{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T08:09:10Z","timestamp":1794557350833,"version":"4.9.1"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002920","name":"Research Grants Council, University Grants Committee","doi-asserted-by":"publisher","award":["0001274"],"award-info":[{"award-number":["0001274"]}],"id":[{"id":"10.13039\/501100002920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","award":["P0038706"],"award-info":[{"award-number":["P0038706"]}],"id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","award":["P0001274"],"award-info":[{"award-number":["P0001274"]}],"id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","award":["P0030234"],"award-info":[{"award-number":["P0030234"]}],"id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","award":["0038706"],"award-info":[{"award-number":["0038706"]}],"id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004377","name":"Hong Kong Polytechnic University","doi-asserted-by":"publisher","award":["0030234"],"award-info":[{"award-number":["0030234"]}],"id":[{"id":"10.13039\/501100004377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hazardous Materials"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.jhazmat.2022.129698","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T11:57:16Z","timestamp":1659009436000},"page":"129698","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":85,"special_numbering":"C","title":["Dietary exposure to polystyrene nanoplastics impairs fasting-induced lipolysis in adipose tissue from high-fat diet fed mice"],"prefix":"10.1016","volume":"440","author":[{"given":"Ho Ting","family":"Shiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KeKao","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth King Yip","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben Chi-Bun","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James Kar-Hei","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhazmat.2022.129698_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145806","article-title":"The 2019 global pandemic and plastic pollution prevention measures: Playing catch-up","volume":"774","author":"da Costa","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jhazmat.2022.129698_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1700782","article-title":"Production, use, and fate of all plastics ever made","volume":"3","author":"Geyer","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.jhazmat.2022.129698_bib3","doi-asserted-by":"crossref","unstructured":"Evangeliou, N., Grythe, H., Kylling, A., and Stohl, A., 2021, Global emission, atmospheric transport and deposition trends of microplastics originating from road traffic. in EGU General Assembly Conference Abstracts.","DOI":"10.5194\/egusphere-egu21-16513"},{"key":"10.1016\/j.jhazmat.2022.129698_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e06343","article-title":"COVID pollution: impact of COVID-19 pandemic on global plastic waste footprint","volume":"7","author":"Benson","year":"2021","journal-title":"Heliyon"},{"key":"10.1016\/j.jhazmat.2022.129698_bib5","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2111530118","article-title":"Plastic waste release caused by COVID-19 and its fate in the global ocean","volume":"118","author":"Peng","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jhazmat.2022.129698_bib6","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.1021\/acssuschemeng.9b06635","article-title":"Degradation Rates of Plastics in the Environment","volume":"8","author":"Chamas","year":"2020","journal-title":"Acs Sustain Chem. Eng."},{"key":"10.1016\/j.jhazmat.2022.129698_bib7","article-title":"Aquatic ecotoxicity testing of nanoplastics: lessons learned from nanoecotoxicology","volume":"Vol. 2015","author":"Hartmann","year":"2015","journal-title":"ASLO Aquat. Sci. Meet."},{"key":"10.1016\/j.jhazmat.2022.129698_bib8","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.envpol.2018.01.024","article-title":"Current opinion: What is a nanoplastic?","volume":"235","author":"Gigault","year":"2018","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jhazmat.2022.129698_bib9","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1021\/acs.est.8b05297","article-title":"Are We Speaking the Same Language? Recommendations for a Definition and Categorization Framework for Plastic Debris","volume":"53","author":"Hartmann","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.etap.2019.03.001","article-title":"Microplastics in the marine environment: Current trends in environmental pollution and mechanisms of toxicological profile","volume":"68","author":"Alimba","year":"2019","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.jhazmat.2022.129698_bib11","doi-asserted-by":"crossref","first-page":"7068","DOI":"10.1021\/acs.est.9b01517","article-title":"Human consumption of microplastics","volume":"53","author":"Cox","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s00128-021-03180-0","article-title":"Airborne microplastics: a review on the occurrence, migration and risks to humans","volume":"107","author":"Wang","year":"2021","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib13","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.watres.2019.02.054","article-title":"Microplastics in freshwaters and drinking water: Critical review and assessment of data quality","volume":"155","author":"Koelmans","year":"2019","journal-title":"Water Res"},{"key":"10.1016\/j.jhazmat.2022.129698_bib14","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/s41467-018-03465-9","article-title":"Turning microplastics into nanoplastics through digestive fragmentation by Antarctic krill","volume":"9","author":"Dawson","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jhazmat.2022.129698_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11051-015-3029-y","article-title":"Bioavailability and biodistribution of differently charged polystyrene nanoparticles upon oral exposure in rats","volume":"17","author":"Walczak","year":"2015","journal-title":"J. Nanopart. Res."