{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:15:31Z","timestamp":1788228931363,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002641","name":"Konkuk University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002641","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Ginseng Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jgr.2026.101083","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:54:11Z","timestamp":1782284051000},"page":"101083","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reglid: novel glycolipids from Korean red ginseng marc"],"prefix":"10.1016","volume":"50","author":[{"given":"Ji-Hun","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hee","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yebeen","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Mee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun-Hye","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ik-Hyun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0265-242X","authenticated-orcid":false,"given":"Seung-Yeol","family":"Nah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jgr.2026.101083_bib1","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.3346\/jkms.2016.31.12.1879","article-title":"Efficacy of ginseng supplements on fatigue and physical performance: a meta-analysis","volume":"31","author":"Bach","year":"2016","journal-title":"J Kor Med Sci"},{"key":"10.1016\/j.jgr.2026.101083_bib2","doi-asserted-by":"crossref","DOI":"10.2174\/0127724344376497251007045815","article-title":"Exploring the therapeutic potential of Panax ginseng: a comprehensive review of its pharmacological applications","author":"Sharma","year":"2025","journal-title":"Recent Adv Antiinfect Drug Discov"},{"issue":"2","key":"10.1016\/j.jgr.2026.101083_bib3","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1248\/cpb.22.421","article-title":"Studies on the saponins of ginseng. I. Structures of Ginsenoside-Ro, -Rb1, -Rb2, -Rc and -Rd","volume":"22","author":"Sanada","year":"1974","journal-title":"Chem Pharmaceut Bull"},{"issue":"5","key":"10.1016\/j.jgr.2026.101083_bib4","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1055\/s-2007-969758","article-title":"Partial structure of Panaxan a, a hypoglycaemic glycan of Panax Ginseng roots","volume":"50","author":"Tomoda","year":"1984","journal-title":"Planta Med"},{"issue":"1","key":"10.1016\/j.jgr.2026.101083_bib5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.5142\/jgr.2011.35.1.092","article-title":"Novel glycolipoproteins from ginseng","volume":"35","author":"Pyo","year":"2011","journal-title":"J Ginseng Res"},{"issue":"2","key":"10.1016\/j.jgr.2026.101083_bib6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/S10059-012-2216-z","article-title":"Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity","volume":"33","author":"Hwang","year":"2012","journal-title":"Mol Cells"},{"key":"10.1016\/j.jgr.2026.101083_bib7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fphys.2014.00098","article-title":"Ginseng ginsenoside pharmacology in the nervous system: involvement in the regulation of ion channels and receptors","volume":"5","author":"Nah","year":"2014","journal-title":"Front Physiol"},{"issue":"9","key":"10.1016\/j.jgr.2026.101083_bib8","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1002\/jsfa.6497","article-title":"Effects of dietary supplementation of red ginseng marc and \u03b1-tocopherol on the growth performance and meat quality of broiler chicken","volume":"94","author":"Kim","year":"2014","journal-title":"J Sci Food Agric"},{"issue":"11","key":"10.1016\/j.jgr.2026.101083_bib9","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.3390\/nu15112574","article-title":"Preparation of Red Ginseng Marc-derived gintonin and its application as a skin nutrient","volume":"15","author":"Lee","year":"2023","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.jgr.2026.101083_bib10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1142\/S0192415X25500028","article-title":"Korean red Ginseng Marc-derived gintonin improves alzheimer's cognitive dysfunction by upregulating LPAR1","volume":"53","author":"Ha","year":"2025","journal-title":"Am J Chin Med"},{"issue":"23","key":"10.1016\/j.jgr.2026.101083_bib11","doi-asserted-by":"crossref","first-page":"3794","DOI":"10.3390\/nu17233794","article-title":"Lipid-enriched gintonin from Korean red Ginseng Marc alleviates obesity via oral and central administration in diet-induced Obese mice","volume":"17","author":"Yasmin","year":"2025","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.jgr.2026.101083_bib12","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jgr.2022.10.001","article-title":"A