{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T22:51:41Z","timestamp":1763765501409},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Hepatology"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1016\/j.jhep.2005.03.024","type":"journal-article","created":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T13:39:29Z","timestamp":1117633169000},"page":"687-695","source":"Crossref","is-referenced-by-count":24,"title":["Deficient Stat3 DNA-binding is associated with high Pias3 expression and a positive anti-apoptotic balance in human end-stage alcoholic and hepatitis C cirrhosis"],"prefix":"10.1016","volume":"43","author":[{"given":"Peter","family":"St\u00e4rkel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"De Saeger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Leclercq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alastair","family":"Strain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Horsmans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"year":"1998","series-title":"Liver growth and repair","key":"10.1016\/j.jhep.2005.03.024_bib1"},{"key":"10.1016\/j.jhep.2005.03.024_bib2","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1172\/JCI19974","article-title":"Hepatoprotection via the IL-6\/Stat3 pathway","volume":"112","author":"Taub","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2005.03.024_bib3","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.hep.2003.09.034","article-title":"Transcription factors in liver development, differentiation, and regeneration","volume":"38","author":"Costa","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.03.024_bib4","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1034\/j.1600-0676.2003.00812.x","article-title":"The molecular physiology of liver regeneration following partial hepatectomy","volume":"23","author":"Mangnall","year":"2003","journal-title":"Liver Int"},{"key":"10.1016\/j.jhep.2005.03.024_bib5","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1073\/pnas.94.4.1441","article-title":"Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor","volume":"94","author":"Yamada","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2005.03.024_bib6","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.274.5291.1379","article-title":"Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice","volume":"274","author":"Cressman","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jhep.2005.03.024_bib7","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1006\/bbrc.1997.7531","article-title":"Effects of short and long term ethanol on the activation of signal transducer and activator transcription factor 3 in normal and regenerating liver","volume":"239","author":"Chen","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jhep.2005.03.024_bib8","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S0014-5793(99)01031-5","article-title":"Ethanol rapidly inhibits IL-6-activated STAT3 and C\/EBP mRNA expression in freshly isolated rat hepatocytes","volume":"457","author":"Chen","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jhep.2005.03.024_bib9","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0014-5793(02)03099-5","article-title":"Ethanol inhibits leptin-induced STAT3 activation in Huh7 cells","volume":"525","author":"Degawa-Yamauchi","year":"2002","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jhep.2005.03.024_bib10","doi-asserted-by":"crossref","unstructured":"Jaruga B, Hong F, Kim WH, Sun R, Fan S, Gao B. Chronic alcohol consumption accelerates liver injury in t cell-mediated hepatitis: alcohol dysregulation of NF-kappa B and Stat signaling pathways. Am J Physiol Gastrointest Liver Physiol 2004;287:G471\u2013G479.","DOI":"10.1152\/ajpgi.00018.2004"},{"key":"10.1016\/j.jhep.2005.03.024_bib11","doi-asserted-by":"crossref","first-page":"28562","DOI":"10.1074\/jbc.M210485200","article-title":"Hepatitis C virus core protein differently regulates the Jak-Stat signaling pathway under interleukin-6 and interferon-gamma stimuli","volume":"278","author":"Hosui","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2005.03.024_bib12","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/S0006-2952(02)01300-X","article-title":"Endoplasmic reticulum (ER) stress: hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and Stat-3","volume":"64","author":"Waris","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.jhep.2005.03.024_bib13","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1084\/jem.20012127","article-title":"Activation of Stat3 by the hepatitis C virus core protein leads to cellular transformation","volume":"196","author":"Yoshida","year":"2002","journal-title":"J Exp Med"},{"key":"10.1016\/j.jhep.2005.03.024_bib14","doi-asserted-by":"crossref","first-page":"9599","DOI":"10.1073\/pnas.171311298","article-title":"Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates Stat-3 and NF-kappa