta1-42 toxicity in astrocytes","volume":"8","author":"Hettiarachchi","year":"2017","journal-title":"Cell Death Dis"},{"issue":"6","key":"10.1016\/j.jgr.2021.07.003_bib6","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/jnr.20681","article-title":"Cultured astrocytes from heme oxygenase-1 knockout mice are more vulnerable to heme-mediated oxidative injury","volume":"82","author":"Chen-Roetling","year":"2005","journal-title":"J\u00a0Neurosci Res"},{"issue":"3","key":"10.1016\/j.jgr.2021.07.003_bib7","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.bbrc.2006.03.058","article-title":"Carbon monoxide mediates heme oxygenase 1 induction via Nrf2 activation in hepatoma cells","volume":"343","author":"Lee","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.jgr.2021.07.003_bib8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1042\/BJ20080018","article-title":"Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin","volume":"413","author":"Tudor","year":"2008","journal-title":"Biochem J"},{"issue":"1","key":"10.1016\/j.jgr.2021.07.003_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.trsl.2015.06.011","article-title":"Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation","volume":"167","author":"Ryter","year":"2016","journal-title":"Transl Res"},{"issue":"2","key":"10.1016\/j.jgr.2021.07.003_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.bbrc.2016.09.063","article-title":"Carbon monoxide stimulates astrocytic mitochondrial biogenesis via L-type Ca2+ channel-mediated PGC-1alpha\/ERRalpha activation","volume":"479","author":"Choi","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"10.1016\/j.jgr.2021.07.003_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202039","article-title":"Heme oxygenase metabolites improve astrocytic mitochondrial function via a Ca2+-dependent HIF-1alpha\/ERRalpha circuit","volume":"13","author":"Choi","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.jgr.2021.07.003_bib12","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1042\/AN20120006","article-title":"Hypoxia-inducible factor 1 protects hypoxic astrocytes against glutamate toxicity","volume":"4","author":"Badawi","year":"2012","journal-title":"ASN Neuro"},{"issue":"6406","key":"10.1016\/j.jgr.2021.07.003_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan8821","article-title":"Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model","volume":"361","author":"Choi","year":"2018","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.jgr.2021.07.003_bib14","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.bbrc.2006.08.129","article-title":"20(S)-Ginsenoside Rg3 prevents endothelial cell apoptosis via inhibition of a mitochondrial caspase pathway","volume":"349","author":"Min","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.jgr.2021.07.003_bib15","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neulet.2004.10.030","article-title":"Neuroprotective effect of 20(S)-ginsenoside Rg3 on cerebral ischemia in rats","volume":"374","author":"Tian","year":"2005","journal-title":"Neurosci Lett"},{"issue":"4","key":"10.1016\/j.jgr.2021.07.003_bib16","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.bbabio.2013.10.004","article-title":"Structures of mitochondrial oxidative phosphorylation supercomplexes and mechanisms for their stabilisation","volume":"1837","author":"Chaban","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"10.1016\/j.jgr.2021.07.003_bib17","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1111\/j.1460-9568.2009.06712.x","article-title":"The induction of HIF-1 reduces astrocyte activation by amyloid beta peptide","volume":"29","author":"Schubert","year":"2009","journal-title":"Eur J Neurosci"},{"issue":"1","key":"10.1016\/j.jgr.2021.07.003_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12779\/dnd.2021.20.1.1","article-title":"Glia-like cells from human mesenchymal stem cells protect neural stem cells in an in\u00a0vitro model of alzheimer's disease by reducing NLRP-3 inflammasome","volume":"20","author":"Hwang","year":"2021","journal-title":"Dement Neurocogn Disord"},{"issue":"11","key":"10.1016\/j.jgr.2021.07.003_bib19","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1038\/nm.4188","article-title":"Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury","volume":"22","author":"Choi","year":"2016","journal-title":"Nat Med"},{"issue":"35","key":"10.1016\/j.jgr.2021.07.003_bib20","doi-asserted-by":"crossref","first-page":"10995","DOI":"10.1523\/JNEUROSCI.3399-09.2009","article-title":"Doublecortin associates with microtubules preferentially in regions of the axon displaying actin-rich protrusive structures","volume":"29","author":"Tint","year":"2009","journal-title":"J\u00a0Neurosci"},{"issue":"1","key":"10.1016\/j.jgr.2021.07.003_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s10456-013-9387-0","article-title":"TRAIL negatively regulates VEGF-induced angiogenesis via caspase-8-mediated enzymatic and