{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:43:04Z","timestamp":1771008184087,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2017,7,1]],"date-time":"2017-07-01T00:00:00Z","timestamp":1498867200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81421005"],"award-info":[{"award-number":["81421005"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hazardous Materials"],"published-print":{"date-parts":[[2017,7]]},"DOI":"10.1016\/j.jhazmat.2017.03.025","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:15:37Z","timestamp":1489450537000},"page":"265-274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Label-free pharmacological profiling based on dynamic mass redistribution for characterization and authentication of hazardous natural products"],"prefix":"10.1016","volume":"333","author":[{"given":"Hui-Peng","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huailing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-Qi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhazmat.2017.03.025_bib0005","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","article-title":"Natural products as sources of new drugs from 1981 to 2014","volume":"79","author":"Newman","year":"2016","journal-title":"J Nat. Prod."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0010","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.chroma.2016.06.009","article-title":"A strategy for screening active lead compounds and functional compound combinations from herbal medicines based on pharmacophore filtering and knockout\/knockin chromatography","volume":"1456","author":"Song","year":"2016","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0015","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.3748\/wjg.15.3073","article-title":"A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity","volume":"15","author":"Hasani-Ranjbar","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0020","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jchromb.2014.05.001","article-title":"Screening for selective inhibitors of xanthine oxidase from Flos Chrysanthemum usingultrafiltration LC-MS combined with enzyme channel blocking","volume":"961","author":"Song","year":"2014","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0025","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1055\/s-2006-947209","article-title":"Authentication is fundamental for standardization of Chinese medicines","volume":"72","author":"Zhao","year":"2006","journal-title":"Planta Med."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0030","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/jemt.20693","article-title":"Authentication of the 31 species of toxic and potent Chinese materia medica by light microscopy, part 3: two species of T\/PCMM from flowers and their common adulterants","volume":"72","author":"Chu","year":"2009","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0035","first-page":"29","article-title":"Safety issues of Chinese medicine: a review of intoxication cases in Hong Kong","volume":"1","author":"Ng","year":"2009","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0040","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1039\/C5FO00995B","article-title":"Plant species forbidden in health food and their toxic constituents, toxicology and detoxification","volume":"7","author":"Xu","year":"2016","journal-title":"Food Funct."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0045","first-page":"1584","article-title":"Authentication of misidentified crude herbal drugs marketed in Pakistan","volume":"4","author":"Zafar","year":"2010","journal-title":"J. Med. Plants Res."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0050","first-page":"4443","article-title":"Chemotaxonomic standardization of herbal drugs milk thistle and globe thistle","volume":"20","author":"Ahmad","year":"2008","journal-title":"Asian J. Chem."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0055","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jemt.20213","article-title":"Application of microscopy in authentication of Chinese patent medicine-Bo Ying compound","volume":"67","author":"Zhao","year":"2005","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0060","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.jpba.2010.01.025","article-title":"Chemical pattern-aided classification to simplify the intricacy of morphological taxonomy of Epimedium species using chromatographic fingerprinting","volume":"52","author":"Xie","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0065","article-title":"Authentication of the medicinal plants in Fabaceae by DNA barcoding technique","volume":"75","author":"Gao","year":"2009","journal-title":"Planta Med."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0070","doi-asserted-by":"crossref","first-page":"101","DOI":"10.5897\/IJBC11.163","article-title":"Standardization of herbal medicines-A review","volume":"4","author":"Kunle","year":"2012","journal-title":"Int. J. Biodivers. Conserv."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0075","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jhazmat.2011.11.029","article-title":"Establishment of a bioassay for the toxicity evaluation and quality control of Aconitum herbs","volume":"199","author":"Qin","year":"2012","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0080","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1039\/C4CC08728C","article-title":"A strategy for screening of high-quality enzyme inhibitors from herbal medicines based on ultrafiltration LC-MS and in silico molecular docking","volume":"51","author":"Song","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0085","doi-asserted-by":"crossref","first-page":"23840","DOI":"10.1038\/srep23840","article-title":"A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines","volume":"6","author":"Song","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0090","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.3390\/ijms13022219","article-title":"Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology","volume":"13","author":"Pohanka","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0095","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.ddtec.2010.05.001","article-title":"Label-free receptor assays","volume":"7","author":"Fang","year":"2011","journal-title":"Drug Discov. Today Technol."