{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:07:58Z","timestamp":1793732878713,"version":"4.6.1"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32373130"],"award-info":[{"award-number":["32373130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Hazardous Materials"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.jhazmat.2026.141069","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:11:34Z","timestamp":1767744694000},"page":"141069","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Molecular and histopathological mechanisms underlying pesticide-induced disruption of the hypothalamic\u2013pituitary\u2013gonadal axis in Japanese medaka"],"prefix":"10.1016","volume":"503","author":[{"given":"Muhammad","family":"Jawad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Nasir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jhazmat.2026.141069_bib1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3390\/insects6010152","article-title":"Integrated pest management for sustainable intensification of agriculture in Asia and Africa","volume":"6","author":"Pretty","year":"2015","journal-title":"Insects"},{"issue":"1","key":"10.1016\/j.jhazmat.2026.141069_bib2","first-page":"1","article-title":"Impact of pesticides use in agriculture: their benefits and hazards","volume":"2","author":"Aktar","year":"2009","journal-title":"Inter Toxicol"},{"issue":"2","key":"10.1016\/j.jhazmat.2026.141069_bib3","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/fes3.108","article-title":"Pesticides, environment, and food safety","volume":"6","author":"Carvalho","year":"2017","journal-title":"Food Energy Secur"},{"issue":"6","key":"10.1016\/j.jhazmat.2026.141069_bib4","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.3390\/ijerph8062265","article-title":"Effect of endocrine disruptor pesticides: a review","volume":"8","author":"Mnif","year":"2011","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.jhazmat.2026.141069_bib5","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.scitotenv.2018.10.441","article-title":"Pesticide residues in European agricultural soils - A hidden reality unfolded","volume":"653","author":"Silva","year":"2019","journal-title":"Sci Total Environ"},{"issue":"3","key":"10.1016\/j.jhazmat.2026.141069_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/toxics9030042","article-title":"Heavy metals and pesticides toxicity in agricultural soil and plants: ecological risks and human health implications","volume":"9","author":"Alengebawy","year":"2021","journal-title":"Toxics"},{"key":"10.1016\/j.jhazmat.2026.141069_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2022.120308","article-title":"Dietary exposure to environmentally relevant pesticide mixtures impairs swimming performance and lipid homeostatic gene expression in Juvenile Chinook salmon at elevated water temperatures","volume":"314","author":"Fuller","year":"2022","journal-title":"Environ Pollut"},{"issue":"Pt 3","key":"10.1016\/j.jhazmat.2026.141069_bib8","article-title":"Surface water contamination from pesticide mixtures and risks to aquatic life in a high-input agricultural region of Brazil","volume":"308","author":"Monticelli Barizon","year":"2022","journal-title":"Chemosphere"},{"issue":"2","key":"10.1016\/j.jhazmat.2026.141069_bib9","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/03601230601123292","article-title":"The effects of fenvalerate on different tissues of freshwater fish Cirrhinus mrigala","volume":"42","author":"Velmurugan","year":"2007","journal-title":"J Environ Sci Health B"},{"issue":"4","key":"10.1016\/j.jhazmat.2026.141069_bib10","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1897\/03-652.1","article-title":"Analyzing effects of pesticides on invertebrate communities in streams","volume":"24","author":"Liess","year":"2005","journal-title":"Environ Toxicol Chem"},{"issue":"12","key":"10.1016\/j.jhazmat.2026.141069_bib11","doi-asserted-by":"crossref","first-page":"14498","DOI":"10.1007\/s11356-020-11651-w","article-title":"Effects of fenvalerate concentrations and its chiral isomers on bacterial community structure in the sediment environment of aquaculture ponds","volume":"28","author":"Song","year":"2021","journal-title":"Environ Sci Pollut Res Int"},{"issue":"7","key":"10.1016\/j.jhazmat.2026.141069_bib12","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S1001-0742(09)60227-8","article-title":"Photodegradation