{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:26:45Z","timestamp":1787563605474,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,11,1]],"date-time":"2016-11-01T00:00:00Z","timestamp":1477958400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41271491"],"award-info":[{"award-number":["41271491"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hazardous Materials"],"published-print":{"date-parts":[[2016,11]]},"DOI":"10.1016\/j.jhazmat.2016.06.054","type":"journal-article","created":{"date-parts":[[2016,6,28]],"date-time":"2016-06-28T09:30:06Z","timestamp":1467106206000},"page":"109-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Whole-body aerosol exposure of cadmium chloride (CdCl2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice"],"prefix":"10.1016","volume":"318","author":[{"given":"Yuanhong","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0515-5680","authenticated-orcid":false,"given":"Shuyun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoqi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlie","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishu","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4003-7919","authenticated-orcid":false,"given":"Qiaoxiang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhazmat.2016.06.054_bib0005","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.scitotenv.2009.09.044","article-title":"E-waste: an assessment of global production and environmental impacts","volume":"408","author":"Robinson","year":"2009","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0010","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.envpol.2007.01.044","article-title":"Export of toxic chemicals: a review of the case of uncontrolled electronic-waste recycling","volume":"149","author":"Wong","year":"2007","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0015","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1016\/j.scitotenv.2008.10.063","article-title":"Life cycle assessment study of a Chinese desktop personal computer","volume":"407","author":"Duan","year":"2009","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0020","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1177\/0734242X06062499","article-title":"Electrical and electronic waste management in China: progress and the barriers to overcome","volume":"24","author":"Liu","year":"2006","journal-title":"Waste Manage. Res."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0025","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.proenv.2012.10.070","article-title":"Present status of e-waste disposal and recycling in China","volume":"16","author":"Wei","year":"2012","journal-title":"Procedia Environ. Sci."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0030","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.chroma.2008.08.035","article-title":"Analytical and environmental aspects of the flame retardant tetrabromobisphenol-A and its derivatives","volume":"1216","author":"Covaci","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0035","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.chemosphere.2005.12.007","article-title":"Levels and trends of brominated flame retardants in the European environment","volume":"64","author":"Law","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0040","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.scitotenv.2015.09.038","article-title":"Tetrabromobisphenol A and heavy metal exposure via dust ingestion in an e-waste recycling region in Southeast China","volume":"541","author":"Wu","year":"2016","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0045","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.1007\/s11356-014-3773-z","article-title":"Characterization of heavy metals and brominated flame retardants in the indoor and outdoor dust of e-waste workshops: implication for on-site human exposure","volume":"22","author":"Xu","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0050","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1007\/s11356-014-3399-1","article-title":"Distribution of metals and brominated flame retardants (BFRs) in sediments, soils and plants from an informal e-waste dismantling site South China","volume":"22","author":"Wang","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0055","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1016\/j.scitotenv.2010.04.018","article-title":"Monitoring of lead cadmium, chromium and nickel in placenta from an e-waste recycling town in China","volume":"408","author":"Guo","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0060","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1021\/es071873x","article-title":"Heavy metals concentrations of surface dust from e-Waste recycling and its human health implications in southeast China","volume":"42","author":"Leung","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0065","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s10661-010-1638-6","article-title":"Assessment of cadmium exposure for neonates in Guiyu, an electronic waste pollution site of China","volume":"177","author":"Li","year":"2011","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0070","doi-asserted-by":"crossref","first-page":"12011","DOI":"10.1007\/s11356-015-4463-1","article-title":"Bioaccumulative characteristics of tetrabromobisphenol A and hexabromocyclododecanes in multi-tissues of prey and predator fish from an e-waste site, South China","volume":"22","author":"Tang","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0075","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nm902","article-title":"Cadmium mimics the in vivo effects of estrogen in the uterus and mammary gland","volume":"9","author":"Johnson","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0080","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.etap.2006.11.009","article-title":"Cadmium neurotoxicity","volume":"23","author":"M\u00e9ndez-Armenta","year":"2007","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0085","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0300-483X(98)00032-8","article-title":"Cadmium induces apoptosis differentially on immune system cell lines","volume":"128","author":"Tsangaris","year":"1998","journal-title":"Toxicology"},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0090","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/0041-008X(85)90181-4","article-title":"Cadmium-induced hepatic and renal injury in chronically exposed rats: likely role of hepatic cadmium-metallothionein in nephrotoxicity","volume":"77","author":"Dudley","year":"1985","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0095","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1034\/j.1600-0773.2003.920408.x","volume":"92","author":"Olsen","year":"2003","journal-title":"Pharmacol. Toxicol."