{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:42:08Z","timestamp":1761648128453},"reference-count":52,"publisher":"Elsevier BV","issue":"1","content-domain":{"domain":["em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal de Gyn\u00e9cologie Obst\u00e9trique et Biologie de la Reproduction"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.jgyn.2013.08.013","type":"journal-article","created":{"date-parts":[[2013,12,15]],"date-time":"2013-12-15T02:00:17Z","timestamp":1387072817000},"page":"5-11","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interpr\u00e9tation des valeurs atypiques des marqueurs s\u00e9riques"],"prefix":"10.1016","volume":"43","author":[{"given":"C.","family":"Geyl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Subtil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Vaast","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Coulon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Clouqueur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Deruelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Debarge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgyn.2013.08.013_bib0005","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/aje\/kwr240","article-title":"Epidemiology of Down syndrome: new insight into the multidimensional interactions among genetic and environmental risk factors in the oocyte","volume":"174","author":"Ghosh","year":"2011","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0010","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1002\/ajmg.a.34252","article-title":"Neurodevelopmental outcomes in children with Down syndrome and congenital heart defects","volume":"155A","author":"Visootsak","year":"2011","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0015","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/j.1600-0412.1999.780509.x","article-title":"Second trimester maternal serum screening using alpha-fetoprotein, free beta human chorionic gonadotropin and maternal age specific risk: result of chromosomal abnormalities detected in screen positive for Down syndrome in an Asian population","volume":"78","author":"Chao","year":"1999","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0020","series-title":"Annales du contr\u00f4le national de qualit\u00e9 des analyses de biologie m\u00e9dicale","year":"2010"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0025","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S1701-2163(16)32973-5","article-title":"Obstetrical complications associated with abnormal maternal serum markers analytes","volume":"30","author":"Gagnon","year":"2008","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0030","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/pd.600","article-title":"Frequency and clinical consequences of extremely high maternal serum PAPP-A levels","volume":"23","author":"Cuckle","year":"2003","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0035","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/pd.2715","article-title":"First trimester maternal serum PAPP-A and free \u03b2-hCG levels in hyperemesis gravidarum","volume":"31","author":"Derbent","year":"2011","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0040","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ejogrb.2011.03.004","article-title":"Decreased PAPP-A is associated with preeclampsia, premature delivery and small for gestational age infants but not with placental abruption","volume":"157","author":"Ranta","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0045","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.placenta.2011.01.016","article-title":"First trimester serum analytes, biophysical tests and the association with pathological morphometry in the placenta of pregnancies with preeclampsia and fetal growth restriction","volume":"32","author":"Odibo","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0050","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/j.cca.2010.06.024","article-title":"Screening for adverse pregnancy outcome at early gestational age","volume":"411","author":"Hourrier","year":"2010","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0055","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/(SICI)1097-0223(199908)19:8<706::AID-PD613>3.0.CO;2-W","article-title":"Second trimester pregnancy associated plasma protein A levels are reduced in Cornelia de Lange syndrome pregnancies","volume":"19","author":"Aitken","year":"1999","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0060","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/0002-9378(90)90700-H","article-title":"Maternal serum Down syndrome screening: free beta-protein is a more effective marker than human chorionic gonadotropin","volume":"163","author":"Macri","year":"1990","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0065","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/1097-0223(200009)20:9<770::AID-PD923>3.0.CO;2-Y","article-title":"Maternal serum total hCG and free \u03b2-hCG in the first trimester from trisomy 21\u00a0pregnancies","volume":"20","author":"Spencer","year":"2000","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0070","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-0223(200004)20:4<311::AID-PD809>3.0.CO;2-P","article-title":"Is maternal serum total hCG a marker of trisomy 21\u00a0in the first trimester of pregnancy?","volume":"20","author":"Spencer","year":"2000","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0075","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/pd.2347","article-title":"Is maternal renal disease a cause of elevated free beta-hCG in first trimester aneuploidy screening?","volume":"29","author":"Spencer","year":"2009","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0080","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/pd.2858","article-title":"PAPP-A and free \u03b2-hCG in relation to admission to neonatal intensive care unit and neonatal disease","volume":"31","author":"Kirkegaard","year":"2011","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0085","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0140-6736(72)91634-0","article-title":"Alpha-fetoprotein in the antenatal diagnosis of anencephaly and spina bifida","volume":"2","author":"Brock","year":"1972","journal-title":"Lancet"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0090","first-page":"1323","article-title":"Maternal serum alpha-fetoprotein measurement in antenatal screening for anencephaly and spina bifida in early pregnancy. Report of UK collaborative study on alpha-fetoprotein in relation to neural tube defects","volume":"1","author":"Wald","year":"1977","journal-title":"Lancet"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0095","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1471-0528.2000.tb11709.x","article-title":"Maternal serum alpha-fetoprotein screening for open neural tube defects: revised statistical parameters","volume":"107","author":"Wald","year":"2000","journal-title":"BJOG"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0100","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1136\/jms.7.2.74","article-title":"Assay precision of serum alpha-fetoprotein in antenatal screening for neural tube defects and Down's syndrome","volume":"7","author":"Wald","year":"2000","journal-title":"J Med Screen"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0105","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/uog.3865","article-title":"Prenatal diagnosis of open and closed spina bifida","volume":"28","author":"Ghi","year":"2006","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0110","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/01.AOG.0000178780.63956.3b","article-title":"Routine ultrasonography compared with maternal serum alpha-fetoprotein for neural tube defect screening","volume":"106","author":"Norem","year":"2005","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0115","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S1028-4559(08)60125-4","article-title":"Prenatal diagnosis, fetal surgery, recurrence risk and differential diagnosis of neural tube defects","volume":"47","author":"Chen","year":"2008","journal-title":"Taiwan J Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0120","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.cll.2010.04.010","article-title":"Screening for open neural tube defects","volume":"30","author":"Krantz","year":"2010","journal-title":"Clin Lab Med"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0125","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-2008-1040756","article-title":"Maternal serum alpha-fetoprotein levels in chorioangiomas","volume":"11","author":"Khong","year":"1994","journal-title":"Am J Perinatol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0130","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/pd.1970120115","article-title":"Not all chorioangiomas are associated with elevated maternal serum alpha-fetoprotein","volume":"12","author":"Jauniaux","year":"1992","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0135","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.jpedsurg.2007.07.047","article-title":"Fetal and neonatal hepatic tumors","volume":"42","author":"Isaacs","year":"2007","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0140","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0002-9378(89)90501-2","article-title":"Predictive values, relative risks, and overall benefits of high and low maternal serum alpha-fetoprotein screening in singleton pregnancies: new epidemiologic data","volume":"161","author":"Milunsky","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0145","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1067\/S0002-9378(03)00769-5","article-title":"Unexplained elevated maternal serum alpha-fetoprotein and\/or human chorionic gonadotropin and the risk of adverse outcomes","volume":"189","author":"Chandra","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0150","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1067\/mob.2001.114864","article-title":"The association of abnormal alpha-fetoprotein and adverse pregnancy outcome: does increased fetal surveillance affect pregnancy outcome?","volume":"184","author":"Huerta-Enochian","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0155","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejogrb.2009.04.017","article-title":"Is elevated maternal serum alpha-fetoprotein in the second trimester of pregnancy associated with increased preterm birth risk? A systematic review and meta-analysis","volume":"145","author":"Yuan","year":"2009","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0160","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/pd.3932","article-title":"Second trimester maternal serum markers and placenta accreta","volume":"32","author":"Dreux","year":"2012","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0165","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1097\/AOG.0b013e3181da7929","article-title":"Fetomaternal hemorrhage","volume":"115","author":"Wylie","year":"2010","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0170","article-title":"Comment interpr\u00e9ter les marqueurs s\u00e9riques de trisomie 21","volume":"26-27","author":"Col","year":"2007","journal-title":"Lett Actual Perinat"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0175","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/pd.756","article-title":"Medically assisted reproduction and second trimester maternal serum marker screening for Down syndrome","volume":"23","author":"Muller","year":"2003","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0180","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/clinchem\/37.6.809","article-title":"Evaluation of an assay of the free beta-subunit of choriogonadotropin and its potential value in screening for