mechanism of deltamethrin and fenvalerate","volume":"22","author":"Liu","year":"2010","journal-title":"J Environ Sci"},{"key":"10.1016\/j.jhazmat.2026.141069_bib13","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.chemosphere.2017.10.115","article-title":"Pyrethroid pesticide residues in the global environment: an overview","volume":"191","author":"Tang","year":"2018","journal-title":"Chemosphere"},{"issue":"5","key":"10.1016\/j.jhazmat.2026.141069_bib14","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s11356-008-0018-z","article-title":"The zebrafish embryo model in environmental risk assessment--applications beyond acute toxicity testing","volume":"15","author":"Scholz","year":"2008","journal-title":"Environ Sci Pollut Res Int"},{"issue":"3","key":"10.1016\/j.jhazmat.2026.141069_bib15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.toxlet.2010.05.021","article-title":"Exposure to fenvalerate causes brain impairment during zebrafish development","volume":"197","author":"Gu","year":"2010","journal-title":"Toxicol Lett"},{"issue":"10","key":"10.1016\/j.jhazmat.2026.141069_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205403","article-title":"Maternal fenvalerate exposure during pregnancy impairs growth and neurobehavioral development in mouse offspring","volume":"13","author":"Liu","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.jhazmat.2026.141069_bib17","doi-asserted-by":"crossref","DOI":"10.3389\/fenvs.2022.975634","article-title":"Exposure to fenvalerate and tebuconazole exhibits combined acute toxicity in zebrafish and behavioral abnormalities in larvae","volume":"10","author":"Yao","year":"2022","journal-title":"Front Environ Sci"},{"issue":"7","key":"10.1016\/j.jhazmat.2026.141069_bib18","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/tox.22563","article-title":"Synergistic potential of fenvalerate and triadimefon on endocrine disruption and oxidative stress during rare minnow embryo development","volume":"33","author":"Wu","year":"2018","journal-title":"Environ Toxicol"},{"issue":"23-24","key":"10.1016\/j.jhazmat.2026.141069_bib19","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1080\/15287394.2017.1384167","article-title":"Mechanisms underlying melatonin-mediated prevention of fenvalerate-induced behavioral and oxidative toxicity in zebrafish","volume":"80","author":"Han","year":"2017","journal-title":"J Toxicol Environ Health A"},{"issue":"19","key":"10.1016\/j.jhazmat.2026.141069_bib20","doi-asserted-by":"crossref","first-page":"7193","DOI":"10.1021\/es8009309","article-title":"Azole fungicides: occurrence and fate in wastewater and surface waters","volume":"42","author":"Kahle","year":"2008","journal-title":"Environ Sci Technol"},{"issue":"3","key":"10.1016\/j.jhazmat.2026.141069_bib21","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.envpol.2009.10.014","article-title":"Assessing pesticide concentrations and fluxes in the stream of a small vineyard catchment--effect of sampling frequency","volume":"158","author":"Rabiet","year":"2010","journal-title":"Environ Pollut"},{"issue":"3","key":"10.1016\/j.jhazmat.2026.141069_bib22","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s00216-006-1004-2","article-title":"Selective solid-phase extraction of tebuconazole in biological and environmental samples using molecularly imprinted polymers","volume":"387","author":"Hu","year":"2007","journal-title":"Anal Bioanal Chem"},{"issue":"5","key":"10.1016\/j.jhazmat.2026.141069_bib23","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.chemosphere.2013.04.001","article-title":"Assessment of cytogenetic damage in bovine peripheral lymphocytes exposed to in vitro tebuconazole-based fungicide","volume":"92","author":"\u0160ivikov\u00e1","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.jhazmat.2026.141069_bib24","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.envpol.2019.03.067","article-title":"Endocrine disrupting effects of tebuconazole on different life stages of zebrafish (Danio rerio)","volume":"249","author":"Li","year":"2019","journal-title":"Environ Pollut"},{"key":"10.1016\/j.jhazmat.2026.141069_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.132182","article-title":"Phthalates (PAEs) and reproductive toxicity: hypothalamic-pituitary-gonadal (HPG) axis aspects","volume":"459","author":"Zhang","year":"2023","journal-title":"J Hazard Mater"},{"issue":"3","key":"10.1016\/j.jhazmat.2026.141069_bib26","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.yfrne.2010.04.002","article-title":"GnRH signaling, the gonadotrope and endocrine control of fertility","volume":"31","author":"Bliss","year":"2010","journal-title":"Front Neuroendocr"},{"key":"10.1016\/j.jhazmat.2026.141069_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.110877","article-title":"Mathematical modeling approaches of cellular endocrinology within the hypothalamo-pituitary-gonadal axis","volume":"518","author":"Cl\u00e9ment","year":"2020","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"10.1016\/j.jhazmat.2026.141069_bib28","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3109\/09513590.2014.959917","article-title":"Common features and differences of the hypothalamic-pituitary-gonadal axis in male and female","volume":"31","author":"Dagklis","year":"2015","journal-title":"Gynecol Endocrinol"},{"issue":"Pt B","key":"10.1016\/j.jhazmat.2026.141069_bib29","article-title":"Polystyrene microplastics cause tissue damages, sex-specific reproductive disruption and transgenerational effects in marine medaka (Oryzias melastigma)","volume":"254","author":"Wang","year":"2019","journal-title":"Environ Pollut"},{"key":"10.1016\/j.jhazmat.2026.141069_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.153043","article-title":"Adverse effects of antiepileptic drugs on hormones of the hypothalamic-pituitary-gonadal axis in males: a review","volume":"465","author":"Atli Eklioglu","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.jhazmat.2026.141069_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.114634","article-title":"Exposure to bisphenol A alternatives bisphenol AF and fluorene-9-bisphenol induces gonadal injuries in male zebrafish","volume":"253","author":"Meng","year":"2023","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.jhazmat.2026.141069_bib32","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.marenvres.2017.04.006","article-title":"Detection of endocrine disrupting chemicals and evidence of their effects on the HPG axis of the European anchovy Engraulis encrasicolus","volume":"127","author":"Miccoli","year":"2017","journal-title":"Mar Environ Res"},{"key":"10.1016\/j.jhazmat.2026.141069_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122795","article-title":"Individual and combined toxicogenetic effects of microplastics and heavy metals (Cd, Pb, and Zn) perturb gut microbiota homeostasis and gonadal development in marine medaka (Oryzias melastigma)","volume":"397","author":"Yan","year":"2020","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jhazmat.2026.141069_bib34","article-title":"Pyrethroids toxicity to male reproductive system and offspring as a function of oxidative stress induction: rodent studies","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.jhazmat.2026.141069_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2025.140295","article-title":"Microbial dysbiosis and hepatic inflammation under combined pesticide exposure: Insights into gut\u2013liver axis disruption in Japanese medaka","volume":"499","author":"Jawad","year":"2025","journal-title":"J Hazard Mater"},{"key":"10.1016\/j.jhazmat.2026.141069_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.161838","article-title":"Chronic nanoplastic exposure induced oxidative and immune stress in medaka gonad","volume":"869","author":"Zhou","year":"2023","journal-title":"Sci Total Environ"},{"key":"10.1016\/j.jhazmat.2026.141069_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2023.106422","article-title":"Low particle concentrations of nanoplastics impair the gut health of medaka","volume":"256","author":"Zhou","year":"2023","journal-title":"Aquat Toxicol"},{"issue":"1","key":"10.1016\/j.jhazmat.2026.141069_bib38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nrg704","article-title":"Medaka--a model organism from the far East","volume":"3","author":"Wittbrodt","year":"2002","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.jhazmat.2026.141069_bib39","article-title":"Deficiency of interleukin-17 receptor A1 induces microbiota disruption in the intestine of Japanese medaka, Oryzias latipes","volume":"40","author":"Okamura","year":"2021","journal-title":"Comparative