{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:25:21Z","timestamp":1776986721581,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.jhep.2004.03.010","type":"journal-article","created":{"date-parts":[[2004,4,10]],"date-time":"2004-04-10T10:51:45Z","timestamp":1081594305000},"page":"67-74","source":"Crossref","is-referenced-by-count":46,"title":["Phenprocoumon-induced liver disease ranges from mild acute hepatitis to (sub-) acute liver failure"],"prefix":"10.1016","volume":"41","author":[{"given":"Carl C.","family":"Schimanski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Burg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"M\u00f6hler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"H\u00f6hler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Kanzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerd","family":"Otto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Galle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ansgar W.","family":"Lohse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2004.03.010_BIB1","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1056\/NEJM199106273242606","article-title":"Oral anticoagulant drugs","volume":"324","author":"Hirsh","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2004.03.010_BIB2","first-page":"271","article-title":"Coumarin necrosis\u2014a review of the literature","volume":"103","author":"Cole","year":"1988","journal-title":"Surgery"},{"key":"10.1016\/j.jhep.2004.03.010_BIB3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2165\/00128071-200102020-00003","article-title":"Cutaneous reactions to anticoagulants. Recognition and management","volume":"2","author":"Harenberg","year":"2001","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.jhep.2004.03.010_BIB4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1517\/14740338.1.3.287","article-title":"Anticoagulant-related skin reactions","volume":"1","author":"Jorg","year":"2002","journal-title":"Expert Opin Drug Saf"},{"key":"10.1016\/j.jhep.2004.03.010_BIB5","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/0168-8278(90)90214-C","article-title":"Phenprocoumon-induced hepatitis mimicking non-A, non-B hepatitis","volume":"11","author":"de Man","year":"1990","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2004.03.010_BIB6","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/S0140-6736(76)92134-6","article-title":"Letter: phenprocoumon-induced jaundice","volume":"1","author":"den Boer","year":"1976","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2004.03.010_BIB7","first-page":"1529","article-title":"Phenprocoumon-induzierte nekrotisierende hepatitis","volume":"120","author":"Ehrenforth","year":"1995","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1016\/j.jhep.2004.03.010_BIB8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1055\/s-2007-996428","article-title":"Liver damage induced by coumarin anticoagulants","volume":"25","author":"Ehrenforth","year":"1999","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.jhep.2004.03.010_BIB9","first-page":"348","article-title":"Coumarin-induced hepatic necrosis","volume":"92","author":"Ghosh","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.jhep.2004.03.010_BIB10","first-page":"1477","article-title":"Syncumar induced toxic liver damage","volume":"131","author":"Gondocs","year":"1990","journal-title":"Orv Hetil"},{"key":"10.1016\/j.jhep.2004.03.010_BIB11","first-page":"413","article-title":"Thrombosed St. Jude medical prosthesis with drug induced hepatitis due to warfarin potassium\u2014a case report","volume":"42","author":"Matsukawa","year":"1994","journal-title":"Nippon Kyobu Geka Gakkai Zasshi"},{"key":"10.1016\/j.jhep.2004.03.010_BIB12","first-page":"223","article-title":"Cytolytic hepatitis related to the oral anticoagulant phenprocoumon","volume":"19","author":"Hautekeete","year":"1995","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1016\/j.jhep.2004.03.010_BIB13","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1055\/s-2008-1055506","article-title":"Phenprocoumon-induzierte cholestatische hepatitis","volume":"120","author":"Woolley","year":"1995","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1016\/j.jhep.2004.03.010_BIB14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0002-9343(97)00174-5","article-title":"Phenprocoumon-induced hepatitis delaying precise diagnosis in a thrombophilic patient with activated protein C resistance due to factor V R506Q mutation","volume":"103","author":"Wuillemin","year":"1997","journal-title":"Am J Med"},{"key":"10.1016\/j.jhep.2004.03.010_BIB15","first-page":"223","article-title":"Acute cytolytic hepatitis caused by coumarin. 