},{"key":"10.1016\/j.jhazmat.2022.129698_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3109\/10611869509015936","article-title":"Factors affecting the oral uptake and translocation of polystyrene nanoparticles: histological and analytical evidence","volume":"3","author":"Florence","year":"1995","journal-title":"J. Drug Target"},{"key":"10.1016\/j.jhazmat.2022.129698_bib17","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.arabjc.2017.05.011","article-title":"Nanoparticles: Properties, applications and toxicities","volume":"12","author":"Khan","year":"2019","journal-title":"Arab J. Chem."},{"key":"10.1016\/j.jhazmat.2022.129698_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107199","article-title":"Discovery and quantification of plastic particle pollution in human blood","volume":"163","author":"Leslie","year":"2022","journal-title":"Environ. Int"},{"key":"10.1016\/j.jhazmat.2022.129698_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17051509","article-title":"Toxicity of microplastics and nanoplastics in mammalian systems","volume":"17","author":"Yong","year":"2020","journal-title":"Int J. Environ. Res Public Health"},{"key":"10.1016\/j.jhazmat.2022.129698_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.07.065","article-title":"Accumulation of different shapes of microplastics initiates intestinal injury and gut microbiota dysbiosis in the gut of zebrafish","volume":"236","author":"Qiao","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2022.129698_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122773","article-title":"Nanoplastics impair the intestinal health of the juvenile large yellow croaker Larimichthys crocea","volume":"397","author":"Gu","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jhazmat.2022.129698_bib22","doi-asserted-by":"crossref","first-page":"4054","DOI":"10.1021\/acs.est.6b00183","article-title":"Uptake and Accumulation of Polystyrene Microplastics in Zebrafish (Danio rerio) and Toxic Effects in Liver","volume":"50","author":"Lu","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113024","article-title":"Polystyrene microplastics cause tissue damages, sex-specific reproductive disruption and transgenerational effects in marine medaka (Oryzias melastigma)","volume":"254","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jhazmat.2022.129698_bib24","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.scitotenv.2018.06.186","article-title":"Maternal transfer of nanoplastics to offspring in zebrafish (Danio rerio): A case study with nanopolystyrene","volume":"643","author":"Pitt","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jhazmat.2022.129698_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122693","article-title":"Toxicological effects of nano- and micro-polystyrene plastics on red tilapia: Are larger plastic particles more harmless?","volume":"396","author":"Ding","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jhazmat.2022.129698_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122058","article-title":"Toxicity comparison of nano-sized and micron-sized microplastics to Goldfish Carassius auratus Larvae","volume":"388","author":"Yang","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jhazmat.2022.129698_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127705","article-title":"Plastic nanoparticles cause mild inflammation, disrupt metabolic pathways, change the gut microbiota and affect reproduction in zebrafish: A full generation multi-omics study","volume":"424","author":"Marana","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jhazmat.2022.129698_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125562","article-title":"Immuno-modulatory effects of nanoplastics and humic acids in the European seabass (Dicentrarchus labrax)","volume":"414","author":"Brandts","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jhazmat.2022.129698_bib29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.aquatox.2017.11.017","article-title":"Uptake, tissue distribution, and toxicity of polystyrene nanoparticles in developing zebrafish (Danio rerio)","volume":"194","author":"Pitt","year":"2018","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122621","article-title":"Barrier function of zebrafish embryonic chorions against microplastics and nanoplastics and its impact on embryo development","volume":"395","author":"Duan","year":"2020","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jhazmat.2022.129698_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123263","article-title":"Microplastic ingestion induces behavioral