{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:09:53Z","timestamp":1792642193281,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ginseng Research"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.jgr.2021.10.001","type":"journal-article","created":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T19:11:15Z","timestamp":1634152275000},"page":"550-560","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2\/NF-\u03baB and MAPK-Nrf2\/NF-\u03baB pathways"],"prefix":"10.1016","volume":"46","author":[{"given":"Chang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangchang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingzhi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianhua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhehu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Joon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8058-7822","authenticated-orcid":false,"given":"Guanghai","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgr.2021.10.001_bib1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/all.13072","article-title":"Allergy in severe asthma","volume":"72","author":"Del Giacco","year":"2017","journal-title":"Allergy"},{"key":"10.1016\/j.jgr.2021.10.001_bib2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.4049\/jimmunol.1502416","article-title":"Role of CCL7 in type I hypersensitivity reactions in murine experimental allergic conjunctivitis","volume":"198","author":"Kuo","year":"2017","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jgr.2021.10.001_bib3","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/02770903.2019.1585870","article-title":"Altered mast cell activity in response to rhinovirus infection provides novel insight into asthma","volume":"57","author":"Liu","year":"2020","journal-title":"J\u00a0Asthma"},{"key":"10.1016\/j.jgr.2021.10.001_bib4","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.jid.2019.01.013","article-title":"Yin-yang of IL-33 in human skin mast cells: reduced degranulation, but augmented histamine synthesis through p38 activation","volume":"139","author":"Babina","year":"2019","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.jgr.2021.10.001_bib5","first-page":"462","volume":"vol. 32","author":"Zhou","year":"2016"},{"key":"10.1016\/j.jgr.2021.10.001_bib6","first-page":"410","article-title":"IL-4 enhances IL-3 and IL-8 gene expression in a human leukemic mast cell line","volume":"84","author":"Buckley","year":"1995","journal-title":"Immunology"},{"key":"10.1016\/j.jgr.2021.10.001_bib7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s11010-015-2554-4","article-title":"Impaired expression of the mitochondrial calcium uniporter suppresses mast cell degranulation","volume":"410","author":"Furuno","year":"2015","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jgr.2021.10.001_bib8","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/286722a0","article-title":"A\u00a0binding site on mast cells and basophils for the anti-allergic drug cromolyn","volume":"286","author":"Mazurek","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.jgr.2021.10.001_bib9","doi-asserted-by":"crossref","first-page":"821","DOI":"10.3389\/fimmu.2019.00821","article-title":"Mast cells and their progenitors in allergic asthma","volume":"10","author":"M\u00e9ndez-Enr\u00edquez","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jgr.2021.10.001_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01937","article-title":"IgG-independent Co-aggregation of Fc\u03b5RI and Fc\u03b3RIIB results in LYN- and SHIP1-dependent tyrosine phosphorylation of Fc\u03b3RIIB in murine bone marrow-derived mast cells","volume":"9","author":"Gast","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.jgr.2021.10.001_bib11","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.jaci.2016.01.017","article-title":"Repeated Fc\u03b5RI triggering reveals modified mast cell function related to chronic allergic responses in tissue","volume":"138","author":"Suurmond","year":"2016","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jgr.2021.10.001_bib12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ceca.2017.08.002","article-title":"Differential Ca(2+) mobilization and mast cell degranulation by Fc\u03b5RI- and GPCR-mediated signaling","volume":"67","author":"Chen","year":"2017","journal-title":"Cell Calcium"},{"key":"10.1016\/j.jgr.2021.10.001_bib13","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1007\/s12035-018-1177-7","article-title":"Mast cell proteases activate astrocytes and glia-neurons and release Interleukin-33 by activating p38 and ERK1\/2 MAPKs and NF-\u03baB","volume":"56","author":"Kempuraj","year":"2019","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jgr.2021.10.001_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00250","article-title":"BCAP regulates dendritic cell maturation through the dual-regulation of NF-\u03baB and PI3K\/AKT signaling during infection","volume":"11","author":"Miao","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jgr.2021.10.001_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12252-3","article-title":"Polydatin inhibits mast cell-mediated allergic inflammation by targeting PI3K\/Akt, MAPK, NF-\u03baB and Nrf2\/HO-1 pathways","volume":"7","author":"Ye","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jgr.2021.10.001_bib16","doi-asserted-by":"crossref","first-page":"7003","DOI":"10.1007\/s00253-019-09951-4","article-title":"High-density immobilization of a ginsenoside-transforming \u03b2-glucosidase for enhanced food-grade production of minor ginsenosides","volume":"103","author":"Cui","year":"2019","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.jgr.2021.10.001_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2019.110578","article-title":"Preclinical safety of ginsenoside compound K: acute, and 26-week oral toxicity studies in mice and