Biochem Physiol Part D Genom Proteomics"},{"key":"10.1016\/j.jhazmat.2026.141069_bib40","first-page":"2","article-title":"Fish, Acute Toxicity Test. OECD guidelines for the testing of chemicals","volume":"203","author":"OECD","year":"1992","journal-title":"Section"},{"key":"10.1016\/j.jhazmat.2026.141069_bib41","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.chemosphere.2017.04.029","article-title":"Tebuconazole alters morphological, behavioral and neurochemical parameters in larvae and adult zebrafish (Danio rerio)","volume":"180","author":"Altenhofen","year":"2017","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.jhazmat.2026.141069_bib42","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bbrc.2012.08.016","article-title":"Reprint of \u201cGlutathione peroxidase activity in selenium-deficient rat liver","volume":"425","author":"Lawrence","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"issue":"22","key":"10.1016\/j.jhazmat.2026.141069_bib43","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1016\/S0021-9258(18)63504-5","article-title":"Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)","volume":"244","author":"McCord","year":"1969","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhazmat.2026.141069_bib44","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Methods Enzym"},{"issue":"2-3","key":"10.1016\/j.jhazmat.2026.141069_bib45","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0009-8981(91)90067-M","article-title":"A simple method for determination of serum catalase activity and revision of reference range","volume":"196","author":"G\u00f3th","year":"1991","journal-title":"Clin Chim Acta"},{"issue":"9","key":"10.1016\/j.jhazmat.2026.141069_bib46","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/elps.200305844","article-title":"Blue silver: a very sensitive colloidal Coomassie G-250 staining for proteome analysis","volume":"25","author":"Candiano","year":"2004","journal-title":"Electrophoresis"},{"issue":"6","key":"10.1016\/j.jhazmat.2026.141069_bib47","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1002\/etc.5620210629","article-title":"Integrated biomarker response: a useful tool for ecological risk assessment","volume":"21","author":"Beliaeff","year":"2002","journal-title":"Environ Toxicol Chem"},{"issue":"5","key":"10.1016\/j.jhazmat.2026.141069_bib48","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1007\/s11356-012-1359-1","article-title":"A novel \"Integrated Biomarker Response\" calculation based on reference deviation concept","volume":"20","author":"Sanchez","year":"2013","journal-title":"Environ Sci Pollut Res Int"},{"issue":"3","key":"10.1016\/j.jhazmat.2026.141069_bib49","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1289\/ehp.0800096","article-title":"The synergistic toxicity of pesticide mixtures: implications for risk assessment and the conservation of endangered Pacific salmon","volume":"117","author":"Laetz","year":"2009","journal-title":"Environ Health Perspect"},{"issue":"9","key":"10.1016\/j.jhazmat.2026.141069_bib50","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1007\/s00204-011-0654-9","article-title":"Fenvalerate induces germ cell apoptosis in mouse testes through the Fas\/FasL signaling pathway","volume":"85","author":"Zhao","year":"2011","journal-title":"Arch Toxicol"},{"issue":"1","key":"10.1016\/j.jhazmat.2026.141069_bib51","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.toxlet.2009.08.007","article-title":"Lactational fenvalerate exposure permanently impairs testicular development and spermatogenesis in mice","volume":"191","author":"Zhang","year":"2009","journal-title":"Toxicol Lett"},{"issue":"2","key":"10.1016\/j.jhazmat.2026.141069_bib52","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/toxsci\/62.2.339","article-title":"The effects of perinatal tebuconazole exposure on adult neurological, immunological, and reproductive function in rats","volume":"62","author":"Moser","year":"2001","journal-title":"Toxicol Sci"},{"issue":"2","key":"10.1016\/j.jhazmat.2026.141069_bib53","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12562-015-0957-5","article-title":"Vitellogenesis and choriogenesis in fishes","volume":"82","author":"Hara","year":"2016","journal-title":"Fish Sci"},{"key":"10.1016\/j.jhazmat.2026.141069_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.820241","article-title":"Sex