disorders in mice: A preliminary study on the trophic transfer effects via tadpoles and fish","volume":"401","author":"da Costa Araujo","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jhazmat.2022.129698_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.129476","article-title":"Toxicity of polystyrene nanoplastics and zinc oxide to mice","volume":"271","author":"Estrela","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2022.129698_bib33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12989-020-00358-y","article-title":"The plastic brain: neurotoxicity of micro- and nanoplastics","volume":"17","author":"Prust","year":"2020","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126092","article-title":"Systematic toxicity evaluation of polystyrene nanoplastics on mice and molecular mechanism investigation about their internalization into Caco-2 cells","volume":"417","author":"Xu","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jhazmat.2022.129698_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.145758","article-title":"A comparative review of microplastics and nanoplastics: Toxicity hazards on digestive, reproductive and nervous system","volume":"774","author":"Yin","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jhazmat.2022.129698_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.130826","article-title":"Evidence from in vitro and in vivo studies on the potential health repercussions of micro- and nanoplastics","volume":"280","author":"Gonzalez-Acedo","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2022.129698_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.724989","article-title":"A review of human exposure to microplastics and insights into microplastics as obesogens","volume":"12","author":"Kannan","year":"2021","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.jhazmat.2022.129698_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126069","article-title":"Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology","volume":"416","author":"Lu","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jhazmat.2022.129698_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113238","article-title":"Intratracheal administration of polystyrene microplastics induces pulmonary fibrosis by activating oxidative stress and Wnt\/beta-catenin signaling pathway in mice","volume":"232","author":"Li","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jhazmat.2022.129698_bib40","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.scitotenv.2018.08.353","article-title":"Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice","volume":"649","author":"Jin","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jhazmat.2022.129698_bib41","doi-asserted-by":"crossref","first-page":"10978","DOI":"10.1021\/acs.est.9b03191","article-title":"Maternal Polystyrene Microplastic Exposure during Gestation and Lactation Altered Metabolic Homeostasis in the Dams and Their F1 and F2 Offspring","volume":"53","author":"Luo","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib42","doi-asserted-by":"crossref","unstructured":"Li, L., Xu, M., He, C., Wang, H., and Hu, Q. (2021) Polystyrene nanoplastics potentiate the development of hepatic fibrosis in high fat diet fed mice. Environ Toxicol.","DOI":"10.1002\/tox.23404"},{"key":"10.1016\/j.jhazmat.2022.129698_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.114158","article-title":"The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge","volume":"261","author":"Amereh","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jhazmat.2022.129698_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.110133","article-title":"Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway","volume":"190","author":"Xie","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jhazmat.2022.129698_bib45","doi-asserted-by":"crossref","first-page":"8849","DOI":"10.1021\/acs.est.6b01441","article-title":"Microplastic Size-Dependent Toxicity, Oxidative Stress Induction, and p-JNK and p-p38 Activation in the Monogonont Rotifer (Brachionus koreanus)","volume":"50","author":"Jeong","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib46","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.envpol.2017.05.048","article-title":"Ingestion of micro- and nanoplastics in Daphnia magna - Quantification of body burdens and assessment of feeding rates and reproduction","volume":"228","author":"Rist","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jhazmat.2022.129698_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2019.120861","article-title":"Impacts of polystyrene microplastics on the behavior and metabolism in a marine demersal teleost, black rockfish (Sebastes schlegelii)","volume":"380","author":"Yin","year":"2019","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jhazmat.2022.129698_bib48","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.scitotenv.2018.03.051","article-title":"Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice","volume":"631\u2013632","author":"Lu","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jhazmat.2022.129698_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113239","article-title":"Polystyrene bead ingestion promotes adiposity and cardiometabolic disease in