{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:15:04Z","timestamp":1791288904120,"version":"4.3.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.jhep.2005.02.052","type":"journal-article","created":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T13:39:29Z","timestamp":1117633169000},"page":"499-507","source":"Crossref","is-referenced-by-count":173,"title":["Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2"],"prefix":"10.1016","volume":"43","author":[{"given":"Zehava","family":"Vadasz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofra","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gal","family":"Akiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stela","family":"Gengrinovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert M.","family":"Kagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaacov","family":"Baruch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer Ben","family":"Izhak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gera","family":"Neufeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jhep.2005.02.052_bib1","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/S0344-0338(11)80995-7","article-title":"Lysyl oxidase: mechanism, regulation and relationship to liver fibrosis","volume":"190","author":"Kagan","year":"1994","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.jhep.2005.02.052_bib2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0945-053X(98)90012-9","article-title":"Lysyl oxidase: properties, regulation and multiple functions in biology","volume":"16","author":"Smith-Mungo","year":"1998","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jhep.2005.02.052_bib3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0006-291X(83)90987-7","article-title":"Histone H1 is a substrate for lysyl oxidase and contains endogenous sodium borotritide-reducible residues","volume":"115","author":"Kagan","year":"1983","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2005.02.052_bib4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/jcb.10304","article-title":"Lysyl oxidase oxidizes basic fibroblast growth factor and inactivates its mitogenic potential","volume":"88","author":"Li","year":"2003","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jhep.2005.02.052_bib5","doi-asserted-by":"crossref","first-page":"11203","DOI":"10.1016\/S0021-9258(18)90847-1","article-title":"Influence of sequence and charge on the specificity of lysyl oxidase toward protein and synthetic peptide substrates","volume":"259","author":"Kagan","year":"1984","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2005.02.052_bib6","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1021\/bm010012s","article-title":"Lysyl oxidase-catalyzed cross-linking and insolubilization reactions of Lys-containing polypeptides and synthetic adhesive proteins","volume":"2","author":"Ohkawa","year":"2001","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.jhep.2005.02.052_bib7","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/1097-4644(20001215)79:4<576::AID-JCB60>3.0.CO;2-A","article-title":"Fully processed lysyl oxidase catalyst translocates from the extracellular space into nuclei of aortic smooth-muscle cells","volume":"79","author":"Nellaiappan","year":"2000","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jhep.2005.02.052_bib8","doi-asserted-by":"crossref","first-page":"36341","DOI":"10.1074\/jbc.M003362200","article-title":"Lysyl oxidase activates the transcription activity of human collagene III promoter. Possible involvement of Ku antigen","volume":"275","author":"Giampuzzi","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2005.02.052_bib9","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1161\/01.CIR.0000038109.84500.1E","article-title":"Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice","volume":"106","author":"Maki","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.jhep.2005.02.052_bib10","doi-asserted-by":"crossref","first-page":"14387","DOI":"10.1074\/jbc.M210144200","article-title":"Lysyl oxidase is required for vascular and diaphragmatic development in mice","volume":"278","author":"Hornstra","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2005.02.052_bib11","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1074\/jbc.270.13.7176","article-title":"A new gene with sequence and structural similarity to the gene encoding human lysyl oxidase","volume":"270","author":"Kim","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2005.02.052_bib12","doi-asserted-by":"crossref","first-page":"8157","DOI":"10.1074\/jbc.272.13.8157","article-title":"Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence","volume":"272","author":"Saito","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2005.02.052_bib13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1101\/gr.9.1.53","article-title":"Comparative sequence of human and mouse BAC clones from the mnd2 region of chromosome 2p13","volume":"9","author":"Jang","year":"1999","journal-title":"Genome Res"},{"key":"10.1016\/j.jhep.2005.02.052_bib14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0945-053X(01)00124-X","article-title":"Cloning and characterization of a human lysyl oxidase-like 3 gene (hLOXL3)","volume":"20","author":"Huang","year":"2001","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jhep.2005.02.052_bib15","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0945-053X(01)00157-3","article-title":"Cloning and characterization of a fifth human lysyl oxidase isoenzyme: the third member of the lysyl oxidase-related subfamily with four scavenger receptor cysteine-rich domains","volume":"20","author":"Maki","year":"2001","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jhep.2005.02.052_bib16","doi-asserted-by":"crossref","first-page":"12939","DOI":"10.1074\/jbc.274.18.12939","article-title":"The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues","volume":"274","author":"Jourdan-Le Saux","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2005.02.052_bib17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1042\/0264-6021:3550381","article-title":"Cloning and characterization of a fourth human lysyl oxidase isoenzyme","volume":"355","author":"Maki","year":"2001","journal-title":"Biochem J"},{"key":"10.1016\/j.jhep.2005.02.052_bib18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/geno.2001.6545","article-title":"Central nervous system, uterus, heart, and leukocyte expression of the loxl3 gene, encoding a novel lysyl oxidase-like protein","volume":"74","author":"Jourdan-Le Saux","year":"2001","journal-title":"Genomics"},{"key":"10.1016\/j.jhep.2005.02.052_bib19","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0945-053X(01)00161-5","article-title":"A novel human lysyl oxidase-like gene (LOXL4) on chromosome 10q24 has an altered scavenger receptor cysteine rich domain","volume":"20","author":"Asuncion","year":"2001","journal-title":"Matrix