B","volume":"98","author":"Gong","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jhep.2005.03.024_bib15","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1099\/0022-1317-80-5-1179","article-title":"Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth","volume":"80","author":"Ghosh","year":"1999","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jhep.2005.03.024_bib16","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0002-9440(10)64884-5","article-title":"Insights into pathobiology of hepatitis C virus-associated cirrhosis: analysis of intrahepatic differential gene expression","volume":"160","author":"Shackel","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2005.03.024_bib17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1023\/A:1014472430976","article-title":"Apoptosis and apoptosis related proteins in chronic viral liver disease","volume":"7","author":"Papakyriakou","year":"2002","journal-title":"Apoptosis"},{"key":"10.1016\/j.jhep.2005.03.024_bib18","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/S1590-8658(01)80109-2","article-title":"Relationship between apoptosis, tumor necrosis factor, and cell proliferation in chronic cholestasis","volume":"33","author":"Floreani","year":"2001","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.jhep.2005.03.024_bib19","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1365-2893.2001.00267.x","article-title":"Imbalance between cytoproliferation and apoptosis in hepatitis C virus related chronic liver disease","volume":"8","author":"Farinati","year":"2001","journal-title":"J Viral Hepat"},{"key":"10.1016\/j.jhep.2005.03.024_bib20","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1038\/sj.cdd.4401119","article-title":"Apoptosis in hapatitis C virus infection","volume":"10","author":"Bantel","year":"2003","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jhep.2005.03.024_bib21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/viro.1996.0644","article-title":"Suppression of apoptotic cell death by hepatitis C virus core protein","volume":"226","author":"Ray","year":"1996","journal-title":"Virology"},{"key":"10.1016\/j.jhep.2005.03.024_bib22","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1053\/jhep.2003.09024","article-title":"Hepatitis C virus and liver disease: global transcriptional profile and identification of potential markers","volume":"38","author":"Smith","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.03.024_bib23","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1046\/j.0106-9543.2002.01595.x","article-title":"Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis","volume":"22","author":"Tinmouth","year":"2002","journal-title":"Liver"},{"key":"10.1016\/j.jhep.2005.03.024_bib24","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1590-8658(01)80071-2","article-title":"Bile duct cell apoptosis is a rare event in primary biliary cirrhosis","volume":"33","author":"Ballardini","year":"2001","journal-title":"Dig Liver Dis"},{"key":"10.1016\/j.jhep.2005.03.024_bib25","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1097\/01.MP.0000097367.56816.5E","article-title":"Potential role of bcl-2 and bax mRNA and protein expression in chronic hepatitis type B and C: a clinicopathologic study","volume":"16","author":"Tsamandas","year":"2003","journal-title":"Mod Pathol"},{"key":"10.1016\/j.jhep.2005.03.024_bib26","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0002-9440(10)63852-7","article-title":"Expression and DNA-binding activity of signal transducer and activator of transcription 3 in alcoholic cirrhosis compared to normal liver and primary biliary cirrhosis in humans","volume":"162","author":"Starkel","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jhep.2005.03.024_bib27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0168-8278(03)00176-4","article-title":"Retrorsine: a kinetic study of its influence on rat liver regeneration in the portal branch ligation model","volume":"39","author":"Picard","year":"2003","journal-title":"J Hepatol"},{"key":"10.1016\/j.jhep.2005.03.024_bib28","first-page":"463","article-title":"The CIS\/SOCS proteins: a family of cytokine-indcible regulators of signaling","volume":"10","author":"Gisselbrecht","year":"1999","journal-title":"Eur Cytokine Netw"},{"key":"10.1016\/j.jhep.2005.03.024_bib29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev.immunol.18.1.143","article-title":"Negative regulation of cytokine signaling pathways","volume":"18","author":"Yasukawa","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jhep.2005.03.024_bib30","first-page":"294","article-title":"Transcriptional responses to polypeptide ligands: the JAK-STAT pathway","volume":"154","author":"Schindler","year":"1995","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.jhep.2005.03.024_bib31","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1126\/science.278.5344.1803","article-title":"Specific