mice","volume":"232","author":"Zhao","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.jhazmat.2022.129698_bib50","article-title":"Effects of oral administration of polystyrene nanoplastics on plasma glucose metabolism in mice","volume":"132607","author":"Fan","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2022.129698_bib51","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.envpol.2017.08.058","article-title":"Microplastic pollution in the surface waters of the Bohai Sea, China","volume":"231","author":"Zhang","year":"2017","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jhazmat.2022.129698_bib52","doi-asserted-by":"crossref","first-page":"12300","DOI":"10.1021\/acs.est.9b02540","article-title":"Plastic teabags release billions of microparticles and nanoparticles into tea","volume":"53","author":"Hernandez","year":"2019","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib53","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1021\/acs.estlett.1c00559","article-title":"Occurrence of polyethylene terephthalate and polycarbonate microplastics in infant and adult feces","volume":"8","author":"Zhang","year":"2021","journal-title":"Environ. Sci. Technol. Lett."},{"key":"10.1016\/j.jhazmat.2022.129698_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.152562","article-title":"Effects of temperature and particle concentration on aggregation of nanoplastics in freshwater and seawater","volume":"817","author":"Lee","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jhazmat.2022.129698_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2021.154861","article-title":"Pharmacological inhibition of acyl-coenzyme A:cholesterol acyltransferase alleviates obesity and insulin resistance in diet-induced obese mice by regulating food intake","volume":"123","author":"Zhu","year":"2021","journal-title":"Metabolism"},{"key":"10.1016\/j.jhazmat.2022.129698_bib56","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/cpmo.2","article-title":"Intestinal preparation techniques for histological analysis in the mouse","volume":"6","author":"Williams","year":"2016","journal-title":"Curr. Protoc. Mouse Biol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib57","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1194\/jlr.M081745","article-title":"In vitro exploration of ACAT contributions to lipid droplet formation during adipogenesis","volume":"59","author":"Zhu","year":"2018","journal-title":"J. Lipid Res"},{"key":"10.1016\/j.jhazmat.2022.129698_bib58","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/B978-0-12-800280-3.00010-4","article-title":"Measurement of lipolysis","volume":"538","author":"Schweiger","year":"2014","journal-title":"Methods Enzym."},{"key":"10.1016\/j.jhazmat.2022.129698_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.125632","article-title":"Microplastics in the human digestive environment: A focus on the potential and challenges facing in vitro gut model development","volume":"415","author":"Fournier","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jhazmat.2022.129698_bib60","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jgh3.12457","article-title":"Detection of microplastics in human colectomy specimens","volume":"5","author":"Ibrahim","year":"2021","journal-title":"JGH Open"},{"key":"10.1016\/j.jhazmat.2022.129698_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2021.146523","article-title":"Cellular internalization and release of polystyrene microplastics and nanoplastics","volume":"779","author":"Liu","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jhazmat.2022.129698_bib62","first-page":"272","article-title":"Nanoplastics as a potential environmental health factor: effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells","volume":"7","author":"Cort\u00e9s","year":"2020","journal-title":"Environ. Sci.: Nano"},{"key":"10.1016\/j.jhazmat.2022.129698_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2021.112609","article-title":"Toxicity, uptake, and nuclear translocation of ingested micro-nanoplastics in an in vitro model of the small intestinal epithelium","volume":"158","author":"DeLoid","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.128411","article-title":"Effect of polystyrene nanoplastics and their degraded forms on stem cell fate","volume":"430","author":"Im","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jhazmat.2022.129698_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.127861","article-title":"A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells","volume":"427","author":"Danopoulos","year":"2022","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jhazmat.2022.129698_bib66","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/s41574-021-00471-8","article-title":"Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics","volume":"17","author":"Morigny","year":"2021","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib67","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1038\/s42255-021-00493-6","article-title":"Lipolysis: cellular mechanisms for lipid mobilization from fat stores","volume":"3","author":"Grabner","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.jhazmat.2022.129698_bib68","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12951-015-0149-6","article-title":"The autophagic response to polystyrene nanoparticles is mediated by transcription factor EB and depends