{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:34:38Z","timestamp":1791290078997,"version":"4.3.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","award":["R- 148-000-267-114"],"award-info":[{"award-number":["R- 148-000-267-114"]}],"id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001348","name":"Agency for Science, Technology and Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001352","name":"National University of Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001352","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hazardous Materials"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.jhazmat.2020.123712","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T22:09:30Z","timestamp":1597788570000},"page":"123712","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Development of novel alternative hair dyes to hazardous para-phenylenediamine"],"prefix":"10.1016","volume":"402","author":[{"given":"Gopalakrishnan","family":"Venkatesan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Dancik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arup","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hpone Myint","family":"Kyaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramasamy","family":"Srinivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3878-1722","authenticated-orcid":false,"suffix":"Jr.","given":"Thomas L.","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Bigliardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bigliardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9520-473X","authenticated-orcid":false,"given":"Giorgia","family":"Pastorin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhazmat.2020.123712_bib0005","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/jid.2008.209","article-title":"Skin sensitization to p-phenylenediamine: the diverging roles of oxidation and N-acetylation for dendritic cell activation and the immune response","volume":"129","author":"Aeby","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0010","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1600-0536.2009.01528.x","article-title":"Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals","volume":"60","author":"An","year":"2009","journal-title":"Contact Derm."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0015","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1016\/j.jece.2018.04.041","article-title":"Assessment of several advanced oxidation processes applied in the treatment of environmental concern constituents from a real hair dye wastewater","volume":"6","author":"Bessegato","year":"2018","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0020","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/bjd.13412","article-title":"Cross\u2010elicitation responses to 2\u2010methoxymethyl\u2010p\u2010phenylenediamine under hair dye use conditions in p\u2010phenylenediamine\u2010allergic individuals","volume":"172","author":"Bl\u00f6meke","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0025","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.tiv.2009.06.030","article-title":"Transepidermal water loss for probing full-thickness skin barrier function: correlation with tritiated water flux, sensitivity to punctures and diverse surfactant exposures","volume":"23","author":"Elmahjoubi","year":"2009","journal-title":"Toxi. in. vitro."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0030","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/jat.3354","article-title":"Is skin penetration a determining factor in skin sensitization potential and potency? Refuting the notion of a LogKow threshold for skin sensitization","volume":"37","author":"Fitzpatrick","year":"2017","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0035","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/toxsci\/kfh213","article-title":"Development of a peptide reactivity assay for screening contact allergens","volume":"81","author":"Gerberick","year":"2004","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0040","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/toxsci\/kfm064","article-title":"Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach","volume":"97","author":"Gerberick","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0045","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1021\/acs.chemrestox.5b00294","article-title":"In vitro priming of Na\u00efve T-cells with p-Phenylenediamine and Bandrowski\u2019s base","volume":"28","author":"Gibson","year":"2015","journal-title":"Chemi. Res. Toxicol."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0050","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.taap.2013.11.016","article-title":"Introduction of a methoxymethyl side chain into p-phenylenediamine attenuates its sensitizing potency and reduces the risk of allergy induction","volume":"274","author":"Goebel","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0055","article-title":"Process for dyeing keratin fibers comprising 1,4-diamino-2-methoxymethylbenzene and salts thereof","author":"Goettel","year":"2003","journal-title":"United States Patent"},{"key":"10.1016\/j.jhazmat.2020.123712_bib0060","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.microc.2014.05.007","article-title":"Voltammetric sensor for simultaneous determination of p-phenylenediamine and resorcinol in permanent hair dyeing and tap water by composite carbon nanotubes\/chitosan modified electrode","volume":"116","author":"Hudari","year":"2014","journal-title":"Microchem. J."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0065","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2131\/jts.43.741","article-title":"The performance of an in vitro skin sensitization test IL-8 Luc assay (OECD 442E), and the integrated approach with direct peptide reactive assay (DPRA)","volume":"43","author":"Kimura","year":"2018","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0070","first-page":"e259","article-title":"Skin integrity testing and monitoring of in vitro tape stripping by capacitance\u2010based sensor imaging","volume":"19","author":"Klang","year":"2013","journal-title":"Ski. Res. Technol."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0075","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1080\/10408444.2018.1429386","article-title":"Non-animal methods to predict skin sensitization (II): an assessment of defined approaches","volume":"48","author":"Kleinstreuer","year":"2018","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0080","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/bjd.14390","article-title":"Continuous usage of a hair dye product containing 2-methoxymethyl-para-phenylenediamine by hair-dye-allergic individuals","volume":"174","author":"Kock","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0085","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2310\/6620.2009.08089","article-title":"Consumer allergy to oxidative hair coloring products: epidemiologic data in the literature","volume":"20","author":"Krasteva","year":"2009","journal-title":"Dermatitis."