inhibition of Stat3 signal transduction by PIAS3","volume":"278","author":"Chung","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.jhep.2005.03.024_bib32","doi-asserted-by":"crossref","first-page":"28411","DOI":"10.1074\/jbc.M202807200","article-title":"STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration","volume":"277","author":"Li","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2005.03.024_bib33","doi-asserted-by":"crossref","first-page":"11281","DOI":"10.1074\/jbc.M208470200","article-title":"Interleukin-6\/glycoprotein 130-dependent pathways are protective during liver regeneration","volume":"278","author":"Wuestefeld","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jhep.2005.03.024_bib34","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1128\/MCB.21.2.414-424.2001","article-title":"Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury","volume":"21","author":"Leu","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.jhep.2005.03.024_bib35","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1172\/JCI200317970","article-title":"Stat3 protects against Fas-induced liver injury by redox-dependent and-independent mechanisms","volume":"112","author":"Haga","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jhep.2005.03.024_bib36","first-page":"488","article-title":"IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3","volume":"17","author":"Bode","year":"2003","journal-title":"Fed Am Soc Exp Biol J"},{"key":"10.1016\/j.jhep.2005.03.024_bib37","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/S0016-5085(03)00290-7","article-title":"Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice","volume":"124","author":"Blindenbacher","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2005.03.024_bib38","doi-asserted-by":"crossref","first-page":"8469","DOI":"10.1128\/JVI.73.10.8469-8475.1999","article-title":"Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-Stat pathway","volume":"73","author":"Heim","year":"1999","journal-title":"J Virol"},{"key":"10.1016\/j.jhep.2005.03.024_bib39","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1053\/j.gastro.2003.10.076","article-title":"Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A","volume":"126","author":"Duong","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jhep.2005.03.024_bib40","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1097\/00007890-199806270-00001","article-title":"Effects of explosive brain death on cytokine activation of peripheral organs in the rat","volume":"65","author":"Takada","year":"1998","journal-title":"Transplantation"},{"key":"10.1016\/j.jhep.2005.03.024_bib41","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/sj.onc.1205016","article-title":"Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in liver: involvement of induction of Bcl-2 and Bcl-x(L) proteins","volume":"21","author":"Hong","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.jhep.2005.03.024_bib42","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/hep.20400","article-title":"Interleukin 6 alleviates hepatic steatosis and ischemia\/reperfusion injury in mice with fatty liver disease","volume":"40","author":"Hong","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jhep.2005.03.024_bib43","first-page":"1319","article-title":"Differential Pias3 expression in human malignancy","volume":"11","author":"Wang","year":"2004","journal-title":"Oncol Rep"},{"key":"10.1016\/j.jhep.2005.03.024_bib44","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0344-0338(99)80089-2","article-title":"Bcl-2 protein expression in acute and chronic hepatitis, cirrhosis and hepatocellular carcinoma","volume":"195","author":"Nakopoulou","year":"1999","journal-title":"Pathol Res Pract"},{"key":"10.1016\/j.jhep.2005.03.024_bib45","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0046-8177(00)80217-8","article-title":"Expression of Bcl-2 familial proteins is reduced in small bile duct lesions of primary biliary cirrhosis","volume":"31","author":"Iwata","year":"2000","journal-title":"Hum Pathol"},{"key":"10.1016\/j.jhep.2005.03.024_bib46","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/hep.510250505","article-title":"Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis","volume":"25","author":"Koga","year":"1997","journal-title":"Hepatology"}],"container-title":["Journal of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827805003193?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168827805003193?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T14:44:37Z","timestamp":1586270677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168827805003193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["S0168827805003193"],"URL":"https:\/\/doi.org\/10.1016\/j.jhep.2005.03.024","relation":{},"ISSN":["0168-8278"],"issn-type":[{"type":"print","value":"0168-8278"}],"subject":[],"published":{"date-parts":[[2005,10]]}}}