on surface charge","volume":"13","author":"Song","year":"2015","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib69","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1080\/17435390.2019.1640913","article-title":"Targeted metabolomics reveals differential biological effects of nanoplastics and nanoZnO in human lung cells","volume":"13","author":"Lim","year":"2019","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.jhazmat.2022.129698_bib70","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/S0022-2275(20)32429-9","article-title":"Decreased expression and function of adipocyte hormone-sensitive lipase in subcutaneous fat cells of obese subjects","volume":"40","author":"Large","year":"1999","journal-title":"J. Lipid Res"},{"key":"10.1016\/j.jhazmat.2022.129698_bib71","unstructured":"AnonU.S.Department of Health and Human Services, F., Center for Drug Evaluation and Research, 2005, Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers."},{"key":"10.1016\/j.jhazmat.2022.129698_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113122","article-title":"Maternal exposure to different sizes of polystyrene microplastics during gestation causes metabolic disorders in their offspring","volume":"255","author":"Luo","year":"2019","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.jhazmat.2022.129698_bib73","first-page":"228","article-title":"Alterations in adipocyte adenylate cyclase activity in morbidly obese and formerly morbidly obese humans","volume":"108","author":"Martin","year":"1990","journal-title":"Surgery"},{"key":"10.1016\/j.jhazmat.2022.129698_bib74","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/advances\/nmz061","article-title":"Negative effects of a high-fat diet on intestinal permeability: a review","volume":"11","author":"Rohr","year":"2020","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.jhazmat.2022.129698_bib75","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/ajg.2011.44","article-title":"Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature","volume":"106","author":"Hou","year":"2011","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib76","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1177\/1091581816653363","article-title":"Intravenous administration of multiwalled carbon nanotubes aggravates high-fat diet-induced nonalcoholic steatohepatitis in sprague dawley rats","volume":"35","author":"Xu","year":"2016","journal-title":"Int J. Toxicol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.125492","article-title":"Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice","volume":"244","author":"Li","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2022.129698_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105916","article-title":"Microplastics release phthalate esters and cause aggravated adverse effects in the mouse gut","volume":"143","author":"Deng","year":"2020","journal-title":"Environ. Int"},{"key":"10.1016\/j.jhazmat.2022.129698_bib79","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12989-020-00387-7","article-title":"Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature","volume":"17","author":"Hirt","year":"2020","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.jhazmat.2022.129698_bib80","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jhazmat.2018.06.017","article-title":"Evidence that microplastics aggravate the toxicity of organophosphorus flame retardants in mice (Mus musculus)","volume":"357","author":"Deng","year":"2018","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.jhazmat.2022.129698_bib81","doi-asserted-by":"crossref","first-page":"46687","DOI":"10.1038\/srep46687","article-title":"Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure","volume":"7","author":"Deng","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jhazmat.2022.129698_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143085","article-title":"Proinflammatory properties and lipid disturbance of polystyrene microplastics in the livers of mice with acute colitis","volume":"750","author":"Zheng","year":"2021","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.jhazmat.2022.129698_bib83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0146675","article-title":"Effects of excess energy intake on glucose and lipid metabolism in C57BL\/6 mice","volume":"11","author":"Pang","year":"2016","journal-title":"PLoS One"}],"container-title":["Journal of Hazardous Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304389422014911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304389422014911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:39:43Z","timestamp":1778632783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304389422014911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":83,"alternative-id":["S0304389422014911"],"URL":"https:\/\/doi.org\/10.1016\/j.jhazmat.2022.129698","relation":{},"ISSN":["0304-3894"],"issn-type":[{"value":"0304-3894","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary exposure to polystyrene nanoplastics impairs fasting-induced lipolysis in adipose tissue from high-fat diet fed mice","name":"articletitle","label":"Article Title"},{"value":"Journal of Hazardous Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhazmat.2022.129698","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"129698"}}