{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:36:57Z","timestamp":1791139017327,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal de Gyn\u00e9cologie Obst\u00e9trique et Biologie de la Reproduction"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.jgyn.2014.12.011","type":"journal-article","created":{"date-parts":[[2015,2,7]],"date-time":"2015-02-07T20:36:41Z","timestamp":1423341401000},"page":"203-211","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pharmacologie du m\u00e9thotrexate"],"prefix":"10.1016","volume":"44","author":[{"given":"L.","family":"Lagarce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Zenut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Lain\u00e9-Cessac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jgyn.2014.12.011_bib0005","series-title":"Les bases pharmacologiques de l\u2019utilisation des m\u00e9dicaments","author":"Hardman","year":"1996"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0010","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/GRF.0b013e3182510a35","article-title":"Methotrexate: the pharmacology behind medical treatment for ectopic pregnancy","volume":"55","author":"Stika","year":"2012","journal-title":"Clin Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0015","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0162-3109(00)00189-2","article-title":"Mechanisms of action of methotrexate","volume":"47","author":"Genestier","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0020","first-page":"215","article-title":"Pharmacological treatment of ectopic pregnancy","volume":"48","author":"Bourget","year":"1993","journal-title":"Therapie"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0025","series-title":"Micromedex","year":"2014"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0030","series-title":"Medications and mother's milk","author":"Hale","year":"2010"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0035","first-page":"494","article-title":"Methotrexate use in a lactating woman with an ectopic pregnancy","volume":"85","author":"Tanaka","year":"2009","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0040","first-page":"399","article-title":"Pharmacokinetics of methotrexate and clinical response associated in the medical treatment of ectopic pregnancies","volume":"46","author":"Bourget","year":"1991","journal-title":"Therapie"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0045","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/S0015-0282(16)54923-1","article-title":"Pharmacokinetics of methotrexate after local tubal injection for conservative treatment of ectopic pregnancy","volume":"57","author":"Schiff","year":"1992","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0050","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/S0002-9378(97)70089-9","article-title":"Methotrexate pharmacokinetics and effects in women receiving methotrexate 50mg and 60mg per square meter for early abortion","volume":"177","author":"Creinin","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0055","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1365-2141.2009.07765.x","article-title":"Advances in individual prediction of methotrexate toxicity: a review","volume":"146","author":"Schmiegelow","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0060","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0140-6736(97)05487-1","article-title":"Randomised trial of systemic methotrexate versus laparoscopic salpingostomy in tubal pregnancy","volume":"350","author":"Hajenius","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0065","first-page":"CD000324","article-title":"Interventions for tubal ectopic pregnancy","volume":"1","author":"Hajenius","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0070","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0029-7844(02)03158-7","article-title":"The medical management of ectopic pregnancy: a meta-analysis comparing \u201csingle dose\u201d and \u201cmultidose\u201d regimens","volume":"101","author":"Barnhart","year":"2003","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0075","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.bpobgyn.2008.12.007","article-title":"Conservative management of tubal ectopic pregnancy","volume":"23","author":"van Mello","year":"2009","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0080","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.fertnstert.2012.03.037","article-title":"Role of routine monitoring of liver and renal function during treatment of ectopic pregnancies with single-dose methotrexate protocol","volume":"98","author":"Clark","year":"2012","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0085","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1080\/01443610802163773","article-title":"Is routine monitoring of hepatic and renal function beneficial following single-dose methotrexate treatment for ectopic pregnancy? A 4-year review of experience from a teaching hospital","volume":"28","author":"Darbhamulla","year":"2008","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0090","first-page":"871","article-title":"Fatal multiorgan toxicity indced by low dose methotrexate for evacuate an ectopic pregnancy","volume":"36","author":"Salouage","year":"2013","journal-title":"Drug Saf"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0095","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/01.AOG.0000172374.72125.3e","article-title":"A cautionary tale: fatal outcome of methotrexate therapy given for management of ectopic pregnancy","volume":"107","author":"Kelly","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0100","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1097\/01.AOG.0000220536.61966.df","article-title":"A cautionary tale: fatal outcome of methotrexate therapy given for management of ectopic pregnancy","volume":"107","author":"Teal","year":"2006","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0105","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00228-013-1608-3","article-title":"Almost a tragedy: severe methotrexate toxicity in a hemodialysis patient treated for ectopic pregnancy","volume":"70","author":"Willner","year":"2014","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0110","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0029-7844(96)00370-5","article-title":"Methotrexate prophylaxis for persistent ectopic pregnancy after conservative treatment by salpingostomy","volume":"89","author":"Graczykowski","year":"1997","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0115","first-page":"258","article-title":"Febrile neutropenia following single dose methotrexate for medical management of ectopic pregnancy: case report","volume":"23","author":"Gungor Ugurlucan","year":"2013","journal-title":"Turkiye Klinikleri Jinekoloji Obstrtrik"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0120","first-page":"2012","article-title":"Life-threatening complications following multidose methotrexate for medical management of ectopic pregnancy","author":"Dasari","year":"2012","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0125","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/0029-7844(96)00252-9","article-title":"Life-threatening neutropenia following methotrexate treatment of ectopic pregnancy: a report of two cases","volume":"88","author":"Isaacs","year":"1996","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0130","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/014436100434893","article-title":"A fatal methotrexate-treated case of ectopic pregnancy with genital tuberculosis","volume":"20","author":"Chhabra","year":"2000","journal-title":"J Obstet Gynaecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0135","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/0002-9378(87)90315-2","article-title":"Nonsurgical