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0100","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.drudis.2010.06.008","article-title":"Label-free whole-cell assays: expanding the scope of GPCR screening","volume":"15","author":"Scott","year":"2010","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0105","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/adt.2007.126","article-title":"Evaluation of dynamic mass redistribution technology for pharmacological studies of recombinant and endogenously expressed G protein-coupled receptors","volume":"6","author":"Lee","year":"2008","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0110","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1089\/15406580360545107","article-title":"High throughput screening technologies for direct cyclic AMP measurement","volume":"1","author":"Gabriel","year":"2003","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0115","doi-asserted-by":"crossref","first-page":"18975","DOI":"10.1074\/jbc.M112.427062","article-title":"Cardiomyocyte ATP production metabolic flexibility, and survival require calcium flux through cardiac ryanodine receptors in vivo","volume":"288","author":"Bround","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0120","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1021\/ac050887n","article-title":"Characteristics of dynamic mass redistribution of epidermal growth factor receptor signaling in living cells measured with label-free optical biosensors","volume":"77","author":"Fang","year":"2005","journal-title":"Anal. Chem."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0125","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1038\/nprot.2011.386","article-title":"Applying label-free dynamic mass redistribution technology to frame signaling of G protein-coupled receptors noninvasively in living cells","volume":"6","author":"Schr\u00f6der","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0130","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/nbt.1671","article-title":"Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements","volume":"28","author":"Schr\u00f6der","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0135","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nchembio.1384","article-title":"Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor","volume":"10","author":"Bock","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0140","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2004350","article-title":"Decoding signaling and function of the orphan G protein\u2013coupled receptor GPR17 with a small-molecule agonist","volume":"6","author":"Hennen","year":"2013","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0145","first-page":"e51307","article-title":"Use of label-free optical biosensors to detect modulation of potassium channels by G-protein coupled receptors","volume":"10","author":"Fleming","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0150","volume":"vol. 1","author":"China Pharmacopeia Committee","year":"2015"},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0155","doi-asserted-by":"crossref","first-page":"26368","DOI":"10.1039\/C4RA03609C","article-title":"Label-free cell phenotypic profiling identifies pharmacologically active compounds in two Traditional Chinese Medicinal plants","volume":"4","author":"Zhang","year":"2014","journal-title":"RSC. Adv."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0160","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.foodchem.2011.01.095","article-title":"Fingerprint-efficacy study of artificial Calculus bovis in quality control of Chinese materia medica","volume":"127","author":"Kong","year":"2011","journal-title":"Food Chem."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0165","doi-asserted-by":"crossref","first-page":"36677","DOI":"10.1074\/jbc.M111.270561","article-title":"MicroRNA-99a inhibits hepatocellular carcinoma growth and correlates with prognosis of patients with hepatocellular carcinoma","volume":"286","author":"Li","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0170","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1093\/bioinformatics\/bti141","article-title":"PermutMatrix: a graphical environment to arrange gene expression profiles in optimal linear order","volume":"21","author":"Caraux","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0175","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jpba.2015.06.021","article-title":"Discovery of characteristic chemical markers for classification of aconite herbs by chromatographic profile and probabilistic neural network","volume":"115","author":"Yang","year":"2015","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0180","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.chroma.2014.04.015","article-title":"Identification of effective combinatorial markers for quality standardization of herbal medicines","volume":"1345","author":"Shi","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0185","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.coph.2014.02.006","article-title":"Muscarinic acetylcholine receptor X-ray structures: potential implications for drug development","volume":"16","author":"Kruse","year":"2014","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.jhazmat.2017.03.025_bib0190","doi-asserted-by":"crossref","first-page":"10982","DOI":"10.1073\/pnas.1309755110","article-title":"Activation and dynamic network of the M2 muscarinic receptor","volume":"110","author":"Miao","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Journal of Hazardous Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304389417301917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304389417301917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T16:55:23Z","timestamp":1759596923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304389417301917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":38,"alternative-id":["S0304389417301917"],"URL":"https:\/\/doi.org\/10.1016\/j.jhazmat.2017.03.025","relation":{},"ISSN":["0304-3894"],"issn-type":[{"value":"0304-3894","type":"print"}],"subject":[],"published":{"date-parts":[[2017,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Label-free pharmacological profiling based on dynamic mass redistribution for characterization and authentication of hazardous natural products","name":"articletitle","label":"Article Title"},{"value":"Journal of Hazardous Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhazmat.2017.03.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}