rats","volume":"131","author":"Gao","year":"2019","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jgr.2021.10.001_bib18","doi-asserted-by":"crossref","first-page":"8195","DOI":"10.2147\/IJN.S221328","article-title":"Photoluminescent and self-assembled hyaluronic acid-zinc oxide-ginsenoside Rh2 nanoparticles and their potential caspase-9 apoptotic mechanism towards cancer cell lines","volume":"14","author":"Kim","year":"2019","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.jgr.2021.10.001_bib19","doi-asserted-by":"crossref","first-page":"6946","DOI":"10.3892\/mmr.2015.4272","article-title":"Ginsenoside Rh2 attenuates allergic airway inflammation by modulating nuclear factor-\u03baB activation in a murine model of asthma","volume":"12","author":"Li","year":"2015","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.jgr.2021.10.001_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20246111","article-title":"Ginsenoside Rh2 ameliorates atopic dermatitis in NC\/nga mice by suppressing NF-kappaB-Mediated thymic stromal lymphopoietin expression and T helper type 2 differentiation","volume":"20","author":"Ko","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jgr.2021.10.001_bib21","first-page":"23","article-title":"Combined effect of sodium selenite and ginsenoside Rh2 on HCT116 human colorectal carcinoma cells","volume":"19","author":"Zhu","year":"2016","journal-title":"Arch Iran Med"},{"key":"10.1016\/j.jgr.2021.10.001_bib22","first-page":"630","article-title":"Reversal effect of ginsenoside Rh2 on oxaliplatin-resistant colon cancer cells and its mechanism","volume":"18","author":"Ma","year":"2019","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jgr.2021.10.001_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13020-018-0168-y","article-title":"Ginsenoside G-Rh2 synergizes with SMI-4a in anti-melanoma activity through autophagic cell death","volume":"13","author":"Lv","year":"2018","journal-title":"Chin Med"},{"key":"10.1016\/j.jgr.2021.10.001_bib24","article-title":"The identification of molecular target of (20S) ginsenoside Rh2 for its anti-cancer activity","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.jgr.2021.10.001_bib25","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbrc.2016.03.007","article-title":"Cornuside inhibits mast cell-mediated allergic response by down-regulating MAPK and NF-\u03baB signaling pathways","volume":"473","author":"Li","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jgr.2021.10.001_bib26","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1248\/bpb.b17-00463","article-title":"Ginsenoside Rh2 inhibited proliferation by inducing ROS mediated ER stress dependent apoptosis in lung cancer cells","volume":"40","author":"Ge","year":"2017","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.jgr.2021.10.001_bib27","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jgr.2016.08.004","article-title":"Role of ginsenosides, the main active components of Panax ginseng, in inflammatory responses and diseases","volume":"41","author":"Kim","year":"2017","journal-title":"J\u00a0Ginseng Res"},{"key":"10.1016\/j.jgr.2021.10.001_bib28","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/mc.20673","article-title":"Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release","volume":"50","author":"Li","year":"2011","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.jgr.2021.10.001_bib29","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3109\/09513590.2013.829444","article-title":"Relaxin has anti-apoptotic effects on human trophoblast-derived HTR-8\/SV neo cells","volume":"29","author":"Lodhi","year":"2013","journal-title":"Gynecol Endocrinol"},{"key":"10.1016\/j.jgr.2021.10.001_bib30","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s11325-018-01774-3","article-title":"Polysomnographic characteristics of adolescents with asthma and low risk for sleep-disordered breathing","volume":"23","author":"Khassawneh","year":"2019","journal-title":"Sleep Breath"},{"key":"10.1016\/j.jgr.2021.10.001_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112136","article-title":"Total glucosides of peony improve ovalbumin-induced allergic asthma by inhibiting mast cell degranulation","volume":"244","author":"Shou","year":"2019","journal-title":"J\u00a0Ethnopharmacol"},{"key":"10.1016\/j.jgr.2021.10.001_bib32","first-page":"262","article-title":"[Effects of 18\u03b2-sodium glycyrrhetinic acid on TNF-\u03b1 expression in rats with allergic rhinitis]","volume":"33","author":"She","year":"2019","journal-title":"Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"10.1016\/j.jgr.2021.10.001_bib33","doi-asserted-by":"crossref","first-page":"17406","DOI":"10.18632\/oncotarget.24227","article-title":"The role of particulate matters on methylation of IFN-\u03b3 and IL-4 promoter genes in pediatric allergic rhinitis","volume":"9","author":"Li","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.jgr.2021.10.001_bib34","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2018.1440166","article-title":"Neurotensin\/IL-8 pathway orchestrates local inflammatory response and tumor invasion by inducing M2 polarization of Tumor-Associated macrophages and epithelial-mesenchymal transition of hepatocellular carcinoma cells","volume":"7","author":"Xiao","year":"2018","journal-title":"OncoImmunology"},{"key":"10.1016\/j.jgr.2021.10.001_bib35","doi-asserted-by":"crossref","first-page":"218","DOI":"10.4049\/jimmunol.1602035","article-title":"IL-1\u03b2 induces pathologically activated osteoclasts bearing extremely high levels of resorbing activity: a possible pathological subpopulation of osteoclasts, accompanied by suppressed expression of Kindlin-3 and talin-1","volume":"200","author":"Shiratori","year":"2018","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jgr.2021.10.001_bib36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12906-015-0607-6","article-title":"Rhamnus