{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T05:38:04Z","timestamp":1784353084913,"version":"3.55.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ginseng Research"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.jgr.2024.09.005","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T17:16:15Z","timestamp":1727370975000},"page":"53-63","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Non-saponin from Panax ginseng maintains blood-brain barrier integrity by inhibiting NF-\u03baB and p38 MAP kinase signaling pathways to prevent the progression of experimental autoimmune encephalomyelitis"],"prefix":"10.1016","volume":"49","author":[{"given":"Jinhee","family":"Oh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujeong","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Woo","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Sung","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Kwan","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9934-2390","authenticated-orcid":false,"given":"Yoonsung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Yeol","family":"Nah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1036-0494","authenticated-orcid":false,"given":"Ik-Hyun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgr.2024.09.005_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41572-018-0041-4","article-title":"Multiple sclerosis","volume":"4","author":"Filippi","year":"2018","journal-title":"Nat Rev Dis Prim"},{"key":"10.1016\/j.jgr.2024.09.005_bib2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1001\/jama.2020.26858","article-title":"Diagnosis and treatment of multiple sclerosis: a review","volume":"325","author":"McGinley","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.jgr.2024.09.005_bib3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1056\/NEJMra1401483","article-title":"Multiple sclerosis","volume":"378","author":"Reich","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jgr.2024.09.005_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12974-016-0701-9","article-title":"1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype","volume":"13","author":"Plastira","year":"2016","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jgr.2024.09.005_bib5","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.neuron.2018.01.021","article-title":"Multiple sclerosis: mechanisms and immunotherapy","volume":"97","author":"Baecher-Allan","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.jgr.2024.09.005_bib6","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.3892\/etm.2017.4410","article-title":"Multiple sclerosis: pathology, diagnosis and treatments","volume":"13","author":"Huang","year":"2017","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jgr.2024.09.005_bib7","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S1474-4422(19)30245-5","article-title":"Ocrelizumab for primary progressive multiple sclerosis","volume":"18","author":"Adler","year":"2019","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jgr.2024.09.005_bib8","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.molmed.2013.08.001","article-title":"Nuclear factor kappa B (NF-kappaB) in multiple sclerosis pathology","volume":"19","author":"Mc Guire","year":"2013","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.jgr.2024.09.005_bib9","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fnmol.2016.00084","article-title":"NF-kappaB pathways in the pathogenesis of multiple sclerosis and the therapeutic implications","volume":"9","author":"Leibowitz","year":"2016","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.jgr.2024.09.005_bib10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.55782\/ane-2022-005","article-title":"Blocking of NF-kB\/p38 MAPK pathways mitigates oligodendrocyte pathology in a model of neonatal white matter injury","volume":"82","author":"Al-Griw","year":"2022","journal-title":"Acta Neurobiol Exp"},{"key":"10.1016\/j.jgr.2024.09.005_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173523","article-title":"Icariin ameliorates the progression of experimental autoimmune encephalomyelitis by down-regulating the major inflammatory signal pathways in a mouse relapse-remission model of multiple sclerosis","volume":"885","author":"Cong","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jgr.2024.09.005_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115435","article-title":"Modulation of p38 MAPK and Nrf2\/HO-1\/NLRP3 inflammasome signaling and pyroptosis outline the anti-neuroinflammatory and remyelinating characters of Clemastine in EAE rat model","volume":"209","author":"Motawi","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jgr.2024.09.005_bib13","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.jgr.2017.04.013","article-title":"Korean Red Ginseng mitigates spinal demyelination in a model of acute multiple sclerosis by downregulating p38 mitogen-activated protein kinase and nuclear factor-kappaB signaling