novel protocol for batch-separating gintonin-enriched, polysaccharide-enriched, and crude ginsenoside-containing fractions from Panax ginseng","volume":"47","author":"Lee","year":"2023","journal-title":"J Ginseng Res"},{"issue":"2","key":"10.1016\/j.jgr.2026.101083_bib13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jgr.2017.11.006","article-title":"Bioactive lipids in gintonin-enriched fraction from ginseng","volume":"43","author":"Cho","year":"2019","journal-title":"J Ginseng Res"},{"issue":"4","key":"10.1016\/j.jgr.2026.101083_bib14","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jgr.2015.05.002","article-title":"A brief method for preparation of gintonin-enriched fraction from ginseng","volume":"39","author":"Choi","year":"2015","journal-title":"J Ginseng Res"},{"issue":"12","key":"10.1016\/j.jgr.2026.101083_bib15","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1111\/jocd.14068","article-title":"Lysophosphatidylcholine exerts an anti-skin photoaging effect via heat shock protein 70 induction","volume":"20","author":"Hwang","year":"2021","journal-title":"J Cosmet Dermatol"},{"issue":"18","key":"10.1016\/j.jgr.2026.101083_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241814094","article-title":"Gintonin-induced wound-healing-related responses involve epidermal-growth-factor-like effects in keratinocytes","volume":"24","author":"Won","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.jgr.2026.101083_bib17","article-title":"Autophagy and mitophagy in dermatological disease: a comprehensive review from molecular pathways to therapeutic frontiers","volume":"21","author":"D'Ambrosio","year":"2025","journal-title":"Biol Direct"},{"issue":"1","key":"10.1016\/j.jgr.2026.101083_bib18","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jgr.2018.08.004","article-title":"Gintonin stimulates autophagic flux in primary cortical astrocytes","volume":"44","author":"Rahman","year":"2020","journal-title":"J Ginseng Res"},{"issue":"7","key":"10.1016\/j.jgr.2026.101083_bib19","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3390\/antiox14070804","article-title":"Argan Callus extract restores skin cells via AMPK-dependent regulation of energy metabolism, autophagy, and inflammatory pathways","volume":"14","author":"Hartinger","year":"2025","journal-title":"Antioxidants"},{"issue":"21","key":"10.1016\/j.jgr.2026.101083_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262110752","article-title":"Skin-whitening effects of Cannabinol (CBN) through melanin inhibition in B16F10 melanoma cells","volume":"26","author":"Han","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"12","key":"10.1016\/j.jgr.2026.101083_bib21","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/2211-5463.12152","article-title":"The molecular mechanism by which saturated lysophosphatidylcholine attenuates the metastatic capacity of Melanoma cells","volume":"6","author":"Ross","year":"2016","journal-title":"FEBS Open Bio"},{"issue":"7","key":"10.1016\/j.jgr.2026.101083_bib22","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1158\/1535-7163.MCT-19-1095","article-title":"Inhibition of tumor cell growth and cancer stem cell expansion by a bispecific antibody targeting Egfr and Her3","volume":"19","author":"Rau","year":"2020","journal-title":"Mol Cancer Therapeut"},{"issue":"5","key":"10.1016\/j.jgr.2026.101083_bib23","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.jgr.2023.04.005","article-title":"Effect of anti-skin disorders of ginsenosides- A systematic review","volume":"47","author":"Cong","year":"2023","journal-title":"J Ginseng Res"},{"issue":"2","key":"10.1016\/j.jgr.2026.101083_bib24","doi-asserted-by":"crossref","first-page":"734","DOI":"10.3390\/ijms22020734","article-title":"Tyrosinase nanoparticles: understanding the melanogenesis pathway by isolating the products of tyrosinase enzymatic reaction","volume":"22","author":"Varghese","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10.1016\/j.jgr.2026.101083_bib25","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.3390\/ma5091661","article-title":"Natural melanogenesis inhibitors acting through the down-regulation of tyrosinase activity","volume":"5","author":"Chang","year":"2012","journal-title":"Materials"},{"issue":"8","key":"10.1016\/j.jgr.2026.101083_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22081303","article-title":"Upregulation of melanogenesis and tyrosinase activity: potential agents for