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0090","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.taap.2015.05.016","article-title":"Extrapolation of systemic bioavailability assessing skin absorption and epidermal and hepatic metabolism of aromatic amine hair dyes in vitro","volume":"287","author":"Manwaring","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0095","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1111\/j.1398-9995.2011.02652.x","article-title":"Mechanisms of chemical-induced innate immunity in allergic contact dermatitis","volume":"66","author":"Martin","year":"2011","journal-title":"Allergy"},{"key":"10.1016\/j.jhazmat.2020.123712_bib0100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J.Immu.Methods."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0105","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2147\/JAA.S90265","article-title":"Para-phenylenediamine allergy: current perspectives on diagnosis and management","volume":"10","author":"Mukkanna","year":"2017","journal-title":"J. Asthma Allergy"},{"key":"10.1016\/j.jhazmat.2020.123712_bib0110","series-title":"TG 442C In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA)","author":"OECD","year":"2015"},{"key":"10.1016\/j.jhazmat.2020.123712_bib0115","unstructured":"Procter and Gamble, Hair dyes comprising 1,4-diamino-2-methoxymethylbenzene, Canadian Patent Application, CA2576189, 2007."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0120","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1111\/j.1476-5381.2009.00311.x","article-title":"Fluvastatin inhibits expression of the chemokine MDC\/CCL22 induced by interferon-\u03b3 in HaCaT cells, a human keratinocyte cell line","volume":"157","author":"Qi","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0125","series-title":"Basic Criteria for the in Vitro Assessment of Dermal Absorption of Cosmetic Ingredients","author":"SCCS (Scientific Committee on Consumer Safety)","year":"2010"},{"key":"10.1016\/j.jhazmat.2020.123712_bib0130","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s40521-014-0024-y","article-title":"P-phenylenediamine and risk of sensitization in children","volume":"1","author":"Schwensen","year":"2014","journal-title":"Curr. Treat. Options Allergy"},{"key":"10.1016\/j.jhazmat.2020.123712_bib0135","first-page":"853","article-title":"Cooxidation of p-Phenylenediamine and resorcinol in hair dyes","volume":"25","author":"Shah","year":"1972","journal-title":"J. Soc. Cosmet. Chem."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0140","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1600-0536.2008.01427.x","article-title":"Epidemiological data on consumer allergy to p-phenylenediamine","volume":"59","author":"Thyssen","year":"2008","journal-title":"Contact Derm."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0145","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1039\/C4NP00106K","article-title":"Ester coupling reactions\u2013 an enduring challenge in the chemical synthesis of bioactive natural products","volume":"32","author":"Tsakos","year":"2015","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.tox.2017.06.008","article-title":"Quantitative structure-skin permeability relationships","volume":"387","author":"Tsakovska","year":"2017","journal-title":"Toxicol"},{"key":"10.1016\/j.jhazmat.2020.123712_bib0155","doi-asserted-by":"crossref","first-page":"16188","DOI":"10.1039\/C9NJ03362A","article-title":"Facile synthesis of oligo anilines as permanent hair dyes: how chemical modifications impart colour and avoid toxicity","volume":"43","author":"Venkatesan","year":"2019","journal-title":"N. Jour. Chem."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0160","first-page":"321","article-title":"Allergic contact dermatitis in children: which factors are relevant? Pediatric","volume":"24","author":"Waard-van der Spek","year":"2013","journal-title":"Allergy. Immunol."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0165","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1365-2222.2006.02561.x","article-title":"p-Phenylenediamine allergy : the role of Bandrowski\u2019s base","volume":"36","author":"White","year":"2006","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.jhazmat.2020.123712_bib0170","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fphar.2016.00053","article-title":"Evaluation of a high-throughput peptide reactivity format assay for assessment of the skin sensitization potential of chemicals","volume":"7","author":"Wong","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0175","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0887-2333(03)00006-7","article-title":"Evaluation of the skin sensitization potential of chemicals using expression of co-stimulatory molecules, CD54 and CD86, on the naive THP-1 cell line","volume":"17","author":"Yoshida","year":"2003","journal-title":"Toxicol. In. Vitro."},{"key":"10.1016\/j.jhazmat.2020.123712_bib0180","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/DER.0000000000000230","article-title":"Tolerance to a hair dye product containing 2-Methoxymethyl-P-Phenylenediamine in an ethnically diverse population of P-Phenylenediamine-Allergic individuals","volume":"27","author":"Zahir","year":"2016","journal-title":"Dermatitis"},{"key":"10.1016\/j.jhazmat.2020.123712_bib0185","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.toxlet.2015.09.026","article-title":"The oxidation of P-Phenylenediamine, an ingredient used for permanent hair dyeing purposes, leads to the formation of hydroxyl radicals: oxidative stress and DNA damage in human immortalized keratinocytes","volume":"239","author":"Zanoni","year":"2015","journal-title":"Toxicol. Lett."}],"container-title":["Journal of Hazardous Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304389420316988?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304389420316988?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T14:56:29Z","timestamp":1778684189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304389420316988"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":37,"alternative-id":["S0304389420316988"],"URL":"https:\/\/doi.org\/10.1016\/j.jhazmat.2020.123712","relation":{},"ISSN":["0304-3894"],"issn-type":[{"value":"0304-3894","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of novel alternative hair dyes to hazardous para-phenylenediamine","name":"articletitle","label":"Article Title"},{"value":"Journal of Hazardous Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhazmat.2020.123712","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"123712"}}