{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:08:08Z","timestamp":1793531288941,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51209125"],"award-info":[{"award-number":["51209125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Foundation for the Doctoral Program of Higher Education of China","award":["20110131120014"],"award-info":[{"award-number":["20110131120014"]}]},{"name":"Promotive Research Foundation for Young and Middle-aged Scientists of Shandong Province of China","award":["2013BSE27073"],"award-info":[{"award-number":["2013BSE27073"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hazardous Materials"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.jhazmat.2014.11.027","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T16:49:07Z","timestamp":1416847747000},"page":"517-524","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Influence of coexisting spiramycin contaminant on the harm of Microcystis aeruginosa at different nitrogen levels"],"prefix":"10.1016","volume":"285","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhazmat.2014.11.027_bib0005","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.hal.2004.12.004","article-title":"Bloom dynamics and biological control of a high biomass HAB species in European coastal waters: a Phaeocystis case study","volume":"4","author":"Veldhuis","year":"2005","journal-title":"Harmful Algae"},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0010","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.plaphy.2013.01.011","article-title":"Phosphate deficiency (N\/P 40:1) induces mcyD transcription and microcystin synthesis in Microcystis aeruginosa PCC7806","volume":"65","author":"Kuniyoshi","year":"2013","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0015","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1021\/es103538b","article-title":"Global gene expression profiling in larval zebrafish exposed to microcystin-LR and microcystis reveals endocrine disrupting effects of cyanobacteria","volume":"45","author":"Rogers","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0020","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.hal.2009.02.004","article-title":"The effects of temperature and nutrients on the growth and dynamics of toxic and non-toxic strains of Microcystis during cyanobacteria blooms","volume":"8","author":"Davis","year":"2009","journal-title":"Harmful Algae"},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.hal.2007.05.012","article-title":"Statistical study on the effects of environmental factors on the growth and microcystins production of bloom-forming cyanobacterium Microcystis aeruginosa","volume":"7","author":"Jiang","year":"2008","journal-title":"Harmful Algae"},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0030","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1128\/AEM.67.1.278-283.2001","article-title":"Cellular microcystin content in N-limited Microcystis aeruginosa can be predicted from growth rate","volume":"67","author":"Long","year":"2001","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0035","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/tox.20106","article-title":"Microcystin content of Microcystis aeruginosa is modulated by nitrogen uptake rate relative to specific growth rate or carbon fixation rate","volume":"20","author":"Downing","year":"2005","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0040","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1128\/AEM.67.8.3340-3349.2001","article-title":"Ecological aspects of ntcA gene expression and its use as an indicator of the nitrogen status of marine Synechococcus spp","volume":"67","author":"Lindell","year":"2001","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0045","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.scitotenv.2004.09.028","article-title":"Differential sensitivity of three cyanobacterial and five green algal species to organotins and pyrethroids pesticides","volume":"341","author":"Ma","year":"2005","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0050","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.jhazmat.2012.08.029","article-title":"Low concentrations of polycyclic aromatic hydrocarbons promote the growth of Microcystis aeruginosa","volume":"237\u2013238","author":"Zhu","year":"2012","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0055","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ecoenv.2010.10.015","article-title":"Effects of minocycline and its degradation products on the growth of Microcystis aeruginosa","volume":"74","author":"Stoichev","year":"2011","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemosphere.2010.04.011","article-title":"Comparing the sensitivity of algal: cyanobacterial and bacterial bioassays to different groups of antibiotics","volume":"80","author":"Van der Grinten","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0065","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.chemosphere.2012.01.031","article-title":"Phytoplankton toxicity of the antibiotic chlortetracycline and its UV light degradation products","volume":"87","author":"Chen","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0070","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s10646-011-0845-4","article-title":"Analyses of gene expression and physiological changes in Microcystis aeruginosa reveal the phytotoxicities of three environmental pollutants","volume":"21","author":"Qian","year":"2012","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0075","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ecoenv.2011.10.027","article-title":"Influences of two antibiotic contaminants on the production, release and toxicity of microcystins","volume":"77","author":"Liu","year":"2012","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0080","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.aquatox.2011.01.016","article-title":"Temperature-dependent sensitivity of growth and photosynthesis of Scenedesmus obliquus: Navicula pelliculosa and two strains of Microcystis aeruginosa to the herbicide atrazine","volume":"103","author":"Chalifour","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0085","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bse.2011.12.015","article-title":"Combined effects of temperature light intensity, and nitrogen concentration on the growth and polysaccharide content of Microcystis aeruginosa in batch culture","volume":"41","author":"Yang","year":"2012","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0090","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1007\/s11270-013-1494-4","article-title":"Response of toxic cyanobacterium Microcystis aeruginosa to environmental pollution","volume":"224","author":"Polyak","year":"2013","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0095","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.jhazmat.2010.03.110","article-title":"Source, occurrence and fate of antibiotics in the Italian aquatic environment","volume":"179","author":"Zuccato","year":"2010","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0100","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.hal.2012.01.003","article-title":"Detection and identification of potentially toxic cyanobacteria: ubiquitous distribution of Microcystis aeruginosa and Cuspidothrix issatschenkoi in Japanese lakes","volume":"16","author":"Hodoki","year":"2012","journal-title":"Harmful Algae"},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0105","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.chemosphere.2010.10.010","article-title":"Growth