pathways","volume":"42","author":"Lee","year":"2018","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jgr.2024.09.005_bib14","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.arcmed.2014.11.013","article-title":"Role of the blood-brain barrier in multiple sclerosis","volume":"45","author":"Ortiz","year":"2014","journal-title":"Arch Med Res"},{"key":"10.1016\/j.jgr.2024.09.005_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168370","article-title":"Reviewing the significance of blood-brain barrier disruption in multiple sclerosis pathology and treatment","volume":"22","author":"Balasa","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jgr.2024.09.005_bib16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/med.21380","article-title":"Natural product-based drug discovery","volume":"36","author":"Li","year":"2016","journal-title":"Med Res Rev"},{"key":"10.1016\/j.jgr.2024.09.005_bib17","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1016\/j.apsb.2022.08.022","article-title":"New opportunities and challenges of natural products research: when target identification meets single-cell multiomics","volume":"12","author":"Zhu","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.jgr.2024.09.005_bib18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jgr.2022.02.006","article-title":"Can Panax ginseng help control cytokine storm in COVID-19?","volume":"46","author":"Choi","year":"2022","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jgr.2024.09.005_bib19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jgr.2020.02.004","article-title":"Pharmacological potential of ginseng and its major component ginsenosides","volume":"45","author":"Ratan","year":"2021","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jgr.2024.09.005_bib20","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.jgr.2020.09.001","article-title":"Rg3-enriched Korean Red Ginseng extract inhibits blood-brain barrier disruption in an animal model of multiple sclerosis by modulating expression of NADPH oxidase 2 and 4","volume":"45","author":"Lee","year":"2021","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jgr.2024.09.005_bib21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.jgr.2020.01.005","article-title":"Physiological and pharmacological features of the non-saponin components in Korean Red Ginseng","volume":"44","author":"Hyun","year":"2020","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jgr.2024.09.005_bib22","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jgr.2022.09.008","article-title":"Proteomic analysis for the effects of non-saponin fraction with rich polysaccharide from Korean Red Ginseng on Alzheimer's disease in a mouse model","volume":"47","author":"Kim","year":"2023","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jgr.2024.09.005_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130516","article-title":"Korean red ginseng polysaccharide as a potential therapeutic agent targeting tau pathology in Alzheimer's disease","volume":"263","author":"Kim","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.jgr.2024.09.005_bib24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jgr.2023.08.002","article-title":"Panaxcerol D from Panax ginseng ameliorates the memory impairment induced by cholinergic blockade or Abeta(25-35) peptide in mice","volume":"48","author":"Park","year":"2024","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jgr.2024.09.005_bib25","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jgr.2021.04.007","article-title":"The effects of Korean Red Ginseng-derived components on oligodendrocyte lineage cells: distinct facilitatory roles of the non-saponin and saponin fractions, and Rb1, in proliferation, differentiation and myelination","volume":"46","author":"Lee","year":"2022","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jgr.2024.09.005_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175824","article-title":"AFG, an important maillard reaction product in red ginseng, alleviates D-galactose-induced brain aging in mice via correcting mitochondrial dysfunction induced by ROS accumulation","volume":"952","author":"Zhang","year":"2023","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jgr.2024.09.005_bib27","doi-asserted-by":"crossref","first-page":"5754","DOI":"10.1021\/acs.jafc.9b00540","article-title":"Arginyl-fructosyl-glucose, a major maillard reaction product of red ginseng, attenuates cisplatin-induced acute kidney injury by regulating nuclear factor kappaB and phosphatidylinositol 3-kinase\/protein kinase B signaling pathways","volume":"67","author":"Li","year":"2019","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.jgr.2024.09.005_bib28","article-title":"Antidiabetic effects of arginyl-fructosyl-glucose, a nonsaponin fraction from ginseng processing in streptozotocin-induced type 2 diabetic mice through regulating the PI3K\/AKT\/GSK-3beta and Bcl-2\/Bax signaling pathways","volume":"2020","author":"Liu","year":"2020","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.jgr.2024.09.005_bib29","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.jgr.2023.02.006","article-title":"Newly