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0100","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0197-0186(03)00044-5","article-title":"The effect of brominated flame retardants on neurotransmitter uptake into rat brain synaptosomes and vesicles","volume":"43","author":"Mariussen","year":"2003","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0105","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0300-483X(02)00442-0","article-title":"The flame retardants tetrabromobisphenol A and tetrabromobisphenol A\u2013bisallylether suppress the induction of interleukin-2 receptor \u03b1 chain (CD25) in murine splenocytes","volume":"184","author":"Pullen","year":"2003","journal-title":"Toxicology"},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0110","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.toxlet.2004.01.001","article-title":"Unexpected nephrotoxicity induced by tetrabromobisphenol A in newborn rats","volume":"150","author":"Fukuda","year":"2004","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0115","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.aquatox.2004.05.007","article-title":"Effects of the brominated flame retardants hexabromocyclododecane (HBCDD) and tetrabromobisphenol A (TBBPA), on hepatic enzymes and other biomarkers in juvenile rainbow trout and feral eelpout","volume":"69","author":"Ronisz","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0120","series-title":"Cadmium and Cadmium Compounds. Ullmann's Encyclopedia of Industrial Chemistry","author":"Schulte-Schrepping","year":"2000"},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0125","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1021\/es802593t","article-title":"Respiratory and dermal exposure to organophosphorus flame retardants and tetrabromobisphenol a at five work environments","volume":"43","author":"M\u00e4kinen","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0130","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"Smith","year":"1985","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0135","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1038\/nprot.2006.378","article-title":"Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method","volume":"1","author":"Rahman","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0140","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0003-2697(90)90668-Y","article-title":"Automated assays for superoxide dismutase catalase, glutathione peroxidase, and glutathione reductase activity","volume":"184","author":"Wheeler","year":"1990","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0145","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0150","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1080\/09603123.2013.835032","article-title":"Cellular mechanisms of cadmium-induced toxicity: a review","volume":"24","author":"Rani","year":"2014","journal-title":"Int. J. Environ. Health Res."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0155","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.etap.2006.08.007","article-title":"Flame retardant tetrabromobisphenol A induced hepatic changes in ICR male mice","volume":"23","author":"Tada","year":"2007","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0160","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.fct.2006.03.006","article-title":"Effects of tetrabromobisphenol A brominated flame retardant, in ICR mice after prenatal and postnatal exposure","volume":"44","author":"Tada","year":"2006","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0165","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.aquatox.2014.10.011","article-title":"Impact of co-exposure with lead and decabromodiphenyl ether (BDE-209) on thyroid function in zebrafish larvae","volume":"157","author":"Zhu","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0170","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0006-2952(03)00504-5","article-title":"The changing faces of glutathione, a cellular protagonist","volume":"66","author":"Pompella","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0175","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.3892\/ol.2012.931","article-title":"Redox status expressed as GSH: GSSG ratio as a marker for oxidative stress in paediatric tumour patients","volume":"4","author":"Zitka","year":"2012","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0180","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm_00000011","article-title":"Cytotoxicity and stress gene microarray analysis in cadmium-exposed CRL-1439 normal rat liver cells","author":"Latinwo","year":"1998","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0185","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.margen.2014.09.004","article-title":"Deep sequencing of the scallop Chlamys farreri transcriptome response to tetrabromobisphenol A (TBBPA) stress","volume":"19","author":"Hu","year":"2015","journal-title":"Mar. Genomics"},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0190","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0891-5849(98)00196-8","article-title":"Biomarkers of free radical damage: applications in experimental animals and in humans","volume":"26","author":"de Zwart","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0195","first-page":"1211","article-title":"Effect of Cd2+, In3+ Ce3+, Tb3+, Eu3+ and Gd3+ on lipoperoxidation and glutathione level in liver of mice and rats. Protective effect of zinc","volume":"41","author":"Caisova","year":"1986","journal-title":"Biologia (Bratisl.)"},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0200","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF02977789","article-title":"Induction of phase I, II and III drug metabolism\/transport by xenobiotics","volume":"28","author":"Xu","year":"2005","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0205","doi-asserted-by":"crossref","first-page":"61","DOI":"10.5487\/TR.2011.27.2.061","article-title":"Molecular mechanism of tetrabromobisphenol a (TBBPA)-induced target organ toxicity in Sprague-Dawley male rats","volume":"27","author":"Choi","year":"2011","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0210","first-page":"122","article-title":"Subacute effect of decabromodiphenyl ethane on hepatotoxicity and hepatic enzyme activity in rats","volume":"27","author":"Sun","year":"2014","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0215","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.tox.2005.10.019","article-title":"Subacute effects of the brominated flame retardants hexabromocyclododecane and tetrabromobisphenol A on hepatic cytochrome P450 levels in rats","volume":"218","author":"Germer","year":"2006","journal-title":"Toxicology"},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0220","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.aquatox.2012.02.010","article-title":"Metabolism of polybrominated diphenyl ethers and tetrabromobisphenol A by fish liver subcellular fractions in vitro","volume":"114\u2013115","author":"Shen","year":"2012","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0225","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/bioinformatics\/bti737","article-title":"Integrating time-course microarray gene expression profiles with cytotoxicity for identification of biomarkers in primary rat hepatocytes exposed to cadmium","volume":"22","author":"Tan","year":"2006","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0230","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0891-5849(88)90025-1","article-title":"Radical formation during the peroxidase catalyzed metabolism of carcinogens and xenobiotics: the reactivity of these radicals with GSH, DNA, and unsaturated lipid","volume":"4","author":"O'Brien","year":"1988","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.jhazmat.2016.06.054_bib0235","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.taap.2010.01.013","article-title":"Nrf2 the rescue: effects of the antioxidative\/electrophilic response on the liver","volume":"244","author":"Klaassen","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Journal of Hazardous Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304389416306094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304389416306094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T21:38:14Z","timestamp":1565386694000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304389416306094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":47,"alternative-id":["S0304389416306094"],"URL":"https:\/\/doi.org\/10.1016\/j.jhazmat.2016.06.054","relation":{},"ISSN":["0304-3894"],"issn-type":[{"value":"0304-3894","type":"print"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whole-body aerosol exposure of cadmium chloride (CdCl2) and tetrabromobisphenol A (TBBPA) induced hepatic changes in CD-1 male mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Hazardous Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhazmat.2016.06.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}