davurica leaf extract inhibits Fyn activation by antigen in mast cells for anti-allergic activity","volume":"15","author":"Kim","year":"2015","journal-title":"BMC Compl Alternative Med"},{"key":"10.1016\/j.jgr.2021.10.001_bib37","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.cellsig.2019.01.010","article-title":"Fine particulate matter (PM(2.5)) enhances Fc\u03b5RI-mediated signaling and mast cell function","volume":"5 7","author":"Jin","year":"2019","journal-title":"Cell Signal"},{"key":"10.1016\/j.jgr.2021.10.001_bib38","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.rmed.2011.09.007","article-title":"The role of mast cells in allergic inflammation","volume":"106","author":"Amin","year":"2012","journal-title":"Respir Med"},{"key":"10.1016\/j.jgr.2021.10.001_bib39","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jcma.2015.08.012","article-title":"Antiallergic effect of gami-hyunggyeyeongyotang on ovalbumin-induced allergic rhinitis in mouse and human mast cells","volume":"79","author":"Im","year":"2016","journal-title":"J\u00a0Chin Med Assoc"},{"key":"10.1016\/j.jgr.2021.10.001_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105800","article-title":"A\u00a0mast-cell-specific receptor mediates Iopamidol induced immediate IgE-independent anaphylactoid reactions","volume":"75","author":"Jiang","year":"2019","journal-title":"Int Immunopharm"},{"key":"10.1016\/j.jgr.2021.10.001_bib41","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.taap.2019.01.019","article-title":"Dehydroandrographolide inhibits IgE-mediated anaphylactic reactions via calcium signaling pathway","volume":"366","author":"Che","year":"2019","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.jgr.2021.10.001_bib42","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s12250-018-0032-3","article-title":"Porcine Fc\u03b5RI mediates porcine reproductive and respiratory syndrome virus multiplication and regulates the inflammatory reaction","volume":"33","author":"Shi","year":"2018","journal-title":"Virol Sin"},{"key":"10.1016\/j.jgr.2021.10.001_bib43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12964-016-0135-0","article-title":"Differential Lyn-dependence of the SHIP1-deficient mast cell phenotype","volume":"14","author":"Nunes de Miranda","year":"2016","journal-title":"Cell Commun Signal"},{"key":"10.1016\/j.jgr.2021.10.001_bib44","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s12640-015-9533-0","article-title":"Mast cell serotonin immunoregulatory effects impacting on neuronal function: implications for neurodegenerative and psychiatric disorders","volume":"28","author":"Conti","year":"2015","journal-title":"Neurotox Res"},{"key":"10.1016\/j.jgr.2021.10.001_bib45","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s11882-008-0004-z","article-title":"A\u00a0current understanding of Fc epsilon RI-dependent mast cell activation","volume":"8","author":"Rivera","year":"2008","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jgr.2021.10.001_bib46","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.jaci.2017.10.010","article-title":"Mechanisms of allergen immunotherapy for inhaled allergens and predictive biomarkers","volume":"140","author":"Shamji","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.jgr.2021.10.001_bib47","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1016\/j.bmcl.2018.09.007","article-title":"Inhibitor for Fc\u03b5RI expression on mast cell from Verbasucum thapsus L","volume":"28","author":"Tamura","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.jgr.2021.10.001_bib48","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.3748\/wjg.v25.i24.3044","article-title":"Effect of NLRC5 on activation and reversion of hepatic stellate cells by regulating the nuclear factor-\u03baB signaling pathway","volume":"25","author":"Zhang","year":"2019","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jgr.2021.10.001_bib49","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ijbiomac.2018.06.130","article-title":"Orientin-mediated Nrf2\/HO-1 signal alleviates H(2)O(2)-induced oxidative damage via induction of JNK and PI3K\/AKT activation","volume":"118","author":"Xiao","year":"2018","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jgr.2021.10.001_bib50","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.exger.2016.11.009","article-title":"Insulin-like growth factor-1 protects SH-SY5Y cells against \u03b2-amyloid-induced apoptosis via the PI3K\/Akt-Nrf2 pathway","volume":"87","author":"Wang","year":"2017","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.jgr.2021.10.001_bib51","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/s41368-018-0039-5","article-title":"Caffeic acid phenethyl ester protects against oxidative stress and dampens inflammation via heme oxygenase 1","volume":"11","author":"St\u00e4hli","year":"2019","journal-title":"Int J Oral Sci"}],"container-title":["Journal of Ginseng Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1226845321001548?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1226845321001548?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:17:40Z","timestamp":1761124660000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1226845321001548"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":51,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S1226845321001548"],"URL":"https:\/\/doi.org\/10.1016\/j.jgr.2021.10.001","relation":{},"ISSN":["1226-8453"],"issn-type":[{"value":"1226-8453","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2\/NF-\u03baB and MAPK-Nrf2\/NF-\u03baB pathways","name":"articletitle","label":"Article Title"},{"value":"Journal of Ginseng Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgr.2021.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Korean Society of Ginseng. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}