identified maltol derivatives in Korean Red Ginseng and their biological influence as antioxidant and anti-inflammatory agents","volume":"47","author":"Cho","year":"2023","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jgr.2024.09.005_bib30","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jgr.2019.12.004","article-title":"The non-saponin fraction of Korean Red Ginseng (KGC05P0) decreases glucose uptake and transport in vitro and modulates glucose production via down-regulation of the PI3K\/AKT pathway in vivo","volume":"44","author":"Park","year":"2020","journal-title":"J Ginseng Res"},{"key":"10.1016\/j.jgr.2024.09.005_bib31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jgr.2016.07.004","article-title":"In situ analysis of chemical components induced by steaming between fresh ginseng, steamed ginseng, and red ginseng","volume":"41","author":"Ahn","year":"2017","journal-title":"J Ginseng Res."},{"key":"10.1016\/j.jgr.2024.09.005_bib32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature11556","article-title":"A call for transparent reporting to optimize the predictive value of preclinical research","volume":"490","author":"Landis","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jgr.2024.09.005_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155065","article-title":"Ginsenoside-Re inhibits experimental autoimmune encephalomyelitis as a mouse model of multiple sclerosis by downregulating TLR4\/MyD88\/NF-kappaB signaling pathways","volume":"122","author":"Oh","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.jgr.2024.09.005_bib34","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s12974-021-02278-w","article-title":"Inhibition of lysophosphatidic acid receptor 1-3 deteriorates experimental autoimmune encephalomyelitis by inducing oxidative stress","volume":"18","author":"Choi","year":"2021","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jgr.2024.09.005_bib35","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s12035-014-9012-2","article-title":"Bee venom acupuncture alleviates experimental autoimmune encephalomyelitis by upregulating regulatory T cells and suppressing Th1 and Th17 responses","volume":"53","author":"Lee","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jgr.2024.09.005_bib36","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13024-016-0116-1","article-title":"IKKbeta-mediated inflammatory myeloid cell activation exacerbates experimental autoimmune encephalomyelitis by potentiating Th1\/Th17 cell activation and compromising blood brain barrier","volume":"11","author":"Lee","year":"2016","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.jgr.2024.09.005_bib37","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1007\/s12035-015-9131-4","article-title":"Korean red ginseng and ginsenoside-Rb1\/-rg1 alleviate experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells and upregulating regulatory T cells","volume":"53","author":"Lee","year":"2016","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.jgr.2024.09.005_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138592","article-title":"An oriental medicine, hyungbangpaedok-san attenuates motor paralysis in an experimental model of multiple sclerosis by regulating the T cell response","volume":"10","author":"Choi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jgr.2024.09.005_bib39","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.bbi.2020.12.004","article-title":"Gintonin mitigates experimental autoimmune encephalomyelitis by stabilization of Nrf2 signaling via stimulation of lysophosphatidic acid receptors","volume":"93","author":"Choi","year":"2021","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jgr.2024.09.005_bib40","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1006\/bbrc.2001.5388","article-title":"Iba1 is an actin-cross-linking protein in macrophages\/microglia","volume":"286","author":"Sasaki","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jgr.2024.09.005_bib41","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.3389\/fimmu.2017.01695","article-title":"Differentiation and transmigration of CD4 T cells in neuroinflammation and autoimmunity","volume":"8","author":"Sonar","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.jgr.2024.09.005_bib42","doi-asserted-by":"crossref","first-page":"27","DOI":"10.5493\/wjem.v4.i3.27","article-title":"Multiple sclerosis and the role of immune cells","volume":"4","author":"Hoglund","year":"2014","journal-title":"World J Exp Med"},{"key":"10.1016\/j.jgr.2024.09.005_bib43","doi-asserted-by":"crossref","first-page":"947","DOI":"10.3389\/fimmu.2020.00947","article-title":"Interleukin-17 in chronic inflammatory neurological diseases","volume":"11","author":"Milovanovic","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.jgr.2024.09.005_bib44","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.bbadis.2015.10.004","article-title":"Glial influences on BBB functions and molecular players in immune cell