2 cases","volume":"21","author":"Koch","year":"1997","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1016\/j.jhep.2004.03.010_BIB16","first-page":"1456","article-title":"Hepatotoxic reaction to warfarin in a recovering hepatitis patient with hypoalbuminenia","volume":"50","author":"Bamanikar","year":"2002","journal-title":"J Assoc Physicians India"},{"key":"10.1016\/j.jhep.2004.03.010_BIB17","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1055\/s-0037-1613920","article-title":"Phenprocoumon-induced hepatitis in a patient with a combined hereditary hemostatic disorder","volume":"83","author":"Bux-Gewehr","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jhep.2004.03.010_BIB18","first-page":"929","article-title":"Akute nekrotisierende Hepatitis: eine ungewohnliche Nebenwirkung oraler Antikoagulantien","volume":"89","author":"Capoferri","year":"2000","journal-title":"Schweiz Rundsch Med Prax"},{"key":"10.1016\/j.jhep.2004.03.010_BIB19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0015-6264(79)90289-X","article-title":"Critical review of the toxicology of coumarin with special reference to interspecies differences in metabolism and hepatotoxic response and their significance to man","volume":"17","author":"Cohen","year":"1979","journal-title":"Food Cosmet Toxicol"},{"key":"10.1016\/j.jhep.2004.03.010_BIB20","first-page":"91","article-title":"Phenprocoumon-induced liver failure","volume":"43","author":"de Man","year":"1993","journal-title":"Neth J Med"},{"key":"10.1016\/j.jhep.2004.03.010_BIB21","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1080\/003655201300192076","article-title":"Idiosyncratic drug allergic phenprocoumon-induced hepatitis with subacute liver failure initially misdiagnosed as autoimmune hepatitis","volume":"36","author":"Hinrichsen","year":"2001","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.jhep.2004.03.010_BIB22","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0168-8278(05)80326-5","article-title":"Drug-induced hepatitis: a rare complication of oral anticoagulants","volume":"21","author":"Hohler","year":"1994","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2004.03.010_BIB23","first-page":"12","article-title":"Ein Fall von Leberschadigung nach Cumarin-Medikation","volume":"62","author":"Kreiter","year":"1967","journal-title":"Med Klin"},{"key":"10.1016\/j.jhep.2004.03.010_BIB24","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1024\/0040-5930.56.9.513","article-title":"Ein Fall von Leberschadigung nach Cumarin-Medikation","volume":"56","author":"Kremer Hovinga","year":"1999","journal-title":"Ther Umsch"},{"key":"10.1016\/j.jhep.2004.03.010_BIB25","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1200\/JCO.1997.15.9.3167","article-title":"Coumarin-induced hepatotoxicity","volume":"15","author":"Loprinzi","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jhep.2004.03.010_BIB26","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1159\/000007710","article-title":"Subacute liver failure induced by phenprocoumon treatment","volume":"60","author":"Mix","year":"1999","journal-title":"Digestion"},{"key":"10.1016\/j.jhep.2004.03.010_BIB27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1159\/000070397","article-title":"Acenocoumarol is not a safe alternative for anticoagulation in phenprocoumon-induced hepatic failure. Report of two cases","volume":"67","author":"Neef","year":"2003","journal-title":"Digestion"},{"key":"10.1016\/j.jhep.2004.03.010_BIB28","first-page":"732","article-title":"Cholestatic hepatitis secondary to the use of acenocoumarin","volume":"82","author":"Quintana","year":"1997","journal-title":"Haematologica"},{"key":"10.1016\/j.jhep.2004.03.010_BIB29","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.0954-6820.1978.tb08449.x","article-title":"Intrahepatic jaundice due to warfarin therapy","volume":"204","author":"Rehnqvist","year":"1978","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.jhep.2004.03.010_BIB30","first-page":"524","article-title":"Research on the effects of long-term anticoagulant therapy on the liver","volume":"208","author":"Renschler","year":"1963","journal-title":"Dtsch Arch Klin Med"},{"key":"10.1016\/j.jhep.2004.03.010_BIB31","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1055\/s-2001-12889","article-title":"Phenprocoumon-assoziierte nekrotisierende hepatitis","volume":"126","author":"Schneider","year":"2001","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1016\/j.jhep.2004.03.010_BIB32","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1001\/archinte.1980.00330190040016","article-title":"Coumarin-associated hepatitis. Report of two cases","volume":"140","author":"Slagboom","year":"1980","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.jhep.2004.03.010_BIB33","first-page":"1172","article-title":"Toxic hepatitis induced by cardiovascular agents","volume":"43","author":"Tanaka","year":"1985","journal-title":"Nippon Rinsho"},{"key":"10.1016\/j.jhep.2004.03.010_BIB34","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1055\/s-2001-17308","article-title":"Phenprocoumon-assoziierte nekrotisierende hepatitis","volume":"126","author":"Weber","year":"2001","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1016\/j.jhep.2004.03.010_BIB35","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/pds.693","article-title":"Adverse