specific transcriptional regulation of gonadal steroidogenesis in teleost fishes","volume":"13","author":"Sharma","year":"2022","journal-title":"Front Endocrinol"},{"issue":"2","key":"10.1016\/j.jhazmat.2026.141069_bib55","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1210\/endo.142.2.7928","article-title":"Distinct cytochrome P450 aromatase isoforms in zebrafish (Danio rerio) brain and ovary are differentially programmed and estrogen regulated during early development","volume":"142","author":"Kishida","year":"2001","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/j.jhazmat.2026.141069_bib56","doi-asserted-by":"crossref","first-page":"5060","DOI":"10.1210\/en.2006-1400","article-title":"Expression, structure, function, and evolution of gonadotropin-releasing hormone (GnRH) receptors GnRH-R1SHS and GnRH-R2PEY in the teleost, Astatotilapia burtoni","volume":"148","author":"Flanagan","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.jhazmat.2026.141069_bib57","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jhazmat.2014.02.013","article-title":"Persistent endocrine disruption effects in medaka fish with early life-stage exposure to a triazole-containing aromatase inhibitor (letrozole)","volume":"277","author":"Liao","year":"2014","journal-title":"J Hazard Mater"},{"issue":"5","key":"10.1016\/j.jhazmat.2026.141069_bib58","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3390\/fishes10050223","article-title":"Assessing the Effects of Pesticides on Aquacultured Fish and Ecosystems: A Comprehensive Environmental Health Review","volume":"10","author":"Burch","year":"2025","journal-title":"Fishes"},{"key":"10.1016\/j.jhazmat.2026.141069_bib59","article-title":"Pyrethroids toxicity to male reproductive system and offspring as a function of oxidative stress induction: rodent studies","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Endocrinol"},{"issue":"5","key":"10.1016\/j.jhazmat.2026.141069_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph20053928","article-title":"Molecular Mechanisms of Tebuconazole Affecting the Social Behavior and Reproduction of Zebrafish","volume":"20","author":"Yan","year":"2023","journal-title":"Int J Environ Res Public Health"},{"issue":"12","key":"10.1016\/j.jhazmat.2026.141069_bib61","doi-asserted-by":"crossref","DOI":"10.3390\/toxics11121003","article-title":"The Developmental Toxicity and Endocrine-Disrupting Effects of Fenpropathrin on Gobiocypris rarus during the Early Life Stage","volume":"11","author":"Wang","year":"2023","journal-title":"Toxics"},{"issue":"11","key":"10.1016\/j.jhazmat.2026.141069_bib62","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1191\/0960327102ht298oa","article-title":"Steroidogenic alterations in testes and sera of rats exposed to formulated fenvalerate by inhalation","volume":"21","author":"Mani","year":"2002","journal-title":"Hum Exp Toxicol"},{"issue":"2","key":"10.1016\/j.jhazmat.2026.141069_bib63","first-page":"133","article-title":"Effects of fenvalerate exposure during puberty on oxidative stress in male rat testis","volume":"38","author":"Jing-jing","year":"2018","journal-title":"Journal Shanghai Jiaotong University (Medical Science)"},{"key":"10.1016\/j.jhazmat.2026.141069_bib64","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.fct.2017.01.011","article-title":"Effects of six priority controlled phthalate esters with long-term low-dose integrated exposure on male reproductive toxicity in rats","volume":"101","author":"Gao","year":"2017","journal-title":"Food Chem Toxicol"},{"issue":"8","key":"10.1016\/j.jhazmat.2026.141069_bib65","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1002\/tox.22575","article-title":"Effects of tebuconazole on cytochrome P450 enzymes, oxidative stress, and endocrine disruption in male rats","volume":"33","author":"Yang","year":"2018","journal-title":"Environ Toxicol"},{"issue":"13","key":"10.1016\/j.jhazmat.2026.141069_bib66","doi-asserted-by":"crossref","first-page":"7050","DOI":"10.3390\/ijms25137050","article-title":"Tebuconazole Induces Mouse Fetal Testes Damage via ROS Generation in an Organ Culture Method","volume":"25","author":"Lee","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.jhazmat.2026.141069_bib67","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/etc.5581","article-title":"AOP