Biol"},{"key":"10.1016\/j.jhep.2005.02.052_bib20","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1002\/hep.1840140635","article-title":"Serum lysyl oxidase activity in chronic liver disease in comparison with serum levels of prolyl hydroxylase and laminin","volume":"14","author":"Murawaki","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.02.052_bib21","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1073\/pnas.75.6.2945","article-title":"Biochemical and immunochemical study of lysyl oxidase in experimental hepatic fibrosis in the rat","volume":"75","author":"Siegel","year":"1978","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2005.02.052_bib22","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1006\/bbrc.1994.1269","article-title":"Lysyl oxidase cDNA of myofibroblast from mouse fibrotic liver","volume":"199","author":"Jourdan-Le Saux","year":"1994","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2005.02.052_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/(SICI)1097-4644(19990201)72:2<181::AID-JCB3>3.0.CO;2-D","article-title":"Coexpression of the lysyl oxidase-like gene (LOXL) and the gene encoding type III procollagen in induced liver fibrosis","volume":"72","author":"Kim","year":"1999","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jhep.2005.02.052_bib24","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/ng1297","article-title":"Elastic fiber homeostasis requires lysyl oxidase-like 1 protein","volume":"36","author":"Liu","year":"2004","journal-title":"Nat Genet"},{"key":"10.1016\/j.jhep.2005.02.052_bib25","first-page":"1657","article-title":"Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivo","volume":"63","author":"Akiri","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2005.02.052_bib26","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1053\/j.gastro.2003.05.010","article-title":"Wilson disease","volume":"125","author":"Gitlin","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2005.02.052_bib27","first-page":"115","article-title":"Hepatic copper accumulation in patients with primary biliary cirrhosis","volume":"55","author":"Takeshima","year":"1993","journal-title":"Nagoya J Med Sci"},{"key":"10.1016\/j.jhep.2005.02.052_bib28","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1136\/jcp.38.6.653","article-title":"Hepatic copper distribution in primary biliary cirrhosis shown by the scanning proton microprobe","volume":"38","author":"Vaux","year":"1985","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.jhep.2005.02.052_bib29","series-title":"Laboratory methods in histotechnology","author":"Prophet","year":"1992"},{"key":"10.1016\/j.jhep.2005.02.052_bib30","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1006\/bbrc.2001.4958","article-title":"Neuroendocrine cells along the digestive tract express Neuropilin-2","volume":"284","author":"Cohen","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2005.02.052_bib31","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1073\/pnas.77.7.4216","article-title":"Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity","volume":"77","author":"Urlaub","year":"1980","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2005.02.052_bib32","first-page":"1594","article-title":"Selective killing of methotrexate-resistant cells carrying amplified dihydrofolate reductase genes","volume":"41","author":"Urlaub","year":"1981","journal-title":"Cancer Res"},{"key":"10.1016\/j.jhep.2005.02.052_bib33","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1021\/bi00472a016","article-title":"Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequence","volume":"29","author":"Trackman","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.jhep.2005.02.052_bib34","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1073\/pnas.71.12.4826","article-title":"Biosynthesis of collagen crosslinks: increased activity of purified lysyl oxidase with reconstituted collagen fibrils","volume":"71","author":"Siegel","year":"1974","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2005.02.052_bib35","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1021\/bi00825a004","article-title":"Cross-linking of collagen and elastin. Properties of lysyl oxidase","volume":"9","author":"Siegel","year":"1970","journal-title":"Biochemistry"},{"key":"10.1016\/j.jhep.2005.02.052_bib36","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1165\/ajrcmb\/5.3.206","article-title":"Properties and function of lysyl oxidase","volume":"5","author":"Kagan","year":"1991","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.jhep.2005.02.052_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0079-6603(01)70012-8","article-title":"Lysyl oxidases: a novel multifunctional amine oxidase family","volume":"70","author":"Csiszar","year":"2001","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"10.1016\/j.jhep.2005.02.052_bib38","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/1097-4644(20000915)78:4<550::AID-JCB4>3.0.CO;2-8","article-title":"Hydrogen peroxide-mediated, lysyl oxidase-dependent chemotaxis of vascular smooth muscle cells","volume":"78","author":"Li","year":"2000","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.jhep.2005.02.052_bib39","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1093\/jn\/129.12.2143","article-title":"Activation of chick tendon lysyl oxidase in response to dietary copper","volume":"129","author":"Rucker","year":"1999","journal-title":"J Nutr"},{"key":"10.1016\/j.jhep.2005.02.052_bib40","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1046\/j.1365-2036.2003.01813.x","article-title":"Review article: diagnosis and current therapy of Wilson's disease","volume":"19","author":"Ferenci","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jhep.2005.02.052_bib41","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1177\/153537020222600712","article-title":"Copper control as an antiangiogenic anticancer therapy: lessons from treating Wilson's disease","volume":"226","author":"Brewer","year":"2001","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.jhep.2005.02.052_bib42","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1517\/14728222.7.3.405","article-title":"Antiangiogenic therapy through copper chelation","volume":"7","author":"Sproull","year":"2003","journal-title":"Expert Opin Ther Targets"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827805003004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827805003004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T09:16:20Z","timestamp":1683105380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827805003004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0168827805003004"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2005.02.052","relation":{},"ISSN":["0168-8278"],"issn-type":[{"value":"0168-8278","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}