Down's syndrome","volume":"37","author":"Spencer","year":"1991","journal-title":"Clin Chem"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0185","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/pd.1970070904","article-title":"Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities","volume":"7","author":"Bogart","year":"1987","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0190","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/pd.1970090602","article-title":"Human chorionic gonadotropin levels in pregnancies with aneuploid fetuses","volume":"9","author":"Bogart","year":"1989","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0195","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/0002-9378(93)90701-J","article-title":"An association between elevated levels of human chorionic gonadotropin in the mid-trimester and adverse pregnancy outcome","volume":"168","author":"Lieppman","year":"1993","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0200","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/pd.1970130106","article-title":"Prospective maternal serum human chorionic gonadotropin screening for the risk of fetal chromosome anomalies and of subsequent fetal and neonatal deaths","volume":"13","author":"Muller","year":"1993","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0205","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.placenta.2011.01.018","article-title":"Villous trophoblast abnormalities in extremely preterm deliveries with elevated second trimester maternal serum hCG or inhibin-A","volume":"32","author":"Fitzgerald","year":"2011","journal-title":"Placenta"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0210","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/pd.438","article-title":"Second trimester trisomy 21\u00a0maternal serum marker screening. Results of a countrywide study of 854,902\u00a0patients","volume":"22","author":"Muller","year":"2002","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0215","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/pd.139","article-title":"Second trimester maternal serum analytes in triploid pregnancies: correlation with phenotype and sex chromosome complement","volume":"21","author":"Benn","year":"2001","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0220","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1471-0528.1988.tb06601.x","article-title":"Low second trimester maternal serum unconjugated oestriol in pregnancies with Down's syndrome","volume":"95","author":"Canick","year":"1988","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0225","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.arcped.2005.01.007","article-title":"[Adrenal hypoplasia congenita: four new cases in children]","volume":"12","author":"P\u00e9lissier","year":"2005","journal-title":"Arch Pediatr"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0265","series-title":"Int\u00e9r\u00eat de l\u2019\u0153striol s\u00e9rique maternel au 2e trimestre de la grossesse","author":"Leporrier","year":"2009"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0235","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1471-0528.1996.tb09738.x","article-title":"The usefulness of hCG and unconjugated oestriol in prenatal diagnosis of trisomy 18","volume":"103","author":"Leporrier","year":"1996","journal-title":"Br J Obstet Gynaecol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0240","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/pd.2588","article-title":"Prevalence of steroid sulfatase deficiency in California according to race and ethnicity","volume":"30","author":"Craig","year":"2010","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0245","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/pd.2284","article-title":"Maternal urine and serum steroid measurements to identify steroid sulfatase deficiency (STSD) in second trimester pregnancies","volume":"29","author":"Marcos","year":"2009","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0250","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1479-828X.1999.tb03384.x","article-title":"Low maternal serum oestriol at mid-trimester may indicate a fetal disorder of cholesterol biosynthesis","volume":"39","author":"Craig","year":"1999","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0255","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/(SICI)1097-0223(199808)18:8<789::AID-PD345>3.0.CO;2-9","article-title":"Steroid sulphatase deficiency is the major cause of extremely low oestriol production at mid-pregnancy: a urinary steroid assay for the discrimination of steroid sulphatase deficiency from other causes","volume":"18","author":"Glass","year":"1998","journal-title":"Prenat Diagn"},{"key":"10.1016\/j.jgyn.2013.08.013_bib0260","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000020906","article-title":"Antenatal therapy of Smith-Lemli-Opitz syndrome","volume":"14","author":"Irons","year":"1999","journal-title":"Fetal Diagn Ther"}],"container-title":["Journal de Gyn\u00e9cologie Obst\u00e9trique et Biologie de la Reproduction"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0368231513002147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0368231513002147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T04:04:05Z","timestamp":1597205045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0368231513002147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0368231513002147"],"URL":"https:\/\/doi.org\/10.1016\/j.jgyn.2013.08.013","relation":{},"ISSN":["0368-2315"],"issn-type":[{"value":"0368-2315","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interpr\u00e9tation des valeurs atypiques des marqueurs s\u00e9riques","name":"articletitle","label":"Article Title"},{"value":"Journal de Gyn\u00e9cologie Obst\u00e9trique et Biologie de la Reproduction","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgyn.2013.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}