photosynthesis and antioxidant responses of two microalgal species, Chlorella vulgaris and Selenastrum capricornutum, to nonylphenol stress","volume":"82","author":"Gao","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0110","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye biding","volume":"72","author":"Braford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0115","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jhazmat.2014.07.002","article-title":"Combined effects of two antibiotic contaminants on Microcystis aeruginosa","volume":"279","author":"Liu","year":"2014","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0120","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.chemosphere.2009.01.021","article-title":"Allelopathic mechanism of pyrogallol to Microcystis aeruginosa PCC7806 (Cyanobacteria): from views of gene expression and antioxidant system","volume":"75","author":"Shao","year":"2009","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0125","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.chemosphere.2013.06.031","article-title":"Mechanisms of photosynthetic inactivation on growth suppression of Microcystis aeruginosa under UV-C stress","volume":"93","author":"Tao","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0130","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u2206\u2206CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0135","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.etap.2013.01.006","article-title":"Toxicity studies of tetracycline on Microcystis aeruginosa and Selenastrum capricornutum","volume":"35","author":"Yang","year":"2013","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0140","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/tox.20636","article-title":"Effects of streptomycin on growth of algae Chlorella vulgaris and Microcystis aeruginosa","volume":"27","author":"Qian","year":"2012","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0145","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0005-2787(68)90504-2","article-title":"Mechanism of inhibition of protein synthesis by spiramycin","volume":"166","author":"Ahmed","year":"1968","journal-title":"Biochim. Biophys. Acta"},{"issue":"Suppl. B","key":"10.1016\/j.jhazmat.2014.11.027_bib0150","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jac\/22.Supplement_B.13","article-title":"Mechanism of action of spiramycin and other macrolides","volume":"22","author":"Brisson-No\u00ebl","year":"1988","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0155","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1007\/s00248-004-0054-2","article-title":"Medium N:P ratios and specific growth rate comodulate microcystin and protein content in Microcystis aeruginosa PCC7806 and M. aeruginosa UV027","volume":"49","author":"Downing","year":"2005","journal-title":"Microb. Ecol."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0160","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.envexpbot.2009.09.003","article-title":"Carbon, nitrogen and antioxidant enzyme responses of Potamogeton crispus to both low-light and high-nutrient stresses","volume":"68","author":"Zhang","year":"2009","journal-title":"Environ. Exp. Bot."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0165","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.chemosphere.2010.03.042","article-title":"Cellular responses: biodegradation and bioaccumulation of endocrine disrupting chemicals in marine diatom Navicula incerta","volume":"80","author":"Liu","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0170","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00248-001-0041-9","article-title":"Effect of nitrogen and phosphorus on growth of toxic and nontoxic Microcystis strains and on intracellular microcystin concentrations","volume":"43","author":"V\u00e9zie","year":"2002","journal-title":"Microb. Ecol."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0175","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF00042982","article-title":"Minireview: regulation of cyanobacterial pigment-protein composition and organization by environmental factors","volume":"18","author":"Riethman","year":"1988","journal-title":"Photosynth. Res."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0180","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0031-9422(96)00573-0","article-title":"Effect of irradiance on fatty acid carotenoid, total protein composition and growth of Microcystis aeruginosa","volume":"44","author":"Walsh","year":"1997","journal-title":"Phytochemistry"},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0185","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1105\/tpc.3.4.383","article-title":"Expression of a higher plant psbA gene in Synechocystis 6803 yields a functional hybrid photosystem II reaction center complex","volume":"3","author":"Nixon","year":"1991","journal-title":"Plant Cell"},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0190","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1093\/jxb\/erm242","article-title":"Rubiscolytics: fate of Rubisco after its enzymatic function in a cell is terminated","volume":"59","author":"Feller","year":"2008","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0195","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s10811-013-0057-9","article-title":"Algicidal activity and potential mechanisms of ginkgolic acids isolated from Ginkgo biloba exocarp on Microcystis aeruginosa","volume":"26","author":"Zhang","year":"2014","journal-title":"J. Appl. Phycol."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0200","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1529-8817.2006.00176.x","article-title":"Exploring the natural role of microcystins\u2014a review of effects on photoautotrophic organisms","volume":"42","author":"Babica","year":"2006","journal-title":"J. Phycol."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0205","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.aquatox.2013.10.023","article-title":"Enantioselective changes in oxidative stress and toxin release in Microcystis aeruginosa exposed to chiral herbicide diclofop acid","volume":"146","author":"Ye","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.jhazmat.2014.11.027_bib0210","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s10646-010-0500-5","article-title":"Microcystin-LR synthesis as response to nitrogen: transcriptional analysis of the mcyD gene in Microcystis aeruginosa PCC7806","volume":"19","author":"Sevilla","year":"2010","journal-title":"Ecotoxicology"}],"container-title":["Journal of Hazardous Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304389414009340?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304389414009340?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T09:21:37Z","timestamp":1538040097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304389414009340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":42,"alternative-id":["S0304389414009340"],"URL":"https:\/\/doi.org\/10.1016\/j.jhazmat.2014.11.027","relation":{},"ISSN":["0304-3894"],"issn-type":[{"value":"0304-3894","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of coexisting spiramycin contaminant on the harm of Microcystis aeruginosa at different nitrogen levels","name":"articletitle","label":"Article Title"},{"value":"Journal of Hazardous Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhazmat.2014.11.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}