{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T18:20:26Z","timestamp":1777054826981,"version":"3.51.4"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hazardous Materials"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.jhazmat.2023.132575","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T12:47:26Z","timestamp":1695127646000},"page":"132575","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Toxic effects and potential mechanisms of zinc pyrithione (ZPT) exposure on sperm and testicular injury in zebrafish"],"prefix":"10.1016","volume":"461","author":[{"given":"Jinyuan","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mogellah John","family":"Panga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4931-5010","authenticated-orcid":false,"given":"Clara","family":"Appiah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladimir","family":"Retyunskiy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2852-7432","authenticated-orcid":false,"given":"Ye","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhazmat.2023.132575_bib1","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s11626-016-0061-x","article-title":"Mitochondrial membrane potential (MMP) regulates sperm motility","volume":"52","author":"Agnihotri","year":"2016","journal-title":"Vitr Cell Dev Biol-Anim"},{"issue":"11","key":"10.1016\/j.jhazmat.2023.132575_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e05589","article-title":"In vivo exposure to codeine induces reproductive toxicity: role of HER2 and p53\/Bcl-2 signaling pathway","volume":"6","author":"Ajayi","year":"2020","journal-title":"Heliyon"},{"key":"10.1016\/j.jhazmat.2023.132575_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153148","article-title":"Sodium arsenite accelerates D-galactose-induced aging in the testis of the rat: Evidence for mitochondrial oxidative damage, NF-kB, JNK, and apoptosis pathways","volume":"470","author":"Akbari","year":"2022","journal-title":"Toxicology"},{"issue":"2","key":"10.1016\/j.jhazmat.2023.132575_bib4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0092-8674(00)81334-3","article-title":"Human ICE\/CED-3 protease nomenclature","volume":"87","author":"Alnemri","year":"1996","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jhazmat.2023.132575_bib5","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1677\/joe.0.1560043","article-title":"Thyroid hormone effects on androgen receptor messenger RNA expression in rat Sertoli and peritubular cells","volume":"156","author":"Arambepola","year":"1998","journal-title":"J Endocrinol"},{"issue":"4","key":"10.1016\/j.jhazmat.2023.132575_bib6","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1046\/j.1467-2494.2003.00183.x","article-title":"A double\u2010blind randomized vehicle\u2010controlled clinical trial investigating the effect of ZnPTO dose on the scalp vs. antidandruff efficacy and antimycotic activity","volume":"25","author":"Bailey","year":"2003","journal-title":"Int J Cosmet Sci"},{"issue":"5\u20136","key":"10.1016\/j.jhazmat.2023.132575_bib7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/08927010500456589","article-title":"Toxicity assessment of the antifouling compound zinc pyrithione using early developmental stages of the ascidian Ciona intestinalis","volume":"21","author":"Bellas","year":"2005","journal-title":"Biofouling"},{"issue":"11","key":"10.1016\/j.jhazmat.2023.132575_bib8","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.marpolbul.2005.06.010","article-title":"Embryotoxicity of the antifouling biocide zinc pyrithione to sea urchin (Paracentrotus lividus) and mussel (Mytilus edulis)","volume":"50","author":"Bellas","year":"2005","journal-title":"Mar Pollut Bull"},{"issue":"5","key":"10.1016\/j.jhazmat.2023.132575_bib9","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.bbadis.2016.11.010","article-title":"Mitochondrial dysfunction and oxidative stress in metabolic disorders - a step towards mitochondria based therapeutic strategies","volume":"1863","author":"Bhatti","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1\u20132","key":"10.1016\/j.jhazmat.2023.132575_bib10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.chroma.2006.07.068","article-title":"Improved method for the determination of zinc pyrithione in environmental water samples incorporating on-line extraction and preconcentration coupled with liquid