non-enzymatic functions","volume":"17","author":"Na","year":"2014","journal-title":"Angiogenesis"},{"issue":"5847","key":"10.1016\/j.jgr.2021.07.003_bib22","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1126\/science.1147949","article-title":"Life with oxygen","volume":"318","author":"Semenza","year":"2007","journal-title":"Science"},{"issue":"42","key":"10.1016\/j.jgr.2021.07.003_bib23","doi-asserted-by":"crossref","first-page":"32116","DOI":"10.1074\/jbc.M110.131284","article-title":"Carbon monoxide promotes VEGF expression by increasing HIF-1alpha protein level via two distinct mechanisms, translational activation and stabilization of HIF-1alpha protein","volume":"285","author":"Choi","year":"2010","journal-title":"J\u00a0Biol Chem"},{"issue":"15","key":"10.1016\/j.jgr.2021.07.003_bib24","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1128\/MCB.25.15.6415-6426.2005","article-title":"Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha","volume":"25","author":"Chan","year":"2005","journal-title":"Mol Cell Biol"},{"issue":"5516","key":"10.1016\/j.jgr.2021.07.003_bib25","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1126\/science.1059817","article-title":"HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing","volume":"292","author":"Ivan","year":"2001","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.jgr.2021.07.003_bib26","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1172\/JCI3145","article-title":"Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer","volume":"102","author":"Arenberg","year":"1998","journal-title":"J\u00a0Clin Invest"},{"issue":"8","key":"10.1016\/j.jgr.2021.07.003_bib27","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1158\/0008-5472.CAN-05-2570","article-title":"Growth-regulated oncogene is pivotal in thrombin-induced angiogenesis","volume":"66","author":"Caunt","year":"2006","journal-title":"Cancer Res"},{"issue":"10","key":"10.1016\/j.jgr.2021.07.003_bib28","doi-asserted-by":"crossref","first-page":"6968","DOI":"10.1167\/iovs.14-15029","article-title":"Interleukin-17 induces angiogenesis in human choroidal endothelial cells in\u00a0vitro","volume":"55","author":"Chen","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"10.1016\/j.jgr.2021.07.003_bib29","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1007\/s12015-016-9706-0","article-title":"CXCL12\/SDF-1-Dependent retinal migration of endogenous bone marrow-derived stem cells improves visual function after pharmacologically induced retinal degeneration","volume":"13","author":"Enzmann","year":"2017","journal-title":"Stem Cell Rev"},{"issue":"12","key":"10.1016\/j.jgr.2021.07.003_bib30","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1172\/JCI200317977","article-title":"VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia","volume":"111","author":"Sun","year":"2003","journal-title":"J\u00a0Clin Invest"},{"issue":"1","key":"10.1016\/j.jgr.2021.07.003_bib31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2174\/156720506775697133","article-title":"VEGF, a mediator of the effect of experience on hippocampal neurogenesis","volume":"3","author":"During","year":"2006","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.jgr.2021.07.003_bib32","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3389\/fnins.2017.00590","article-title":"The role of SDF-1\/CXCR4\/CXCR7 in neuronal regeneration after cerebral ischemia","volume":"11","author":"Cheng","year":"2017","journal-title":"Front Neurosci"},{"issue":"6","key":"10.1016\/j.jgr.2021.07.003_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.284","article-title":"Critical role of astrocytic interleukin-17 A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice","volume":"7","author":"Lin","year":"2016","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.jgr.2021.07.003_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/nan.12107","article-title":"Adult neurogenesis and its role in neuropsychiatric disease, brain repair and normal brain function","volume":"40","author":"Braun","year":"2014","journal-title":"Neuropathol Appl Neurobiol"}],"container-title":["Journal of Ginseng Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S122684532100107X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S122684532100107X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:17:15Z","timestamp":1761124635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S122684532100107X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["S122684532100107X"],"URL":"https:\/\/doi.org\/10.1016\/j.jgr.2021.07.003","relation":{},"ISSN":["1226-8453"],"issn-type":[{"value":"1226-8453","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prophylactic role of Korean Red Ginseng in astrocytic mitochondrial biogenesis through HIF-1\u03b1","name":"articletitle","label":"Article Title"},{"value":"Journal of Ginseng Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgr.2021.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}