trafficking","volume":"1862","author":"Lecuyer","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jgr.2024.09.005_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/370804","article-title":"Parthenolide is neuroprotective in rat experimental stroke model: downregulating NF-kappaB, phospho-p38MAPK, and caspase-1 and ameliorating BBB permeability","volume":"2013","author":"Dong","year":"2013","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.jgr.2024.09.005_bib46","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fphar.2019.00286","article-title":"Targeting microglia and macrophages: a potential treatment strategy for multiple sclerosis","volume":"10","author":"Wang","year":"2019","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jgr.2024.09.005_bib47","doi-asserted-by":"crossref","first-page":"575","DOI":"10.15171\/apb.2018.066","article-title":"A review of herbal therapy in multiple sclerosis","volume":"8","author":"Mojaverrostami","year":"2018","journal-title":"Adv Pharmaceut Bull"},{"key":"10.1016\/j.jgr.2024.09.005_bib48","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s12987-020-00230-3","article-title":"A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity","volume":"17","author":"Kadry","year":"2020","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.jgr.2024.09.005_bib49","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12974-019-1403-x","article-title":"Blood-brain barrier permeability and physical exercise","volume":"16","author":"Malkiewicz","year":"2019","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.jgr.2024.09.005_bib50","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3892\/etm.2021.9741","article-title":"Ginseng gintonin attenuates the disruptions of brain microvascular permeability and microvascular endothelium junctional proteins in an APPswe\/PSEN-1 double-transgenic mouse model of Alphalzheimer's disease","volume":"21","author":"Jang","year":"2021","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.jgr.2024.09.005_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.661838","article-title":"Blood-brain barrier dysfunction amplifies the development of neuroinflammation: understanding of cellular events in brain microvascular endothelial cells for prevention and treatment of BBB dysfunction","volume":"15","author":"Takata","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.jgr.2024.09.005_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2014.08.007","article-title":"The blood-brain barrier in neuroimmunology: tales of separation and assimilation","volume":"44","author":"Banks","year":"2015","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jgr.2024.09.005_bib53","article-title":"Mechanistic studies of gypenosides in microglial state transition and its implications in depression-like behaviors: role of TLR4\/MyD88\/NF-kappaB signaling","volume":"13","author":"Cao","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.jgr.2024.09.005_bib54","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bbi.2020.04.052","article-title":"USP8 protects against lipopolysaccharide-induced cognitive and motor deficits by modulating microglia phenotypes through TLR4\/MyD88\/NF-kappaB signaling pathway in mice","volume":"88","author":"Zhao","year":"2020","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jgr.2024.09.005_bib55","doi-asserted-by":"crossref","first-page":"11283","DOI":"10.1039\/D2FO00776B","article-title":"Arginyl-fructosyl-glucose, a major Maillard reaction product of red ginseng mitigates cisplatin-evoked intestinal toxicity in vivo and in vitro","volume":"13","author":"Liu","year":"2022","journal-title":"Food Funct"},{"key":"10.1016\/j.jgr.2024.09.005_bib56","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bbi.2019.03.001","article-title":"Gintonin, a ginseng-derived ingredient, as a novel therapeutic strategy for Huntington's disease: activation of the Nrf2 pathway through lysophosphatidic acid receptors","volume":"80","author":"Jang","year":"2019","journal-title":"Brain Behav Immun"}],"container-title":["Journal of Ginseng Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1226845324001362?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1226845324001362?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T15:54:20Z","timestamp":1736178860000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1226845324001362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S1226845324001362"],"URL":"https:\/\/doi.org\/10.1016\/j.jgr.2024.09.005","relation":{},"ISSN":["1226-8453"],"issn-type":[{"value":"1226-8453","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-saponin from Panax ginseng maintains blood-brain barrier integrity by inhibiting NF-\u03baB and p38 MAP kinase signaling pathways to prevent the progression of experimental autoimmune encephalomyelitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Ginseng Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgr.2024.09.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Korean Society of Ginseng. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}