chromatography atmospheric pressure chemical ionisation mass spectrometry","volume":"1132","author":"Bones","year":"2006","journal-title":"J Chromatogr A"},{"key":"10.1016\/j.jhazmat.2023.132575_bib11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.freeradbiomed.2021.02.043","article-title":"Mitochondrial ROS and mitochondria-targeted antioxidants in the aged heart","volume":"167","author":"Bou-Teen","year":"2021","journal-title":"Free Radic Biol Med"},{"issue":"2\u20133","key":"10.1016\/j.jhazmat.2023.132575_bib12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1159\/000471849","article-title":"Untreated Psoriasis Impairs Male Fertility: A Case-Control Study","volume":"233","author":"Caldarola","year":"2017","journal-title":"Dermatology"},{"issue":"2","key":"10.1016\/j.jhazmat.2023.132575_bib13","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.bbamcr.2011.09.013","article-title":"Zinc pyrithione induces ERK- and PKC-dependent necrosis distinct from TPEN-induced apoptosis in prostate cancer cells","volume":"1823","author":"Carraway","year":"2012","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"10.1016\/j.jhazmat.2023.132575_bib14","doi-asserted-by":"crossref","DOI":"10.4161\/spmg.24194","article-title":"Role of poly(ADP-ribose) polymerases in male reproduction","volume":"3","author":"Celik-Ozenci","year":"2013","journal-title":"Spermatogenesis"},{"issue":"2","key":"10.1016\/j.jhazmat.2023.132575_bib15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1530\/REP-09-0167","article-title":"Arsenic inhibits in vitro spermatogenesis and induces germ cell apoptosis in Japanese eel (Anguilla japonica)","volume":"138","author":"Celino","year":"2009","journal-title":"Reproduction"},{"key":"10.1016\/j.jhazmat.2023.132575_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2022.129382","article-title":"Adverse effects of SYP-3343 on zebrafish development via ROS-mediated mitochondrial dysfunction","volume":"437","author":"Chen","year":"2022","journal-title":"J Hazard Mater"},{"issue":"9","key":"10.1016\/j.jhazmat.2023.132575_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/md15090264","article-title":"Review on molecular mechanisms of antifouling compounds: an update since 2012","volume":"15","author":"Chen","year":"2017","journal-title":"Mar Drugs"},{"issue":"1","key":"10.1016\/j.jhazmat.2023.132575_bib18","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1080\/21691401.2020.1770266","article-title":"Anti-tumour activity of zinc ionophore pyrithione in human ovarian cancer cells through inhibition of proliferation and migration and promotion of lysosome-mitochondrial apoptosis","volume":"48","author":"Chen","year":"2020","journal-title":"Artif Cells, Nanomed, Biotechnol"},{"issue":"4","key":"10.1016\/j.jhazmat.2023.132575_bib19","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.chemosphere.2012.02.070","article-title":"Determination of detoxification to Daphnia magna of four pharmaceuticals and seven surfactants by activated sludge","volume":"88","author":"Dave","year":"2012","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.jhazmat.2023.132575_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1046\/j.1365-2672.1998.00477.x","article-title":"Pyrithione biocide interactions with bacterial phospholipid head groups","volume":"85","author":"Dinning","year":"1998","journal-title":"J Appl Microbiol"},{"issue":"4","key":"10.1016\/j.jhazmat.2023.132575_bib21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3109\/19396368.2012.700442","article-title":"Proteomic discovery of diverse immunity molecules in mammalian spermatozoa","volume":"58","author":"Dorus","year":"2012","journal-title":"Syst Biol Reprod Med"},{"key":"10.1016\/j.jhazmat.2023.132575_bib22","doi-asserted-by":"crossref","unstructured":"Dutta, S., Henkel, R., Sengupta, P., Agarwal, A., 2020. Physiological role of ROS in sperm function. Male infertility: Contemporary clinical approaches, Andrology, ART and antioxidants, 337\u2013345.","DOI":"10.1007\/978-3-030-32300-4_27"},{"issue":"10","key":"10.1016\/j.jhazmat.2023.132575_bib23","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/02772248.2020.1824258","article-title":"Cytotoxic, genotoxic, oxidative, and irritant effects of zinc pyrithione in vitro","volume":"102","author":"G\u00fcner","year":"2020","journal-title":"Toxicol Environ Chem"},{"key":"10.1016\/j.jhazmat.2023.132575_bib24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF03260057","article-title":"Catalase enzyme mutations and their association with diseases","volume":"8","author":"G\u00f3th","year":"2004","journal-title":"Mol Diagn"},{"issue":"21","key":"10.1016\/j.jhazmat.2023.132575_bib25","first-page":"2003","article-title":"Oxidative stress, mitochondrial damage and neurodegenerative diseases","volume":"8","author":"Guo","year":"2013","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jhazmat.2023.132575_bib26","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF02697367","article-title":"Anaphylatoxins: their role in bacterial infection and inflammation","volume":"37","author":"Haas","year":"2007","journal-title":"Immunol Res"},{"issue":"3","key":"10.1016\/j.jhazmat.2023.132575_bib27","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1079\/BJN19890140","article-title":"Effects of dietary trans-fatty acids on reproductive performance of Wistar rats","volume":"61","author":"Hanis","year":"1989","journal-title":"Br J Nutr"},{"key":"10.1016\/j.jhazmat.2023.132575_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.113142","article-title":"Transgenerational effects of parental bisphenol S exposure on zebrafish (Danio rerio) reproduction","volume":"165","author":"Hao","year":"2022","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jhazmat.2023.132575_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2020.111276","article-title":"Exposure to sublethal concentrations of zinc pyrithione inhibits growth and survival of marine polychaete through induction of oxidative stress and DNA damage","volume":"156","author":"Haque","year":"2020","journal-title":"Mar Pollut Bull"},{"key":"10.1016\/j.jhazmat.2023.132575_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.marpolbul.2020.111276","article-title":"Exposure to sublethal concentrations of zinc pyrithione inhibits growth and survival of marine polychaete through induction of oxidative stress and DNA damage","volume":"156","author":"Haque","year":"2020","journal-title":"Mar Pollut Bull"},{"issue":"1","key":"10.1016\/j.jhazmat.2023.132575_bib31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jri.2009.04.005","article-title":"Differential changes in CD4+ and CD8+ effector and regulatory T lymphocyte subsets in the testis of rats undergoing autoimmune orchitis","volume":"81","author":"Jacobo","year":"2009","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.jhazmat.2023.132575_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.123430","article-title":"Polystyrene microplastics induced male reproductive toxicity in mice","volume":"401","author":"Jin","year":"2021","journal-title":"J Hazard Mater"},{"issue":"2","key":"10.1016\/j.jhazmat.2023.132575_bib33","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.marpolbul.2016.11.047","article-title":"Acute toxicity of organic antifouling biocides to phytoplankton Nitzschia pungens and zooplankton Artemia larvae","volume":"124","author":"Jung","year":"2017","journal-title":"Mar Pollut Bull"},{"issue":"2","key":"10.1016\/j.jhazmat.2023.132575_bib34","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.marpolbul.2016.11.047","article-title":"Acute toxicity of organic antifouling biocides to phytoplankton Nitzschia pungens and zooplankton Artemia larvae","volume":"124","author":"Jung","year":"2017","journal-title":"Mar Pollut Bull"},{"issue":"4","key":"10.1016\/j.jhazmat.2023.132575_bib35","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1080\/02757540.2022.2047951","article-title":"Oxidative stress-induced apoptotic changes after acute exposure to antifouling agent zinc pyrithione (ZnPT) in Mytilus galloprovincialis Lamark (Mediterranean mussels) tissues","volume":"38","author":"Katalay","year":"2022","journal-title":"Chem Ecol"},{"issue":"2","key":"10.1016\/j.jhazmat.2023.132575_bib36","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0160-4120(03)00176-4","article-title":"Worldwide occurrence and effects of antifouling paint booster biocides in the aquatic environment: a review","volume":"30","author":"Konstantinou","year":"2004","journal-title":"Environ Int"},{"issue":"1\u20133","key":"10.1016\/j.jhazmat.2023.132575_bib37","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.scitotenv.2007.07.023","article-title":"Toxicity of four antifouling biocides and their mixtures on the brine