drug events in hospitalized patients treated with cardiovascular drugs and anticoagulants","volume":"11","author":"Zaidenstein","year":"2002","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.jhep.2004.03.010_BIB36","first-page":"2109","article-title":"Leberschaden durch Coumarin-Antikoagulantien: Erfahrungen der IKS und der SANZ","volume":"126","author":"Ciorciaro","year":"1996","journal-title":"Schweiz Med Wochenschr"},{"key":"10.1016\/j.jhep.2004.03.010_BIB37","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-0676.1998.tb00129.x","article-title":"Fulminant hepatic failure associated with dicoumarol therapy","volume":"18","author":"Castedal","year":"1998","journal-title":"Liver"},{"key":"10.1016\/j.jhep.2004.03.010_BIB38","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0140-6736(00)02799-9","article-title":"Adverse drug reactions: definitions, diagnosis, and management","volume":"356","author":"Edwards","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jhep.2004.03.010_BIB39","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0168-8278(00)80127-0","article-title":"Clinical diagnostic scale: a useful tool in the evaluation of suspected hepatotoxic adverse drug reactions","volume":"33","author":"Aithal","year":"2000","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2004.03.010_BIB40","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1055\/s-2003-42161","article-title":"Phenprocoumon-induziertes Leberversagen","volume":"128","author":"Cordes","year":"2003","journal-title":"Dtsch Med Wochenschr"},{"key":"10.1016\/j.jhep.2004.03.010_BIB41","doi-asserted-by":"crossref","first-page":"106","DOI":"10.5694\/j.1326-5377.1995.tb126130.x","article-title":"Liver failure while taking coumarin","volume":"163","author":"Bassett","year":"1995","journal-title":"Med J Aust"},{"key":"10.1016\/j.jhep.2004.03.010_BIB42","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1177\/106002809302700220","article-title":"Hepatotoxicity associated with angiotensin-converting enzyme inhibitors","volume":"27","author":"Hagley","year":"1993","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jhep.2004.03.010_BIB43","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1345\/aph.1A055","article-title":"Fatal hepatotoxicity associated with enalapril","volume":"35","author":"Gonzalez de la Puente","year":"2001","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jhep.2004.03.010_BIB44","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/PL00001983","article-title":"Acute liver failure due to enalapril","volume":"25","author":"Jeserich","year":"2000","journal-title":"Herz"},{"key":"10.1016\/j.jhep.2004.03.010_BIB45","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF00561379","article-title":"Biliary excretion of phenprocoumon and metabolites","volume":"35","author":"de Vries","year":"1988","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.jhep.2004.03.010_BIB46","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/clpt.1987.154","article-title":"The effect of sulfinpyrazone on the disposition of pseudoracemic phenprocoumon in humans","volume":"42","author":"Heimark","year":"1987","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.jhep.2004.03.010_BIB47","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJM199510263331706","article-title":"Drug-induced hepatotoxicity","volume":"333","author":"Lee","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2004.03.010_BIB48","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1056\/NEJMra021844","article-title":"Drug-induced hepatotoxicity","volume":"349","author":"Lee","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jhep.2004.03.010_BIB49","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0278-6915(02)00036-4","article-title":"Studies on the disposition, metabolism and hepatotoxicity of coumarin in the rat and Syrian hamster","volume":"40","author":"Lake","year":"2002","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.jhep.2004.03.010_BIB50","doi-asserted-by":"crossref","first-page":"193","DOI":"10.5414\/CPP41193","article-title":"Safety aspects of a coumarin-troxerutin combination regarding liver function in a double-blind placebo-controlled study","volume":"41","author":"Schmeck-Lindau","year":"2003","journal-title":"Int J Clin Pharmacol"},{"key":"10.1016\/j.jhep.2004.03.010_BIB51","series-title":"Arzneiverordnungsreport 2003","author":"Schwabe","year":"2003"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827804001059?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827804001059?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T23:20:04Z","timestamp":1585696804000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827804001059"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0168827804001059"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2004.03.010","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}