vitiligo","volume":"22","author":"Niu","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.jgr.2026.101083_bib27","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.2147\/DMSO.S371370","article-title":"Lysophosphatidylcholine (17:0) improves HFD-induced hyperglycemia & insulin resistance: a mechanistic mice model study","volume":"15","author":"Bao","year":"2022","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"5","key":"10.1016\/j.jgr.2026.101083_bib28","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3390\/ijms20051149","article-title":"An updated review of Lysophosphatidylcholine metabolism in human diseases","volume":"20","author":"Law","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jgr.2026.101083_bib29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.mce.2017.12.002","article-title":"Lysophosphatidylcholine and its phosphorothioate analogues potentiate insulin secretion via GPR40 (FFAR1), GPR55 and GPR119 receptors in a different manner","volume":"472","author":"Drzazga","year":"2018","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"10.1016\/j.jgr.2026.101083_bib30","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1073\/pnas.2536801100","article-title":"T cell chemotaxis to lysophosphatidylcholine through the G2A receptor","volume":"101","author":"Radu","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"issue":"5","key":"10.1016\/j.jgr.2026.101083_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0065155","article-title":"Acyl chain-dependent effect of lysophosphatidylcholine on endothelium-dependent vasorelaxation","volume":"8","author":"Rao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jgr.2026.101083_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1587776","article-title":"Improved survival and neurological outcomes with lysophosphatidylcholine supplementation in severe cardiac arrest model","volume":"16","author":"Shoaib","year":"2025","journal-title":"Front Pharmacol"},{"issue":"3","key":"10.1016\/j.jgr.2026.101083_bib33","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/ana.26296","article-title":"Preserving brain LPC-DHA by plasma supplementation attenuates brain injury after cardiac arrest","volume":"91","author":"Nishikimi","year":"2022","journal-title":"Ann Neurol"},{"issue":"1","key":"10.1016\/j.jgr.2026.101083_bib34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12944-016-0305-5","article-title":"Effects of different fatty acids composition of phosphatidylcholine on brain function of dementia mice induced by scopolamine","volume":"15","author":"Zhou","year":"2016","journal-title":"Lipids Health Dis"},{"issue":"1","key":"10.1016\/j.jgr.2026.101083_bib35","doi-asserted-by":"crossref","first-page":"L91","DOI":"10.1152\/ajplung.00508.2005","article-title":"Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4","volume":"291","author":"Qiao","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.jgr.2026.101083_bib36","doi-asserted-by":"crossref","DOI":"10.5402\/2012\/506160","article-title":"Ganglioside biochemistry","volume":"2012","author":"Kolter","year":"2012","journal-title":"ISRN Biochem."},{"issue":"9","key":"10.1016\/j.jgr.2026.101083_bib37","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1002\/2211-5463.13651","article-title":"Glycolipids in Parkinson's disease: beyond neuronal function","volume":"13","author":"Spanos","year":"2023","journal-title":"FEBS Open Bio"},{"issue":"3","key":"10.1016\/j.jgr.2026.101083_bib38","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.bmc.2007.10.026","article-title":"Glycolipids as immunostimulating agents","volume":"16","author":"Wu","year":"2008","journal-title":"Bioorg Med Chem"}],"container-title":["Journal of Ginseng Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1226845326001090?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1226845326001090?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:20:40Z","timestamp":1788225640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1226845326001090"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1226845326001090"],"URL":"https:\/\/doi.org\/10.1016\/j.jgr.2026.101083","relation":{},"ISSN":["1226-8453"],"issn-type":[{"value":"1226-8453","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reglid: novel glycolipids from Korean red ginseng marc","name":"articletitle","label":"Article Title"},{"value":"Journal of Ginseng Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgr.2026.101083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Korean Society of Ginseng. Publishing services by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"101083"}}