shrimp Artemia salina","volume":"387","author":"Koutsaftis","year":"2007","journal-title":"Sci Total Environ"},{"issue":"40","key":"10.1016\/j.jhazmat.2023.132575_bib38","doi-asserted-by":"crossref","first-page":"47382","DOI":"10.1021\/acsami.1c14113","article-title":"In situ functionalization of cellulose with zinc pyrithione for antimicrobial applications","volume":"13","author":"Kumari","year":"2021","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.jhazmat.2023.132575_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2020.105503","article-title":"Tributyltin impaired spermatogenesis and reproductive behavior in male zebra\ufb01sh","volume":"224","author":"Lan","year":"2020","journal-title":"Aquat Toxicol"},{"issue":"1","key":"10.1016\/j.jhazmat.2023.132575_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-12522-w","article-title":"Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility","volume":"10","author":"Lee","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.jhazmat.2023.132575_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106472","article-title":"Developmental exposure to chlordecone induces transgenerational effects in somatic prostate tissue which are associated with epigenetic histone trimethylation changes","volume":"152","author":"Legoff","year":"2021","journal-title":"Environ Int"},{"key":"10.1016\/j.jhazmat.2023.132575_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.106307","article-title":"BDE-209 and DBDPE induce male reproductive toxicity through telomere-related cell senescence and apoptosis in SD rat","volume":"146","author":"Li","year":"2021","journal-title":"Environ Int"},{"key":"10.1016\/j.jhazmat.2023.132575_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128178","article-title":"Interleukin 17A deficiency alleviates fluoride-induced testicular injury by inhibiting the immune response and apoptosis","volume":"263","author":"Li","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2023.132575_bib44","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.envpol.2017.12.099","article-title":"TERT regulates telomere-related senescence and apoptosis through DNA damage response in male germ cells exposed to BPDE in vitro and to B[a]P in vivo","volume":"235","author":"Ling","year":"2018","journal-title":"Environ Pollut"},{"key":"10.1016\/j.jhazmat.2023.132575_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2022.134726","article-title":"Triphenyltin disrupts the testicular microenvironment and reduces sperm quality in adult male rats","volume":"301","author":"Lu","year":"2022","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2023.132575_bib46","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.aquatox.2016.05.029","article-title":"Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17\u03b1-ethinylestradiol and fadrozole exposures","volume":"177","author":"Luzio","year":"2016","journal-title":"Aquat Toxicol"},{"issue":"5","key":"10.1016\/j.jhazmat.2023.132575_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2021.106442","article-title":"Amikacin in combination with zinc pyrithione prevents growth of a carbapenem-resistant\/multidrug-resistant Klebsiella pneumoniae isolate","volume":"58","author":"Magallon","year":"2021","journal-title":"Int J Antimicrob Agents"},{"issue":"18","key":"10.1016\/j.jhazmat.2023.132575_bib48","doi-asserted-by":"crossref","first-page":"9730","DOI":"10.3390\/ijms22189730","article-title":"Targeted delivery of zinc pyrithione to skin epithelia","volume":"22","author":"Mangion","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.jhazmat.2023.132575_bib49","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10495-005-0811-9","article-title":"Zinc pyrithione induces apoptosis and increases expression of Bim","volume":"10","author":"Mann","year":"2005","journal-title":"Apoptosis"},{"issue":"9\u201310","key":"10.1016\/j.jhazmat.2023.132575_bib50","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.marpolbul.2003.11.013","article-title":"Indirect estimation of degradation time for zinc pyrithione and copper pyrithione in seawater","volume":"48","author":"Maraldo","year":"2004","journal-title":"Mar Pollut Bull"},{"issue":"1\u20132","key":"10.1016\/j.jhazmat.2023.132575_bib51","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.aquatox.2010.12.015","article-title":"Novel antifouling agent-zinc pyrithione: stress induction and genotoxicity to the marine mussel Mytilus galloprovincialis","volume":"102","author":"Marcheselli","year":"2011","journal-title":"Aquat Toxicol"},{"issue":"4","key":"10.1016\/j.jhazmat.2023.132575_bib52","doi-asserted-by":"crossref","first-page":"a008656","DOI":"10.1101\/cshperspect.a008656","article-title":"Caspase functions in cell death and disease","volume":"5","author":"McIlwain","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.jhazmat.2023.132575_bib53","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.fsi.2019.06.048","article-title":"Waterborne zinc pyrithione modulates immunity, biochemical, and antioxidant parameters in the blood of olive flounder","volume":"92","author":"Min","year":"2019","journal-title":"Fish Shellfish Immunol"},{"issue":"1","key":"10.1016\/j.jhazmat.2023.132575_bib54","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jri.2005.11.002","article-title":"Spermatogenic cells distal to the blood\u2013testis barrier in rats lack C3 convertase regulators and may be at risk of complement-mediated injury","volume":"69","author":"Mizuno","year":"2006","journal-title":"J Reprod Immunol"},{"key":"10.1016\/j.jhazmat.2023.132575_bib55","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ecoenv.2018.06.026","article-title":"Apoptosis in HepG2 cells induced by zinc pyrithione via mitochondrial dysfunction pathway: involvement of zinc accumulation and oxidative stress","volume":"161","author":"Mo","year":"2018","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.jhazmat.2023.132575_bib56","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s12562-010-0221-y","article-title":"Effect of tributyltin oxide exposure on the F 0 and F 1 generations of a marine teleost, the mummichog Fundulus heteroclitus","volume":"76","author":"Mochida","year":"2010","journal-title":"Fish Sci"},{"key":"10.1016\/j.jhazmat.2023.132575_bib57","first-page":"57","article-title":"Genes differentially expressed in testis of a marine fish, the mummichog (Fundulus heteroclitus) after exposure to tributyltin oxide","volume":"32","author":"Mochida","year":"2008","journal-title":"Coast Mar Sci"},{"key":"10.1016\/j.jhazmat.2023.132575_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152528","article-title":"Tert-butylhydroquinone preserve testicular steroidogenesis and spermatogenesis in cisplatin-intoxicated rats by targeting oxidative stress, inflammation and apoptosis","volume":"441","author":"Nna","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/j.jhazmat.2023.132575_bib59","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.aquatox.2018.08.021","article-title":"Effects of zinc pyrithione on biochemical parameters of the freshwater Asian clam Corbicula fluminea","volume":"204","author":"Nogueira","year":"2018","journal-title":"Aquat Toxicol"},{"issue":"9","key":"10.1016\/j.jhazmat.2023.132575_bib60","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1007\/s10646-015-1525-6","article-title":"Ecotoxicological effect of zinc pyrithione in the freshwater fish Gambusia holbrooki","volume":"24","author":"Nunes","year":"2015","journal-title":"Ecotoxicology"},{"issue":"11","key":"10.1016\/j.jhazmat.2023.132575_bib61","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.chemosphere.2012.01.052","article-title":"Nanomolar concentrations of zinc pyrithione increase cell susceptibility to oxidative stress induced by hydrogen peroxide in rat thymocytes","volume":"87","author":"Oyama","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2023.132575_bib62","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1007\/s10495-006-0039-3","article-title":"Insights into male germ cell apoptosis due to depletion of gonadotropins caused by GnRH antagonists","volume":"12","author":"Pareek","year":"2007","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.jhazmat.2023.132575_bib63","first-page":"1","article-title":"Understanding the mechanism of action of the anti-dandruff agent zinc pyrithione against Malassezia restricta","volume":"8","author":"Park","year":"2018","journal-title":"Sci Rep."