Report: Adverse Outcome Pathways for Aromatase Inhibition or Androgen Receptor Agonism Leading to Male-Biased Sex Ratio and Population Decline in Fish","volume":"42","author":"Ankley","year":"2023","journal-title":"Environ Toxicol Chem"},{"key":"10.1016\/j.jhazmat.2026.141069_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.153412","article-title":"Endocrine disruption by azole fungicides in fish: a review of the evidence","volume":"822","author":"Huang","year":"2022","journal-title":"Sci Total Environ"},{"issue":"8","key":"10.1016\/j.jhazmat.2026.141069_bib69","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11080502","article-title":"Roles of estrogens in the healthy and diseased oviparous vertebrate liver","volume":"11","author":"Tramunt","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.jhazmat.2026.141069_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115563","article-title":"Are changes in vitellogenin concentrations in fish reliable indicators of chemical-induced endocrine activity?","volume":"266","author":"Brown","year":"2023","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.jhazmat.2026.141069_bib71","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.878286","article-title":"Oxidative stress causes masculinization of genetically female medaka without elevating cortisol","volume":"13","author":"Mukai","year":"2022","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jhazmat.2026.141069_bib72","doi-asserted-by":"crossref","first-page":"5328773","DOI":"10.1155\/anu\/5328773","article-title":"Mechanisms of pesticide toxicity in fish: insights into the ameliorative role of plant-derived compounds-a review","volume":"2025","author":"Moezzi","year":"2025","journal-title":"Aquac Nutr"},{"key":"10.1016\/j.jhazmat.2026.141069_bib73","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cotox.2017.10.004","article-title":"Oxidative stress in reproductive toxicology","volume":"7","author":"Archibong","year":"2018","journal-title":"Curr Opin Toxicol"},{"issue":"7","key":"10.1016\/j.jhazmat.2026.141069_bib74","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1007\/s11356-012-0978-x","article-title":"Immunotoxic effects of environmental toxicants in fish - how to assess them?","volume":"19","author":"Segner","year":"2011","journal-title":"Environ Sci Pollut Res Int"},{"key":"10.1016\/j.jhazmat.2026.141069_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112870","article-title":"Toxicity inhibition strategy of microplastics to aquatic organisms through molecular docking, molecular dynamics simulation and molecular modification","volume":"226","author":"Chen","year":"2021","journal-title":"Ecotoxicol Environ Saf"},{"issue":"12","key":"10.1016\/j.jhazmat.2026.141069_bib76","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1021\/jm2000689","article-title":"Structure-based design of potent aromatase inhibitors by high-throughput docking","volume":"54","author":"Caporuscio","year":"2011","journal-title":"J Med Chem"},{"issue":"8","key":"10.1016\/j.jhazmat.2026.141069_bib77","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1002\/etc.4757","article-title":"Application of biomarker tools using bivalve models toward the development of adverse outcome pathways for contaminants of emerging concern","volume":"39","author":"Khan","year":"2020","journal-title":"Environ Toxicol Chem"}],"container-title":["Journal of Hazardous Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304389426000476?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304389426000476?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:49:40Z","timestamp":1783943380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304389426000476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":77,"alternative-id":["S0304389426000476"],"URL":"https:\/\/doi.org\/10.1016\/j.jhazmat.2026.141069","relation":{},"ISSN":["0304-3894"],"issn-type":[{"value":"0304-3894","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular and histopathological mechanisms underlying pesticide-induced disruption of the hypothalamic\u2013pituitary\u2013gonadal axis in Japanese medaka","name":"articletitle","label":"Article Title"},{"value":"Journal of Hazardous Materials","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jhazmat.2026.141069","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"141069"}}