therapy to preserve oviduct function in patients with tubal pregnancies","volume":"156","author":"Ichinoe","year":"1987","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0140","first-page":"740","article-title":"Nonsurgical management of ectopic pregnancy associated with severe hyperstimulation syndrome","volume":"66","author":"Chotiner","year":"1985","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0145","first-page":"520","article-title":"Methotrexate pneumonitis in nonsurgical treatment of ectopic pregnancy","volume":"80","author":"Schoenfeld","year":"1992","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0150","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0002-9378(97)70578-7","article-title":"Methotrexate pneumonitis after systemic treatment for ectopic pregnancy","volume":"176","author":"Horrigan","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0155","first-page":"379","article-title":"Methotrexate and the photodermatitis reactivation reaction: a case report and review of the literature","volume":"66","author":"Khan","year":"2000","journal-title":"Cutis"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0160","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1016\/j.jaad.2009.09.015","article-title":"Atypical methotrexate-induced ultraviolet recall phenomenon during the treatment of ectopic pregnancy","volume":"63","author":"Wackowski","year":"2010","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0165","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1097\/01.AOG.0000127941.83892.e1","article-title":"A rare drug reaction to methotrexate after treatment for ectopic pregnancy","volume":"103","author":"Straka","year":"2004","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0170","first-page":"754","article-title":"Single-dose methotrexate for treatment of ectopic pregnancy","volume":"77","author":"Stovall","year":"1991","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0175","first-page":"807","article-title":"Ectopic pregnancy. Diagnostic and therapeutic algorithms minimizing surgical intervention","volume":"38","author":"Stovall","year":"1993","journal-title":"J Reprod Med"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0180","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/0248-8663(96)83098-0","article-title":"Dose expression of antineoplastic drugs","volume":"17","author":"Favre","year":"1996","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0185","first-page":"647","article-title":"Use of body weight and body surface area in dosing of anticancer agents in adult patients","volume":"94","author":"Leveque","year":"2007","journal-title":"Bull Cancer"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0190","first-page":"CD000951","article-title":"Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis","volume":"5","author":"Shea","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0195","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s100249900069","article-title":"Methotrexate-resistant form of dihydrofolate reductase protects transgenic murine embryos from teratogenic effects of methotrexate","volume":"1","author":"Sutton","year":"1998","journal-title":"Pediatr Dev Pathol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0200","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/bdra.23003","article-title":"Teratogen update: methotrexate","volume":"94","author":"Hyoun","year":"2012","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0205","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/tera.1420170314","article-title":"Aminopterin and methotrexate: folic acid deficiency","volume":"17","author":"Warkany","year":"1978","journal-title":"Teratology"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0210","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/art.1780400527","article-title":"Multiple congenital anomalies associated with weekly low-dose methotrexate treatment of the mother","volume":"40","author":"Buckley","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0215","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/qjmed\/92.10.551","article-title":"The effects of methotrexate on pregnancy, fertility and lactation","volume":"92","author":"Lloyd","year":"1999","journal-title":"QJM"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0220","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.fertnstert.2011.06.014","article-title":"Importance of timing of gestational exposure to methotrexate for its teratogenic effects when used in setting of misdiagnosis of ectopic pregnancy","volume":"96","author":"Poggi","year":"2011","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0225","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1007\/s00246-011-9913-z","article-title":"Congenital cardiac defects: a possible association of aminopterin syndrome and in utero methotrexate exposure?","volume":"32","author":"Piggott","year":"2011","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0230","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ijgo.2007.05.039","article-title":"Methotrexate embryopathy after therapy for misdiagnosed ectopic pregnancy","volume":"99","author":"Usta","year":"2007","journal-title":"Int J Gynaecol Obstet"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0235","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S1701-2163(16)30422-4","article-title":"Methotrexate embryopathy in a surviving intrauterine fetus after presumed diagnosis of ectopic pregnancy: case report","volume":"26","author":"Addar","year":"2004","journal-title":"J Obstet Gynaecol Can"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0240","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ajog.2011.07.002","article-title":"Outcome following high-dose methotrexate in pregnancies misdiagnosed as ectopic","volume":"205","author":"Nurmohamed","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0245","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/ajmg.a.20503","article-title":"Methotrexate\/misoprostol embryopathy: report of four cases resulting from failed medical abortion","volume":"123A","author":"Adam","year":"2003","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0250","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/tera.1420470605","article-title":"Clinical teratology counseling and consultation case report: low dose methotrexate exposure in the early weeks of pregnancy","volume":"47","author":"Feldkamp","year":"1993","journal-title":"Teratology"},{"key":"10.1016\/j.jgyn.2014.12.011_bib0255","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/art.38368","article-title":"Pregnancy outcome after methotrexate treatment for rheumatic disease prior to or during early pregnancy: a prospective multicenter cohort study","volume":"66","author":"Weber-Schoendorfer","year":"2014","journal-title":"Arthritis Rheumatol"}],"container-title":["Journal de Gyn\u00e9cologie Obst\u00e9trique et Biologie de la Reproduction"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0368231514003445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0368231514003445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T11:21:26Z","timestamp":1537874486000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0368231514003445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0368231514003445"],"URL":"https:\/\/doi.org\/10.1016\/j.jgyn.2014.12.011","relation":{},"ISSN":["0368-2315"],"issn-type":[{"value":"0368-2315","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacologie du m\u00e9thotrexate","name":"articletitle","label":"Article Title"},{"value":"Journal de Gyn\u00e9cologie Obst\u00e9trique et Biologie de la Reproduction","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jgyn.2014.12.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}