},{"issue":"s2","key":"10.1016\/j.jhazmat.2023.132575_bib64","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1365-2133.2011.10571.x","article-title":"The antifungal mechanism of action of zinc pyrithione","volume":"165","author":"Reeder","year":"2011","journal-title":"Br J Dermatol"},{"issue":"1","key":"10.1016\/j.jhazmat.2023.132575_bib65","doi-asserted-by":"crossref","DOI":"10.1111\/and.13581","article-title":"Oxidative stress in the pathophysiology of male infertility","volume":"53","author":"Ritchie","year":"2021","journal-title":"Andrologia"},{"issue":"4","key":"10.1016\/j.jhazmat.2023.132575_bib66","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22996","article-title":"Studies on male gonadal toxicity of bisphenol A in diabetic rats: an example of exacerbation effect","volume":"36","author":"Sahu","year":"2022","journal-title":"J Biochem Mol Toxicol"},{"issue":"1\u20132","key":"10.1016\/j.jhazmat.2023.132575_bib67","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jri.2005.06.003","article-title":"Bacterial infection and semen quality","volume":"67","author":"Sanocka-Maciejewska","year":"2005","journal-title":"J Reprod Immunol"},{"issue":"2","key":"10.1016\/j.jhazmat.2023.132575_bib68","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1439-0272.2008.00837.x","article-title":"Chronic orchitis: a neglected cause of male infertility?","volume":"40","author":"Schuppe","year":"2008","journal-title":"Andrologia"},{"issue":"2","key":"10.1016\/j.jhazmat.2023.132575_bib69","first-page":"140","article-title":"Zinc pyrithione: a topical antimicrobial with complex pharmaceutics","volume":"15","author":"Schwartz","year":"2016","journal-title":"J Drugs Dermatol"},{"issue":"2","key":"10.1016\/j.jhazmat.2023.132575_bib70","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.fsi.2012.05.016","article-title":"Expression of complement component C7 and involvement in innate immune responses to bacteria in grass carp","volume":"33","author":"Shen","year":"2012","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.jhazmat.2023.132575_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103402","article-title":"Standard and biochemical toxicological effects of zinc pyrithione in Daphnia magna and Daphnia longispina","volume":"80","author":"Sousa","year":"2020","journal-title":"Environ Toxicol Pharmacol"},{"issue":"6","key":"10.1016\/j.jhazmat.2023.132575_bib72","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.apjr.2016.10.008","article-title":"Mitochondrion: features, functions and comparative analysis of specific probes in detecting sperm cell damages","volume":"5","author":"Srivastava","year":"2016","journal-title":"Asian Pac J Reprod"},{"issue":"2","key":"10.1016\/j.jhazmat.2023.132575_bib73","first-page":"187","article-title":"Devicyprin induced gonadal impairment in a freshwater food fish, Channa punctatus (Bloch)","volume":"29","author":"Srivastava","year":"2008","journal-title":"J Environ Biol"},{"issue":"2","key":"10.1016\/j.jhazmat.2023.132575_bib74","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.virol.2010.12.045","article-title":"Complement and viral pathogenesis","volume":"411","author":"Stoermer","year":"2011","journal-title":"Virology"},{"issue":"21","key":"10.1016\/j.jhazmat.2023.132575_bib75","doi-asserted-by":"crossref","DOI":"10.1242\/dev.199836","article-title":"Zinc is an intracellular signal during sperm activation in Caenorhabditis elegans","volume":"148","author":"Tan","year":"2021","journal-title":"Development"},{"issue":"1\u20133","key":"10.1016\/j.jhazmat.2023.132575_bib76","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/08927010009386308","article-title":"Pyrithiones as antifoulants: environmental chemistry and preliminary risk assessment","volume":"15","author":"Turley","year":"2000","journal-title":"Biofouling"},{"issue":"1","key":"10.1016\/j.jhazmat.2023.132575_bib77","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/08927010500044351","article-title":"Pyrithiones as antifoulants: environmental fate and loss of toxicity","volume":"21","author":"Turley","year":"2005","journal-title":"Biofouling"},{"key":"10.1016\/j.jhazmat.2023.132575_bib78","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mito.2017.01.001","article-title":"Mitochondria in teleost spermatozoa","volume":"34","author":"Ulloa-Rodriguez","year":"2017","journal-title":"Mitochondrion"},{"issue":"6","key":"10.1016\/j.jhazmat.2023.132575_bib79","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1600-0897.2007.00530.x","article-title":"Effects of isomeric fatty acids on reproductive parameters in mice","volume":"58","author":"Veaute","year":"2007","journal-title":"Am J Reprod Immunol"},{"key":"10.1016\/j.jhazmat.2023.132575_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124316","article-title":"Multiple transcriptomic profiling: p53 signaling pathway is involved in DEHP-induced prepubertal testicular injury via promoting cell apoptosis and inhibiting cell proliferation of Leydig cells","volume":"406","author":"Wang","year":"2021","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jhazmat.2023.132575_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113393","article-title":"Zinc pyrithione exposure compromises oocyte maturation through involving in spindle assembly and zinc accumulation","volume":"234","author":"Wang","year":"2022","journal-title":"Ecotoxicol Environ Saf"},{"issue":"Pt 1","key":"10.1016\/j.jhazmat.2023.132575_bib82","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1042\/bj3600039","article-title":"Characterization of zebrafish caspase-3 and induction of apoptosis through ceramide generation in fish fathead minnow tailbud cells and zebrafish embryo","volume":"360","author":"Yabu","year":"2001","journal-title":"Biochem J"},{"key":"10.1016\/j.jhazmat.2023.132575_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2019.104984","article-title":"Zinc pyrithione induces immobilization of human spermatozoa and suppresses the response of the cAMP\/PKA signaling pathway","volume":"137","author":"Yang","year":"2019","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.jhazmat.2023.132575_bib84","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.aquatox.2017.02.013","article-title":"Diethylstilbestrol, flutamide and their combination impaired the spermatogenesis of male adult zebrafish through disrupting HPG axis, meiosis and apoptosis","volume":"185","author":"Yin","year":"2017","journal-title":"Aquat Toxicol"},{"issue":"3","key":"10.1016\/j.jhazmat.2023.132575_bib85","doi-asserted-by":"crossref","first-page":"124","DOI":"10.15586\/aei.v51i3.854","article-title":"TFAP2C exacerbates psoriasis-like inflammation by promoting Th17 and Th1 cells activation through regulating TEAD4 transcription","volume":"51","author":"Zhang","year":"2023","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.jhazmat.2023.132575_bib86","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/190945","article-title":"Leptin level and oxidative stress contribute to obesity-induced low testosterone in murine testicular tissue","volume":"2014","author":"Zhao","year":"2014","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.jhazmat.2023.132575_bib87","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.chemosphere.2018.04.010","article-title":"Acute toxic responses of embryo-larval zebrafish to zinc pyrithione (ZPT) reveal embryological and developmental toxicity","volume":"205","author":"Zhao","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2023.132575_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127177","article-title":"Gender-differentiated metabolic abnormalities of adult zebrafish with zinc pyrithione (ZPT)-induced hepatotoxicity","volume":"257","author":"Zhao","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2023.132575_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2022.106195","article-title":"Zinc pyrithione (ZPT)-induced embryonic toxicogenomic responses reveal involvement of oxidative damage, apoptosis, endoplasmic reticulum (ER) stress and autophagy","volume":"248","author":"Zhao","year":"2022","journal-title":"Aquat Toxicol"}],"container-title":["Journal of Hazardous Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304389423018587?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304389423018587?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T19:32:53Z","timestamp":1759606373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304389423018587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":89,"alternative-id":["S0304389423018587"],"URL":"https:\/\/doi.org\/10.1016\/j.jhazmat.2023.132575","relation":{},"ISSN":["0304-3894"],"issn-type":[{"value":"0304-3894","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toxic effects and potential mechanisms of zinc pyrithione (ZPT) exposure on sperm and testicular injury in zebrafish","name":"articletitle","label":"Article Title"},{"value":"Journal of Hazardous Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhazmat.2023.132575","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"132575"}}